Duovir N (150+200+300)mg Tablet
Available Dosages
| SKU | 575 |
|---|---|
| Generic For | Duovir- N |
| Strength | (150+200+300)mg |
| Active Ingredient | Lamivudine, Nevirapine and Zidovudine |
| Pack Size | Qty | Price Per Pill or Unit | Price | Cart | |
|---|---|---|---|---|---|
| 30 Capsules | US$ 0.96 | US$ 28.6520%US$ 36.00 | |||
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| 60 Capsules | US$ 0.83 | US$ 50.0031%US$ 72.00 | |||
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| 90 Capsules | US$ 0.78 | US$ 70.0035%US$ 108.00 | |||
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Duovir N Tablet (Lamivudine) for HIV & Hepatitis B
Duovir N (150+200+300)mg Tablet is a fixed-dose combination of three drugs commonly used in the management of human deficiency syndrome virus (HIV). Both lamivudine and zidovudine come under the category of drugs called antiretroviral drugs (ARV) while Nevirapine is a non-nucleoside reverse transcriptase inhibitor (NNRTI). These three drugs can also be used separately with other drugs for combination treatment of HIV or can be used together. The administration of Duovir-N reduces the ability of the virus to replicate, and they can thus reduce the damage that the HIV does over time to an individual’s defense system and other vital organs. The medicine does not eliminate or cure your HIV, but can control it. Patients receiving ART are less susceptible to opportunistic infections malignancies, and other health issues.
What is Duovir- N used for?
Duovir- N is a medicine useful in treating HIV infection. It helps prevent the virus from reproducing and spreading further. Remember, it may improve your condition, but is not a cure for HIV infection. HIV is a disease spread by unprotected sexual contact or contact with blood with an infected individual.
How does Duovir- N work?
The medicine reduces the amount of HIV in your body and keeps it at a low level. Its administration also increases the CD4 count. These CD4 cells play a significant role in maintaining a healthy immune system to fight against infections.
What medications interact with Duovir- N?
These are some medicines that can affect the action of Duovir-N. The following are the ones that should not be taken with this combination drug:
- Rifampin
- St. John’s wort
- Stavudine
- Fosamprenavir
- Ribavirin
- Tipranavir
- Atazanavir
- Efavirenz
- Emtricitabine
The drugs that can affect the mode of action of Duovir-N are listed below:
- Antifungal medicine like Fluconazole
- Oral contraceptive pills
- Anticonvulsants like valproic acid, phenytoin
- Anticancer drug like doxorubicin
- Warfarin, a medicine used to prevent blood clots
- Antimalarials like lumefantrine, artemisinines, atovaquone, quinine, artesunate, halofantrine
- Antibiotics like rifabutin, clarithromycin
When should Duovir- N not be used?
- Do not take this combination drug if you are hypersensitive to Lamivudine, Zidovudine, Nevirapine, other inactive components of the medication.
- It should not be administered to patients with a very low blood count or low white blood cell count.
- The medicine is not suitable for patients who are suffering from permanent liver disorder or marked changes in liver function.
- Avoid taking it if you have ever suffered from liver inflammation, severe skin reaction or liver problem while taking nevirapine containing products.
How should Duovir- N be taken?
The medicine can be taken before or after consuming food. The recommended dose in adults and children with a body weight of 25 kg or ore is one tablet two times a day. It should not be given to children weighing less than 25 kg since appropriate dose reductions can be made by the physician.
If you have renal disorders, then your physician will reduce your dose that suits your condition. Your physician can also change your combination drug to separate formulations of zidovudine, lamivudine, and nevirapine, which are available in the form of capsules, tablets, or liquid suspensions.
How long should you take Duovir- N?
Because Duovir-N control and doses, cure your problem, you will need to consume it continuously. You are not advised to discontinue the treatment unless your physician tells you to.
Missed dose of Duovir-N
If you accidently miss a dose of Duovir-N and notice within six hours, you can take the forgotten dose as soon as possible. After this, continue with your normal dosing schedule. In case, you notice later, then simply leave the missed pill and take the next dose on time. You are not supposed to double up the dose to compensate the missed combination pill.
How should Duovir- N be stored?
- Keep it out of the reach of children and pets
- Store it at controlled room temperature
- Keep it away from direct sun rays and moisture
What are the side effects of Duovir- N?
Major side effects of the medicine include a decrease in the blood cells, muscle pain, weight loss, rash, nausea, headache, cough, liver enlargement, and muscle breakdown.
Get immediate medical attention in case of these symptoms troubles you.
What is Duovir N used for?
Duovir N contains lamivudine 150mg, zidovudine 300mg, and nevirapine 200mg — a triple fixed-dose combination (FDC) providing a complete HIV treatment regimen in a single tablet taken twice daily. This all-in-one formulation simplifies HIV therapy to one tablet twice daily, improving adherence compared to separate tablet regimens. It combines two NRTIs (lamivudine + zidovudine) with an NNRTI (nevirapine) — the three drug classes required for effective HIV suppression. It is used in resource-limited settings and where simplified triple therapy is appropriate.
How does Duovir N provide complete HIV triple therapy?
Duovir N works on HIV replication through two complementary mechanisms: (1) Lamivudine and zidovudine (NRTIs) inhibit HIV reverse transcriptase as chain-terminating nucleoside analogues — blocking conversion of HIV RNA to DNA; (2) Nevirapine (NNRTI) binds directly to HIV reverse transcriptase at an allosteric site distinct from the active site — inhibiting enzyme conformation and activity. The combined triple therapy achieves HIV RNA suppression to undetectable levels (<50 copies/mL) in the majority of adherent patients, enabling CD4 recovery and immune reconstitution.
How should Duovir N be taken?
Duovir N is taken as one tablet twice daily (morning and evening, approximately 12 hours apart). It can be taken with or without food — food reduces zidovudine-related nausea. Nevirapine requires a 14-day lead-in period at half the dose to reduce rash risk: initiate with nevirapine 200mg once daily (not twice daily) for the first 14 days, then increase to standard twice-daily dosing. This lead-in period applies even when using the combined FDC — some clinicians use separate formulations for the lead-in period before switching to the FDC. Adherence is paramount — never miss doses.
What liver toxicity risk does Duovir N's nevirapine component carry?
Nevirapine causes hepatotoxicity in approximately 4–6% of patients — the most serious and potentially life-threatening side effect of this regimen. Risk is highest in the first 18 weeks. High-risk groups: women with CD4 >250 cells/mm³ (contraindicated for initiation) and men with CD4 >400 cells/mm³ (contraindicated for initiation). Monitor LFTs at baseline, 2 weeks, 4 weeks, then every 3 months. Symptoms: jaundice, dark urine, right upper quadrant pain, fatigue, nausea — stop immediately and do not rechallenge. Severe hypersensitivity with rash and liver toxicity (Steven-Johnson overlap) can be fatal.
What is the nevirapine rash risk in Duovir N and how is it managed?
Nevirapine causes rash in 15–20% of patients — typically maculopapular, occurring in the first 6 weeks. The 14-day lead-in period at half dose significantly reduces rash severity. Mild rash (no systemic symptoms) — continue therapy and monitor closely; antihistamines may help. Moderate rash (extensive, blistering, mucosal involvement) — stop nevirapine permanently; switch to an alternative NNRTI or a different regimen. Severe rash (Stevens-Johnson syndrome, toxic epidermal necrolysis) — stop all medications immediately, provide emergency care. Never restart nevirapine after a severe rash reaction.
Is Duovir N safe in HIV-positive patients who are also pregnant?
Duovir N requires individual risk assessment in pregnancy. Zidovudine has a long safety record in pregnancy and is still used in prevention of mother-to-child transmission (PMTCT). Lamivudine is considered safe. Nevirapine — the concern: high CD4 counts (>250 in women) increase hepatotoxicity risk, and many pregnant women have relatively preserved CD4. Current WHO guidelines prefer dolutegravir-based regimens for HIV in pregnancy over nevirapine-containing regimens due to better safety profile and superior efficacy. Specialist obstetric-HIV team guidance is essential before continuing or switching regimens in pregnancy.
What drug interactions affect Duovir N?
Nevirapine strongly induces CYP3A4 and CYP2B6 — reducing plasma levels of many co-medications: protease inhibitors (not combined with nevirapine as sole third agent), hormonal contraceptives (significantly reduced — non-hormonal contraception essential), rifampicin further increases nevirapine metabolism. Zidovudine is hepatically glucuronidated — rifampicin reduces AZT levels; avoid stavudine combination (antagonism). Lamivudine: trimethoprim increases levels; emtricitabine contraindicated (same resistance profile). Azole antifungals raise nevirapine levels. Always consult an HIV pharmacist before adding any new medication.
How does Duovir N compare to Triomune (lamivudine/stavudine/nevirapine)?
Duovir N and Triomune are both combination medicines used to treat HIV infection. Both contain lamivudine and nevirapine, but Duovir N contains zidovudine, while Triomune contains stavudine. Zidovudine is generally preferred today because stavudine has a higher risk of long-term side effects such as nerve damage, fat redistribution, and pancreatitis. Both medicines help reduce the amount of HIV in the body and improve immune function. However, modern HIV treatment guidelines usually favor safer and better-tolerated combinations over stavudine-based therapies.
Is Duovir N equivalent to Triomune-based triple therapy?
Duovir N (lamivudine/zidovudine/nevirapine) provides the same three drug classes as the reference triple therapy (NRTI+NRTI+NNRTI). It is a generic fixed-dose combination providing complete HIV triple therapy in one tablet twice daily at significantly lower cost than separate branded components — essential for HIV treatment access globally.
Can I order Duovir N from PremiumRxDrugs for international delivery?
Yes. PremiumRxDrugs.com ships Duovir N to the USA, UK, Australia, and many other countries. Our genuine manufacturer-verified HIV antiretrovirals, competitive pricing, and free worldwide shipping on qualifying orders make us a trusted international pharmacy for complete triple-drug HIV therapy.
What monitoring is required during Duovir N therapy?
Essential monitoring: LFTs at baseline, weeks 2, 4, 8, 12, then every 3 months — for nevirapine hepatotoxicity detection; FBC every 3–6 months — for zidovudine-induced anaemia/neutropenia; HIV viral load every 3–6 months (target: undetectable <50 copies/mL); CD4 count every 3–6 months; fasting glucose and lipids annually; renal function every 6 months; genotypic resistance testing if viral load >200 copies/mL (virological failure). Watch for rash within first 6 weeks. Educate patients about hepatotoxicity and rash warning signs — seek care immediately if these develop.
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