Efavir 200mg
Available Dosages
| Description | . |
|---|---|
| SKU | 361 |
| Generic For | N/A |
| Strength | 200 mg |
| Active Ingredient | Efavirenz |
Out Of Stock
Efavir 200mg (Efavirenz) for HIV Treatment
Efavir 200 mg (Efavirenz) belongs to a class of drugs called reverse transcriptase inhibitors, which also includes Zalcitabine, Zidovudine, didanosine, and lamivudine. It belongs to a subclass of reverse transcriptase inhibitors, referred to as non-nucleoside reverse transcriptase inhibitors that include nevirapine and delavirdine. It is always taken in combination with other HIV drugs, to treat infections with Human deficiency (HIV). The name of the medicine is Efavir, and it contains Efavirenz as an active ingredient. The drug is safe and effective in children younger than three months and who weigh less than 3.5 kg.
What is Efavir 200 mg (Efavirenz) used for?
Efavir 200 mg (Efavirenz) is a prescription Human Immunodeficiency Virus type 1 (HIV-1) drug, used to treat in adults and in children, who are at least three months old and weigh at least 3.5 kg. Human Immunodeficiency virus is a virus that causes Acquired Immunodeficiency Syndrome or AIDS. The medicine stops HIV from multiplying but does not cure the disease.
Buy Efavir 200 mg online to treat HIV infection.
How does Efavir work?
Efavir stop HIV from multiplying, by preventing the reverse transcriptase enzyme from working. The enzyme changes HIV’s genetic material (RNA) into the form of DNA. The step has to take place before HIV’s genetic code gets inserted into an infected cell’s genetic codes.
How should Efavir 200 mg be taken?
- Efavir 200 mg comes in the form of capsule. Swallow the capsule with a glass of water.
- To treat adults and adolescents who weigh 40 kg or more: The recommended dose of Efavirenz is one 600 mg capsule every day, ideally at bedtime. Taking the drug at bedtime reduces the risk of having side effects.
- Take the capsule when you are empty stomach, or take it with low-calorie food.
- To treat patients who weigh less than 40 kg: An oral solution or capsule containing a small amount of Efavirenz can be used.
- Take the tablet exactly as prescribed by the doctor. Do not alter the dosage plan.
- Overdose: Seek medical attention immediately, in the case of an overdose of Efavirenz.
Missed dose of Efavir 200 mg
If you have forgotten a dose, take it as soon you remember and go back to your usual dosing schedule. If the time to take the next dose is near, leave the forgotten dose and take the next dose. Do not double up the dose to compensate the missed one.
- Take the capsule for as long as your doctor recommended.
What are the side effects of Efavir 200 mg?
Like other medicines, Efavir 200 mg may cause adverse effects. Seek medical attention, in case the following troubles arise:
- Concentration troubles
- Vomiting
- Nausea
- Unusual dreams
- Dizziness
- Trouble sleeping
- Headache
- Diarrhea
Some adverse effects of Efavir 200 mg can be serious. Visit the doctor immediately, in the following situations.
- Severe depression
- Suicidal thoughts
- Aggression
- Severe depression
- Extreme fear
- Hallucinations
What medications interact with Efavir 200 mg?
The following medicines should be avoided, in case doctor recommends you Efavirenz to avoid possible drug interactions.
- Methylergonovine
- Midazolam
- Pimozide
- Ergotamine
- Dihydroergotamine
- Cisapride
- Triazolam
- Pimozide
Precautions
Tell the doctor before consuming Efavir:
- If you are hypersensitive to the drug, or its components
- If you are taking alcohol beverages
- If you are going for surgery, or a dental surgery
- If you have or ever had depression, seizures, high cholesterol, or other mental problems, or liver, pancreas or heart disease
- The drug may cause dizziness. Do not drive or use machinery, while taking Efavirenz as these activities may require a high degree of mental attention
- If you are pregnant or intending to become pregnant. You should discuss the benefits and risks of taking Efavir capsules during pregnancy. Breastfeeding women are advised not to take Efavirenz as it may pass into breast milk and harm the nursing baby
- Do not consume alcohol while using Efavirenz, as with all antihistamine drugs
- The medicine is not intended to use in children aged under two years
General
- Do not forget to see the expiry date of the product.
- Keep the drug reach out of children.
- It should not be given to anybody, even if they have the same problems.
- Always keep the written record of your medications.
What is Efavir 200mg used for?
Efavir 200mg contains efavirenz 200mg — a non-nucleoside reverse transcriptase inhibitor (NNRTI) used in combination antiretroviral therapy for HIV-1 infection. Efavirenz inhibits HIV reverse transcriptase non-competitively, blocking viral RNA-to-DNA conversion. The 200mg strength is one of three standard strengths (50mg, 200mg, 600mg); the full adult dose is typically 600mg once daily (three 200mg tablets). It is combined with two NRTIs (typically tenofovir + lamivudine or emtricitabine) as part of triple antiretroviral therapy.
How should Efavir 200mg be dosed for HIV treatment?
The standard adult dose is efavirenz 600mg once daily at bedtime — using three 200mg tablets together. Bedtime dosing reduces the impact of CNS side effects (dizziness, vivid dreams, somnolence) by allowing patients to sleep through the peak drug level period. Take on an empty stomach or with a light, low-fat meal — high-fat meals increase efavirenz absorption by 50%, worsening CNS toxicity risk. Efavirenz is typically part of a fixed-dose combination (e.g. Efavirenz/Tenofovir/Emtricitabine in single-tablet regimens) — individual 200mg tablets are used when FDC formulations are unavailable.
What CNS side effects does Efavir 200mg cause?
Efavirenz's most distinctive side effects are CNS-related, occurring in 40–50% of patients: vivid dreams or nightmares, dizziness and lightheadedness (especially on standing), impaired concentration, insomnia or somnolence, and unusual sensory experiences (tingling, altered taste/smell, visual disturbance). These effects are most pronounced in the first 2–4 weeks and gradually improve as the CNS adapts. Bedtime dosing minimises daytime impact. Severe psychiatric effects (depression, suicidal ideation, psychosis) occur in <1% — pre-existing psychiatric history increases risk and requires careful monitoring.
Is Efavir 200mg safe during pregnancy?
Efavirenz is not recommended in the first trimester of pregnancy — animal teratogenicity studies showed neural tube defects at high doses. However, human registry data (over 7,000 first-trimester exposures) does not confirm a significant increase in birth defects above background rates. WHO guidelines now state that the evidence does not support contraindication in women of childbearing potential, particularly where alternative NNRTI options are not available. Despite this, many guidelines prefer dolutegravir-based regimens in women of childbearing potential due to superior safety profile, efficacy, and tolerability.
What drug interactions are most important with Efavir 200mg?
Efavirenz is a potent inducer of CYP3A4 and CYP2B6 — significantly reducing plasma levels of co-administered drugs metabolised by these enzymes: protease inhibitors (lopinavir, atazanavir — need boosting), rifampicin (rifampicin increases efavirenz metabolism — dose increase to 800mg may be needed), hormonal contraceptives (oestrogen and progesterone levels significantly reduced — non-hormonal contraception essential), methadone (withdrawal risk — dose increase needed), statins (atorvastatin, simvastatin levels reduced), warfarin (INR changes — monitor carefully), and antifungals (voriconazole contraindicated — levels markedly reduced).
Is there a risk of drug resistance with Efavir 200mg?
Efavirenz has a low genetic resistance barrier — a single K103N mutation in HIV reverse transcriptase confers high-level resistance to efavirenz AND all first-generation NNRTIs (nevirapine, delavirdine). This single-mutation resistance makes efavirenz vulnerable to virological failure with poor adherence — even brief periods of subtherapeutic levels can select resistant mutations. Baseline resistance testing before initiation is essential. Second-generation NNRTIs (rilpivirine, doravirine, etravirine) retain activity against the K103N mutation and are used for patients failing efavirenz-based therapy.
How does Efavir 200mg compare to nevirapine for HIV treatment?
Efavir 200mg (efavirenz) and nevirapine are both antiretroviral medicines used to treat HIV infection. They work by blocking reverse transcriptase, an enzyme the HIV virus needs to multiply. Efavirenz is often preferred because it is generally more effective with once-daily dosing and has a lower risk of severe liver problems. However, it may cause side effects like dizziness, vivid dreams, or sleep disturbances. Nevirapine may be used in certain patients but carries a higher risk of liver and skin reactions in some people.
Is Efavir 200mg the same as Sustiva 200mg?
Yes. Efavir 200mg and branded Sustiva 200mg both contain efavirenz 200mg in bioequivalent formulations. Efavir is the generic alternative providing the same HIV NNRTI therapy at significantly lower cost — important for HIV treatment programmes in resource-limited settings where cost is a primary determinant of regimen choice.
Can I order Efavir 200mg from PremiumRxDrugs for delivery to Australia?
Yes. PremiumRxDrugs.com ships Efavir 200mg to Australia, the USA, UK, and many other countries. Our genuine manufacturer-verified antiretrovirals, competitive pricing, and free worldwide shipping on qualifying orders make us a reliable international pharmacy for efavirenz-based HIV regimens.
What side effects and precautions apply to Efavir 200mg?
Key precautions: take at bedtime to mitigate CNS effects. Avoid alcohol and CNS depressants — additive effects worsen dizziness and somnolence. Use effective non-hormonal contraception (hormonal contraception unreliable due to CYP induction). Screen for psychiatric history before initiation — depression screening at each visit. Driving may be impaired, especially during the first 2–4 weeks — advise caution. Do not stop efavirenz abruptly in triple regimens without specialist advice — stopping any single drug in a regimen risks the other agents being taken as functional monotherapy, promoting resistance selection.
How do CNS symptoms from Efavir 200mg typically evolve over time?
CNS symptoms from efavirenz follow a predictable time course in most patients. The first 72 hours are typically the most intense — dizziness, vivid dreams, dissociation, and concentration difficulty peak at day 1–3. By weeks 2–4, symptoms significantly improve as CNS adaptation occurs. By month 3, most patients report minimal or no CNS symptoms. Approximately 5–10% of patients have persistent CNS symptoms requiring consideration of efavirenz substitution. If CNS symptoms persist beyond 3 months or worsen, genotypic testing to exclude resistance and consideration of switching to a different NNRTI (rilpivirine, doravirine) or integrase inhibitor is appropriate.
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