SKU	1121
Generic For	Loxin TZ
Strength	600 mg /200 mg
Manufacturer	Dynamic Labs
Active Ingredient	Tinidazole Ofloxacin

Product Description

Oflox TZ 600/200 mg (Tinidazole Ofloxacin) – Affordable Loxin TZ Alternative

Oflox TZ 600/ 200 mg tablets contain Ofloxacin and Tinidazole as its active pharmaceutical ingredients. Ofloxacin is a quinolone antibiotic, known for treating a wide variety of bacterial infections in many different parts of the body. Tinidazole is a nitro imidazole, which has broad spectrum bacteriocidal activity against Protozoa and some anaerobic bacteria. However, this medicine will not work for colds, flu, or other virus infections.

What is Oflox TZ used for?

Oflox TZ 600/200 mg is an antibiotic, belongs to a quinolone family of medicines used in the treatment of a bacterial infection. This drug is indicated for the treatment of sinus, chest infections, urine infections, anthrax or plague, kidney infections, ear and lung infection, and some skin infections. An anti-parasitic, prescribed for trichomoniasis, giardiasis, bacterial vaginosis, and amebiasis.

How does Oflox TZ work?

Oflox TZ 600 mg/ 200 mg is a combination drug contains two active pharmaceutical ingredients Ofloxacin and Tinidazole.

Ofloxacinis the is an antibiotic and its antibacterial activity resides primarily in the L-isomer. It is a fluoroquinolone antimicrobials that works by inhibitingthe bacteria IV and DNA gyrase enzymes which is a essential requirement for DNA formation. Thus, it kills the bacteria which are responsible for the infection. This way, it stops the growth of bacteria and cure infections.

Tinidazole is a nitro imidazole which has broad spectrum bacteriocidal activity against Protozoa and some anaerobic bacteria. It works by rupturing and destabilizing the DNA other critical biomolecules. This results in DNA breakage. This is how it works by stopping the growth of bacteria and protozoa that kills the causative agent and thus cure infections

Effects of alcohol on Oflox TZ

Oflox TZ 600 mg/200 mg mg tablets may cause dizzinessand if it is taken with alcohol, the condition may get worsen. Therefore, it is safe to avoid alcohol consumption during the treatment with Oflox TZ

Precautions

What medications interact with Ofloz TZ?

Tell your physician if you are consuming any other drugs, including prescription and non-prescription drugs, herbal supplements, and vitamins. Especially, tell your physician if you take:

Antacids containing magnesium, calcium, or aluminum
Warfarin
Probenecid
Potassium citrate
Sodium citrate
Multivitamins
Cyclosporine
NSAIDs such as ibuprofen
Amiodarone
Quinidine

Keep a list of medicines you take and show it to your doctor every time you get a new medicine.

When should OfloxTZ not be used?

Do not take Oflox TZ 600 mg/200 mg if:

You are suffering from glucose 6 phosphate deficiency
You have Myasthenia Gravis
You are pregnant or plan to get pregnant.
You have any kidney problem
You are allergic to any of the components in Oflox TZ 600 mg/200 mg tablets.

Dosage Instructions

Side Effects

What are the side effects of Oflox TZ?

Oflox TZ 600/200 mg tablets may cause serious side effects including:

Heart disease. Patients who have a history of heart disease and who take Oflox TZmay show a slight increase in heart problems, therefore it is advised to discuss about the same with your doctor before taking this drug.
Liver problems. The drug may cause inflammation of the liver. Using this drug in this condition need to monitor and examine your condition with your doctor. Therefore, consult your doctor before starting up with this drug.
Diabetes. This drug is not suitable for diabetes patients, it may cause serious changes in blood sugar. In this case, consult your doctor before taking this medicine.
Tendonitis. If the patient has ever experienced a problem of tendons, called tendonitis, it may cause serious side effect therefore, in this case you should inform your doctor about your medical history before starting up this medicament.

Common side effects that may occur while taking Oflox TZ 600 mg/200 mg tablets include:

Diarrhea
Stomach upset
Trouble in sleeping
Constipation
Nausea
Headache
Unusual weakness
Vomiting
Fast or irregular heartbeat
Chest pain
Fast heart rate
Abdominal or stomach pain
Cramping
Trouble breathing
Blood or mucus in your stool

How to Use

How should Oflox TZ be taken?

Take one Oflox TZ tablet every day, with or without food.
If you have taken overdose Oflox TZ tablets by mistake, contact your doctor immediately. Remember do not take any additional tablet until your doctor prescribed you to do so.

Contact your doctor if you experience any unwanted health changes while taking this medicine.

How long should you take Oflox TZ?

Take Oflox TZ 600 mg/200 mg exactly as prescribed by your physician. Keep taking the medicine for as long as your doctor prescribes it for you.

Missed dose of Oflox TZ?

If you miss the dose take it as soon as you remember, skip the missed dose if it is too late and take the next dose at the correct dosing time. Never take a double dose at one time.

How should Oflox TZ be stored?

Store it at room temperature
Keep the tablets in its original packet until it is time to take them
Do not store it or any other medicine in the bathroom or near a sink
Keep away from heat, moisture, and light
Keep the medicine where children cannot reach

Infographics

FAQ

What is Oflox TZ 200/600mg used for?

Oflox TZ is a combination tablet containing ofloxacin (200mg) and tinidazole (600mg). It combines a fluoroquinolone antibiotic (ofloxacin) that targets a broad range of bacteria with an antiprotozoal and anti-anaerobic medicine (tinidazole) that covers anaerobic bacteria and protozoa. It is used for mixed infections where both aerobic bacteria and anaerobic organisms or protozoa may be involved — including gastrointestinal infections, pelvic inflammatory disease, complicated gynaecological infections, and mixed abdominal infections. The combination provides comprehensive coverage in a single tablet.

Who should not take Oflox TZ?

Oflox TZ should not be taken by anyone allergic to ofloxacin, other fluoroquinolones, tinidazole, or metronidazole. It must not be taken by people with epilepsy, heart rhythm abnormalities (QT prolongation), a history of fluoroquinolone-related tendon damage, myasthenia gravis, or severe liver or kidney disease. It is contraindicated during pregnancy — particularly the first trimester — and during breastfeeding. Children and teenagers should not take this combination tablet. Always inform your doctor of your complete medical history and all medications before starting this treatment.

What is the standard dose of Oflox TZ for adults?

The usual adult dose is one tablet taken twice daily, with food. The course duration varies by infection type — typically 5 to 7 days for most gastrointestinal or gynaecological infections. For more complicated infections, the doctor may prescribe a longer course. This combination is generally used as a short course — prolonged use increases the risk of fluoroquinolone-related side effects (tendon damage, CNS effects) and tinidazole-related effects. Always follow your doctor's exact dosing instructions and complete the full prescribed course.

Should Oflox TZ be taken with food?

Yes — Oflox TZ should be taken with food or immediately after a meal. The tinidazole component can cause significant nausea and stomach upset on an empty stomach, and food substantially reduces these effects. As with all ofloxacin-containing products, avoid taking the tablet at the same time as antacids containing aluminium or magnesium, iron supplements, zinc, or calcium-rich dairy products — these reduce ofloxacin absorption. Separate these by at least 2 hours before or 6 hours after the Oflox TZ dose. Take each tablet with a full glass of water.

Can I drink alcohol while taking Oflox TZ?

No — alcohol must be strictly avoided during the Oflox TZ course and for at least 72 hours (3 days) after the last tablet. The tinidazole component causes a severe disulfiram-like reaction when combined with alcohol — including intense flushing, severe headache, nausea, vomiting, rapid heartbeat, and potentially dangerous blood pressure changes. This reaction is extremely unpleasant and potentially medically serious. The ofloxacin component also causes dizziness and headache that alcohol further worsens. Avoid all alcohol — including in drinks, some medicines, and mouthwashes — throughout this period.

Is Oflox TZ safe during pregnancy or breastfeeding?

Oflox TZ is not recommended during pregnancy. Ofloxacin (a fluoroquinolone) may affect foetal cartilage development based on animal studies, and tinidazole is avoided during the first trimester as a precautionary measure. Safer antibiotic combinations are available for pregnant women. Both ofloxacin and tinidazole pass into breast milk — breastfeeding is not recommended while taking Oflox TZ. Breastfeeding should be suspended for at least 3 days after the last dose. If you are pregnant or breastfeeding and need treatment for an infection, always inform your doctor so a safe alternative can be chosen.

How does Oflox TZ work, and why use a combination?

Ofloxacin kills a wide range of aerobic bacteria by interfering with their ability to replicate their DNA. Tinidazole kills anaerobic bacteria (bacteria that live without oxygen, often found in the gut, pelvis, and dental tissues) and protozoa (parasites). Many gastrointestinal, pelvic, and abdominal infections involve a mixture of aerobic and anaerobic organisms — single antibiotics often fail to cover both groups. The combination in Oflox TZ provides comprehensive polymicrobial (mixed bacterial) coverage in a single tablet, which is both more effective and more convenient than taking two separate medicines with their own dosing schedules.

Does Oflox TZ interact with other medications?

Oflox TZ has a combined interaction profile from both its components. Ofloxacin can raise theophylline (asthma medicine) to toxic levels and enhance the blood-thinning effect of warfarin. It can worsen the QT-prolonging effect of certain heart medicines, and combined with NSAIDs, it may increase seizure risk. Tinidazole enhances the effect of warfarin (the same interaction applies for both components), can raise lithium levels, and causes the alcohol (disulfiram-like) reaction. All drug interactions of both ofloxacin and tinidazole apply when taking this combination. Always share a complete medication list with your doctor.

What should I do if I miss a dose of Oflox TZ?

Take the missed dose as soon as you remember — with food. If the next scheduled dose is close, skip the missed one and continue normally. Do not take two tablets at once. For most courses (5–7 days), consistent twice-daily dosing is important for maintaining effective antibiotic levels and ensuring complete treatment. Phone reminders linked to your two daily mealtimes provide the most practical way to avoid missed doses. Contact your doctor or pharmacist if you are unsure what to do after a missed dose.

Can Oflox TZ be used for traveller's diarrhoea?

Yes — Oflox TZ can be used for traveller's diarrhoea where both bacterial and protozoal causes are suspected. Ofloxacin covers common bacterial causes of traveller's diarrhoea including E. coli, Shigella, Salmonella, and Campylobacter. Tinidazole covers protozoal causes including Giardia and Entamoeba histolytica. In regions where both bacteria and protozoa are common causes of traveller's diarrhoea — particularly in parts of South Asia, Southeast Asia, and Africa — a combination like Oflox TZ can be a practical choice for broad-spectrum treatment, particularly when laboratory testing is not available.

What are the common side effects of ofloxacin-tinidazole combination?

Common side effects include nausea, vomiting, stomach discomfort, and diarrhoea — taking the tablet with food significantly reduces these. A metallic or bitter taste in the mouth is a very characteristic side effect of tinidazole. Headache and dizziness are reported with ofloxacin. Increased sensitivity of the skin to sunlight (from ofloxacin) means sunscreen use is recommended during the course. Darkening of the urine may occur (from tinidazole — this is harmless). As with all antibiotics, oral or vaginal thrush can develop. Most side effects are mild and resolve after the short course is completed.

What side effects of ofloxacin-tinidazole need urgent medical attention?

Seek emergency care for signs of a severe allergic reaction — sudden widespread rash or hives, facial or throat swelling, breathing difficulty, or collapse. If you accidentally consume alcohol and experience severe flushing, vomiting, or rapid heartbeat during the course or within 3 days after, seek medical help immediately. Stop the tablets and contact your doctor if you develop tendon pain or swelling (especially in the Achilles tendon). Neurological symptoms (seizures, confusion, hallucinations) and heart palpitations need urgent evaluation. Tingling or numbness in the hands or feet (peripheral neuropathy) requires prompt medical review.

Oflox TZ 600 mg /200 mg