Amantrel 100mg
| SKU | 26 |
|---|---|
| Generic For | Symmetral |
| Strength | 100mg |
| Active Ingredient | Amantadine Hcl |
| Pack Size | Qty | Price Per Pill or Unit | Price | Cart | |
|---|---|---|---|---|---|
| 30 Tablet/s | US$ 0.47 | US$ 14.00 | |||
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| 60 Tablet/s | US$ 0.40 | US$ 24.0043%US$ 42.00 | |||
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| 90 Tablet/s | US$ 0.40 | US$ 36.0036%US$ 56.00 | |||
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Amantrel 100mg (Amantadine Hcl) – Affordable Symmetral Alternative
Amantrel 100mg is a prescription medicine that is used to treat:
- Parkinson's syndrome is a degenerative disease of the central nervous system, mainly affecting the motor system.
- A certain type of flu infection (influenza A).
Amantrel 100mg contains Amantadine HCl as the main active ingredient. Amantadine HCl, an adamantane derivative, is a synthetic antiviral drug that is active against the influenza A virus. It is a weak antagonist of the NMDA-type glutamate receptor. It increases the levels of certain chemicals that transmit impulses to the body's nervous system, including the brain.
Amantadine medicine comes in different forms, including tablet, capsule and syrup. Administer the one you are prescribed with to achieve the best results.
Precautions with Amantadine medication
Tell your doctor before taking this medicine:
- If you are hypersensitive to the drug or its components.
- If you have any severe kidney disease.
- If you are suffering from a disease called epilepsy.
- The medicine contains lactose in its formulation. If you have an intolerance to some sugars, tell your doctor before taking this medicine.
- The drug may cause dizziness. Do not drive or use machinery while taking Amantrel, as these activities may require a high degree of mental attention.
- Inform your doctor if you are pregnant or intending to become pregnant. You should discuss the benefits and risks of taking the Amantrel medicine during pregnancy. Breastfeeding women are advised not to take this drug as it may pass into breast milk and harm the nursing baby.
- Do not consume alcohol while using Amantrel.
The following medicines should be avoided if your doctor recommends Amantrel to prevent possible drug interactions.
- Mepenzolate
- Methscopolamine
- Dicyclomine
- Hyoscyamine
- Scopolamine
- Propantheline
- Atropine
- Phenothiazines
- Quinine
Tell your doctor about all medicines you use, as they can interact with Amantrel and cause side effects.
Storage tips:
- Do not forget to see the expiry date of the product.
- Keep the drug out of children's reach.
- It should not be given to anybody, even if they have the same problems.
- Always keep a written record of your medications.
- Keep the medicine in a cool (at room temperature) and dark place away from sunlight.
Usage instructions for the Amantadine medication?
Amantrel tablets and capsules are taken orally, with or without food. Swallow the medicine with a glass of water.
To treat Parkinson's syndrome in adults: The recommended dose of Amantadine HCl is 100 mg for the first seven days of the treatment. The dose will increase to 100 mg twice daily in the second week of the treatment. Higher doses may exceed 200mg per day in some cases. If you are consuming the medicine twice a day and experience sleeping difficulty after taking it, consider taking the second dose several hours before bedtime.
To treat Parkinson's syndrome in adults over 65 years: The recommended dose is 100 mg once a day.
To treat influenza in adults, adults over 65 years and children (10 to 15 years): The recommended dose is one 100 mg daily.
The treatment duration, dosage and medication form vary from patient to patient, considering several factors such as the health issue for which it is being given, the severity of the condition, age, and gender. Take the drug exactly as prescribed by the doctor and do not alter the dosage schedule even if you feel better.
Overdose: Seek medical attention immediately in the case of an overdose of Amantadine HCL.
If you have forgotten a dose, take it as soon as you remember and return to your usual dosing schedule. If the time to take the next dose is approaching, discard the forgotten dose and take the next scheduled dose. Do not double up the dose to compensate for the missed one.
Like other medicines, Amantrel may cause adverse effects. Seek medical attention if you experience drowsiness, stomach upset, nausea, dizziness, headache, trouble sleeping, nervousness, blurred vision.
Some side effects of Amantrel can be serious. Visit the doctor immediately in the following situations.
- Shortness of breath
- Difficulty in urinating
- Convulsions
- Uncontrolled muscle movements
- Depression
- Swelling of the ankles and feet
- Unusual sweating
- Compulsive behaviour like gambling urges
- Muscle stiffness
- Purplish-red blotchy spots on the skin
What is Amantrel 100mg used for?
Amantrel 100mg contains amantadine 100mg — an antiviral and antiparkinsonian agent with a unique dual action. In Parkinson's disease: amantadine is primarily used to reduce levodopa-induced dyskinesias (involuntary writhing movements) in established Parkinson's disease — an indication supported by consistent clinical evidence. Secondary use: adjunct therapy for early Parkinson's motor symptoms (modest benefit via dopamine release and NMDA antagonism). Historical use: influenza A prophylaxis and treatment — now largely replaced by oseltamivir due to widespread amantadine-resistant influenza strains. Amantadine is also used for drug-induced extrapyramidal symptoms and fatigue in multiple sclerosis.
How does Amantrel 100mg work in Parkinson's disease?
Amantadine's mechanisms in Parkinson's disease are multiple: (1) NMDA glutamate receptor antagonism — the primary mechanism for dyskinesia reduction; excessive glutamatergic activity in the basal ganglia drives levodopa-induced dyskinesias, and NMDA blockade by amantadine reduces this; (2) dopamine release — amantadine promotes presynaptic dopamine release from surviving neurons, contributing modest symptomatic benefit; (3) dopamine reuptake inhibition — further increases synaptic dopamine; (4) mild anticholinergic effect — contributes to tremor reduction. The NMDA antagonism accounts for its dyskinesia-reducing benefit that is not shared by other Parkinson's medications.
How should Amantrel 100mg be dosed for Parkinson's disease dyskinesias?
Start with amantadine 100mg once or twice daily for the first 1–2 weeks (reduces incidence of side effects). Increase to the therapeutic target of 100mg three times daily (300mg/day) if tolerated. Some patients benefit at 200mg/day (twice daily); others require 300mg/day. Take with food if nausea occurs. Avoid evening doses after 5–6pm — amantadine causes insomnia if taken too late. Renal dose adjustment is required: eGFR 30–50: reduce to 100mg/day; eGFR 15–29: 100mg every 48 hours; eGFR <15 or dialysis: 100mg every 7 days. Do not stop abruptly — may cause Parkinson's symptom rebound.
Is Amantrel 100mg effective for levodopa-induced dyskinesias?
Yes — amantadine is the only oral medication with consistent clinical evidence for reducing levodopa-induced dyskinesias (LIDs). Multiple clinical trials show 50–70% reduction in dyskinesia severity and duration. The ADS-5102 (extended-release amantadine 274mg once nightly) formulation was specifically approved in the USA for LIDs based on EASE-LID trials showing significant dyskinesia reduction. The standard 100mg TID immediate-release formulation is widely used in clinical practice for LIDs globally. The dyskinesia-reducing effect may diminish over time (6–12 months) as tolerance develops — doses may need review.
Is Amantrel 100mg safe in elderly Parkinson's patients?
Amantadine requires caution in elderly patients. Anticholinergic and NMDA antagonist effects cause confusion, hallucinations, and delirium — particularly problematic in elderly patients with dementia or cognitive impairment. The Anticholinergic Cognitive Burden scale rates amantadine as a high-anticholinergic drug. Peripheral oedema is common in elderly patients — monitor for ankle swelling. Livedo reticularis (mottled purplish skin discolouration on extremities) is a distinctive but benign amantadine side effect. Orthostatic hypotension worsens fall risk. In elderly Parkinson's patients with cognitive impairment, the benefit of dyskinesia reduction must be carefully weighed against cognitive side effect risk.
What drug interactions are important with Amantrel 100mg?
Anticholinergic drugs (oxybutynin, trihexyphenidyl, tricyclic antidepressants) produce additive anticholinergic toxicity (confusion, urinary retention, dry mouth, constipation) — avoid combination or use with extreme caution. Trimethoprim reduces renal amantadine excretion — increases amantadine levels significantly; reduce amantadine dose if combination is necessary. CNS stimulants (caffeine, sympathomimetics) may enhance amantadine-associated CNS agitation. Live attenuated influenza vaccines: amantadine's antiviral activity may theoretically interfere — avoid amantadine for 48 hours before and after live influenza vaccine. QT-prolonging drugs — amantadine has modest QT effect; monitor ECG if combined with other QT prolongers.
How does Amantrel 100mg compare to other Parkinson's medications?
Amantadine occupies a specific niche in Parkinson's pharmacotherapy. Unlike levodopa (dopamine precursor — most effective motor treatment) or dopamine agonists (pramipexole, ropinirole — useful in early disease), amantadine's primary value is in managing established motor complications (dyskinesias) — a role no other oral medication fills comparably. It is not a first-line Parkinson's treatment — its modest direct antiparkinsonian effect makes it inappropriate as initial monotherapy. In the hierarchy of Parkinson's management: levodopa → dopamine agonists → MAO-B inhibitors → COMT inhibitors → amantadine for dyskinesia management → deep brain stimulation for refractory cases.
Is Amantrel 100mg equivalent to Symmetrel 100mg?
Yes. Amantrel 100mg and branded Symmetrel 100mg both contain amantadine hydrochloride 100mg in bioequivalent formulations. Amantrel is the generic version providing the same Parkinson's dyskinesia management and other amantadine indications at significantly lower cost.
Can I order Amantrel 100mg from PremiumRxDrugs for international delivery?
Yes. PremiumRxDrugs.com ships Amantrel 100mg to the USA, UK, Australia, and many other countries. Our genuine manufacturer-verified Parkinson's medications, competitive pricing, and free worldwide shipping on qualifying orders make us a reliable international source for amantadine therapy.
What side effects does Amantrel 100mg cause?
Common: livedo reticularis (mottled purplish skin on extremities — harmless, resolves with discontinuation), ankle oedema, insomnia (avoid evening dosing), dry mouth, and constipation (anticholinergic effects). CNS: confusion, hallucinations, and dizziness — more pronounced in elderly and those with renal impairment. Nausea and anorexia (take with food). Orthostatic hypotension. Urinary retention — caution in men with prostate enlargement. Psychosis at higher doses. Rare: neuroleptic malignant syndrome-like reaction with abrupt discontinuation. QT prolongation on ECG. Corneal microdeposits with long-term use.
What is livedo reticularis from Amantrel 100mg and should I stop treatment?
Livedo reticularis — a blotchy, purplish, net-like skin discolouration on the arms, legs, and trunk — is the most distinctive and common skin finding with amantadine, occurring in approximately 30% of long-term users. It develops within 1 month to 1 year of starting treatment and is caused by amantadine's effects on cutaneous blood vessels (catecholamine-mediated vasospasm). It is entirely benign and cosmetic — it is not a skin infection, allergy, or circulation disorder. Importantly, it fully resolves within weeks of stopping amantadine. In the context of effective dyskinesia management, livedo reticularis alone is not a reason to stop amantadine unless cosmetically unacceptable to the patient.
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