Glizid 40mg
Available Dosages
| SKU | 483 |
|---|---|
| Generic For | Diamicron |
| Strength | 40mg |
| Manufacturer | Panacea (India). |
| Active Ingredient | Gliclazide |
| Pack Size | Qty | Price Per Pill or Unit | Price | Cart | |
|---|---|---|---|---|---|
| 30 Tablet/s | US$ 0.15 | US$ 4.63 | |||
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| 60 Tablet/s | US$ 0.15 | US$ 9.27 | |||
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| 90 Tablet/s | US$ 0.15 | US$ 13.91 | |||
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Glizid 40mg – Affordable Diamicron Alternative for Type 2 Diabetes
Glizid 40mg is best known for lowering blood sugar levels in type 2 diabetes mellitus (non-insulin-dependent diabetes). This is a second-generation sulphonylurea oral hypoglycaemic agent used to treat non-insulin-dependent diabetes mellitus. It is used in conjunction with diet and exercise regimens to control high blood sugar in non-insulin-dependent diabetic patients. Generally, diabetic people can substitute their antidiabetic drugs with Glizid medicine for greater effects.
Gliclazide, the main active ingredient in Glizid, helps lower blood sugar levels by correcting both defective insulin secretion and peripheral insulin resistance. With this drug, you can control high blood sugar and thereby prevent its symptoms, including kidney disease, heart disease, blindness, and blood circulation problems. This medicine is also very affordable to take and works well against diabetes when diet and physical exercise are not proving to be effective enough for controlling blood sugar.
Glizid 40 mg should not be used in patients with known hypersensitivity to Gliclazide or to any of the ingredients of the formulation. Do not take this antidiabetic medication if you have insulin-dependent diabetes type 1 diabetes. This antidiabetic is not recommended if you have ketone bodies and sugar in your urine, a condition known as ketoacidosis, or a diabetic pre-coma. Gliclazide is not generally recommended in cases of kidney or liver disease. Also, the use of antidiabetic medication is contraindicated in pregnant and breastfeeding women.
During treatment, regular monitoring of your blood sugar level and glycated haemoglobin (HbA1c) is required. You may have considerably low blood sugar levels. The symptoms include intense hunger, headache, nausea, vomiting, sleep disturbances, irritability, fatigue, confusion, reduced alertness, tremor, dizziness, sensory disturbances, feelings of helplessness, poor concentration, and impaired reaction time. If you have a family history of, or have confirmed, the hereditary condition glucose-6-phosphate dehydrogenase (G6PD) deficiency. Fluctuations in blood sugar levels can occur when Glizid 40 mg is prescribed alongside antibiotic medicines, such as fluoroquinolones, especially in elderly patients. In this case, your healthcare specialist will remind you to monitor your blood glucose levels regularly.
Glizid 40 mg may interact with some medical elements like salicylates, sulphonamides, oral anticoagulants, phenylbutazone, clofibrate, and MAOIs. You may experience nausea and flushing when taking Glizid with alcohol. Concomitant administration of miconazole, perhexiline or cimetidine with Gliclazide may result in hypoglycemia. Rifampicin, diazoxide, corticosteroids, diuretics, β-blockers, barbiturates, alcohol, estrogens, and sympathomimetic drugs can alter its hypoglycemic effect. Also, inform yoru healthcare specialist if you are taking medicines that contain alcohol.
Hypoglycaemia, or low blood sugar, is the most commonly observed side effect. If the condition remains left untreated, these symptoms could progress to drowsiness, loss of consciousness, or possibly coma.
Other side effects of Glizid 40mg may include diarrhoea, haemolytic anaemia, cholestatic jaundice, skin reactions, leukopenia, thrombocytopenia, gastrointestinal disturbances, vomiting, gastritis, and increased transaminases.
The probable side effects can be classified as:
- Dermatological effects
Urticaria (hives or pale red, raised, itchy bumps on skin), rash, and pruritus (severe itching of the skin)
- Gastrointestinal effects
Constipation, nausea, vomiting, and diarrhoea. This medication may cause hypoglycemia, which may present with symptoms such as dizziness, hunger, sweating, nervousness, shaking, weakness, drowsiness, headache, tingling in the hands or feet, and a fast heartbeat. It’s advised to notify your doctor if you experience any of these symptoms.
- Blood disorders
A reduction in the number of blood cells (for example, platelets, red and white blood cells) may cause prolonged bleeding, bruising, fever, and sore throat. These symptoms usually resolve upon discontinuation of treatment.
- Liver disorders
There have been reports of abnormal liver function that can contribute to yellow skin and eyes. The symptoms generally resolve once the treatment is stopped.
If you develop any of these side effects, speak to your healthcare specialist. This includes any possible side effects not listed in this information guide.
What is Glizid 40mg used for?
Glizid 40mg contains gliclazide 40mg — a second-generation sulfonylurea for type 2 diabetes management. It stimulates insulin secretion from pancreatic beta cells to lower blood glucose. Gliclazide is distinguished from other sulfonylureas by its antioxidant properties (protecting beta cells from oxidative stress) and its relatively low risk of severe hypoglycaemia. The 40mg dose is typically used as a starting or low maintenance dose, with up to 160mg/day in divided doses at the standard-release strength.
What makes gliclazide different from other sulfonylureas?
Gliclazide differs from older sulfonylureas (glibenclamide) and some newer ones (glimepiride) in several ways: it has antioxidant properties that may protect pancreatic beta cells and vascular endothelium; it shows relatively selective action on pancreatic beta cells with some degree of glucose-dependent modulation; and it has a cardiovascular safety record from the ADVANCE trial — demonstrating safe intensive glycaemic control in patients with type 2 diabetes and high cardiovascular risk. These features make gliclazide a trusted, well-studied option.
How should Glizid 40mg be taken?
Glizid 40mg (standard-release) is taken 1–2 times daily, typically with breakfast and the evening meal. If twice daily, take morning and evening doses with food. The standard-release 40mg can also be prescribed as 80mg or 160mg daily in divided doses. Take with or just before meals. Do not skip meals after taking the dose — hypoglycaemia risk increases. Never take two doses together to compensate for a missed dose. Consistent meal timing and dosing minimises blood glucose fluctuations.
How quickly does Glizid 40mg lower blood glucose?
Gliclazide begins stimulating insulin secretion within 1 hour of the dose, with peak blood glucose-lowering effect 2–4 hours post-dose. HbA1c reduction develops over 3 months of consistent therapy. At 40mg once daily (starting dose), the HbA1c reduction is modest (0.4–0.8%). Titrating to 80mg or 160mg daily produces progressively greater reductions. The modified-release (MR) formulation (Gliclazide 80mg MR) is now preferred in many guidelines for once-daily dosing, but standard-release 40mg remains effective for twice-daily use.
Is Glizid 40mg safer than glibenclamide in elderly patients?
Yes — gliclazide is considered significantly safer than glibenclamide (glybenclamide/Daonil) in elderly patients. Glibenclamide has a very long duration of action and active metabolites that accumulate in renal impairment, causing prolonged and life-threatening hypoglycaemia in elderly and CKD patients. Gliclazide's shorter, more predictable action makes hypoglycaemia epiSodiumes more manageable and less severe. Most national diabetes guidelines explicitly recommend against glibenclamide in elderly patients and favour gliclazide or gliclazide MR.
Who should not use Glizid 40mg?
Gliclazide is contraindicated in type 1 diabetes, DKA, severe renal impairment (eGFR <30 ml/min), significant hepatic disease, pregnancy, breastfeeding, and known sulfonamide hypersensitivity. Use with caution in the elderly with mild-moderate CKD — dose reduction and frequent blood glucose monitoring are warranted. Avoid in patients who cannot eat regularly. Interactions with fluconazole, fluoroquinolones, and NSAIDs can increase gliclazide's effect — monitor when starting new medications.
How does Glizid 40mg compare to Glucobay (acarbose) for type 2 diabetes?
Glizid (gliclazide) and Glucobay (acarbose) both lower post-meal blood glucose but by entirely different mechanisms. Gliclazide stimulates insulin secretion from beta cells — effective and well-studied, but causes hypoglycaemia and modest weight gain. Acarbose inhibits intestinal carbohydrate digestion — modest glucose lowering without hypoglycaemia or weight gain, but frequently causes GI side effects (bloating, flatulence). Gliclazide provides greater HbA1c reduction; acarbose is preferred when hypoglycaemia must be avoided and GI side effects are acceptable.
Is Glizid the same as Diamicron?
Yes. Glizid contains gliclazide — the same active ingredient as branded Diamicron (standard-release) tablets. Both are manufactured to bioequivalence standards with identical blood glucose-lowering efficacy. Glizid is the generic formulation, providing the same therapeutic quality as Diamicron at significantly lower cost, making long-term diabetes management more affordable.
Can I order Glizid 40mg from PremiumRxDrugs for international delivery?
Yes. PremiumRxDrugs.com ships Glizid 40mg to the USA, UK, Australia, and many other countries. Their genuine manufacturer-verified medicines, transparent pricing, and free worldwide shipping on qualifying orders make them a reliable international pharmacy for patients managing type 2 diabetes with sulfonylurea therapy.
What side effects does Glizid 40mg cause?
Hypoglycaemia is the primary side effect — risk is lower than with glibenclamide but present, especially if meals are delayed or missed. Weight gain (1–2 kg) is common with improved glycaemic control. GI side effects (nausea, constipation) are occasionally reported. Rare effects include allergic skin reactions, elevated liver enzymes, and blood dyscrasias. Photosensitivity reactions have been reported with some sulfonylureas including gliclazide — use sunscreen during prolonged sun exposure.
What precautions apply when using Glizid 40mg?
Never miss meals after dosing. Carry glucose for hypoglycaemia. Monitor blood glucose regularly. Limit alcohol (potentiates hypoglycaemia). Review all new medications for interactions (especially antifungals, antibiotics, NSAIDs). Monitor renal and hepatic function annually. Use caution in patients with irregular meal patterns, athletic activity, or intercurrent illness. In elderly patients, the lowest effective dose should be maintained to minimise hypoglycaemia risk.
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