Angispan TR 2.5mg
Available Dosages
| SKU | 743 |
|---|---|
| Generic For | Nitroglycerine |
| Strength | 2.5mg |
| Manufacturer | USV Ltd. |
| Active Ingredient | Nitroglycerine |
| Pack Size | Qty | Price Per Pill or Unit | Price | Cart | |
|---|---|---|---|---|---|
| 30 Capsule/s | US$ 0.40 | US$ 12.00 | |||
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| 60 Capsule/s | US$ 0.33 | US$ 20.0017%US$ 24.00 | |||
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| 90 Capsule/s | US$ 0.29 | US$ 26.0028%US$ 36.00 | |||
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Angispan TR 2.5mg (Nitroglycerine)
Angispan TR 2.5 mg
Angispan TR 2.5 mg is a medicine used in treating chest pain and angina. It is specifically formulated for people with certain heart conditions. An individual develops angina when the heart does not get enough oxygen to function and is more likely to occur when you are doing any physical activity such as exercise or after eating. It is considered to be as the first line medications to prevent chest pain in patients with coronary artery disease (COD). Your physician may also prescribe this medication to treat chronic or congestive heart failure. The active ingredient of the medicine is Nitroglycerin, which exerts its mode of action by relaxing veins and arteries in the body.
What is Angispan TR used for?
Angispan TR is useful in treating:
- Cardiac related chest pain
- Pulmonary edema: to raise venous pooling, reducing cardiac preload and after load.
How does Angispan TR work?
Angispan TR works by:
- Smoothing muscle relaxation
- Reducing venous tone, this causes pooling of blood in peripheral veins and decreases return of blood to the heart.
- Dilating coronary arteries
- Decreasing peripheral vascular resistance
- Decreasing myocardial oxygen consumption demand
What does Angispan TR contain?
The medication contains the active component Nitroglycerin, which helps in preventing angina and chest pain. Each capsule delivers contains 2.5 mg of the active ingredient.
What medications interact with Angispan TR?
The antianginal medicine can interact with the following medications and causes harmful effects:
- Tadalafil
- Sildenafil
- Vardenafil
- Antihypertensive agents
- Beta blockers
- Haloperidol
- Phenothiazines
- Calcium channel blockers
- Antihistamines
- Tricyclic antidepressants
How should Angispan TR be used?
Always keep your Angispan TR capsules with you. The capsules may make you feel dizzy when you stand up or lie down on the bed. What you need to do is get up slowly from a sitting or lying position. If you drink alcohol, please ask your physician if the alcohol consumption is safe during the treatment, if yes then how much you can consume a day. All these information should be collected from a physician. Take it as directed by your physician. If you develop chest pain or discomfort in your chest, take the capsule to get instant relief. If you still have pain and do not find any improvement immediately rush to the nearest hospital and do not drive yourself to the hospital because you may be having a heart attack.
When should Angispan TR not be used?
- A patient should not take antispan TR capsules if he/she is hypersensitive to any of the ingredients of the medication.
- It is not suitable for patients with pericardial tamponade.
- Patients with constrictive pericarditis must avoid the use of nitroglycerin.
- Concurrent use of sildenafil, vardenafil, and tadalafil is contraindicated.
Use Angispan TR carefully in the following conditions:
- Head trauma or cerebral hemorrhage
- Severe liver disease
- Hypovolemia
- Glaucoma
- Normal or decreased pulmonary wedge pressure
- Hypertrophic cardiomyopathy
- Malabsorption or hypermotility
What are the side, effects of Angispan TR?
Call your physician if you develop any of these medicine side effects:
- Flushing
- Headache
- Dizziness
- Burning under tongue
- Orthostatic hypotension, particularly in patients taking antihypertensive beta-adrenergic medications and phenothiazines
- Nausea
- Vomiting
Immediately call your physician if you have any of these unwanted effects:
- Increased chest pain
- Itching or swelling
- Dry mouth
- Severe headaches
- Trouble breathing
- Blurred vision
- Severe weakness
- Fainting
Talk your physician if you have any doubt or concerns about taking your antianginal capsules.
How long should Angispan TR be used?
Keep using it until your physician tells you to stop. Do not stop taking it, even if you feel better. Complete the entire course as prescribed by your physician.
Missed dose of Angispan TR
If you forgot to take your anti-anginal drug, apply it as soon as remembered. Do not consume too much of the preparation to make up the missed dose as it may cause unwanted side effects.
How should Angispan TR be stored?
Keep the medicine in its original packet to keep its strength. Place it out of the reach of children.
What is Angispan TR 2.5mg used for?
Angispan TR 2.5mg contains nitroglycerin (glyceryl trinitrate) 2.5mg in a sustained-release (TR = Timed Release) oral tablet formulation. It is used for the prophylaxis (prevention) of angina pectoris in patients with stable coronary artery disease. Unlike sublingual nitroglycerin tablets (used for acute attacks), oral sustained-release nitroglycerin provides prolonged, steady blood levels for ongoing angina prevention. The 2.5mg dose provides a moderate level of vaSodiumilation for patients requiring continuous nitrate therapy.
How does nitroglycerin prevent angina attacks?
Nitroglycerin is metabolised to nitric oxide (NO) in vascular smooth muscle cells. NO activates guanylate cyclase, increasing cGMP and causing smooth muscle relaxation. This produces venodilation (reducing preload — the amount of blood returning to the heart), arteriolar dilation (reducing afterload — cardiac work), and coronary artery dilation (improving oxygen delivery to the myocardium). Together, these effects reduce myocardial oxygen demand and increase coronary blood supply — preventing the ischaemia that causes angina.
How should Angispan TR 2.5mg be taken?
Angispan TR 2.5mg sustained-release tablets are swallowed whole, with or without food, typically twice daily (morning and evening). The TR formulation must not be crushed, chewed, or broken — this destroys the timed-release mechanism and causes an immediate, excessive dose with rapid tolerance development. A nitrate-free interval of 8–12 hours (typically overnight) is essential to prevent nitrate tolerance — the commonest cause of reduced efficacy with ongoing therapy. Take the morning dose early and the second dose by late afternoon.
How long do Angispan TR 2.5mg tablets remain effective?
Each Angispan TR 2.5mg tablet provides 8–12 hours of sustained nitrate release, maintaining vaSodiumilatory levels throughout the dose interval. Regular twice-daily dosing prevents angina during daily activities and physical exertion. The nitrate-free overnight interval prevents tolerance development. Regular reassessment is needed to ensure continued effectiveness — headache is a useful marker of active nitrate effect; disappearance of headache without dose reduction suggests tolerance has developed.
What is nitrate tolerance and how is it avoided?
Nitrate tolerance is a well-documented phenomenon where continuous exposure to nitrates causes progressive loss of their vaSodiumilatory effect — due to depletion of sulfhydryl groups and reactive oxygen species accumulation in vascular smooth muscle. To prevent tolerance, a minimum 8–12 hour nitrate-free interval is required daily. For oral nitroglycerin: take both doses in the first 16 hours of the day, leaving the overnight period nitrate-free. Isosorbide mononitrate has an established asymmetric dosing schedule for the same reason.
Who should not take Angispan TR 2.5mg?
Nitroglycerin is absolutely contraindicated with phosphodiesterase-5 inhibitors (sildenafil/Viagra, tadalafil/Cialis, vardenafil/Levitra) — the combination causes profound, life-threatening hypotension. It is contraindicated in severe hypotension (systolic <90 mmHg), acute circulatory failure, constrictive pericarditis, cardiac tamponade, hypertrophic obstructive cardiomyopathy, and acute MI with very low filling pressures. Severe anaemia and increased intracranial pressure are relative contraindications.
How does Angispan TR 2.5mg compare to Angispan TR 6.5mg?
Both are nitroglycerin sustained-release formulations, but differ in dose: 2.5mg provides a lower level of nitrate vaSodiumilation appropriate for patients with milder angina, those sensitive to nitrate side effects (headache, hypotension), or those starting therapy. The 6.5mg dose provides stronger vaSodiumilation for more frequent or severe angina. Some patients may achieve adequate control on 2.5mg twice daily; others require 6.5mg. The lowest effective dose is preferred to minimise headache and hypotension side effects.
Is Angispan TR the same as Nitrocontin?
Angispan TR and Nitrocontin are both oral sustained-release nitroglycerin tablets. They may differ in their exact release mechanisms but contain the same active ingredient (glyceryl trinitrate) and serve the same purpose — prophylaxis of angina through sustained nitrate blood levels. Angispan TR is a widely available formulation in India and other markets. Bioequivalence between different SR nitrate formulations should be confirmed — always use the same brand consistently once established on therapy.
Can I order Angispan TR 2.5mg from PremiumRxDrugs for international delivery?
Yes. PremiumRxDrugs.com ships Angispan TR 2.5mg to the USA, UK, Australia, and many other countries. Our genuine manufacturer-verified cardiovascular medications, competitive pricing, and free worldwide shipping on qualifying orders make us a trusted source for patients managing stable angina with sustained-release nitrate therapy.
What side effects does nitroglycerin 2.5mg cause?
Headache is the most characteristic side effect — caused by cerebral vaSodiumilation. It typically diminishes after 1–2 weeks of continuous use as vascular tolerance to the headache-producing effect develops (while the anti-anginal effect is maintained with a nitrate-free interval). Dizziness, flushing, and mild hypotension with postural effects are common initially. Reflex tachycardia can occur. Nitrate headache is paradoxically a useful indicator that active nitrate levels are present. Severe or persistent hypotension requires dose reduction.
What precautions are essential when using Angispan TR 2.5mg?
Never combine with PDE-5 inhibitors (sildenafil, tadalafil) — risk of severe, life-threatening hypotension. Swallow tablets whole — never crush or chew SR tablets. Maintain the nitrate-free overnight interval to prevent tolerance. Rise slowly from sitting or lying to prevent orthostatic hypotension. Keep sublingual nitroglycerin spray or tablets for acute angina attacks — Angispan TR is for prevention only and works too slowly for acute relief. Store at room temperature away from heat and humidity.
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