Pangraf 0.5mg
Available Dosages
| SKU | 1044 |
|---|---|
| Generic For | Prograf |
| Strength | 0.5mg |
| Manufacturer | Panacea |
| Active Ingredient | Tacrolimus |
| Pack Size | Qty | Price Per Pill or Unit | Price | Cart | |
|---|---|---|---|---|---|
| 30 Tablet/s | US$ 1.08 | US$ 32.50 | |||
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| 60 Tablet/s | US$ 0.70 | US$ 42.0035%US$ 65.00 | |||
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| 90 Tablet/s | US$ 0.67 | US$ 60.0038%US$ 97.50 | |||
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Pangraf 0.5mg Capsules (Tacrolimus) – Affordable Prograf Alternative
Pangraf .5 mg is available for oral administration as capsules containing 0.5 mg of Tacrolimus. It is an immunosuppressant medication formulated to prevent rejection after organ transplantation. It may also be prescribed to treat nephrotic syndrome when steroids no longer help, or in other immune system diseases. The body's defence system can fight or reject a transplanted organ such as the heart or kidney because it treats the new organ as an attacker.
What is Pangraf .5mg used for?
The medicine is useful in preventing the body from rejecting the newly transplanted kidney, heart, or liver. It is a prescription medicine that legally requires a medical prescription to be dispensed.
How does Pangraf .5mg work?
It works to decrease the immune response and stopping the body reacting to the new organ.
What does Pangraf contain?
Pangraf's active component is an immunosuppressive agent called Tacrolimus. Each capsules
delivers 0.5 mg of the beneficial ingredient.
Effects of grape juice on Pangraf
Pangraf should never be taken along with grapefruit juice as it can affect the way it is absorbed in the body.
What are the medications interact with Pangraf?
Some drugs may affect how well Pangraf is absorbed. Your health care provider will be aware of this. If you are taking herbal medications or nonprescription other medicines, you should always check with your health care provider before taking them. Medicines that can affect the mechanism of action of Tacrolimus are stated below:
- ACE inhibitors
- Danazol
- Voriconazole
- Amphotericin
- Methylprednisolone
- Omeprazole
- Angiotensin II receptor antagonists
- Cisplatin
- Cimetidine
- Cyclosporine
- Potassium-sparing diuretics
- ACE inhibitors
- Aminoglycosides
- Cyclosporine
- Aluminium hydroxide
- Bromocriptine
- Magnesium hydroxide
- Azole antifungals
- Astragalus
- Phenytoin
- Sirolimus
- Protease inhibitors
- Chlorophenicol
- Melatonin
- Carbamazepine
- Echinacea
- St.john's wort
- Caspofungin
- Phenobarbital
When should Pangraf not be used?
Do not take Pangraf 0.5 mg if you are allergic to it.
What are the side effects of Pangraf?
There are potential unwanted effects on almost all medication. Many of the side effects occur in a few people. It is not possible to predict which individual will develop which side effect. Side effects are often temporary, and when reported to the healthcare provider can be treated by adjusting the medication regimen.
Some unwanted effects of the medicine may include:
- Vomiting
- Abdominal pain
- Diarrhoea
- Arthralgia
- Fever
- Leg cramps
- Coagulation defects
- Pure red blood cell aplasia
- Tinnitus
- Anaemia
- Hypertonia
- Abnormal healing
- Risk of skin cancer
- Chills
- Leukocytosis
- Leukopenia
- Thrombocytopenia
- Generalized pain
- Pleural effusion
- Hallucinations
- Somnolence
- Seizures
- Depression
- Hyperkalemia
- Emotional lability
- Psychoses
- Hypomagnesemia
- Insomnia
- Confusion
- Abnormal dreams
- Hyperlipidemia
- Neuropathy
- Constipation
- Metabolic acidosis
- Hyponatremia
- Hyperuricemia
- Nephrotoxicity
- Hyperglycemia
- Rexia
- Cholestatic jaundice
- Diarrhoea
- Gastrointestinal bleeding
- Increased liver enzymes
- Increased appetite, oral thrush
- Dysphagia
- Flatulence
- Urinary tract infections
How should Pangraf be taken?
Taking the correct dose is necessary. The dose of Tacrolimus depends on the patient's condition and may be changed depending on the condition; you will be informed if the dose required to be changed. If you have any doubt about the use of medicine, please ask your health care, provider.
You must take this medicine exactly as prescribed by your health care provider. It is usually taken 2 to 3 times daily, 8 or 12 hours apart. Consuming the doses 12 hours apart will have the best effect. You must swallow the capsules with a glass full of water.
Always take the capsules on an empty stomach. Patients are advised not to eat or drink anything except water for half an hour before and after taking medicine.
Avoid crushing and breaking the capsules as it can be dangerous if it gets into your eyes, nose, or mouth. If this happens, you should immediately wash out with water.
Ask your health care provider how to handle the medication safely. Make sure that you clean your hands before and after taking medicine.
How long should you take Pangraf?
Keep on taking medicine for as long as your health care provider tells you to.
Missed dose of Pangraf
Take the missed dose as soon as possible. You can skip the missed dose if it is almost time to take the next dose. Don't try to take an extra dose to make the missed one. Contact your health care provider to discuss more this.
How should Pangraf be stored?
Store the medicine at room temperature away from heat and moisture. Ensure that it locked away safely and away from children.
What is Pangraf 0.5mg used for in transplant care?
Pangraf 0.5mg contains the lowest standard capsule strength of tacrolimus, used for fine-dose adjustments in stable transplant patients at low-level maintenance. It allows incremental dose changes when tacrolimus trough levels need small reductions — for example, when levels consistently run slightly above target range. The 0.5 mg capsule is also useful for paediatric dosing or when transitioning elderly patients to the minimum effective dose to reduce nephrotoxicity and NODAT risk.
Why is the 0.5mg capsule useful for tacrolimus dose management?
Tacrolimus has a narrow therapeutic index — small dose changes can significantly affect blood levels. The 0.5 mg capsule allows precise titration in 0.5 mg steps, giving transplant physicians flexibility to achieve trough levels within tight target ranges without the large jumps that would result from using only 1 mg or 5 mg capsules. This precision is particularly important for stable long-term transplant patients whose target levels are in the lower range (3–7 ng/mL).
How should Pangraf 0.5mg capsules be taken?
Pangraf 0.5mg capsules are taken twice daily, 12 hours apart, on a consistent schedule relative to meals (either always with or always without food). Grapefruit and grapefruit juice must be avoided at all times. Take capsules whole with water. Even at this low dose, tacrolimus monitoring is essential — blood level measurements guide every dose adjustment. Never alter the dose without instruction from your transplant team.
At what stage of transplantation is the 0.5mg dose typically used?
Pangraf 0.5mg is most commonly used in stable, established transplant patients — typically 12 months or more post-transplant — when the rejection risk has significantly reduced and lower tacrolimus trough levels (3–7 ng/mL) are targeted to minimise nephrotoxicity and metabolic side effects. It is also used when weaning down from higher doses in patients who have experienced toxicity, allowing gradual reduction with careful blood level monitoring.
Is a low-dose tacrolimus regimen safer long-term?
Lower tacrolimus maintenance doses (achievable with 0.5 mg adjustments) are generally associated with less nephrotoxicity, lower rates of new-onset diabetes, and reduced neurotoxicity compared to higher maintenance levels. However, excessively low levels increase the risk of rejection, which can cause irreversible graft damage. The optimal dose is the minimum that maintains effective immunosuppression — a balance assessed through regular blood level monitoring and clinical review.
Can other medications affect tacrolimus 0.5mg blood levels significantly?
Yes — even at 0.5 mg, drug interactions can cause clinically significant changes in tacrolimus levels. CYP3A4 inhibitors (azole antifungals, some antibiotics, diltiazem, verapamil) increase levels; CYP3A4 inducers (rifampicin, St. John's Wort, carbamazepine) decrease levels. Even starting or stopping a proton pump inhibitor can affect levels in some patients. Any new medication requires urgent communication with your transplant team to prevent rejection or toxicity.
How does Pangraf 0.5mg differ from extended-release tacrolimus (Advagraf)?
Pangraf 0.5mg is an immediate-release, twice-daily tacrolimus capsule; Advagraf is an extended-release formulation taken once daily. Extended-release tacrolimus may improve adherence by reducing the twice-daily regimen to once daily. Blood levels behave differently — Advagraf has a lower peak and similar trough compared to immediate-release. Switching between formulations requires dose adjustment and increased monitoring to re-establish correct levels. The 0.5 mg dose allows fine-tuning not available with all extended-release formulations.
Is Pangraf 0.5mg equivalent to low-dose Prograf?
Yes. Pangraf 0.5mg capsules contain tacrolimus 0.5 mg — the same active ingredient as in Prograf capsules at equivalent dose. They are manufactured to bioequivalence standards, delivering the same pharmacokinetics and immunosuppressive effect. Pangraf provides significant cost savings over branded Prograf, which is especially meaningful for transplant patients who require lifelong therapy. Always inform your transplant team when switching brands.
Can I order Pangraf 0.5mg from PremiumRxDrugs for international delivery?
Yes. PremiumRxDrugs.com ships Pangraf 0.5mg and other tacrolimus formulations to patients in the USA, UK, Australia, and many other countries worldwide. Our genuine manufacturer-verified medicines, competitive pricing, discreet worldwide delivery, and free shipping on qualifying orders make us a trusted source for transplant patients who rely on consistent daily immunosuppression.
What side effects occur even at the 0.5mg tacrolimus dose?
Even at the 0.5mg dose, tacrolimus can cause tremor, headache, elevated blood sugar, raised potassium, low magnesium, and mild renal effects. The incidence and severity of these side effects are generally lower at this maintenance dose than at higher doses. Opportunistic infection risk persists with any degree of immunosuppression. Regular blood level and organ function monitoring continues to be essential even at this lowest capsule strength.
What precautions apply when using Pangraf 0.5mg?
The same precautions apply regardless of tacrolimus dose: avoid grapefruit, maintain consistent dosing schedule, report any new medications to your transplant team immediately, use sun protection, and never miss blood level appointments. At 0.5 mg, abrupt discontinuation — even accidentally — can destabilise previously stable trough levels. Keep your medication supply topped up to prevent missed doses, which can trigger rejection even after years of stable transplant function.
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