Martifur 100 mg (Nitrofurantoin) – Affordable Macrodantin Alternative

Name: Martifur 100 mg
Brand: Macrodantin
SKU: 740
Availability: InStock

Martifur 100 mg consists of active ingredient Nitrofurantoin macro is a chemotherapeutic compound of the nitrofuran family. It is a synthetic antimicrobial derived from furan by the addition of a nitro group and a side chain containing hydantoin. The agent is a weak acid, and its solubility is affected by pH. Nitrofurantoin is the main medicinal substance contained in the Martifur tablets.

What is Martifur 100 mg used for?

The drug has been available for the treatment of urinary tract infections. Its current uses include the treatment of uncomplicated urinary tract infections, and protection against urinary tract infections in people prone to current urinary tract infections.

How does Martifur 100 mg work?

Martifur 100 mg works by damaging the bacterial DNA since its reduced form is highly reactive. The activity is made possible by the fast reduction of Nitrofurantoin macro 100 mg inside the bacterial cell by nitrofuran reductase (flavoproteins) to multiple reactive intermediates that attack pyruvate metabolism, respiration, ribosomal proteins, DNA, and other macromolecules within in the cell.

The drug exhibits greater effects on bacterial cells than mammalian cells because bacterial cells activate the medicine fastly. The mode of action for Nitrofurantoin likely is responsible for the low development of resistance to its effects, as the medicine affects many different processes important to the bacterial cell. Buy Martifur 100 mg to treat your urinary tract infection.

Precautions

What medications interact with Martifur 100 mg?

Avoid consuming Martifur, if you are taking the medicines that are given below:

Magnesium Salicylates
Probenecid
Choline magnesium

When should Martifur not be used?

Tell the doctor, before consuming Martifur as it can negatively interact with the given medicines and cause various, unexpected adverse effects:

If you are hypersensitive to the drug, or its components.
If you are suffering from liver or kidney disorders.
If you are consuming any prescription or nonprescription medicines.
If you are suffering from diabetes.
If you are a woman of childbearing potential. You should discuss the positives and negatives of taking Martifur, at the time of pregnancy.
Breastfeeding women are advised not to take Martifur as it may pass into the breast milk and harm the nursing baby.
The drug may cause dizziness. Do not drive or use machinery, while taking Martifur as these activities may require a high degree of mental attention.

How should Martifur 100 mg be stored?

Do not forget to see the expiry date of the product.
Place the medicine away from children.
Store Martifur tablets at a room temperature, away from heat and moisture.
Always keep the written record of your medications.
Avoid freezing the tablets.
Do not share your medicines with your near and dear ones.

Dosage Instructions

How should Martifur be taken?

The drug is present in the form of a tablet. You may take the drug with a meal, or as your doctor suggests. Swallow Martifur tablet with an adequate amount of water.
The dose regimen varies from patient to patient; it depends on the age, weight, and condition of the patients.
Take Martifur tablets strictly according to your doctor’s instruction. Do not alter the dosage plan unless your physician advises you to do so.
Take the medicine regularly to get the best results.
To help you remember, take the tablets at the same time, each day.
In some cases, the condition may become worse when the intake of the medicine is stopped suddenly. Your dose may need to be slowly decreased.
Consume the tablet in the same way as suggested to you. Don’t alter the dosage plan.
Overdose: Seek medical attention immediately, in the case of an overdose of Martifur.

Missed Dose of Martifur

If you have forgotten a dose, take it as soon you remember and go back to your usual dosing schedule. If the time to take the next dose is near, leave the forgotten dose and take the next dose. Do not double the dose to compensate the forgotten one.

Take the tablets for as long as your doctor recommended.

Side Effects

What are the side effects of Martifur 100 mg?

Like other medicines, Martifur may cause adverse effects. Seek medical attention, in case the given troubles arise:

Rust colored urine
Itching in the vagina
Vaginal discharge
Problems related to the stomach
Mild diarrhea
Vomiting

The adverse reactions of Martifur can be dangerous also. Visit the doctor immediately, in the following situations.

Sleeping problems
Severe Dizziness
Illusions
Seizures
Problems related to the vision
Nausea
Tinnitus
Appetite loss
Pain in the chest
Wheezing
Itching
Nightmares
Pruritus
Infection in the upper area of the stomach
Yellowing of the skin and eyes
Change in the color of urine
Change the color of stools
Optic neuritis

How to Use

Infographics

FAQ

What is Martifur 100mg used for?

Martifur 100mg contains nitrofurantoin, an antibiotic that is specifically designed to treat urinary tract infections (UTIs). It is used for uncomplicated lower UTIs in adults — meaning bladder infections (cystitis) where the infection has not spread to the kidneys. Nitrofurantoin works by concentrating specifically in the urine and bladder, where it reaches very high levels that kill the bacteria responsible for the infection (most commonly E. coli). Because it stays in the urinary tract rather than spreading through the body, it is not effective for kidney infections or infections in other organs.

Who should not take Martifur 100mg?

Martifur 100mg should not be taken by people allergic to nitrofurantoin. It must not be used by people with significant kidney disease (reduced kidney function with an eGFR below 45 ml/min/1.73m²) because the antibiotic cannot reach the urine in effective concentrations when the kidneys are not working well enough. It should be avoided in the last few weeks of pregnancy (at or near term) and in newborn babies. People with certain rare inherited conditions — glucose-6-phosphate dehydrogenase (G6PD) deficiency — should not use nitrofurantoin as it can cause the blood cells to break down.

What is the usual dose of Martifur 100mg?

The standard adult dose for treating an uncomplicated UTI is one 100mg modified-release capsule taken twice daily with food. The course for uncomplicated lower UTIs in adults is typically 5 days for women and 7 days for men (men often need a longer course due to a greater risk of upper urinary tract involvement). Nitrofurantoin at 50–100mg once daily can also be taken as long-term preventive therapy for women with recurrent UTIs — your doctor will advise on the appropriate dose and duration for preventive use. Always complete the full course.

Should Martifur 100mg be taken with food?

Yes — Martifur 100mg should always be taken with food or milk. Food significantly improves the absorption of nitrofurantoin and increases the concentration achieved in the urine. Taking it on an empty stomach reduces both absorption and the urine levels needed to kill the infection-causing bacteria. Taking it with meals also substantially reduces the risk of nausea, which is one of the most common side effects of nitrofurantoin. The modified-release (MR) capsule form is designed specifically to reduce side effects compared to older standard-release tablets — always take the MR capsule whole with food.

Is Martifur 100mg safe during pregnancy?

Nitrofurantoin is one of the recommended antibiotics for treating UTIs during pregnancy — particularly in the second trimester. It should be avoided in the first trimester (where possible) and must not be used at or near term (the last few weeks of pregnancy) because of the risk of a specific type of blood cell breakdown in the newborn baby (haemolytic anaemia). For UTIs in early pregnancy, your doctor will weigh the risk of untreated UTI (which can progress to kidney infection and trigger preterm labour) against the risk of the antibiotic and choose the safest option for your stage of pregnancy.

Is Martifur 100mg safe while breastfeeding?

Nitrofurantoin passes into breast milk in small amounts. It is generally considered compatible with breastfeeding in healthy, full-term infants older than 1 month. However, it should be avoided when breastfeeding a newborn (under 1 month old) or a premature infant, as these babies have less developed enzyme systems that could put them at risk of blood cell breakdown (haemolysis). If you are breastfeeding and require antibiotic treatment for a UTI, always inform your doctor — they will confirm whether nitrofurantoin is appropriate for your baby's age or whether an alternative is safer.

How does Martifur 100mg compare to ciprofloxacin for UTIs?

Nitrofurantoin (Martifur) and ciprofloxacin are both used for UTIs but are used in different situations. Nitrofurantoin is preferred as a first-line treatment for uncomplicated lower UTIs (bladder infections) because it has lower resistance rates among common UTI bacteria, is gentler on the wider gut microbiome (gut bacteria balance), and helps preserve fluoroquinolones like ciprofloxacin for when they are truly needed. Nitrofurantoin cannot be used for kidney infections. Ciprofloxacin is reserved for more complicated UTIs, kidney infections, or when nitrofurantoin cannot be used — such as in people with reduced kidney function.

Can I drink alcohol while taking Martifur 100mg?

There is no severe direct interaction between nitrofurantoin and alcohol, but alcohol is best avoided during UTI treatment. Alcohol irritates the bladder lining directly, which can worsen the burning and frequent urination symptoms of cystitis. More importantly, alcohol is dehydrating — and good hydration with water is one of the key elements of recovering from a UTI quickly, as flushing bacteria out of the bladder with adequate urine flow is helpful alongside the antibiotic. For the short 5–7 day course, avoiding alcohol entirely is the most sensible approach.

Does Martifur 100mg interact with other medicines?

Nitrofurantoin can interact with a small number of medicines. Antacids containing magnesium trisilicate reduce nitrofurantoin absorption significantly — avoid these together. Probenecid and sulfinpyrazone (medicines used for gout) can reduce the amount of nitrofurantoin that reaches the urine, potentially making it less effective. Quinolone antibiotics (like norfloxacin or nalidixic acid) may antagonise nitrofurantoin — using both together is generally avoided. Some medicines that can cause lung problems or neuropathy should not be combined with nitrofurantoin for prolonged use. Always share your complete medication list with your doctor.

Why is nitrofurantoin not effective for kidney infections?

Nitrofurantoin is specifically designed to concentrate in the urine and bladder — this is precisely what makes it effective for bladder infections. However, the very property that makes it work well for lower UTIs (staying in the urinary tract rather than spreading through the bloodstream) means it does not achieve therapeutic concentrations in the kidney tissue, the bloodstream, or other tissues. A kidney infection (pyelonephritis) requires an antibiotic that can reach adequate levels in the kidney tissue — such as ciprofloxacin, cephalexin, co-amoxiclav, or trimethoprim. Using nitrofurantoin for a kidney infection risks treatment failure.

What are the common side effects of nitrofurantoin?

The most commonly reported side effect of nitrofurantoin is nausea — which is why taking it with food is essential. The modified-release (MR) formulation in Martifur 100mg is specifically designed to be gentler on the stomach than older standard-release tablets. Some people experience headache, dizziness, and loss of appetite. A notable but harmless side effect is that nitrofurantoin turns the urine a dark yellow or brown colour — this is simply the drug being excreted and is not a cause for concern. Mild skin rash can also occur. Most side effects are mild and resolve once the short course is finished.

What side effects of nitrofurantoin need urgent medical attention?

Seek immediate medical help for signs of a serious allergic reaction (hives, facial or throat swelling, breathing difficulty, or collapse). An unusual but important side effect of nitrofurantoin — particularly with prolonged use — is pulmonary toxicity (lung inflammation), which can present as a new persistent cough, breathlessness, or chest pain during treatment. Report these symptoms to your doctor straight away. Peripheral neuropathy (tingling or numbness in the hands or feet) is another rare but serious effect of long-term use. Jaundice (yellowing of skin or eyes) may indicate liver involvement — seek prompt medical evaluation. These serious effects are very rare with short 5–7 day courses.

SKU	740
Generic For	Macrodantin
Strength	100 mg
Manufacturer	Martin and Harris Laboratories Ltd.
Active Ingredient	Nitrofurantoin

Martifur 100 mg