Istamet 50/1000mg
Available Dosages
| SKU | 1013 |
|---|---|
| Generic For | Janumet |
| Strength | 50+1000mg |
| Manufacturer | Sun Pharma |
| Active Ingredient | Sitagliptin+ Metformin |
| Pack Size | Qty | Price Per Pill or Unit | Price | Cart | |
|---|---|---|---|---|---|
| 30 Tablet/s | US$ 0.67 | US$ 20.00 | |||
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| 60 Tablet/s | US$ 0.58 | US$ 35.0012%US$ 40.00 | |||
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| 90 Tablet/s | US$ 0.56 | US$ 50.0017%US$ 60.00 | |||
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Istamet 50/1000mg – Affordable Janumet Alternative for Type 2 Diabetes
Istamet 50 1000mg is prescribed to lower blood sugar levels in patients with type 2-diabetes. It can be recommended alone or in combination with insulin, or sulfonylurea medicines such as gliclazide, glibenclamide, and glimepiride. This medicine is indicated as an adjunct to diet and exercise for improving glycemic control in type-2 patients. In addition to diet and exercise, this medicine is recommended when the use of the two main active ingredients Metformin or Sitagliptin alone does not adequately control the blood sugar.
What is Istamet 50 1000mg tablet used for?
Istamet 1000mg drug is meant to help control blood glucose levels (type-2 diabetes). It’s used for the patients who either have not achieved good control with metformin or sitagliptin alone or who take both of these. This medicine can be used alone or in combination with insulin, or sulfonylurea medicines such as gliclazide, glibenclamide, and glimepiride.
How does Istamet 1000mg pill work?
All the active ingredients of Istamet pills work in combination to control blood sugar through multiple mechanisms. Sitagliptin phosphate is a member of a class of oral anti-hyperglycemic agents (dipeptidyl peptidase 4 (DPP-4) inhibitors) which can improve glycemic control in the patients with type-2 diabetes by enhancing the levels of active incretin hormones. Sitagliptin can block a certain enzyme, which in turn helps increase the pancreas’s production and encourage the secretion of insulin while blocking the liver’s production of glucose. On the other hand, metformin makes the body’s cells more sensitive to insulin and also lowers the liver’s production of glucose and that your stomach/intestines absorb.
Where to buy Istamet 50/1000mg pill online?
An online medicine shopping website premiumrxdrugs offers you Istamet 50+1000mg tablet at a very reasonable price. You can buy Istamet 50 1000mg online and it will be delivered at your doorstep within a few days.
What does Istamet 50 1000 mg contain?
Istamet 50 1000mg has Sitagliptin and Metformin, making it an effective combination to treat type-2 diabetes. Sitagliptin is available in the strength of 50 mg while 1000 refers to 1000 mg of metformin.
What medications interact with Istamet 50 1000mg tablet?
The administration of Sitagliptin and Metformin with a sulfonylurea or with insulin may invoke an adverse reaction of hypoglycemia. Lab tests also show some minimal interactions of Istamet with the ingredients that include Sitagliptin and Metformin hydrochloride. Such drug interactions may cause hypersensitivity reactions like anaphylaxis, cutaneous vasculitis, exfoliative skin conditions, angioedema, rash, and urticaria.
When should Istamet 50 1000mg not be taken?
People living with a kidney or liver disease should not take Istamet. Like metformin alone, Istamet tablet may raise the risk of lactic acidosis, a condition in which lactic acid builds up in the blood, depriving the body’s tissues of oxygen. If you are highly alcoholic then you should avoid this medicine, as it is more likely to cause kidney disease and heart failure.
What are the side effects of Istamet 50 1000mg tablet?
Much like other prescription medicines, Istamet pill may also cause some side effects. Usually, these side effects are mild and do not render any severe impact on the health of the patient. Some probable side effects of this medicine include:
- Fatigue
- Muscle pain
- Trouble breathing
- Unusual sleepiness
- Sudden stomach or intestinal problems
- Nausea and vomiting or diarrhea
- Cold
- Dizzy or lightheaded
- Irregular heartbeat
The allergic reactions of Istamet 50/1000mg may cause rash, hives, and swelling of the face, lips, tongue, and throat breathing or swallowing. Pancreatitis (inflammation of the pancreas) is another side effect that may lead to some serious consequences.
If you experience an allergic reaction, stop taking Istamet and contact your doctor right away for advice.
How should Istamet 50 1000mg be taken?
The initial dose of Istamet pill is based on the patient's current regimen. Its dosage can be adjusted based on effectiveness and tolerability while not exceeding the maximum recommended daily dose of 100mg Sitagliptin and 2000 mg Metformin extended-release. Usually, the medicine is taken once a day, preferably in the evening.
Missed dose of Istamet 50 1000mg?
If you miss a dose of Istamet 1000mg, take it as soon as you remember. If you have forgotten until it is time for your next dose, then skip the missed dose and go back to your regular schedule.
How Istamet 50 1000mg should be stored?
You can store this drug at room temperature, so your room temperature is good for the purpose.
What is Istamet 50/1000mg used for?
Istamet 50/1000mg is a fixed-dose combination tablet containing sitagliptin 50mg and metformin 1000mg for type 2 diabetes management. It combines a DPP-4 inhibitor (sitagliptin) with metformin's multi-mechanism glucose lowering. Sitagliptin inhibits the DPP-4 enzyme that degrades GLP-1 and GIP — preserving incretin hormones that enhance glucose-dependent insulin secretion and suppress glucagon. Together with metformin's hepatic and peripheral effects, this provides comprehensive glucose control with minimal hypoglycaemia risk.
How does sitagliptin and metformin work together?
Metformin reduces hepatic glucose production and improves peripheral insulin sensitivity — targeting fasting hyperglycaemia. Sitagliptin preserves active GLP-1 and GIP, which stimulate insulin secretion proportional to blood glucose levels — particularly effective against post-meal spikes. This complementary dual mechanism controls blood glucose throughout the day. Clinical trials of sitagliptin/metformin combinations demonstrate 1.5–2.5% HbA1c reduction — significantly greater than either agent alone — without the hypoglycaemia or weight gain associated with sulfonylureas.
How and when should Istamet 50/1000mg be taken?
Istamet 50/1000mg is taken twice daily with meals — typically morning and evening. The metformin component requires food co-administration to minimise GI side effects; the sitagliptin component is food-independent but taking both together simplifies the regimen. Swallow whole with water. Consistent timing with meals improves both tolerability and glycaemic control. Do not crush or chew the tablet. If a dose is missed, take it with the next meal — do not take two doses together.
How long does Istamet 50/1000mg take to lower HbA1c?
The combined sitagliptin/metformin effect begins lowering fasting glucose within the first week as metformin's hepatic effects take hold. Sitagliptin's post-meal glucose improvement is also rapid — measurable within 1–2 weeks. HbA1c reduction — the primary outcome measure — is assessed at 3 months and reaches full effect at 6 months. The 50/1000mg twice-daily dose typically produces HbA1c reductions of 1.5–2.5% depending on baseline. Patients with HbA1c >9% see the greatest absolute reduction.
Does Istamet 50/1000mg cause low blood sugar?
Istamet 50/1000mg has a very low risk of hypoglycaemia when used as monotherapy or in combination with lifestyle intervention. Sitagliptin enhances insulin secretion only in proportion to circulating glucose levels — so it does not cause excessive insulin release when glucose is normal. Metformin alone does not cause hypoglycaemia. Hypoglycaemia can occur when Istamet is combined with sulfonylureas or insulin — in those combinations, the sulfonylurea or insulin dose may need reduction.
Is Istamet 50/1000mg safe in patients with heart failure?
The TECOS trial demonstrated sitagliptin cardiovascular safety in patients with established cardiovascular disease — no increase in heart attack, stroke, or cardiovascular mortality vs. placebo. However, metformin 1000mg is contraindicated in decompensated heart failure (congestive heart failure requiring hospitalisation), which can impair renal clearance and increase lactic acidosis risk. Stable, well-controlled heart failure is not necessarily a contraindication to metformin — consult your cardiologist and diabetologist.
How does Istamet 50/1000mg compare to Glycomet GP 500+2mg (metformin + glimepiride)?
Both Istamet and Glycomet GP combine metformin with a second glucose-lowering agent. Istamet (sitagliptin + metformin): minimal hypoglycaemia, weight-neutral, convenient twice-daily dosing, excellent tolerability. Glycomet GP (glimepiride + metformin): greater HbA1c reduction potential, but causes hypoglycaemia and modest weight gain (1–3 kg). Istamet is preferred when hypoglycaemia risk is a concern (elderly, irregular meals, occupational safety) or weight is a priority. Glycomet GP is preferred when maximal glucose lowering at lower cost is the priority.
Is Istamet 50/1000mg the same as Janumet 50/1000mg?
Yes. Istamet 50/1000mg contains the same active ingredients — sitagliptin 50mg and metformin HCl 1000mg — as branded Janumet 50/1000mg. Both are manufactured to bioequivalence standards with equivalent glucose-lowering efficacy and safety. Istamet is the generic alternative to Janumet, available at a significantly lower cost — making this convenient fixed-dose combination more accessible for long-term diabetes management.
Can I order Istamet 50/1000mg from PremiumRxDrugs for delivery to the UK?
Yes. PremiumRxDrugs.com ships Istamet 50/1000mg and other diabetes medications to the UK, USA, Australia, and many other countries. Their genuine manufacturer-verified medicines, competitive pricing, and free worldwide shipping on qualifying orders make them a dependable international pharmacy for patients requiring this combination diabetes therapy.
What side effects does Istamet 50/1000mg cause?
Metformin-related GI effects (nausea, diarrhoea, abdominal discomfort) are most common in the first 2–4 weeks, greatly reduced by taking with food. Sitagliptin-related effects include upper respiratory tract infections, nasopharyngitis, and headache — generally mild. Pancreatitis has been reported rarely with sitagliptin — seek urgent medical attention if you develop severe persistent abdominal pain. Long-term: vitamin B12 monitoring from metformin. Joint pain (arthralgia) is an uncommon but recognised sitagliptin effect.
What precautions apply to Istamet 50/1000mg users?
Always take with meals. Withhold metformin before contrast procedures; restart 48 hours later. Monitor eGFR at least annually — reduce sitagliptin to 25mg and reduce metformin dose in CKD (eGFR 30–45 ml/min); avoid below 30. Report severe abdominal pain promptly (pancreatitis). Monitor B12 annually after 3 years. Inform your doctor of any joint pain (sitagliptin-associated arthralgia). Avoid alcohol excess. Disclose all medications to check for interactions.
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