Cytomid 250 mg
| SKU | 439 |
|---|---|
| Generic For | Drogenil |
| Strength | 250 mg |
| Active Ingredient | Flutamide |
Out Of Stock
Cytomid 250 mg (Flutamide) – Affordable Drogenil Alternative
Cytomid 250 mg (Flutamide)
Cytomid 250 mg tablets contain Flutamide, a nonsteroidal anti-androgen agent used to treat prostate cancer. Cytomid treats prostate cancer by hindering the effects of testosterone and other androgens.
What is Cytomid used for?
Cytomid may be used alone or along with another medicine (luteinizing hormone-releasing hormone antagonists) in the treatment of prostate, cancer. It is an- anti-androgen medicine that stops the growth of the tumor and also shrinks it.
Prostate cancer is the cancer of the prostate gland. It is a gland present in the male reproductive system.
How does Cytomid work?
Cytomid contains Flutamide, which belongs to a group of medicines called non-steroidal anti-androgens. Flutamide completely blocks dihydrotestosterone binding at androgen receptors, forming inactive complexes, which cannot translocate into the cell nucleus. Formation of inactive receptors hinders androgen-dependent DNA and protein synthesis, resulting in tumor cell growth arrest.
What are the different doses of Cytomid?
Cytomid tablets are available to order online from premiumrxdrugs.com in 250 mg strength. You can buy Cytomid 250 mg online at unbeatable price.
What does Cytomid contain?
Cytomid 250 mg tablets contain the active substance Flutamide; a competitive receptor antagonist, works by blocking the effects of testosterone, thereby inhibiting the growth and spreading of the tumor in the prostate gland.
What are the side effects of Cytomid?
Tell your doctor, if you do not feel well while consuming Cytomid tablets.
All drugs can have undesired side effects. Sometimes they are severe, most of the time they are not. You may require medical help if you get some of the adverse reactions. Inform your doctor, if you notice any of the following and they worry you.
- Breathing difficulty
- Swelling of the face, lips, tongue, or throat.
- Liver damage
- Nausea
- Vomiting
- Loss of appetite
- Flu symptoms
- Itching
- Yellow skin or eyes
- Clay-colored stools
- Dark urine
- Unusual fatigue
- Abdominal pain
These are the most common adverse effects of Cytomid.
Tell your doctor immediately, if you experience:
- Diarrhea
- Skin Rash
- Impotence
- Decreased sperm count
- Bloody urine
- Rectal bleeding or inflammation.
The list of the adverse effects listed above is not complete. If you suffer from any of these or any other unwanted effects, please inform your doctor.
What medications interact with Cytomid 250 mg?
Please tell your doctor, if you are consuming any other medicines, including medicines obtained without a prescription. Your doctor or pharmacist may wish to alter your dose, if you are consuming any of the following.
- Testosterone (patch, injection, gel)
- Anabolic steroids
- Warfarin
- DHEA
These drugs may be affected by Cytomid or may affect how well Cytomid works. You may need a different amount of medicines, or you may need to consume different medicines. You doctor has more information on drugs to be careful with or avoid while consuming Cytomid.
When should Cytomid 250 mg not be used?
Do not take Cytomid 250 mg, if you are allergic to Flutamide or to any ingredients contained in the cytomid tablets.
How should Cytomid 250 mg be taken?
- The recommended dosage is one Cytomid tablet three times daily at intervals of eight hours.
- In combination with an LHRH agonist, Cytomid tablets should be started 24 hours before the initiation of LHRH agonist, to achieve the benefit of the combination therapy.
- In localised prostatic cancer, administration of Cytomid and an LHRH agonist should start eight weeks before radiation therapy and continue through the course of radiation therapy. Before radical prostatectomy, Cytomid should be administered for three months.
- Do not skip doses or stop using Cytomid tablets suddenly. Stopping the medicine suddenly may make your condition worse.
- You should only take the number of tablets that you have been told. Visit your nearest medical centre immediately, if you think that you have taken too many Cytomid tablets by mistake. An accidental overdose of Flutamide may cause side effects like dizziness, decreased activity, loss of appetite, sedation, vomiting, goosebumps, watery eyes and shortness of breath.
- The dose regimen may differ from the information contained in this document. In the case of any confusion, please consult your doctor.
How long should you take Cytomid 250 mg?
Continue taking these tablets regularly every day for as long as your doctor recommends you. Cytomid helps to control your condition, but does not cure it. It is necessary to keep taking these tablets even if you feel well. Do not stop consuming this medicine without consulting with your doctor first.
Missed dose of Cytomid 250 mg
In case, you forget to take the dose and if it is less than 2-4 hours left for the next dose, leave the missed one and take the next dose at the recommended time. Do not double up the dose for the missed one.
How should Cytomid 250 mg be stored?
- Keep it out of the reach of children and away from pets. Avoid exposure to light, moisture, and heat.
- Do not place your tablets in the bathroom or near a sink.
- Do not take any medicine after the expiry date, which is mentioned on the carton.
- Always keep the medicine in the original package.
What is Cytomid 250mg used for?
Cytomid 250mg contains flutamide 250mg — a non-steroidal antiandrogen used primarily in prostate cancer treatment. Flutamide blocks androgen receptors, preventing testosterone and dihydrotestosterone from stimulating prostate tumour growth. Key indications: locally advanced or metastatic prostate cancer — as monotherapy or combined with LHRH agonists (leuprolide, goserelin) for complete androgen blockade (CAB); flare prevention when initiating LHRH agonist therapy (prevents the initial testosterone surge causing disease flare); and occasionally for hirsutism and benign prostatic hyperplasia in specific clinical contexts.
How does flutamide in Cytomid 250mg treat prostate cancer?
Flutamide is a competitive antagonist at androgen receptors — it occupies the androgen receptor without activating it, blocking the receptor from binding testosterone and dihydrotestosterone (the natural androgens that drive prostate cancer cell proliferation). With androgen receptor blockade, androgen-sensitive prostate cancer cells lose their primary growth stimulus. In combination with an LHRH agonist (which suppresses testicular testosterone production), flutamide achieves 'complete androgen blockade' — blocking both testicular and adrenal androgen action on prostate cancer cells. This combined approach is a cornerstone of metastatic prostate cancer systemic therapy.
How should Cytomid 250mg be dosed for prostate cancer?
Standard dose: 250mg three times daily (750mg/day total) — consistently throughout the day. Take with or without food. Doses should be maintained consistently — flutamide's relatively short half-life (5–6 hours) requires TID dosing to maintain adequate androgen receptor blockade throughout the day. When used with an LHRH agonist, flutamide is typically started 1–2 weeks before the LHRH agonist and continued for 4 weeks after — to prevent the LHRH agonist-induced testosterone surge (flare) that can initially worsen bone pain in metastatic disease.
What is the hepatotoxicity risk with Cytomid 250mg?
Flutamide causes hepatotoxicity in 0.5–3% of patients — ranging from asymptomatic transaminase elevation to fatal fulminant hepatic failure. Risk is highest in the first 3 months of therapy. Monitoring: LFTs at baseline, monthly for the first 4 months, then every 3 months thereafter. If ALT/AST exceeds 2–3× upper limit of normal: reduce dose or consider discontinuation; if >5× ULN or symptomatic hepatitis: stop immediately. Symptoms of hepatotoxicity: yellow skin/eyes, dark urine, severe fatigue, right upper quadrant pain — require immediate medical assessment. Do not rechallenge if hepatotoxicity was symptomatic.
What side effects does Cytomid 250mg cause from antiandrogen therapy?
Antiandrogen side effects: gynaecomastia (breast enlargement/tenderness) in 40–70% of patients — the most common side effect of flutamide monotherapy (testosterone levels remain elevated as adrenal and testicular testosterone is not suppressed, leading to peripheral conversion to oestradiol). Hot flushes, loss of libido, and erectile dysfunction. Gastrointestinal: diarrhoea, nausea, and vomiting (most common GI complaint). Interstitial pneumonitis (rare but potentially serious — cough, dyspnoea, monitor). Methaemoglobinaemia (especially in glucose-6-phosphate dehydrogenase deficiency). Photosensitivity — sun protection recommended. Brown/amber urine discolouration (harmless metabolite).
What drug interactions affect Cytomid 250mg?
Warfarin: flutamide significantly increases warfarin effect — monitor INR closely and expect warfarin dose reduction of 30–50% when flutamide is added. LHRH agonists: combined androgen blockade intended pharmacological interaction — monitor for excessive androgen deprivation side effects. Phenytoin, carbamazepine, rifampicin: CYP1A2 inducers may reduce flutamide/hydroxyflutamide plasma levels — reduced antiandrogen effect. Fluvoxamine and cimetidine: CYP1A2 inhibitors may increase flutamide levels. QT-prolonging drugs: flutamide modestly prolongs QT; caution with other QT-prolonging agents. Monitor LFTs when combining with other hepatotoxic medications.
How does Cytomid 250mg compare to bicalutamide for prostate cancer?
Flutamide (Cytomid 250mg TID) and bicalutamide 50mg once daily are both non-steroidal antiandrogens used for prostate cancer. Key differences: bicalutamide is now preferred over flutamide in most guidelines due to: once-daily dosing (vs. TID), better tolerability (less diarrhoea), superior androgen receptor binding affinity, and potentially lower hepatotoxicity risk. Gynacomastia occurs with both agents when used as monotherapy. Flutamide's main remaining advantage is lower cost and longer historical use. For most prostate cancer indications, bicalutamide has largely replaced flutamide in contemporary practice.
Is Cytomid 250mg equivalent to Eulexin 250mg?
Yes. Cytomid 250mg and branded Eulexin 250mg both contain flutamide 250mg in bioequivalent formulations. Cytomid is the generic alternative providing the same antiandrogen therapy for prostate cancer at significantly lower cost — important given the prolonged duration of antiandrogen therapy in advanced prostate cancer.
Can I order Cytomid 250mg from PremiumRxDrugs for international delivery?
Yes. PremiumRxDrugs.com ships Cytomid 250mg to the USA, UK, Australia, and many other countries. Our genuine manufacturer-verified oncology medications, competitive pricing, and free worldwide shipping on qualifying orders make us a reliable international pharmacy for flutamide prostate cancer treatment.
What monitoring is needed during Cytomid 250mg therapy?
LFT monitoring is mandatory: baseline, every month for 4 months, then every 3 months. PSA (prostate-specific antigen) monitoring every 3 months — rising PSA indicates disease progression or antiandrogen withdrawal response (flutamide withdrawal syndrome: paradoxical PSA decline when flutamide is stopped in castration-resistant disease). Testosterone levels in combined androgen blockade regimens. ECG if QT concerns. Annual DEXA scan for bone density (androgen deprivation causes osteoporosis — calcium/vitamin D supplementation and bisphosphonate therapy as indicated). Haematological monitoring if GI side effects are severe.
What is antiandrogen withdrawal syndrome and how does it relate to flutamide?
Antiandrogen withdrawal syndrome (AAWS) — observed with flutamide specifically and other antiandrogens — occurs in castration-resistant prostate cancer (CRPC): paradoxically, stopping flutamide in patients whose tumour has progressed on combined androgen blockade causes a PSA decline in 15–30% of cases. This occurs because in CRPC, androgen receptor mutations develop that make flutamide act as an androgen receptor agonist (stimulating growth) rather than antagonist. When flutamide is stopped, this inadvertent stimulation ceases, causing a PSA fall. AAWS is clinically important — when progression occurs on flutamide, stop it before adding second-line hormonal therapy and observe for 4–6 weeks.
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