Flavedon MR 35 mg (Trimetazidine) – Affordable Vastarel Alternative

Name: Flavedon MR 35 mg
Brand: Vastarel
SKU: 1159
Availability: InStock

Flavedon 35 mg (Trimetazidine)

Flavedon 35 mg consists of an active ingredient Trimetazidine. Trimetazidine is described as the first cytoprotective anti-ischemic agent. It inhibits fatty acid oxidation, and Reactive oxidation species production. Trimetazidine limits oxygen consumption, and preserves mitochondrial functioning during hypoxia. It shows anti-ischemic effects, and vasodilatory effects in vivo.

How does Flavedon work?

Flavedon is a metabolic drug that improves glucose oxidation, and maintains energy metabolism during ischemia. It stops the β oxidation of fatty acids to enhance the glucose oxidation. The glucose oxidation optimises cellular energy processes, and maintains energy metabolism in ischemia or hypoxia. The medicine maintains the cellular homeostasis by increasing the cell tolerance to hypoxia or ischemia. In this way, Trimetazidine decreases the frequency of angina attacks, and gives symptomatic relief to angina pain.

How should Flavedon be taken?

Flavedon is present in the sustained release tablet form. It should be taken twice daily, or as your physician suggests. Swallow the medicine with an adequate amount of water.
Take the tablet exactly as prescribed by the doctor. Do not alter the dosage plan.
The dose regimen varies from patient to patient; it depends on the condition of the patients.
Take Cytogard tablets strictly according to your doctor’s instruction. Do not alter the dosage plan unless your physician advises you to do so.
Take the medicine regularly to get the best results.
To help you remember, take the tablets at the same time, each day.
In some cases, the condition may become worse when the intake of the medicine is stopped suddenly. Your dose may need to be slowly decreased.
Overdose: Seek medical attention immediately, in the case of an overdose of Trimetazidine.
Take the tablets for as long as your physician recommends.

Precautions

What medications interact with Flavedon?

Avoid consuming Flavedon, if you are taking the medicines that are given below:

Ketoconazole
Erythromycin
Ketoconazole
Trazodone
Fluconazole
Sotalol
Barbiturates
Pimozide
Telithromycin
Itraconazole
Trazodone
Fluconazole
Phenytoin
Rifampicin
Verapamil
Ritonavir
Mirtazapine
Nefazodone
Nelfinavir
Bupropion
Diltiazem
Mirtazapine
Josamycin

When should Flavedon not be used?

Avoid taking Flavedon in the following conditions:

If you are hypersensitive to the drug, or its components.
If you are a woman of childbearing potential
Breastfeeding women are advised not to take Trimetazidine as it may pass into the breast milk and harm the nursing baby.

Talk to your doctor, before taking Flavedon if:

If you have allergies to food, medicines, and other substances.
If you are suffering from kidney disorders.
If you are suffering from tremors.
If you are suffering from hypotension.
If you have a history of a stroke, or a heart attack.
If you are suffering from Parkinson’s syndrome.
If you are an elderly person.
If you have undergone pacemaker implantation.
If you are consuming any prescription or non prescription medicines.
If you are hypersensitive to some food products.

How should Flavedon be stored?

The drug may cause dizziness. Do not drive or use machinery, while taking Flavedon, as these activities may require a high degree of mental attention.
Do not forget to see the expiry date of the product.
Store the tablets in a dry place and out of the direct light.
It should be stored at a room temperature.
Place the medicine away from infants.

Dosage Instructions

Side Effects

What are Side effects of Flavedon?

Like other medicines, Flavedon may cause adverse effects. Seek medical attention, in case the given troubles arise:

Headache
Dizziness
Blurred vision
Lightheadedness

Some serious and rare adverse effects that need serious consideration are listed below:

Diarrhea
Sickness
Palpitations
Constipation
High level of uric acid in the blood
Muscle cramps

How to Use

What is Flavedon 35 mg used for?

Flavedon 35 mg is prescribed as a long-term treatment of angina pectoris. The medicine increases coronary flow reserve, thereby delaying the onset of ischemia related with exercise, limits rapid swings in blood pressure without any specific variations in the heart rate, significantly decreases the number of angina attacks, and leads to significant decrease in the use of nitrates. Trimetazidine also improves the left ventricular function in diabetic patients with CHD. Buy Flavedon 35 mg online to treat conditions that are mentioned above.

Infographics

FAQ

What is Flavedon MR 35mg used for?

Flavedon MR 35mg contains trimetazidine modified-release 35mg — the once- or twice-daily formulation of this metabolic anti-anginal agent. The modified-release mechanism provides sustained plasma trimetazidine levels throughout the day with twice-daily dosing, compared to the three-times-daily standard-release 20mg tablet. It is used as add-on therapy for stable angina pectoris in patients not fully controlled on nitrates, beta-blockers, or calcium channel blockers. It improves myocardial energy efficiency during ischaemia without haemodynamic effects.

Why is the MR 35mg formulation preferred over standard-release 20mg TID?

Flavedon MR 35mg provides equivalent anti-anginal metabolic protection as standard-release 20mg three times daily, but with a more convenient twice-daily dosing regimen. Sustained plasma levels with the MR formulation may provide more consistent metabolic cardioprotection throughout the day without the inter-dose troughs of TID standard-release dosing. Simpler twice-daily dosing significantly improves patient adherence compared to three-times-daily regimens — particularly important in elderly patients who often take multiple medications.

How and when should Flavedon MR 35mg be taken?

Flavedon MR 35mg is taken twice daily with meals — morning and evening. The modified-release tablet must be swallowed whole — do not crush, chew, or split it, as this destroys the sustained-release mechanism and delivers the full dose immediately. Take at consistent times each day. Unlike haemodynamic anti-anginals (nitrates, beta-blockers), dose timing relative to physical activity is less critical — trimetazidine provides background metabolic protection throughout the day.

How effective is Flavedon MR 35mg at reducing angina attacks?

Clinical trials demonstrate that trimetazidine MR 35mg twice daily, added to conventional anti-anginal therapy, reduces weekly angina attack frequency by 50% or more compared to conventional therapy alone. Sublingual nitroglycerin consumption decreases significantly. Exercise duration on treadmill testing improves (indicating greater ischaemic threshold). Effects on heart rate, blood pressure, and cardiac output are minimal — the benefit is purely through improved metabolic efficiency of the ischaemic myocardium.

Is Flavedon MR 35mg suitable for elderly angina patients?

Elderly patients (>75 years) require particular caution with trimetazidine MR. While elderly patients often have more severe angina and may benefit from add-on therapy, they are at highest risk of trimetazidine-induced movement disorders (Parkinson-like symptoms, restless legs). The EMA has recommended that trimetazidine should not be used when movement disorders are present. Careful monitoring of gait, balance, and fine motor function at each visit is essential. Dose reduction in renal impairment (eGFR 30–60) is required in elderly patients with CKD.

Who should not take Flavedon MR 35mg?

Contraindications: Parkinson's disease, tremor, muscle rigidity, restless legs syndrome, gait instability, severe renal impairment (eGFR <30 ml/min), and known hypersensitivity to trimetazidine. Avoid in patients with any pre-existing movement disorder. Not available in the USA (not FDA-approved). Use with caution in moderate CKD — dose reduction to 35mg once daily is recommended when eGFR is 30–60 ml/min. Use only as add-on to, never as a replacement for, evidence-based cardiovascular medications.

How does Flavedon MR 35mg compare to ranolazine for angina?

Flavedon MR 35mg (trimetazidine) and ranolazine are both used to help manage angina, or chest pain caused by reduced blood flow to the heart. Trimetazidine helps heart cells use oxygen more efficiently, while ranolazine improves the heart’s energy balance and blood flow function. Both can reduce angina symptoms and improve exercise tolerance. Ranolazine is often used for more persistent angina, while trimetazidine may be preferred as an add-on treatment. The best option depends on symptom severity, other heart conditions, and how well a patient tolerates the medicine.

Is Flavedon MR equivalent to Vastarel MR 35mg?

Yes. Flavedon MR 35mg and Vastarel MR 35mg both contain trimetazidine 35mg in an identical modified-release formulation. Both are bioequivalent with the same metabolic anti-ischaemic mechanism and clinical efficacy. Flavedon is a generic formulation providing the same therapeutic quality as branded Vastarel MR at significantly lower cost.

Can I order Flavedon MR 35mg from PremiumRxDrugs for delivery to the UK?

Yes. PremiumRxDrugs.com ships Flavedon MR 35mg to the UK, USA, Australia, and many other countries. Our genuine manufacturer-verified cardiovascular medications, competitive pricing, and free worldwide shipping on qualifying orders make us a trusted source for patients requiring MR trimetazidine as add-on stable angina therapy.

What side effects does Flavedon MR 35mg cause?

GI side effects (nausea, vomiting, abdominal pain) are most common at initiation, reduced by taking with food. Movement disorders are the main serious side effect: Parkinson-like tremor, muscle rigidity, postural instability, and restless legs syndrome — occurring more commonly in elderly patients and those with CKD. These movement effects are generally reversible on stopping trimetazidine. Less common: dizziness, headache, skin rash. Hepatitis has been reported rarely. Patients taking the MR 35mg formulation report similar side effects to standard-release 20mg TID.

What precautions apply to Flavedon MR 35mg users?

Assess movement and balance at baseline and each follow-up visit. Stop the drug immediately if tremor, gait disturbance, or muscle stiffness develops and seek medical review. Do not use in patients with pre-existing movement disorders. Reduce dose to 35mg once daily in eGFR 30–60 ml/min. Swallow whole — never crush. Ensure optimised evidence-based therapy (beta-blockers, statins, aspirin, ACE inhibitors) is in place before adding trimetazidine. Inform your cardiologist at each visit whether angina frequency has changed on this therapy.

SKU	1159
Generic For	Vastarel
Strength	35mg
Active Ingredient	Trimetazidine

Flavedon MR 35 mg