Lopid– 300 mg (Gemfibrozil)
Lopid is prescribed to treat patients with high serum triglyceride levels. It is also used in treating hypercholesterolemia, type IIa, and IIb mixed dyslipidemias, to regulate lipid levels in the blood. It contains the active component Gemfibrozil, which decreases triglyceride and total cholesterol level, and increases high-density lipoprotein cholesterol level in the body. It belongs to a class of medicines known as fibrates, which are specially formulated to lower the level of lipids in the blood. The medicine is used an adjunct to diet and other nonmedical treatment such as exercise and weight loss programs. It can be taken into consideration when other drugs are not able to reduce the of cardiovascular problems in men who have increased bad cholesterol (LDL) level or are at high risk of a heart problem.
Lopid general information
What is Lopid used for?
Lopid has been designed to manage type II-b hyperlipidemia in patients who do not yet have coronary artery disease and have failed treatment with exercise, diet, weight loss programs, and other agents such as bile acid, niacin, and sequestrants.
How does Lopid work?
Lopid has the active component Gemfibrozil works by inhibiting peripheral lipolysis. It decreases the production of triglyceride by the liver. The action decreases the production of the triglyceride carrier protein and increases high-density lipoprotein (HDL).
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What does Lopid contain?
Lopid is supplied in the form of capsules for oral administration. Each capsule contains 300 mg of the active component Gemfibrozil.
What are the side effects of Lopid?
- Ocular disorders: Blurred vision.
- Hematological disorders: leukopenia, anemia.
- Gastrointestinal issues: diarrhea, heartburn, vomiting, flatulence, abdominal pain, gallstones, vomiting, diarrhea, epigastric pain.
- Dermatological issues: Urticaria, alopecia, rashes.
- Central nervous system: a headache, dizziness.
What medications interact with Lopid?
- Coadministration of repaglinide may increase the risk of severe hypoglycemia. Therefore, concurrent use is contraindicated.
- Lopid may increase the effects of sulfonylurea oral hypoglycemic agents and warfarin. Therefore, the medicine should be used cautiously with theses drugs.
- Avoid concurrent use with HMG-CoA reductase inhibitors as Lopid may increase the risk of rhabdomyolysis.
- The medicine may increase the effect of cyclosporine.
- Coadministration with cholestyramine and colestipol may increase its absorption, therefore, should be administered separately after a gap of at least two hours.
When should Lopid not be used?
- Lopid should not be used in patients with primary biliary cirrhosis.
- It is not recommended for use in patients with known hypersensitivity to Gemfibrozil or other inactive ingredients present in the preparation.
- The safety has not been established in pediatric patients.
- The medicine is not made to use in pregnant ladies.
- It is not suitable for use in lactating women.
The medicine should be used cautiously in patients with the following conditions:
- Liver disorders
- Gallbladder diseases
- Severe renal impairment
How should Lopid be used?
- The recommended dose for adults is 600 mg per day after half an hour before breakfast and dinner.
- Patients should be monitored regarding fat and alcohol consumption.
- Certain lab test should be performed periodically. These may include serum triglyceride and cholesterol levels. Also, assessment of LDL and VLDL level before and during the treatment.
- Patients should be assessed for liver functions on a regular basis during the therapy as the administration of Lopid may increase the alkaline phosphate, LDH, and serum bilirubin. If there is any hepatic impairment found in the test, then the treatment should be discontinued and not resumed.
- Evaluate for electrolyte level every 3 to 6 months, then yearly during the treatment with Gemfibrozil. A slight difference in the electrolyte level may cause a mild increase in leukocyte counts and hemoglobin. It may also cause a decrease in the serum potassium concentration in the blood.
How long should Lopid be used?
Take Lopid 300 mg as long as it is recommended to you. Do not stop in between during the treatment as it may take several weeks or longer to see the effects of this medicine. If your condition still does not improve after the prescribed time, call your physician.
Missed dose of Lopid
Always remember to take the medicine on time. If you miss a dose, then take it as soon as you remember.
How should Lopid be stored?
- Keep it out of the reach of children
- Store the medicine at room temperature
- Ensure that your children and pets don't have access to the medication