Ismo 20mg (Isosorbide Mononitrate) – Affordable Isosorb Mono Alternative

Name: Ismo 20mg
Brand: Isosorb Mono
SKU: 550
Availability: InStock

Ismo 20 mg is a medicine, which is used primarily in the treatment of angina pectoris and acts by dilating the blood vessels to reduce the blood pressure. It can be prescribed for the prevention of angina pectoris; it is used to prevent or at least reduce the occurrence of angina. The main ingredient of the medicine is Isosorbide mononitrate, which works to reduce the workload of the heart by producing venous and arterial dilation. Isosorbide mononitrate falls into the category of drugs known as nitrates.

What is Ismo 20 mg used for?

Ismo is useful:

Preventing long term treatment of coronary heart disease (CHD)
Treating pulmonary hypertension
Long treatment of coronary heart disease
As a combination treatment in patients with chronic congestive heart failure, which is concomitantly being treated with glycosides, ACE inhibitors, diuretics or arterial vasodilating drugs.

How does Ismo 20 mg work?

The medicine is known to relax or widen the blood vessels, making it easy for the heart to pump blood to all parts of the body.

What does Ismo contain?

Ismo is a medication that contains the active ingredient Isosorbide mononitrite. Each tablet delivers 20 mg of the beneficial component.

Precautions

What medications interact with Ismo?

When Ismo is used at the same time as other drugs, the following interactions must be taken into account:

Cough and cold medicines
Lithium supplements
Blood pressure medications
Drosperinone and other medication used for birth control
Erectile dysfunction drugs such as vardenafil and tadalafil
Aspirin
Beta blocker drugs like atenolol

Never start a new medicine or stop any drug before consulting with your physician. Ask your physician for the full list of drugs that can interact with Isosorbide mononitrite.

When should Ismo not be used?

Ismo must not be used in patients with marked hypotension.
It is not suitable for patients with shock, circulatory collapse.
Its use is contraindicated in myocardial infarction with low ventricular filling pressure.
The medicine should not be used in patients with hypersensitivity to organic nitrates.
Do not give to patients with cardiogenic shock unless sufficient end-diastolic pressure is maintained.

Dosage Instructions

Side Effects

What are the side effects of Ismo?

A person using Ismo may experience any of the following side effects:

Nitrate headache
Dizziness
Feeling of weakness
Postural hypotension
Tachycardia
Sore thtroat
Cehst tightness
Dry cough/dry mouth
Stomach pain
Pain or stiffness in joints
Yellowing of skin
Fever
Troubles breathing
Itching
Hives
Skin rashes
Swelling of lips, face, and mouth
Drop in blood pressure
Vomiting
Nausea
Allergci skin reaction
Formation of methaemoglobin

Patients are instructed to inform their physician if they experience any unwanted effects because of Ismo.

How to Use

How should Ismo be used?

The recommended dose of Ismo 20 mg is one tablet two times a day, which may be increased to one tablet thrice daily, depending on the individual’s requirement.
To minimize or to prevent nitrate headache, it is suggested to take to reduce the dose to half a tablet two times a day for the first two days then your physician may increase your dose to one tablet two times a day for the next two days.
Swallow the tablets with plenty of fluid; one tablet can be taken shortly before going to sleep.

How long should you take Ismo?

The treatment is normally a long term therapy. It should be taken daily for as the period it is recommended to you.

Missed dose of Ismo

Take your missed dose of Ismo 20 mg as soon as possible, except when it is near to the time for your next scheduled dose. If the time to take the next dose is close, skip the missed dose and go back to your normal dosing schedule. You are not supposed to take two doses at the same time. If you find difficulty remembering your dose, please ask your physician for some hints.

How should Ismo be stored?

The medicine does not require any special storage conditions
Keep out of the reach of children and pets
Do not take the tablets after the expiry date printed on the package

Infographics

FAQ

What is Ismo 20mg used for?

Ismo 20mg contains isosorbide mononitrate 20 mg, a long-acting nitrate vaSodiumilator used to treat stable angina pectoris (chest pain) prevention and chronic heart failure as an adjunct. As a generic for Imdur / Ismo, it works by releasing nitric oxide in vascular smooth muscle, causing vaSodiumilation — particularly of veins — which reduces cardiac preload, myocardial oxygen demand, and angina frequency. This 20 mg formulation is immediate-release twice-daily dosing for angina prevention, with a nitrate-free interval recommended to prevent tolerance, providing reliable therapeutic control for patients requiring consistent long-term management.

How does isosorbide mononitrate in Ismo 20mg work?

Isosorbide mononitrate works by releasing nitric oxide in vascular smooth muscle, causing vaSodiumilation — particularly of veins — which reduces cardiac preload, myocardial oxygen demand, and angina frequency. This pharmacological action reduces stable angina pectoris effectively, making it an established treatment option in its therapeutic class. At the 20 mg dose, the drug achieves meaningful therapeutic blood levels within hours of administration, with sustained effects lasting throughout a once or twice-daily dosing interval.

What is the correct dosage and schedule for Ismo 20mg?

Ismo 20mg (isosorbide mononitrate 20 mg) is taken as directed by your physician — typically once or twice daily at a consistent time. Swallow the tablet whole with water, with or without food. Do not adjust the dose or frequency without medical guidance. Consistent daily dosing maintains therapeutic drug levels that are essential for sustained blood pressure or cardiovascular management. If a dose is missed, take it as soon as possible unless the next dose is imminent.

How long does Ismo 20mg take to control stable angina pectoris?

Most patients notice an initial therapeutic response to Ismo 20mg within 1–2 weeks of consistent daily use. The full effect at the 20 mg dose typically develops over 2–4 weeks. Cardiovascular benefits — reduced heart attack, stroke, and end-organ damage risk — accrue over months to years of sustained therapy. Blood pressure or other clinical parameter monitoring during the first month helps your doctor determine if the dose is adequate or needs adjustment.

Is Ismo 20mg safe for long-term use in adults?

Ismo 20mg has a well-established safety profile for long-term use when monitored appropriately. Regular blood pressure checks, periodic kidney and liver function tests, and clinical assessments are recommended. Patients with pre-existing organ impairment may require dose adjustments. The risk-benefit profile of long-term isosorbide mononitrate therapy is strongly positive for patients with stable angina pectoris (chest pain) prevention and chronic heart failure as an adjunct, given the significant cardiovascular harm of untreated disease.

Can Ismo 20mg be combined with other blood pressure medications?

Ismo 20mg can be used alongside complementary antihypertensives — such as diuretics or other drug classes — when monotherapy doesn't achieve blood pressure targets. However, combining multiple antihypertensives increases the risk of excessive blood pressure reduction (hypotension). Always inform your doctor and pharmacist of all medications before adding Ismo 20mg to your regimen. Monitoring blood pressure regularly when starting combination therapy is advisable.

How does Ismo 20mg compare to isosorbide dinitrate?

Isosorbide mononitrate (ISMN) and isosorbide dinitrate (ISDN) are both nitrates for angina prevention, but ISMN is the active metabolite — it doesn't require hepatic conversion and has more predictable bioavailability. ISMN's longer duration makes once or twice-daily dosing possible, whereas ISDN typically requires more frequent dosing. ISMN is generally preferred for maintenance angina prevention. The choice between Ismo 20mg and isosorbide dinitrate (Isordil) depends on individual blood pressure response, other health conditions, drug tolerability, and cost. Both are established options; your prescribing physician is best placed to determine which suits your cardiovascular profile.

Is Ismo 20mg a good generic alternative to Imdur / Ismo?

Yes. Ismo 20mg contains the same active ingredient — isosorbide mononitrate — at 20 mg, manufactured to bioequivalence standards that ensure identical pharmacokinetics and clinical outcomes to branded Imdur / Ismo. Patients switching from Imdur / Ismo to Ismo 20mg can expect the same therapeutic control. The major advantage of the generic is cost — significantly more affordable for patients on indefinite long-term therapy.

Can I order Ismo 20mg from PremiumRxDrugs.com with discreet delivery?

Yes. PremiumRxDrugs.com delivers Ismo 20mg in discreet packaging to patients in the USA, UK, Australia, and many other countries worldwide. Our licensed pharmacy model, over a decade of trusted service, and genuine manufacturer-verified medicines — combined with competitive pricing and free shipping on qualifying orders — make us a preferred choice for patients seeking private, affordable access to long-term cardiovascular therapy.

What side effects does Ismo 20mg commonly cause?

Common side effects of isosorbide mononitrate include headache (very common, especially at the start of therapy), dizziness, flushing, low blood pressure, and nausea. Most side effects are dose-related and mild, often resolving as the body adjusts over the first few weeks. Persistent, severe, or worsening symptoms should be reported to your prescriber, who can assess whether dose adjustment or an alternative medication is appropriate for your situation.

Who should not take Ismo 20mg?

Ismo 20mg is contraindicated in patients with severe anaemia, raised intracranial pressure, cardiogenic shock, hypovolemia, concurrent use of PDE5 inhibitors (sildenafil, tadalafil, vardenafil), and known nitrate hypersensitivity. Pregnant women should avoid this medicine, as many cardiovascular drugs carry fetal risk. Always provide your complete medical history — including all diagnosed conditions and current medications — to your prescriber before starting Ismo 20mg. Regular follow-up ensures safety concerns are detected and managed proactively during long-term treatment.

SKU	550
Generic For	Isosorb Mono
Strength	20mg
Manufacturer	ESP Pharma, Inc
Active Ingredient	Isosorbide Mononitrate

Ismo 20mg