Istavel 50mg
Available Dosages
| SKU | 1011 |
|---|---|
| Generic For | Januvia |
| Strength | 50mg |
| Manufacturer | Sun Pharma |
| Active Ingredient | Sitagliptin |
| Pack Size | Qty | Price Per Pill or Unit | Price | Cart | |
|---|---|---|---|---|---|
| 50 Tablet/s | US$ 0.50 | US$ 25.00 | |||
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| 100 Tablet/s | US$ 0.30 | US$ 30.0032%US$ 44.00 | |||
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Istavel 50mg – Affordable Januvia Alternative for Type 2 Diabetes
Istavel 50mg carries the active component Sitagliptin, which is a new class of oral anti-hyperglycemic known as a DP-4 inhibitor for the treatment of type II diabetes. It regulates the level of insulin your body produces after eating. Your physician may prescribe it alone or along with antidiabetic medicines. Controlling high glucose level helps prevent health issues like loss of limbs, blindness, kidney damage, secual function problems, and nerve problems. Proper control of diabetes may also lessen your risk of stroke or heartattack.
What is Istavel 50mg used for?
Istavel 50 is used along withdiet and exercise to improve glycemic control in patients with type two diabetes mellitus. It can be considered as monotherapy or combination therapy with metformin, a sufonylurea, insulin, or thiazolidinedione.
How does Istavel work?
The medicine contains the active component Sitagliptin, which works by inhibiting the enzyme dipeptidyl peptidase-4, which slows down the inactivation of incretin hormone, casuing increased levels of active incretin hormones. These hormones are produced by the intestine, and are involved in regulation of glucose homeostasis. The increased levels of incretin lead to an increase in insulin release and decrease in glucoagon levels. In this way, it improves control of blood glucose level.
What does Istavel contain?
Istavel tablets contain 50 mg of the active ingredient Sitagliptin for oral administration
What medications interact with Istavel 50mg?
It is very important to inform your physician about all the emdiciens that youa re taking. These includes even those you nought without prescription. You should also check with your physician while taking Istavel 50 mg with other medications , to make sure that the combination is safe.
Medicine that can affect the working of this antidiabetic agent are given below:
- Corticosteroid such as prednisolone
- Progestogens and estrogens tose contained in oral contraceptives
- Beta 2 agonists like salmeterol and salbutamol
- Thiazide diuretics like bendroflumethiazide
- Antipsychotic medicines such as chlorpromazine, risperidone, and olanzapine
When should Istavel not be used?
- Istavel is not suitable for patients who are suffering from type 1 diabetes mellitus and diabetic ketoacidois.
- It is contraindicated in patients who have been demonstrated hypersensitivity to Sitagliptin and other active ingredients of the formulation.
How should Istavel be used?
- Take Istavel 50 mg as you have been told by your physician. Continue taking it, even if you feel bette. You can take before or after consuming food. In case of gastrointestinal disturbance, take it with food. Swallow the tablet with one glass of water. You are not supposed to break or crush the pill. Furthermore, follow the diet and workout plan that your physician has told you to do with the treatment.
How long should you use Istavel?
Continue taking Neomercazoe tablets until your physician tells you to stop
Missed dose of Istavel
Take your missed dose of Istavel 50mg as soon as possible, except when it is near to the time for your next dose. If the time to take the next dose is close, skip the missed dose and go back to your normal dosing schedule. You are not supposed to take two doses at the same time. If you find difficulty remembering your dose, please ask your physician for some hints.
How should Istavel be stored?
Keep the emdicine out of the reach of children. Keep it at controlled room temperature. Keep the tablets in its original packet. Place it in a cool, dry place away from heat and moisture.
What are the side effects of Istavel?
Istavel’s possible side effects can affect individuals in different ways. The side effects that are known to be associated with the medicine are as folows:
- Loss of appetite
- Blocked nose
- Upper respiratory tract infection
- Sleepiness
- Sore throat
- Disturbances of the gut such as vomiting, nausea, abdominal pain, constipation, and diarrhea
- Headache
- Weight loss
- Osteoarthritis
- Pain in the arms or legs
- Dizziness
- Swelling of feet or ankles
- Low blood glucose levels
- Excess gasin the stomach and intestines
- Inflammation of the pancreas
What is Istavel 50mg used for?
Istavel 50mg contains sitagliptin 50mg — the intermediate dose used in patients with mild-to-moderate chronic kidney disease (eGFR 30–50 ml/min) or as a component in fixed-dose twice-daily combination products (combined with metformin as Istamet 50/500mg or 50/1000mg). As a standalone tablet, Istavel 50mg is used where the full 100mg dose would accumulate due to moderately reduced renal function. It provides effective DPP-4 inhibition with appropriate safety margins in mild CKD.
How does sitagliptin 50mg control blood glucose in type 2 diabetes?
Sitagliptin inhibits DPP-4 (dipeptidyl peptidase-4), the enzyme that rapidly degrades active GLP-1 and GIP incretin hormones. By prolonging the half-life of these hormones, sitagliptin amplifies their glucose-dependent effects: stimulating insulin secretion after meals and suppressing glucagon release from alpha cells. At 50mg daily, DPP-4 inhibition is approximately 70–80% — sufficient for meaningful post-prandial glucose control, though slightly less than the ~90% inhibition achieved with 100mg.
How should Istavel 50mg be taken?
Istavel 50mg is taken once daily, with or without food, at any consistent time of day. Unlike metformin, it does not need to be taken with meals. Consistent daily timing maintains stable DPP-4 inhibition. If you forget a dose, take it when you remember — unless it is almost time for the next day's dose. Never take two doses on the same day to compensate. Blood glucose and HbA1c monitoring guide dose adequacy — if control is insufficient, the prescribing doctor may adjust within renal-safe dose ranges.
When is sitagliptin 50mg preferred over 100mg?
Sitagliptin 50mg is usually preferred for people who have moderate kidney problems or reduced kidney function. Since the medicine is removed from the body through the kidneys, a lower dose helps prevent the drug from building up in the body and reduces the risk of side effects. Doctors may also choose the 50mg dose based on a patient’s age, overall health, blood sugar levels, or other medicines being used. The correct dose should always be decided by a healthcare professional after evaluating kidney function and treatment needs.
Is sitagliptin 50mg safe in patients with cardiovascular disease?
Yes. The TECOS trial specifically enrolled patients with established cardiovascular disease and demonstrated sitagliptin's cardiovascular safety — non-inferior to placebo for major adverse cardiovascular events (heart attack, stroke, cardiovascular death). Unlike saxagliptin (SAVOR-TIMI trial), sitagliptin did not increase hospitalisation for heart failure. This makes sitagliptin 50mg a preferred diabetes medication in patients with CKD and concurrent cardiovascular disease — a very common combination in type 2 diabetes.
Can sitagliptin 50mg cause pancreatitis?
Post-marketing reports and some pharmacovigilance data suggest a possible association between DPP-4 inhibitors including sitagliptin and acute pancreatitis — though causality has not been definitively established in randomised trials. The absolute risk is very low. Patients with a prior history of pancreatitis should avoid sitagliptin. Seek urgent medical attention for any severe, persistent abdominal pain radiating to the back — this could indicate pancreatitis. Alcohol use and hypertriglyceridaemia are independent pancreatitis risk factors.
How does sitagliptin 50mg compare to linagliptin for CKD patients?
Both sitagliptin (Istavel) and linagliptin (Trajenta) are DPP-4 inhibitors suitable for CKD patients. Linagliptin is primarily eliminated via the biliary/faecal route and requires no dose adjustment for any level of renal impairment — making it theoretically more convenient in CKD. Sitagliptin requires dose reduction to 50mg or 25mg in moderate-severe CKD. Clinical efficacy is comparable. Linagliptin may be preferred in very advanced CKD (eGFR <30 ml/min) where sitagliptin dosing becomes complex.
Is Istavel 50mg equivalent to Januvia 50mg?
Yes. Istavel 50mg and Januvia 50mg both contain sitagliptin 50mg and are bioequivalent. Istavel is the generic formulation providing identical DPP-4 inhibition and glycaemic efficacy as branded Januvia at a significantly lower cost. For patients with CKD requiring long-term dose-adjusted sitagliptin therapy, Istavel 50mg offers the same clinical quality as Januvia at a fraction of the price.
Can I order Istavel 50mg from PremiumRxDrugs for delivery to the USA?
Yes. PremiumRxDrugs.com ships Istavel 50mg to the USA, UK, Australia, and many other countries worldwide. Their genuine manufacturer-verified medicines, competitive pricing, and free worldwide shipping on qualifying orders make them a reliable source for patients with CKD requiring dose-adjusted sitagliptin therapy.
What side effects does Istavel 50mg cause?
Nasopharyngitis, headache, upper respiratory infections, and GI discomfort are the most common side effects. Urinary tract infections occur slightly more frequently than with placebo. Rare but serious: pancreatitis, severe allergic reactions (anaphylaxis, angioedema — stop immediately and seek emergency care), bullous pemphigoid (blistering rash). At 50mg, hypoglycaemia does not occur with monotherapy. When combined with insulin or sulfonylureas, hypoglycaemia risk depends on those agents.
What precautions should I take when using Istavel 50mg?
Monitor eGFR every 3–6 months in CKD. Adjust dose to 25mg if eGFR falls below 30 ml/min. Report severe abdominal pain urgently. Report any blistering skin lesions. Stay well-hydrated (important in CKD). When combined with insulin or sulfonylureas, monitor blood glucose more frequently as these agents carry their own hypoglycaemia risk independent of sitagliptin. Inform all prescribers of CKD status and current sitagliptin dose before any new diabetes medication is added.
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