Natclovir is an antiviral medicine, which slows the growth and spread of cytomegalovirus. It is useful in treating and preventing infections caused by cytomegalovirus. The infection usually occurs in patients who have suppressed body’s defense system such as patients with AIDS and organ transplant patients. The medicine has the active ingredient Gangciclovir, which comes under the category of drugs called nucleoside analogues. The beneficial component blocks the viral DNA replication, a process essential for the virus to grow and multiply. In this way, it stops the virus from spreading in the body.
Natclovir general information
What is Natclovir used for?
Natclovir is used to treat cytomegalovirus (CMV) retinitis in immunocompromised patients, including HIV infected patients. It is used to prevent CMV infection in transplant patients at risk. It is also useful in treating congenital CMV infection in neonates.
How does Natclovir work?
Natclovir comprises of an active component Ganciclovir, which exerts antiviral effect directed preferentially against CMV infected cells.
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What does Natclovir contain?
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What are the side effects of Natclovir?
- Respiratory system disorders: dyspnea
- Dermatological issues: photosensitivity, urticaria, alopecia, rash, pruritus
- Cardiovascular disorders: hypertension, arrhythmias, hypotension, edema
- Central nervous system disorders: abnormal dreams, drowsiness, nervousness, confusion, seizures, headache, malaise, coma
- Gastrointestinal problems: abdominal pain, gastrointestinal bleeding
- Hematological issues: thrombocytopenia, neutropenia, esosinophilia, anemia
- Neurological disorders: tremor, ataxia
- Cardiovascular disorders: hypertension, edema, hypotension, arrhythmias
- Genitouterine disorders: heamturia, gonadal suppression, renal toxicity
- Local issues: pain or phlebitis
- Miscellaneous issues: fever, hypoglycemia
What medications interact with Natclovir?
- Natclovir may increase the risk of bone marrow depression with radiation therapy, antineoplastics, or zidovudine.
- Toxicity of probenecid may be increased if taken along with Natclovir.
- Co-administration of Natclovir with cilastatin or imipenem may increase risk of seizures.
- Concurrent use other nephrotoxic drugs, amphotericin B, or cyclosporine may increase risk of nephrotoxicity.
When should Natclovir not be used?
- Natclovir is not suitable for patients who are hypersensitive to Ganciclovir or acyclovir
- It should not be used in patients with depression or immunosuppression or thrombocytopenia.
Use it with caution in the following conditions:
- Renal impairment
- Geriatric patients
How should Natclovir be used?
Natclovir is available in the form of capsules for oral administration. The dosage of the medicine depends on various factors including age, weight and health condition as well as your response to treatment.
How long should you use Natclovir?
Take Natclovir 250 mg as long as it is recommended to you. Do not stop in between during the treatment as it may take several weeks or longer to see the effects of this medication. If your condition still does not improve after the prescribed time, call your physician.
Missed dose of Natclovir?
Always remember to take the medicine on time. If you miss a dose of Natclovir capsules, then use it as soon as you remember.
How should Natclovir be stored?
- Store the medicine at room temperature
- Ensure that your children and pets don't have access to the medication
- Keep it out of the reach of children