Istamet 50+500 mg

Description Metformin Sitagliptin 50/500 mg Tablet
SKU 1014
Generic For Janumet
Strength 50 + 500 mg
Generic Name Sitagliptin+ Metformin
Manufacturer Sun Pharma
Pack Size Qty Price Per Pill or Unit Price Cart
50 Tablet/s US$ 0.65 US$ 32.50
100 Tablet/s US$ 0.65 US$ 65.00
Add to Compare

Istamet 50+500mg(Metformin Sitagliptin)

Istamet 50/500 mg metformin sitagliptin HCl is a prescribed medicine that comprises two active ingredients one is Sitagliptin Phosphate and Metformin HCl in it. They together improve the blood glucose levels in type 2 diabetes. This drug is administered along with the diet and exercise and helps in lowering increased blood sugar levels of the body.

The ailments Istamet 50/500 mg is used for:

Sitagliptin Phosphate and Metformin HCl is a prescription medicine used for the treatment of type 2 Diabetes. It is given as an adjunct with diet and exercise in the management of Type 2 diabetes.

How does Istamet 50/500 mg tablet work?

Sitagliptin and Metformin HCl help in lowering the blood sugar levels of the body.

Sitagliptin Phosphate

Sitagliptin is a dipeptidyl peptidase 4 inhibitor. It works by increasing the release of Incretin hormone that raises levels of insulin in the body. This, in turn, lowers the glucose production and maintains apt blood glucose levels in the body.

Metformin HCl

This ingredient belongs to the class of Biguanides and acts via multiple mechanisms that collectively produce hypoglycemic effects.  It acts on various sites as stated below:

  • Metformin causes less production of sugar from the liver cells
  • It increases the sensitivity of  cells to insulin, this way  it removes sugar from the blood
  • It also delays intestinal sugar absorption into the blood stream especially after eating

This way, it controls the blood sugar levels. It effectively controls the sugar level between and directly after meals.

 When should you avoid it?

You should not take Sitagliptin Phosphate and Metformin HCl if you:

  • Are hypersensitive towards any of ingredients present in it (Sitagliptin Phosphate and Metformin HCl )
  • Have diabetic ketoacidosis
  • Have type 1 diabetes
  • Are breast feeding
  • Have a history of pancreatitis
  • Are suffering from kidney related problems
  • Have reduced liver functions
  • Are pregnant or planning to become pregnant

How much to take?

There is no fixed therapeutic regimen for the treatment of type 2 diabetes. The dose varies according to the condition of a patient. Many factors such as body weight, the presence of other disease condition and tolerance power are assessed and then a dosage is prescribed. The usual dose starts from 50 mg Sitagliptin Phosphate / 500 mg Metformin hydrochloride and can be increased or decreased depending upon the condition. The doctor will always recommend the best therapeutic dose for you, so that maximum effect is generated with no side effects at all.

Who is the manufacturer?

Istamet 50mg is manufactured by Merck ltd, a pharmaceutical giant and is available on our website in the pack of 28 tablets.

How to take?

Istamet 50/500 mg tabletSitagliptin Phosphate and Metformin HCl are taken exactly as prescribed by your doctor.  Take the tablet with a full glass of water. Don’t crush or chew the tablet. Regular check your blood sugar levels. If you experience extreme low levels of blood sugar, always keep a source of sugar with yourself.

When to take?

Metformin Sitagliptin HCl are generally taken twice daily with meals. Always take the medicine as prescribed by the Doctor.

For how long should it be taken?

This drug is meant to be taken on a regular basis, so keep on taking the drug as long as recommended by the Doctor. Sudden discontinuation can lead to undesired and sever problems.

What if you take too much (overdose)?

If overdose, talk to Doctor or Poisons information centre for advice. Take medical help as soon as possible if you encounter any unusual symptoms like:

  • Tachycardia
  • Excessive hunger
  • Nervousness
  • Nightmares
  • Headache
  • Shakiness
  • Restlessness

What if you miss the dose?

Try to take the medicine at the same time each day; this reduces the chances of missing dose. Consult your Doctor if you miss the Dose. Don’t double up the dose in order to compensate with the previous one.

What are the side effects?

Sitagliptin Phosphate and Metformin HCl is very effective and potent antidiabetic drug. Along with the highly therapeutic drug effect, it also exerts some side effects. This is not essential that everyone will encounter these below-mentioned effects such as:

Very common side effects generally happen in the initial stages of the treatment. With the pace of time, they diminish:

  • Abdominal discomfort and pain
  • Bloating
  • Nausea and vomiting
  • Diarrhoea
  • Flatulence
  • Stuffy nose
  • Joint pain
  • Loss of appetite
  • Throat soreness
  • Change in taste like metallic taste of mouth
  • Constipation

Serious side effects are as follows:

  • Skin rashes, hives
  • Breathing difficulties
  • Swelling of face, lips and tongue
  • Dizziness
  • Muscular pain and cramping
  • Unexplained tiredness and weakness
  • Stomach pain and discomfort

Are there any possible drug interactions?

Always tell the doctor about the medicines you are taking. The doctor will provide you with a list of the drugs that will interact with Sitagliptin Phosphate and Metformin HCl and may hamper its therapeutic efficacy. Some of the drugs that interact with Sitagliptin Phosphate and Metformin HCl are as following:

  • Oral contraceptives
  • Opioid drugs like Morphine
  • Phenothiazines
  • Probenecid
  • Procainamide
  • Somatropin
  • Levothyroxine
  • Trimethoprim
  • Digoxin
  • Cimetidine
  • Steroids like prednisone and Dexamethasone
  • ACE Inhibitors like Ramipril and Enalapril
  • Beta-agonist such as Salbutamol and Formoterol

What are the things to be taken care of?

  • Always take the medicine as per prescription
  • Always store the medicine at the room temperature and away from moisture, heat and light
  • Don’t use the expired drug
  • Always monitor your blood sugar levels
  • Avoid consumption of alcohol while using this drug
  • Don’t share your medicine with anybody, even if they have the same symptoms
  • Keep a complete record of all the medicines you are taking along with this medicine
  • Follow strict diet and exercise regimen while taking this drug


Customer's Review
Copyright © 2024 PremiumRxDrugs. All rights reserved