Entacom 200mg
| SKU | 373 |
|---|---|
| Generic For | Comtan |
| Strength | 200mg |
| Active Ingredient | Entacapone |
| Pack Size | Qty | Price Per Pill or Unit | Price | Cart | |
|---|---|---|---|---|---|
| 30 Tablet/s | US$ 0.34 | US$ 10.14 | |||
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| 60 Tablet/s | US$ 0.34 | US$ 20.28 | |||
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| 90 Tablet/s | US$ 0.34 | US$ 30.40 | |||
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Entacom 200mg (Entacapone) – Affordable Comtan Alternative
Entacom 200mg is available in the form of tablets containing 200 mg Entacapone as the active constituent. Entacapone is known as an inhibitor of caetchol-O-methltransferase (COMT). It is used in combination with other medications for the treatment of Parkinson’s syndrome. Entacom along with two drugs namely carbidopa and levodopa have a longer effect in the brain and helps reduces parkinson’s symptoms for a longer period than levodopa and carbidopa treatment alone. The administration of this combination stops the activity of COMT and metabolization of levodopa, which leads to an overall increase of levodopa remaining in the body.
What is Entacom used for?
Entacom 200 mg is is used as an adjunct to carbidopa and levodopa to treat signs and symtoms of parkinson’s disease (PD) such as stiffness and muscle spasms. This three drugs combination is indicated in the treatment of patients with PD who experience the signs of end-of-dose wearing off.
How does Entacom 200mg work?
Entacom 200mg comprises of the beneficial substance Entacapone, which is a potent inhibitor of COMT. The active ingredient works by blocking the activity of enzyme that breaks down levodopa, which in results helps levodopa effects to last longer for a greater length of time as well as prevents the fading effect before the patient consumes the next dose.
Where to buy Entacom online?
Buy Entacom 200 mg online from premiumrxdrugs, the most reliable online pharmacy store. The medicine is available as tablets to our clients, at an absolute lowest price as compare to other local and online pharmacies.
What does Entacom contain?
Entacom for oral administration is supplied as 200 mg film-coated tablets. Each tablet contains 200 mg of Entacapone.
What are the side effects of Entacom?
- Very common side effects related to the usage of Entacom 200 mg are nausea, abnormal urine, and dyskenia. These symptoms may be more common with the higher doses as compare to the lower doses of the medicine.
- Some of the common adverse effects include dry mouth, diarrhea, constipation, headache, dizziness, leg cramps, postural hypotension, insomnia, dystonia, hallucinations, paroniria fall, vertigo, confusion, and tremor.
- Most of the unwanted effects of this medicine are associated with the increased dopaminergic activity and usually occurs at the starting of the treatment. However, if the levodopa dosage will be reduced, the severity and frequency of these effects may also decrease.
- The other major class of adverse reactions are gastrointestinal effects such as nausea with vomiting, stomach pain, diarrhea, and constipation. The color of the urine may also appear reddish brown by Entacom, but this is not a harmful condition for a PD patient.
- A slight reduction in erythrocyte count and haemoglobin have also been reported during the treatment with Entacapone.
What medications interact with Entacom?
No interaction of Entacapone with carbidopa has been reported. However, concomitant use of Entacom 200 mg with several drugs, including antidepressants, desipramine, venlafaxine, maprotiline, MAO-A inhibitors, and products that are metabolized by COMT is still limited therefore, caution should be taken when Entacom is administered wih these drugs. You should always tell your physician about all the medicines that you use during the treatment with Entacom.
When should Entacom not be used?
- Entacom 200 mg should not be used in patients with a history of neurolepric malignant syndrome.
- It is not meant for use in patients with hepatic impairment.
- It should not be taken by patients with known hypersensitivity to Entacapone or other inactive ingredients of the formulation.
- The medicine is not suitable for patients with phenochromocytoma because of the rasied chance of hypertensive crisis.
How should Entacom be taken?
Entacom should only be administered in combination with carbidopa and levodopa. The maximum recommended dose is 200 mg ten times per day. The medicine increases the effects of levodopa, therefore to reduce these effects, there is a need of adjustment of levodopa dosage within in the first days to first seven days after starting the treatment with Entacom. If you have any doubt related to the usage of the drug please contact your physician. Always follow your physician’s instructions as the dosage of the medicine depends on the severity and condition being treated.
How long should you take Entacom?
The Entacom 200 mg dose should be used as directly recommended by your physician.
Missed dose of Entacom?
If you forget or miss a dose of Entacom 200 mg, do not try to make it up by taking an extra dose. Instead, go back to your normal administration schedule as soon as you can and inform your physician about the dose that you have missed.
How should Entacom be stored?
- Keep the tablets in its original packet only until it is time to take them.
- The medicine should be kept in a cool, dry place where it cannot be exposed to sunlight and moisture.
- Avoid keeping the tablets in the window sill as heat and dampness can destroy some medicines.
- Keep the medicine in a place where children and pets cannot reach.
What is Entacapone and what condition does it treat?
Entacapone is a COMT inhibitor medication used alongside levodopa and carbidopa to treat Parkinson's disease symptoms. Entacom 200mg contains this active ingredient and helps manage motor fluctuations, particularly 'wearing-off' episodes that occur when levodopa effectiveness decreases between doses. This adjunct therapy extends the benefits of levodopa, improving movement control, reducing stiffness, and helping patients maintain better mobility throughout the day. Entacapone doesn't work alone—it must be combined with levodopa-carbidopa treatment to effectively manage Parkinson's motor symptoms.
How does Entacapone work in the body?
Entacapone blocks an enzyme called catechol-O-methyltransferase (COMT) that breaks down levodopa in the bloodstream before it reaches the brain. By inhibiting COMT, Entacom 200mg helps maintain higher, more stable levodopa levels for longer periods. This mechanism allows more levodopa to cross into the brain and convert to dopamine, the neurotransmitter depleted in Parkinson's disease. The result is smoother symptom control with fewer fluctuations between doses. This COMT enzyme blocker essentially makes your existing levodopa therapy work more efficiently throughout the day.
How long does Entacom 200mg take to work?
Entacom 200mg begins working within one hour of taking it with your levodopa dose, with peak effects occurring around two hours after administration. However, the full clinical benefits of this COMT inhibitor often become more noticeable after several days or weeks of consistent use alongside your Parkinson's medication regimen. Patients typically observe reduced 'off' time and smoother motor control as treatment continues. The medication's effects last approximately two hours per dose, which is why it's taken with each levodopa administration throughout the day to maintain steady symptom management.
When and how should I take Entacom 200mg?
Take Entacom 200mg with each dose of your levodopa-carbidopa combination, up to a maximum of eight times daily. This adjunct medication can be taken with or without food, though taking it with meals may reduce potential stomach upset. Swallow the tablet whole without crushing or chewing. The typical dosing schedule matches your existing levodopa regimen—each time you take levodopa, you take one Entacapone tablet alongside it. Your healthcare provider will determine the optimal dosing frequency based on your individual Parkinson's symptom pattern and response to treatment.
Is Entacom 200mg safe for long-term use?
Entacom 200mg is designed for ongoing, long-term use as part of continuous Parkinson's disease management. Clinical studies have demonstrated sustained safety and effectiveness when this COMT inhibitor is used chronically alongside levodopa therapy. Many patients take Entacapone for years without significant issues. Your physician will monitor your treatment through regular check-ups to assess liver function, blood pressure, and overall response. While long-term safety data is generally positive for this adjunctive Parkinson's medication, individual monitoring ensures the treatment continues benefiting you without unwanted complications as your therapy evolves.
Can I take Entacom 200mg with other medicines?
Entacom 200mg can interact with certain medications, particularly MAO inhibitors (except MAO-B selective types like selegiline or rasagiline used in Parkinson's treatment), iron supplements, and drugs metabolized by COMT including some antidepressants. This enzyme inhibitor may intensify effects of medications with catecholamine structures. Always inform your doctor about all prescription drugs, over-the-counter medicines, and supplements you're taking before starting Entacapone therapy. Your healthcare provider will review your complete medication list to identify potential interactions and adjust your Parkinson's treatment regimen safely.
How does Entacom 200mg compare to similar medicines in its class?
Entacom 200mg belongs to the COMT inhibitor class, which also includes tolcapone and opicapone. Unlike tolcapone, which requires liver monitoring due to hepatotoxicity risks, Entacapone has a superior safety profile and doesn't typically necessitate routine liver testing. Compared to newer opicapone (once-daily dosing), Entacom requires administration with each levodopa dose but has extensive long-term safety data and broader availability. All these adjunct medications extend levodopa effectiveness, but Entacapone balances proven efficacy, established safety, and practical dosing for most Parkinson's patients experiencing motor fluctuations.
Is the generic Entacapone as effective as branded versions?
Generic Entacapone contains the identical active pharmaceutical ingredient as branded versions like Entacom 200mg and must meet the same rigorous quality, safety, and efficacy standards set by regulatory authorities. Bioequivalence studies confirm that generic formulations deliver equivalent therapeutic effects for Parkinson's disease management. The COMT-inhibiting action remains consistent regardless of brand or generic status. Many patients successfully use generic Entacapone with identical symptom control compared to branded options, often at more affordable prices. Both forms work equally well as adjunct therapy alongside levodopa-carbidopa combinations for motor fluctuation control.
Why do patients choose PremiumRxDrugs for Entacom 200mg?
Patients select PremiumRxDrugs for their Entacom 200mg prescriptions because of guaranteed medication authenticity, competitive pricing that makes long-term Parkinson's treatment more affordable, and convenient prescription refill management. The licensed pharmacy's discreet international shipping ensures privacy while delivering genuine Entacapone from verified manufacturers. Easy reordering simplifies ongoing COMT inhibitor therapy without repeated pharmacy visits. With responsive customer support, transparent sourcing, and reliable delivery across USA, UK, Australia, Canada and beyond, PremiumRxDrugs has earned patient loyalty for over ten years by combining pharmaceutical quality with accessibility and affordability.
What are the common side effects of Entacapone?
Common Entacapone side effects include harmless orange-brown urine discoloration (occurring in most patients), diarrhea, nausea, abdominal pain, and increased involuntary movements (dyskinesia) due to enhanced levodopa activity. Some people experience dizziness, fatigue, or vivid dreams. The urine color change results from the medication's normal metabolism and doesn't indicate a problem. Dyskinesia often improves with levodopa dose adjustment. Most side effects are mild to moderate and diminish as your body adapts to this COMT inhibitor. Severe diarrhea, significant movement changes, or unusual behavioral symptoms warrant medical attention.
Who should avoid taking Entacapone?
Entacapone is contraindicated for people with pheochromocytoma (adrenal gland tumor), those taking non-selective MAO inhibitors, and patients with liver impairment. Individuals with a history of neuroleptic malignant syndrome or severe uncontrolled movements should use this COMT inhibitor cautiously. Pregnant or breastfeeding women should discuss risks versus benefits with their healthcare provider, as safety data is limited. Patients with low blood pressure, psychiatric conditions, or impulse control disorders require careful evaluation before starting Entacapone therapy. Those allergic to the active ingredient or formulation components should not use this medication.
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