Zocon DT 50mg

Zocon DT 50mg (Fluconazole)

Zocon DT 50 mg is formulated for the treatment of infections caused by fungi including yeasts. It falls into the category of drugs known as triazole antifungal. The drugs of this category are useful in treating a variety of fungal infections. It is an antifungal medication that effectively works against infections in the mouth, the genital tract, the esophagus, and other areas. The medicine has Fluconazole as the active component, which prevents Candida infections in people with weak immune system caused by HIV, bone marrow transplant and cancer. The antifungal agent is quite helpful in slowing down the growth of the fungi that are responsible for causing infection.

What is Zocon DT used for?

Zocon DT is indicated for the treatment of fungal infections caused by susceptible organisms including:

• Serious systematic candidal infections
• Cryptococcal meningitis
• Oropharyngeal or esophageal candidiasis

The medicine is also used for the prevention of candidiasis in patients who have undergone bone marrow transplantation.

How does Zocon DT work?

Zocon DT works by inhibiting synthesis of fungal sterols, a necessary component of the cell membrane. It exerts its mode of action against susceptible organisms.

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What does Zocon DT contain?

Zocon DT has Fluconazole as the main ingredient, which is a good choice for treating fungal infections. Each tablet delivers 50 mg of the active component.

What are the side effects of Zocon DT?

The incidence of side effects is increased in HIV patients.

• Central nervous system disorders- dizziness, seizures, headache
• Endoskeleton issues- hypertriglyceridemia, hypokalemia
• Dermatological problems- Exfoliative skin disorders including stevens-johnson syndrome
• Gastrointestinal disorders- Abdominal discomfort, nausea, hepatotoxicity, diarrhea, vomiting
• Miscellaneous issues- Allergic reactions, including anaphylaxis

What medications interact with Zocon DT?

• Zocon DT may decrease the activity of warfarin.
• Concurrent use with rifabutin, isoniazid, and rifampin may decrease levels.
• Drugs like tacrolimus, zidovudine, theophylline, buspirone, benzodiazepines, rifabutin, nisoldipine, losartan, tricyclic antidepressants, tolbutine, and alfentanil
• Fluconazole may increase levels of tofacitinib.
• Your medicine may antagonize effects of amphotericin B. Avoid concurrent use with voriconazole.

When should Zocon DT not be used?

• Patients with hypersensitivity to Fluconazole or other azole antifungals must not use this medication.

Use the medicine cautiously in the following conditions:

• Underlying liver disease
• Renal insufficiency
• Pregnancy to avoid congenital effects
• Lactation
• Geriatrics

How should Zocon DT be used?

The antifungal medicine comes as a tablet to take once daily with or without food.

Oropharyngeal candidiasis

For adults- The initial recommended dose is 200 mg, and then may increase up to 100 mg daily for at least two weeks.

For children above 14 days- The initial recommended dose is 6 mg/kg, then 3mg/kg/day for two weeks. Discuss the dose regimen for neonates below 14 days.

Esophageal candidiasis

Adults- 200 mg is the preferred dose. The dose may increase to 100 mg once daily for at least two weeks. These patients may take dose up to 400 mg depending on the health condition.

Children above 14 days- The started recommended dose is 6 mg, then 3 to 12 mg/kg daily for at least three weeks.

Vaginal candidiasis

The recommended dose is 150 mg daily for three days then weekly for six months.

Systemic Candidiasis

For adults- 400 mg is the preferred initial dose for patients with systematic candidiasis. The dose may increase to 200 to 800 mg daily for 28 days.

For children- The recommended dose is 6 to 12 mg/kg daily for 28 days.

Cryptococcal meningitis

For adults- Administer 400 mg once daily until favorable clinical response, then the dose may increase to 200 to 800 mg once daily for at least 10 to 12 week.

The recommended dose for suppressive therapy is 200 mg once daily. 

Children- 12 mg/kg daily is the initial recommended dose and then may increase up to 6 to 12 mg/kg daily for a period of at least 10 to 12 weeks. For suppressive therapy, 6 mg/kg daily is the preferred dose.

For Prevention of Candidiasis after bone marrow transplant

Adults- The treatment may begin with the dose of 400 mg once daily and continue for one week.

Children- The suggested dose is 10 to 12 mg/kg daily. Do not take more than 600 mg daily.

For renal impaired patients- 50% of the usual dose is preferred.

When should Zocon DT not be used?

The antifungal agent is not suitable for patients who have ever developed an allergic reaction to any of the ingredients of the medication. The symptoms may include trouble breathing, itching, reddening of the skin, etc.

How long should Zocon DT be used?

Continue taking Zocon DT tablets for as long as they are prescribed to you.

Missed dose of Zocon DT

In case, you miss a dose, take it if the time to take the next dose is far enough otherwise leave that dose and take your next scheduled dose. Avoid doubling up on doses; instead just carry on with your normal dosing regimen.

How should Zocon DT be stored?

Keep the medicine out of the reach of children. Store it at room temperature. Avoid storing it in the bathroom or kitchen to keep them away from heat and moisture.