The Science Behind Melalite Forte: Effective Treatment for Skin Discolouration

Melalite Forte cream is the standard depigmenting or skin-lightening agent. The article describes the mechanism of action of Melalite Forte cream. It also helps you understand the mode of action, method of administration, key side effects, and strategies to improve outcomes with Melalite Forte cream. 

Introduction

Topical hydroquinone has been used for decades to manage hyperpigmentation, including post-inflammatory hyperpigmentation, freckles, melasma and solar lentigines. These hyperpigmentation skin conditions are commonly reported in medical practices and have a significantly negative psychosocial impact on the patient’s quality of life. Apart from its pharmaceutical applications, it is also used for cosmetic purposes.   

What is Melalite Forte cream?

Melalite Forte cream contains the active ingredient hydroquinone, which is a topical treatment for conditions that discolour the skin, such as melasma, acne scars, and age spots. It is a prescription-strength formulation that lightens and fades away darker spots and patches on the skin.   

What skin problems does Melalite Forte cream treat?

The hydroquinone formulation is beneficial for individuals with skin conditions associated with hyperpigmentation. These include:

Melasma: The characteristic features of melasma are brown, tan, and grey patches and freckles. Melasma, also known as chloasma, is often called the “pregnancy mask.” The skin discolouration caused by melasma typically affects the facial skin that gets regular sun exposure. The condition is not life-threatening and is triggered by hormonal changes or as an adverse effect of certain medications. Young women with brown or light brown skin are more likely to develop melasma, though anyone can. The skin condition most often results from pregnancy, birth control pills, or hormonal replacement therapy (used for the treatment of menopause). In some individuals, melasma spots and patches resolve on their own. For example, pregnant women may notice that they fade after some time after delivery.  

Acne scars: When skin pores become blocked by trapped oil or dead skin cells, acne appears as bumps or spots on the face and body. Acne, also known as pimples, can range from whiteheads, blackheads, and discoloured red spots in which the affected pore is filled with pus. Acne is common in adolescence; around 80% of teenagers develop acne, though people of all ages can get acne. Once the affected skin heals, permanent scarring and discolouration may occur in some cases. You may be more likely to develop acne scars if the acne is more severe, if you squeeze or pick your whiteheads or blackheads, if you have been dealing with acne vulgaris for a longer duration, or if you have a family history of them.

Age spots: These are brown and black spots on the skin, also known as liver spots. These marks are often exposed to the sun. They usually occur due to ageing or cellular damage caused by exposure to UV (ultraviolet) rays from the sun. These spots can be painful; however, they may resemble more serious skin conditions.

How does Melalit cream work?

Hydroquinone in the Melalite Forte cream bleaches your skin by reducing the number of melanocytes, which makes melanin (skin pigment that produces your skin tone). In patients with hyperpigmentation, there is increased melanin production due to increased melanocyte production. By controlling these melanocyte cells, your skin will become more evenly toned over time. It may take up to four weeks for the change to take effect. It may take several months of consistent use before you notice a significant improvement in your skin’s appearance. If you can’t see any improvements within three months of using over-the-counter (OTC) products, speak to your dermatologist. They may prescribe a prescription-strength formulation that better suits your needs. 

Is Melalite Forte cream safe for all skin types? 

Hydroquinone formulations, such as Melalite Forte Cream, are generally well-tolerated and safe for use on almost all skin types. Despite animal studies reporting toxicity, the risk of adverse reactions is minimal when the procedure is performed under a dermatologist’s supervision. In most cases, complications arise from using over-the-counter products without medical guidance. Moreover, the hydroquinone formulation is not one-size-fits-all; it may not be effective in every case. People with sensitive skin may experience worsening skin discomfort and be more prone to additional irritation when using Melalite cream, potentially increasing their risk of further irritation. Prolonged use may also worsen existing discolouration, especially in individuals with darker skin.       

How to use it safely?

Generally, it is recommended to test the Melalite Forte cream on a small area first to check for irritation or any adverse effects before applying it full strength. Here are a few practical tips on how to apply the hydroquinone formulation:

• Be sure to clean your hands and face before applying the topical medication.
• Apply the cream to the dry skin area.
• A thin layer of the formulation is enough to cover the affected area and gently rub it in.   
• Rinse your hands after applying the cream to prevent your fingertips from lightning.
• For a successful treatment, it is crucial to protect your skin from the sun. You will need to wear a sun protection factor (SPF) of 30 and protective clothing, including a hat and long-sleeve shirts, every day to avoid direct sun exposure. Direct sunlight can damage the skin and prompt hyperpigmentation to return.  

Potential risks and side effects

Hydroquinone formulations are generally considered safe and well-tolerated, especially when used under medical supervision.  But like any other medication, Melalite too can cause side effects. These may include severe itchiness, skin inflammation, sensitivity, red, itchy rashes, and skin darkening. Long-term use, especially without medical guidance, can lead to ochronosis. This is a skin condition characterised by patches of diffuse bluish or black pigmentation interspersed with curved deposits.

Summary

Melalite forte cream works by suppressing the melanin production, which regulates skin pigmentation. Over time, scars and dark spots tend to fade. However, the effects are reversible; discontinuation of treatment and exposure to sunlight can reverse the effects. Excessive usage can also lead to side effects. Dermatologists usually prescribe it for 3 to 6 months, followed by a maintenance phase where less frequent dosing is required.