Ivabrad 7.5mg
Available Dosages
| SKU | 561 |
|---|---|
| Generic For | Ivabrand |
| Strength | 7.5mg |
| Active Ingredient | Ivabradine |
| Pack Size | Qty | Price Per Pill or Unit | Price | Cart | |
|---|---|---|---|---|---|
| 30 Tablet/s | US$ 0.92 | US$ 27.5021%US$ 35.00 | |||
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| 60 Tablet/s | US$ 0.92 | US$ 55.0021%US$ 70.00 | |||
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| 90 Tablet/s | US$ 0.92 | US$ 82.5021%US$ 105.00 | |||
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Ivabrad 7.5mg (Ivabradine) – Affordable Ivabrand Alternative
Ivabradine is formulated for the symptomatic treatment of chronic stable angina pectoris in patients who are in sinus rhythm and can’t take beta blockers or have an intolerance to beta blockers. Its active component Ivabradine is a novel and useful addition to the class of anti-ischemic medications. The medicine works to lower the heart rate, which is helpful in treating both angina and heart failure. By slowing the heart rate, the heart needs oxygen, thereby minimizing the risk of an angina attack to develop. This is extremely useful at times when angina would be more likely to occur, such as during an exercise session or times of other physical work.
What is Ivabrand used for?
Ivabrand is a medicine available for the management of patients with angina pectoris, but it should only be taken when your symptoms are not controlled with optimized gold standard anti-ischemic therapy.
How does Ivabrand work?
Reduction of heart rate is an important part managing patients with coronary artery disease. Ivabrand allows a simultaneous reduction in oxygen demand and an increase in oxygen supply as well as redistribution of myocardial blood flow. Ivabradine, the active ingredient of the medicine works by inhibiting the If current, which regulates the intrinsic pacemaker activity in the sinoatrial node. The heart rhythm is slowed accordingly.
What does Ivabrand contain?
Ivabrand contains the active ingredient Ivabradine, which is useful in treating symptoms of chronic angina. It reduces the pain related to angina by slowing down the heart beat.
What medications interact with Ivabrand?
If you need to take any of the following medicines while taking Ivabrand 7.5 mg, your heart function will need to be closely monitored.
- Antidepressants such as escitalopram, citalopram, clomipramine
- Antiarrhythmics such as sotalol, dronedarone, amiodarone, quinidine, amiodarone
- Antimicrobials like moxifloxacin, pentamidine, clarithromycin, or erythromycin
- Antimalarials like riamet, halofantrine, mefloquine
- Antipsychotics like sertindole, haloperidol, pimozide, thioridazine
The following medicines should not be taken in combination with Ivabrand:
- Macrolide antibiotics such as telithromycin, erythromycin, clarithromycin
- Azole antifungals like itraconazole, ketoconazole
- Protease inhibitors used for HIV infection such as ritonavir, nelfinavir
- Nefazodone
When should Ivabrand not be used?
Ivabrand is contraindicated in the following conditions:
- AV block
- Sick sinus syndrome
- Severe hypotension and bradycardia or cardiogenic shock
- Acute coronary syndromes
- SA block
Use it with extreme caution in patients who have altered or cardiac conduction.
What are the side effects of Ivabrand?
The following are the side effects that have been commonly reported by patients taking Ivabrand tablets:
- Blurred vision
- Dizziness
- Headache
- Slow heart rate
- Uncontrolled blood pressure
- Luminous visual phenomena
Some rare and uncommon side effects are given below:
- Low blood pressure
- Rash
- Vertigo
- Feeling weak or tired
- Shortness of breath
- Elevated levels of creatinine in the blood
- A vision problem such as double vision
- Palpitations
- Fainting
- Muscle cramps
- Raised levels of white blood cells (eosinophilia).
- Allergic reaction involving swelling of the face, throat, or tongue
The side effects that are explained above are not the only ones that you may experience due to Ivabrand medicine. If you get any side effect that troubles you, contact your physician right away.
How should Ivabrand be taken?
Ivabrand is available in the form of a tablet. The initial recommended dose is 5 mg twice daily. Your physician may increase your dose to 7.5 mg two times a day if required to control symptoms. If the heart rate of a patient drops below 50 beats per minute at rest, the dose should be reduced. In addition, symptoms related to the bradycardia, such as hypotension, fatigue, and dizziness should be monitored on a regular basis.
There is no need of dose adjustment in patients with kidney impairment whose creatinine clearance is above 15ml/minute. Although, no data is available for those with creatinine clearance below 15ml/min and the medicine should therefore be used carefully in patients with renal insufficiency.
No dose adjustment is needed for patients with liver impairment. Exercise caution while using Ivabrand tablets in patients with moderate liver impairment and should not be used in patients with severe liver problems.
The tablet should be taken with food because food delays absorption by one hour and increases plasma exposure by 25%.
How long should you take Ivabrand?
You need to take Ivabrand 7.5 mg for long period and take on a regular basis at the same time so you do not miss the dose. Do not stop Ivabradine treatment unless your health care specialist advises you to do.
Missed dose of Ivabrand
If you forget to take a dose of Ivabrand to slow heartbeat, don’t take extra tablets or a double dose to compensate the missed dose. It is very important to ask your physician for advice on how to start the treatment again.
How should Ivabrand be stored?
Keep your tablets away from children and pets. Store the medicine at controlled room temperature.
What is Ivabrad 7.5mg used for?
Ivabrad 7.5mg contains ivabradine 7.5mg — the maximum recommended dose of this If channel inhibitor. It is used in patients with symptomatic stable angina or chronic heart failure with reduced ejection fraction (HFrEF) who require greater heart rate reduction than the 5mg dose achieves. The 7.5mg twice-daily dose is targeted when resting heart rate remains above 60 m after 2–4 weeks on 5mg, and the therapy is well tolerated without bradycardia.
When should ivabradine be increased to 7.5mg?
Dose escalation to 7.5mg twice daily is recommended after 2–4 weeks on 5mg twice daily if: resting heart rate remains above 60 m, angina symptoms are not adequately controlled, heart failure hospitalisation risk remains elevated, and the patient tolerates the 5mg dose without significant bradycardia or side effects. The target resting heart rate is 50–60 m. If heart rate falls below 50 m at 7.5mg, the dose should be stepped down to 5mg. Maximum daily dose is 15mg (7.5mg twice daily).
How should Ivabrad 7.5mg be taken?
Ivabrad 7.5mg is taken twice daily with meals — typically with breakfast and the evening meal. Consistent twice-daily dosing maintains stable plasma levels and sustained heart rate control throughout the day. Take at approximately the same times each day. Monitor resting heart rate at home regularly — check before taking each dose. If heart rate falls below 50 m, do not take the next dose and contact your cardiologist for dose adjustment. Never take extra doses to compensate for a missed one.
Is ivabradine 7.5mg safe in elderly patients with angina?
Ivabradine 7.5mg can be used in elderly patients with stable angina but requires more careful monitoring. Elderly patients may have lower baseline heart rates, more conduction system disease, and impaired drug clearance — all increasing bradycardia risk. The 5mg dose is often more appropriate in the elderly, with careful assessment before titrating to 7.5mg. The advantage in elderly angina patients is that ivabradine does not reduce blood pressure (unlike beta-blockers) — making it safer in patients with low baseline .
Does ivabradine 7.5mg affect blood pressure or breathing?
Ivabradine at any dose, including 7.5mg, does not affect blood pressure or peripheral vascular resistance — it purely reduces heart rate. This is a major advantage over beta-blockers, which lower blood pressure and can cause bronchoconstriction. Ivabradine is particularly valuable in patients with COPD, asthma, or hypotension where beta-blockers are problematic. It does not affect pulmonary function and can be used safely in patients with significant respiratory disease when heart rate reduction is needed.
Can ivabradine 7.5mg be combined with beta-blockers?
Yes — combining ivabradine 7.5mg with a beta-blocker is a common evidence-based strategy. The BEAUTIFUL and SHIFT trials included patients on beta-blockers alongside ivabradine. Combination provides additional heart rate lowering beyond what either agent achieves alone. However, the combination increases bradycardia risk — careful monitoring is essential. The combination is appropriate when a single agent alone does not achieve the target heart rate of 50–60 m. Start with a low beta-blocker dose and titrate ivabradine based on achieved heart rate.
How does Ivabrad 7.5mg compare to 5mg in outcomes?
The SHIFT trial found ivabradine (titrated to 7.5mg as target) significantly reduced cardiovascular death or heart failure hospitalisation by 18% in HFrEF patients with HR ≥70 m. Greater heart rate reduction correlated with greater clinical benefit — patients achieving the most substantial heart rate lowering (to <60 m) had the best outcomes. The 7.5mg dose, providing maximum If channel blockade, offers the best chance of achieving the target heart rate and corresponding clinical benefit in eligible patients.
Is Ivabrad 7.5mg equivalent to Procoralan 7.5mg?
Yes. Ivabrad 7.5mg contains ivabradine 7.5mg — the same active ingredient and dose as branded Procoralan 7.5mg (international) or Corlanor 7.5mg (USA). Both are bioequivalent with identical heart rate-reducing mechanisms and clinical outcomes. Ivabrad is the generic formulation at significantly lower cost than branded alternatives.
Can I order Ivabrad 7.5mg from PremiumRxDrugs for delivery to Australia?
Yes. PremiumRxDrugs.com ships Ivabrad 7.5mg to Australia, the USA, UK, and many other countries. Our genuine manufacturer-verified heart failure and angina medications, competitive pricing, and free worldwide shipping on qualifying orders make us a reliable source for patients requiring maximum-dose ivabradine therapy.
What side effects does Ivabrad 7.5mg cause?
At the higher 7.5mg dose, bradycardia risk is greater than at 5mg. Heart rate falling below 50 m requires dose reduction. Visual phosphenes (brief flashing lights) occur in 10–15% — generally benign and dose-dependent. Dizziness, headache, and first-degree AV block are occasionally reported. New-onset atrial fibrillation is slightly more common with ivabradine use — monitor for irregular heartbeat. In the BEAUIFUL trial, patients with resting HR <70 m at baseline had no benefit from ivabradine — it is only effective in those with elevated heart rates.
What precautions are critical at the 7.5mg dose?
Monitor resting heart rate before every dose — hold if below 50 m. Report any irregular heartbeat (palpitations, irregular pulse) immediately — new AF on ivabradine requires stopping the drug. Avoid all CYP3A4 inhibitors (clarithromycin, itraconazole, verapamil, diltiazem, grapefruit). Do not use in existing atrial fibrillation. Ensure ECG monitoring if heart rate approaches lower limits. At this maximum dose, any bradycardia-inducing combination (digoxin, beta-blockers) requires particularly careful monitoring.
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