SKU	336
Generic For	Divalproex
Strength	125 mg
Active Ingredient	Divalproex

Product Description

Dicorate ER 125 mg (Divalproex)

Dicorate ER 125 mg is used for controlling the symptoms of various kinds of epileptic seizures and migraine headache. The medicine was discovered in 1881, and it is on the WHO list of important medicines that are needed for the basic health system. Divalproex Sodium is the main active ingredient present in Dicorate ER.

What is Dicorate ER 125 mg used for?

Dicorate ER is available as extended-release tablets that are used for the treatment of seizure disorders and bipolar disorders. The drug is also used for the prevention of migraine pain in the head.

How does Dicorate ER 125 mg work?

Dicorate ER is an anticonvulsant drug that prevents the number of seizures. It works by slowing down the abnormal activeness of the nerve impulse transmission and thus prevents the number of seizures that CNS produces with the brain. It helps the brain to send relaxation signals to the body muscles.

Precautions

The following precautions are necessary before taking Dicorate ER 125 mg:

People who are allergic to Dicorate ER 125 mg (Divalproex Sodium) or any other ingredients present in the drug should avoid Dicorate ER 125 mg
People with food allergies and those with weak immune system should consult their physician before using this drug
People with mental disorders should not take this drug
Avoid Divalproex Sodium if you have any heart/kidney or liver problem
Do not take this drug with other antiepileptic drugs
Avoid the drug if yu are trying to conceive or are pregnant
Avoid this drug if you are breastfeeding

General

Children should keep away from the drug and placed the drug in unreachable location for children
Do not stop the drug suddenly as the withdrawal symptoms are very strong
Do not place the drug in direct sunlight or moisture
Do not share your medicines with anyone who is showing the same symptoms without consulting your physician.

What medications interact with Dicorate ER 125 mg?

Many drugs can interact with Dicorate ER to create adverse health issues. One should thus avoid these drug in combination with Divalproex Sodium:

Certain benzodiazepines
Antidepressant medications
Antihistamine medicines
Muscle relaxant drugs
Erectile dysfunction medicines
Anxiety medicines
Antifungals
Anticoagulants like Warfarin
Migraine headache medicines
Anti-malaria drugs
Medicines for heart attack and stroke prevention
Narcotic painkillers etc.

The list is not complete, ask your physician to provide you the complete list of drugs that may negatively interact with Divalproex Sodium and avoid these drugs. If you are already taking these drugs, then inform your physician about it.

Dosage Instructions

How should Dicorate ER be taken?

Ask your physician about the correct dose of the drug. This ER tablet is prescribed as one tablet once daily. In the case of any confusion, you can ask your physician. One should swallow the tablet as whole, do not break or crush or chew the tablets. If you crush the tablet, all the drug will be released at once and may cause side effects. The dose will be decided by the physician based on the type of condition, the age of the patient and his medical condition.

Overdose: In case you accidentally take an overdose of the drug, then immediately contact your physician in case you feel any discomfort. Use the medicines regularly and wisely to avoid an overdose of the drug.

Missed dose of Dicorate ER 125 mg

In the case of miss a dose do not panic and take the dose as soon as you remember, but if it is less 12 hours left for the dose of this drug then leave the missed dose and take the next dose at the correct time.

Side Effects

What are the side effects of Dicorate ER 125 mg?

Just like other normal drugs Dicorate ER too has some common side effects. These side effects are not necessarily seen in all the people but are the common ones. Here are the common side effects:

• Allergic reactions

• Worsening seizures

• Constant nausea

• Blood pressure changes

• Symptoms of infectivity

• Sadness

• Faintness

• Heartburn

• Belly pain

• Unusual weakness

• Feeling sleepy

• Headache

• Gooey or stuffy nose

• Tiredness

• Blurred vision

• Constipation

• Dizziness

• Audibility loss etc.

Do not get alarmed by the list of side effects as you may or may not have all of them. These side effects are not necessarily to occur at the same time. You may or may not have any of these side effects. In case you feel extreme discomfort, you should always visit your physician.

How to Use

Infographics

FAQ

What is Dicorate ER 125mg used for?

Dicorate ER 125mg contains divalproex Sodiumium 125mg in an extended-release (ER) tablet. Divalproex is used to treat epilepsy (various seizure types), bipolar disorder (to prevent and treat manic epiSodiumes and mood swings), and to prevent migraines. The 125mg ER tablet provides a low starting dose or a fine-tuning dose for patients who need precise dose adjustments. Divalproex releases Sodiumium valproate in the body, which calms abnormal brain electrical activity.

How does divalproex work in the brain?

Divalproex releases valproate in the body, which works in the brain in several ways: it increases levels of a calming brain chemical called GABA (gamma-aminobutyric acid), which reduces excessive nerve firing; it blocks Sodiumium channels, preventing abnormal electrical signals; and it may inhibit certain enzymes that contribute to overactive brain cell activity. Together, these actions make it one of the most broadly effective medicines across many different seizure types and mood disorders.

Why is divalproex used instead of Sodiumium valproate?

Divalproex and Sodiumium valproate both release the same active medicine (valproate) in the body and work identically. Divalproex Sodiumium is a specific chemical form of valproate that tends to cause less stomach irritation than regular Sodiumium valproate — making it easier to tolerate. The extended-release (ER) formulation reduces the number of daily doses needed and provides more even blood levels, further improving tolerability. For many patients, the ER form causes significantly less nausea and stomach discomfort.

What is the correct dose of Dicorate ER 125mg?

The 125mg extended-release tablet is primarily used as a starting dose or for dose fine-tuning. For epilepsy, divalproex is usually started at 10–15mg/kg per day and gradually increased to a maintenance dose of 1000–2000mg per day (sometimes higher) based on seizure control and blood levels. For bipolar disorder, the dose is titrated to achieve blood valproate levels of 50–125 mcg/mL. Your neurologist or psychiatrist will set your exact dose. The ER tablet is usually taken once or twice daily.

Is divalproex ER safe to take with food?

Yes — divalproex ER tablets can be taken with food, and doing so often helps reduce stomach upset. The ER formulation is specifically designed to be gentler on the stomach than immediate-release valproate. Swallow the tablets whole — do not crush, break, or chew them, as this destroys the extended-release mechanism. Taking them at the same time each day helps maintain consistent blood levels. Most patients find taking ER tablets with their main meal once daily is both convenient and well-tolerated.

Can divalproex be used for migraine prevention?

Yes — divalproex (valproate) is one of the approved medicines for preventing migraines in adults. It reduces the frequency and severity of migraine attacks when taken regularly as a preventive treatment. For migraines, the typical dose ranges from 500mg to 1000mg per day. However, divalproex must NOT be used in women who are pregnant or who could become pregnant due to very serious risks of birth defects and developmental problems in the baby. Your neurologist or headache specialist will assess whether it is suitable for you.

What are the serious risks of divalproex during pregnancy?

Divalproex (valproate) carries some of the highest risks of any medicine when taken during pregnancy. It significantly increases the risk of serious birth defects — particularly spina bifida (a defect of the spinal cord) and heart, face, and limb abnormalities. It also causes developmental problems in children exposed before birth, including lower IQ, autism, and difficulties with language and learning. For these reasons, valproate is absolutely contraindicated in pregnancy and should not be used by women who could become pregnant without a specialist's explicit guidance and a pregnancy prevention programme.

What are the common side effects of divalproex?

Common side effects of divalproex include nausea, stomach upset, weight gain, hair loss (sometimes with a change in hair texture), tremor (shaking hands), drowsiness, and dizziness. Nausea and stomach effects are significantly reduced with the ER formulation compared to standard valproate. Hair loss is usually temporary. Tremor can be managed by reducing the dose or adding a low dose of a beta-blocker. Weight gain is a common concern — discuss dietary strategies with your doctor if this becomes significant.

What blood tests are needed with divalproex?

Divalproex requires regular monitoring. Your doctor will check liver function before starting and periodically during treatment, as divalproex can rarely cause serious liver damage (particularly in young children). Blood valproate levels are measured to ensure they are in the therapeutic range. A full blood count is checked, as valproate can reduce platelets (cells that help blood clot). Ammonia levels may be checked if you develop confusion or unusual drowsiness. Women of childbearing age must be enrolled in a formal pregnancy prevention programme.

Who should not take divalproex?

Divalproex must not be taken by pregnant women or women who could become pregnant without a specialist's guidance and a pregnancy prevention programme. It should not be used in people with liver disease or liver failure, or in people with a rare metabolic condition called urea cycle disorder. It should be used with great caution in young children (especially under 2 years) as the risk of serious liver damage is highest in this age group. Anyone with a personal or family history of mitochondrial disease should be assessed carefully before starting.

Can I buy Dicorate ER 125mg online from PremiumRxDrugs?

Yes, Dicorate ER 125mg (divalproex Sodiumium extended-release) is available at PremiumRxDrugs.com. PremiumRxDrugs is a licensed pharmacy with over 10 years of experience supplying genuine, manufacturer-sourced epilepsy and mood disorder medicines worldwide. We understand the need for reliable, quality-assured supply for long-term neurological and psychiatric treatment. Enjoy worldwide shipping, discreet packaging, and free shipping on qualifying orders.

Can divalproex cause weight gain, and how can I manage it?

Weight gain is one of the most commonly reported side effects of divalproex (valproate). It is thought to occur because valproate stimulates appetite and may affect metabolism. For some people the weight gain is modest; for others it can be significant. Practical strategies include eating a balanced, lower-calorie diet, avoiding high-sugar and high-fat snacks, staying physically active with regular exercise, and discussing the issue openly with your doctor at each review. In some cases, the dose may be adjusted or an alternative medicine considered if weight gain is causing significant problems.