Jakura 5 mg
| SKU | 2689 |
|---|---|
| Manufacturer | Hetero Labs Ltd, India |
| Active Ingredient | Tofacitinib |
| Pack Size | Qty | Price Per Pill or Unit | Price | Cart | |
|---|---|---|---|---|---|
| 60 Tablet/s | US$ 0.62 | US$ 37.5025%US$ 50.00 | |||
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| 120 Tablet/s | US$ 0.62 | US$ 75.0025%US$ 100.00 | |||
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Jakura 5 mg contains Tofacitinib as the main active compound and is an oral Janus kinase (JAK) inhibitor. Tofacitinib treats several autoimmune conditions. 5 mg is the common dosage for conditions such as:
- Rheumatoid arthritis - It helps reduce inflammation, pain, and joint damage.
- Psoriatic arthritis - It can help alleviate symptoms of joint pain and swelling.
- Ulcerative colitis - Used in cases where other treatments are not effective.
- Atopic dermatitis - It can reduce the symptoms of eczema.
Tofacitinib helps decrease joint pain and swelling by reducing tenderness and inflammation; it slows down the progression of bone and joint damage. Depending on a patient's health, you may be prescribed Jakura 5mg as a single or combined with other medicines.
How does Tofacitinib work?
This medicine works as below:
- JAK Inhibition - Tofacitinib is classified as a Janus kinase inhibitor (JAK inhibitor). The JAK family includes four enzymes: JAK1, JAK2, JAK3, and TYK2. These enzymes play a critical role in transmitting signals from cytokine receptors on the surface of cells to the inside of the cell, influencing gene expression and immune cell function.
- Blocking cytokine signaling - Cytokines are signaling molecules that regulate immune responses and inflammation. Many cytokines, such as interleukins (IL-2, IL-6, IL-17) and interferons, use the JAK-STAT (Signal Transducer and Activator of Transcription) pathway to exert their effects. Tofacitinib selectively inhibits JAK1 and JAK3 (to a lesser extent), which are involved in the signaling of several pro-inflammatory cytokines. By blocking JAK enzymes, tofacitinib reduces the activity of immune cells that promote inflammation, including T-cells, B-cells, and macrophages.
Reduction of inflammation - In rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis, the immune system mistakenly attacks the body's own tissues, leading to chronic inflammation. By dampening cytokine signaling, tofacitinib helps reduce the inflammatory response, decreasing symptoms like joint pain, swelling, and gut inflammation.
Safety precautions with tofacitinib tablet
Don’t take Jakura 5 mg if allergic to its active component, tofacitinib. Tofacitinib can weaken the immune system, increasing the risk of serious infections, including tuberculosis (TB), bacterial, fungal, or viral infections. Frequent monitoring of liver function tests is recommended if you take this medicine. It can affect blood cell counts, so routine blood tests are often necessary. Inform your doctor about your existing health condition, medicine, and supplements you may be taking to avoid drug interactions. Also, inform your doctor if you are a pregnant or breastfeeding mother.
Tofacitinib tablet side effects
Common side effects of Jakura tofacitinib include upper respiratory infections, headache, nausea, diarrhea, high blood pressure, and increased risk of infection due to its immune-suppressing effects.
Don’t hesitate to consult a doctor if any side effects become bothersome or persist over 2-3 days.
How to use Tofacitinib tablet
Tofacitinib is typically taken orally in tablet form, usually once or twice a day, depending on the condition and the dosage. Following your healthcare provider's instructions regarding dosage, timing, and precautions is important. The tofacitinib dosage can vary depending on the treated condition and whether you take it with other medications.
Tofacitinib can be taken with or without food. You can take it on an empty stomach, but you can take it with food if you experience stomach upset. Swallow the tablet whole with a glass of water. Do not chew, crush, or split the tablet, as this could affect how the medication is absorbed in your body. Try to take your tablet at the same time each day to help you remember. If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. Do not take two doses at once to make up for a missed dose.
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