Pangraf - 5mg
Available Dosages
| Description | Pangraf 5 mg (Tacrolimus) |
|---|---|
| SKU | 1041 |
| Generic For | Prograf |
| Strength | 5mg |
| Manufacturer | Zydus |
| Active Ingredient | Tacrolimus |
Out Of Stock
Pangraf - 5mg (Tacrolimus) – Affordable Prograf Alternative
Pangraf 5 mg is a prescription medicine that should be used under proper medical surveillance. It is formulated to prevent your body from rejecting a kidney, liver, or transplant. It lowers your body’s immune system, which helps your body fight against infection. Your immune system can also help fight or reject a transplanted organ such as kidney or liver. The medicine contains Tacrolimus as the active pharmaceutical ingredient.
What is Pangraf used for?
Pangraf is used to prevent organ rejection in patients who have undergone allergenic liver, heart, or kidney transplantation.
How does Pangraf work?
By inhibiting T-lymphocyte activation, Pangraf prevents transplanted organ rejection.
Where to buy Pangraf online?
Pangraf is available for oral administration in the form of tablets. It is available in the pack sizes of 30, 60, and 90. You can buy Pangraf 5 mg online from our website premiumrxdrugs.com at a quite affordable price.
What does Pangraf contain?
Each pangraf tablet contains 5 mg of the active component Tacrolimus.
What are the side effects of Pangraf?
- Cardiovascular system disorders- Peripheral edema, hypertension
- Dermatological issues-alopecia, pruritus, rash
- Respiratory system disorders- cough, pharyngitis, pulmonary edema, bronchitis, asthma, pneumonia, pleural effusion
- Central nervous system disorders- abnormal dreams, confusion, hallucinations, confusion, somnolence, tremor, headache, insomnia, seizures, psychoses depression, and emotional lability.
- F and E disorders- hyperkalemia, hypomagnesemia, hyperlipidemia, hypophosphatemia, hyponatremia, metabolic alkalosis, hypocalcemia, hyperuricemia, metabolic acidosis
- Neurological issues- neuropathy, paresthesia
- Gastrointestinal issues- dyspepsia, constipation, vomiting, nausea, abdominal pain, constipation, gastrointestinal bleeding, diarrhea, ascites, increased liver enzymes, cholestatic jaundice, cholangitis, dysphagia flatulence, rexia, increased appetite oral thrush
- Endocrine disorders- hyperglycemia
- Genitouterine issues- urinary tract infection, nephrotoxicity
- EENT disorders- amblyopia, abnormal vision, tinnitus
- Hematological issues-thrombocytopenia, anemia, leukopenia, leukocytosis, pure red cell aplasia, coagulation defects
- Musculoskeletal disorders- leg cramps, hypertonia, arthralgia
- Miscellaneous issues- fever, chills, allergic reaction, including anaphylaxis, abnormal healing, the risk of skin cancer, generalized pain
What medications interact with Pangraf?
- The risk of nephrotoxicity is increased by concurrent use of cyclosporine, amphotericin B, aminoglycosides, or cisplatin
- Hyperkalemia may occur with concurrent use of ACE inhibitors, angiotensin II receptor antagonists, and potassium-sparing diuretics.
- Vaccination may be less effective if taken along with Pangraf, therefore avoid the use of live-virus vaccines during the treatment with Tacrolimus.
- The following drugs may increase the levels of Pangraf:
- calcium channel blockers
- Danazol
- Methylprednisolone
- Coriconazole
- Cyclosporine
- Clarithromycin
- Omeprazole
- Cimetidine
- Bromocriptine
- Azole antifungals
- Magnesium hydroxide
- Aluminum hydroxide
- Protease inhibitors
- Lansoprazole
- Chlorophenicol
- The following drugs can decrease Tacrolimus blood levels:
- Rifamycins
- Sirolimus
- Phenobarbital
- Caspofungin
- Phenytoin
- Carbamazepine
- Avoid use of St.john’s wort medicine may decrease tacrolimus blood levels.
- Coadministration of Echinacea, astragalu and melatonin with Pangraf may interfere with immunosuppressants
When should Pangraf not be used?
- Pangraf is not suitable for patients who are hypersensitive to Tacrolimus or castor oil present in the formulation.
- It should be avoided by breastfeeding women.
Use it carefully in the following condition:
- Renal or hepatic impairment
- Exposure to UV light
- Pregnancy
How should Pangraf be taken?
- Patients are instructed to use the medicine daily on a regular basis as directed by your healthcare specialist. Patients are advised to read the prescription before starting the treatment carefully.
- Symptoms of rejection for transplanted organ and stress should be reviewed and notify your health care specialist if they occur.
- To avoid photosensitivity, patients are advised to wear protective clothing and sunscreen.
- One should avoid exposure to mumps, rubella, and chicken pox. If accidently exposed, see a health care professional for prophylactic therapy.
- Make sure that you do not share this medicine with anybody, since they may be suffering from a condition that is not effectively treated by this medicine.
How long should you take Pangraf?
Continue taking these 5 mg tablets for as long as your health care professional recommends.
Missed dose of Pangraf
Make sure that you do not skip or double up on missed doses. If you missed a dose, then talk to your health care specialist for further advice.
How long Pangraf is stored?
Keep the tablets out of the reach of children and away from pets. Don’t freeze the medicine. Store it at controlled room temperature.
What is Pangraf 5mg (tacrolimus) used for?
Pangraf 5mg contains a higher strength of tacrolimus, primarily used in the early post-transplant period or when tacrolimus blood levels need to be elevated to prevent acute rejection. This 5 mg capsule allows physicians to achieve therapeutic drug concentrations quickly after organ transplantation. As therapy progresses and the rejection risk decreases, the dose is typically reduced to maintain lower target trough levels using 0.5 mg or 1 mg capsules.
Why is a higher dose of tacrolimus needed early after transplant?
Immediately after organ transplantation, the immune system's response to the foreign graft is most intense. Higher tacrolimus doses are needed to achieve blood levels (typically 10–15 ng/mL or higher) that suppress this acute rejection response. As the immune response settles over weeks to months, the target level is progressively lowered to minimise long-term nephrotoxicity while maintaining adequate immunosuppression — a process managed by the transplant pharmacist or nephrologist.
How should Pangraf 5mg be dosed and administered?
Pangraf 5mg is taken twice daily, approximately 12 hours apart, on an empty stomach or consistently relative to meals. Swallow the capsule whole — never crush or open it. The dose prescribed by your transplant team is based on your body weight, the type of transplant, and your measured tacrolimus blood levels. Do not adjust the dose independently. Levels must be monitored frequently, especially in the first weeks when dose changes are most common.
How are tacrolimus 5mg doses adjusted over time?
Tacrolimus doses are adjusted based on trough blood level results, which are typically measured before the morning dose. Early post-transplant, levels may be targeted at 10–15 ng/mL, reducing to 5–10 ng/mL after 3–6 months as rejection risk falls. The 5 mg capsule may be used initially, with the dose later transitioned to lower-strength capsules (1 mg, 0.5 mg) for fine-tuned control. Always make adjustments under transplant team supervision.
Is tacrolimus 5mg safe for liver transplant recipients?
Tacrolimus 5mg is commonly used after liver transplantation, and tacrolimus itself is the standard immunosuppressant for liver transplant recipients globally. However, liver transplant patients metabolise tacrolimus through the transplanted liver — function of the new liver affects drug metabolism. As the graft function improves post-transplant, tacrolimus levels can change, requiring more frequent monitoring in the early phase. Hepatotoxicity from tacrolimus itself is rare but should be distinguished from rejection.
Can tacrolimus 5mg cause diabetes?
Yes — new-onset diabetes after transplantation (NODAT) is one of the most clinically significant side effects of tacrolimus. It impairs insulin secretion from pancreatic beta cells via its calcineurin inhibition effect. The 5 mg dose carries a higher NODAT risk than lower maintenance doses. Blood glucose monitoring — particularly fasting glucose and HbA1c — is essential, especially in the first year. NODAT may require insulin or oral antidiabetic treatment and often improves with tacrolimus dose reduction.
How does Pangraf 5mg compare to mycophenolate in transplant immunosuppression?
Pangraf 5mg (tacrolimus) and mycophenolate mofetil (MMF) are not alternatives but typically complementary agents in transplant immunosuppression protocols. Tacrolimus is a calcineurin inhibitor targeting T-cell activation; mycophenolate inhibits purine synthesis to reduce lymphocyte proliferation. Most transplant centres use tacrolimus alongside mycophenolate and low-dose corticosteroids as a triple immunosuppression protocol. They target different immune pathways, providing more comprehensive rejection prevention.
Is Pangraf 5mg equivalent to Prograf 5mg?
Yes. Pangraf 5mg contains tacrolimus 5 mg, the same active ingredient and dose as Prograf 5mg. It is manufactured to bioequivalence standards, delivering the same blood levels and immunosuppressive effect. Pangraf provides the significant cost benefit of a generic formulation — essential for transplant patients who require lifelong medication. Formulation switches should always be coordinated with your transplant pharmacist to ensure stable blood levels.
Can transplant patients order Pangraf 5mg from PremiumRxDrugs internationally?
Yes. PremiumRxDrugs.com ships tacrolimus capsules — including Pangraf 5mg — internationally to the USA, UK, Australia, and many other countries. Our trusted track record of over a decade, genuine manufacturer-verified medicines at competitive prices, and free worldwide shipping on qualifying orders make us a reliable pharmacy for patients on lifelong transplant immunosuppression.
What are the important side effects of tacrolimus 5mg?
At higher doses, tacrolimus 5mg more commonly causes nephrotoxicity (reduced kidney function), hyperglycaemia/NODAT, hypertension, neurotoxicity (tremor, headache, insomnia, rarely seizures), and gastrointestinal effects (diarrhoea, nausea). Elevated potassium and low magnesium are common electrolyte disturbances. Opportunistic infections and post-transplant lymphoproliferative disorder (PTLD) are serious long-term immunosuppression risks requiring vigilance.
What monitoring is required for patients on Pangraf 5mg?
Patients on Pangraf 5mg require frequent tacrolimus trough level measurements (initially weekly, then monthly, then quarterly as stable), plus renal function, potassium, magnesium, fasting glucose, HbA1c, blood pressure, and full blood count monitoring. Skin checks for new lesions are recommended annually due to increased skin cancer risk. Any fever, unusual infection, swollen lymph nodes, or neurological symptoms require prompt medical assessment. Never miss scheduled transplant clinic reviews.
Login
Sign Up
Login
Sign Up