Irovel H 150/12.50mg
Available Dosages
| SKU | 546 |
|---|---|
| Generic For | Avalide |
| Strength | 150/12.50mg |
| Active Ingredient | Irbesartan HCTZ |
Out Of Stock
Irovel H 150/12.50mg (Irbesartan HCTZ) – Affordable Avalide Alternative
Irovel H- 150/12.5 mg (Irbesartan)
Irovel H-150/12.5 mg is a combination of Irbesartan, an angiotensin II receptor antagonist and Hydrochlorothiazide, a thiazide diuretic, used for hypertension in patients not adequately controlled with monotherapy. The medicine is also used as an initial therapy in patients likely to need multiple medicines to attain adequate blood pressure.
Irovel H general information
What is Irovel H-150/12.5 mg used for?
Irovel H-150/12.5 mg tablets are used for the treatment of hypertension. The medicine may also delay progression of diabetic neuropathy and is also used to reduce renal disease progression in patients with hypertension, type 2 diabetes, and proteinuria.
How does Irovel H-150/12.5 mg work?
Irovel H-150/12.5 mg tablets contain the active ingredient Irbesartan, which works by:
- Decreasing the body’s production of substances that can increase the blood pressure level
- Making the blood vessels relax and widen
- Making it easier for the heart to pump blood to all parts of the body
Another active ingredient is Hydrochlorothiazide, which works by increasing the excretion of water and salt out of the body. It reduces the blood pressure within the blood vessels by removing electrolytes and water from the blood stream.
What are the different doses of Irovel H?
Irovel H tablets are available to buy online from premiumrxdrugs.com in Irovel H-150/12.5 mg strength. Buy Irovel H-150/12.5 mg online far cheaper than other local pharmacies.
What does Irovel H-150/12.5 mg contain?
Irovel H is a combination drug that contains Irbesartan and Hydrochlorothiazide as the active ingredients. Each Irovel H tablet contains 150 mg Irbesartan and 12.5 mg Hydrochlorothiazide.
What are the side effects of Irovel H-150/12.5 mg?
Tell your physician, if you do not feel well while consuming Irovel H tablets.
All drugs can have undesired side effects. Sometimes they are severe, most of the time they are not. You may require medical help if you get some of the side effects. Inform your physician, if you notice any of the following and they worry you.
- Nausea
- Headache
- Dry mouth
- Vomiting
- Weakness
These are the most common side effects of Irovel H.
Tell your physician immediately, if you experience:
- Chills
- Swelling
- Fever
- Flu symptoms
- Pain in the chest
- Pale or yellowing skin
- Rapid weight gain
- Appearance of rashes on the skin
- Bradycardia
- Sleeping problems
- Hyperkalemia
- Breathing problems
- Tachycardia
- Palpitations
- Hyperkalemia
- Anxiety disorder
- Itching
The list of the side effects listed above is not complete. If you suffer from any of these or any other unwanted effects, please inform your physician.
What are the medications interact with Irovel H-150/12.5 mg?
Please tell your physician, if you are consuming any other medicines, including medicines obtained without a prescription. Your physician or pharmacist may wish to alter your dose, if you are taking any of the following drugs.
- Drospirenone
- Lithium
- Aspirin
- Enalapril
- Aliskiren
- Naproxen
- Lithium
- Ramipril
These drugs may be affected by Irovel H or may affect how well Irovel H works. You may need a different amount of medicines, or you may need to consume different medicines. Your physician has more information on drugs to be careful with or avoid while taking Irovel H.
When should Irovel H-150/12.5 mg not be used?
- You should not use Irovel H if you are allergic or have hypersensitivity to Irbesartan or to any of the other ingredients of Irovel H.
- It should not be administered in children and adolescents because the efficacy and safety have not been fully established.
- Also, it should not be given to pregnant and breastfeeding women.
How should Irovel H be taken?
- Irovel H tablet is for oral use. Swallow the tablet with a glass full of water. You can take it with or after consuming food.
- Irovel H helps control your problem only if taken on a regular basis; therefore you must take it daily. Take the medicine regularly to get the best results.
- Do not change the dosing schedule, unless your physician advices you to do so.
- You should only take the number of tablets that you have been told. Visit your nearest medical centre immediately, if you think that you have taken too much Irovel H tablets by mistake.
How long should you take Irovel H-150/12.5 mg?
Continue taking Irovel H tablets for as long as your physician recommends you.
Missed dose of Irovel H-150/12.5 mg
In case, you forget to take the dose and if it is less than 2-4 hours left for the next dose, leave the missed one and take the next dose at the recommended time. Do not double up the dose for the missed one.
How should Irovel H-150/12.5 mg be stored?
- Keep it out of the reach of children and away from pets. Avoid exposure to light, moisture, and heat.
- Do not place your tablets in the bathroom or near a sink.
- Do not take any medicine after the expiry date, which is mentioned on the carton.
- Always keep the medicine in the original package.
What is Irovel H 150/12.5mg used for?
Irovel H 150/12.5mg is a fixed-dose combination tablet containing irbesartan 150mg (an ARB) and hydrochlorothiazide (HCTZ) 12.5mg (a thiazide diuretic). It is prescribed for hypertension that is not adequately controlled on either irbesartan or HCTZ alone. The two components work synergistically—irbesartan blocks the RAAS to reduce vasoconstriction and Sodiumium retention, while HCTZ promotes Sodiumium and water excretion through the kidneys. Combined, they provide additive blood pressure lowering through complementary mechanisms. This combination is particularly useful when a single antihypertensive agent at maximum dose is insufficient.
How does the HCTZ in Irovel H enhance irbesartan's blood pressure effect?
Hydrochlorothiazide (HCTZ) causes Sodiumium and water excretion through the kidney, reducing blood volume and thereby lowering blood pressure. This volume depletion activates the RAAS (a compensatory response), which would normally limit the diuretic's antihypertensive effect. Irbesartan blocks this RAAS activation, removing the compensatory vasoconstriction and allowing the full diuretic benefit to be expressed. Conversely, HCTZ reduces the volume-mediated component of blood pressure, making irbesartan's vaSodiumilatory effects more effective. This pharmacological synergy makes the combination substantially more effective than either agent alone—studies show Irovel H reduces blood pressure by 20–25 mmHg systolic, compared to 10–15 mmHg for individual components.
Is Irovel H 150/12.5mg better than taking irbesartan and HCTZ separately?
Clinically, Irovel H 150/12.5mg is equivalent to taking separate irbesartan 150mg and HCTZ 12.5mg tablets—the pharmacokinetic profiles are the same. The advantage of a fixed-dose combination is improved convenience (one tablet instead of two), which significantly improves medication adherence. Studies consistently show that combination pills improve adherence by 20–30% compared to equivalent separate tablets. Better adherence translates directly to better blood pressure control and reduced cardiovascular risk. Irovel H is also often more cost-effective than two separate branded medications, making it practical for long-term hypertension management.
What are the side effects of Irovel H 150/12.5mg?
Side effects reflect both components. Irbesartan-related effects include hyperkalemia (elevated potassium) and rare angioedema. HCTZ-related effects include hypokalemia (low potassium—opposite to irbesartan's effect, which partially offsets this risk), increased blood glucose (concern in pre-diabetics and diabetics), elevated uric acid (gout risk), increased triglycerides, increased calcium levels, and photosensitivity. The combination partly mitigates potassium changes—HCTZ causes potassium loss while irbesartan causes potassium retention, producing a more neutral effect. Dizziness and hypotension can occur. Monitor potassium, glucose, uric acid, and creatinine periodically.
Can patients with diabetes use Irovel H 150/12.5mg?
Diabetic patients can use Irovel H 150/12.5mg, but with specific considerations. HCTZ can worsen glycemic control by reducing insulin secretion—a concern for diabetics or pre-diabetics. The irbesartan component is actually beneficial for diabetic nephropathy. For diabetic patients with significant nephropathy, irbesartan alone (Irovel 300mg) is often preferred over the combination product to avoid HCTZ's adverse metabolic effects. For diabetic patients with hypertension but preserved kidney function where blood glucose is well controlled, Irovel H is a reasonable option with appropriate glucose monitoring.
How does Irovel H compare to Coaprovel or Avalide?
Irovel H 150/12.5mg is therapeutically equivalent to Coaprovel 150/12.5mg (the branded product by Sanofi, marketed as Avalide in the USA)—all contain irbesartan 150mg and hydrochlorothiazide 12.5mg. Coaprovel/Avalide are brand-name products at significantly higher prices. Irovel H is a bioequivalent generic delivering the same clinical effects at substantially lower cost. The choice between branded and generic versions comes down purely to cost preference and availability. Through PremiumRxDrugs.com, Irovel H is available at international generic prices, offering significant savings for patients in Western markets.
Is Irovel H 150/12.5mg safe for kidney disease patients?
Irovel H 150/12.5mg requires caution in kidney disease. Irbesartan is generally renoprotective in mild-to-moderate CKD, but HCTZ is less effective as a diuretic when GFR drops below 30 mL/min and can worsen renal function in advanced CKD. In patients with significant CKD (GFR <30 mL/min), HCTZ is often replaced with a loop diuretic (furosemide). For patients with mild-to-moderate CKD, Irovel H may be used cautiously with regular monitoring of creatinine, potassium, and blood pressure. In diabetic nephropathy requiring maximum irbesartan effect, irbesartan 300mg alone (Irovel 300mg) may be preferred over the combination product.
What monitoring is needed when taking Irovel H 150/12.5mg?
Regular monitoring includes: serum potassium (HCTZ lowers while irbesartan raises—monitor for net effect, particularly in CKD), serum creatinine and eGFR (check at baseline, 2–4 weeks after starting, and every 6–12 months), blood glucose (HCTZ can raise glucose—monitor 3-monthly in diabetics), serum uric acid (HCTZ raises uric acid—monitor if history of gout), and blood pressure (regularly at home and at clinic visits). Electrolyte panel should also include Sodiumium (HCTZ can cause hyponatremia). Annual comprehensive metabolic panel is recommended for patients on long-term Irovel H.
Can Irovel H cause gout?
The HCTZ component of Irovel H raises serum uric acid levels by reducing renal uric acid excretion, increasing gout risk in susceptible patients. If you have a history of gout or elevated uric acid, discuss this risk with your physician before starting Irovel H. Notably, irbesartan itself has very mild uricosuric properties (though much weaker than losartan's), which may partially offset HCTZ's uric acid-raising effect. For hypertensive patients with established gout or high uric acid, irbesartan alone (Irovel 150mg/300mg) without HCTZ may be preferred to avoid worsening uric acid levels.
How should I take Irovel H 150/12.5mg for best results?
Take Irovel H 150/12.5mg once daily at a consistent time—morning is often preferred as the HCTZ diuretic component will cause increased urination during the day rather than disturbing sleep at night. Take with or without food. Morning dosing also allows monitoring of any dizziness or hypotension during waking hours. Do not skip doses—consistent daily use is essential for steady blood pressure control. If you miss a dose, take it when you remember unless it is nearly time for the next dose; never double dose. Store at room temperature, away from moisture and heat.
Is Irovel H 150/12.5mg available without a prescription?
No, Irovel H 150/12.5mg is a prescription-only medication in all major English-speaking countries. Both components (irbesartan and HCTZ) require medical supervision due to their cardiovascular, renal, and metabolic effects. A physician must evaluate your blood pressure, kidney function, electrolytes, and comorbidities before prescribing. PremiumRxDrugs.com requires a valid prescription for all Irovel H orders to comply with pharmaceutical regulations and ensure appropriate medical oversight for blood pressure management.
Why buy Irovel H 150/12.5mg from PremiumRxDrugs.com?
PremiumRxDrugs.com offers genuine Irovel H 150/12.5mg at significantly lower prices than Coaprovel or Avalide at Western pharmacies. Products are sourced from licensed manufacturers with rigorous quality controls. Customers benefit from discreet, tracked international shipping to the USA, UK, Australia, and other countries. Customer support is available for prescription assistance, delivery inquiries, and product questions. For patients requiring combination irbesartan/HCTZ therapy for long-term hypertension management, PremiumRxDrugs.com provides a reliable and affordable supply.
Login
Sign Up
Login
Sign Up