Pantocid DSR 40 mg 30 mg (Pantoprazole + Domperidone)

Name: Pantocid DSR 40 mg 30 mg
Brand: Pantocid DSR
SKU: 785
Availability: InStock

Pantocid DSR 40/30mg Capsule is a combination medicine that contains Pantoprazole and Domperidone as the main active ingredients. Pantoprazole is a substituted benzimidazole that inhibits the secretion of HCL in the stomach by specific action of the proton pumps of the parietal cells. Pan is an acid reducer that lowers the natural acid production in the stomach.

Domperidone is a dopamine antagonist drug with antiemetic properties. The drug does not readily cross the blood-brain barrier (a barrier that separates the circulating blood from the brain extracellular fluid {BEF} in the central nervous system). It seldom causes extra-pyramidical adverse effects, but does cause a rise in the level of prolactin.

What is Pantocid DSR used for?

It is used for:

Short-term treatment of erosive esophagitis related to Gastroesophageal Reflux Disease (GERD)
Maintenance of healing of erosive esophagitis
Pathological hypersecretory conditions including Zollinger-Ellison Syndrome

How does Pantocid DSR work?

Pantocid DSR contains Pantoprazole as one of the main active ingredient. Pantoprazole inhibits gastric acid secretion. Pantoprazole inhibits specifically and doses proportionally H, K+ ATPase, an enzyme, which is responsible for the secretion of gastric acid in the parietal cells of the stomach. The drug works by reducing the amount of acid produced in the stomach.

Another active ingredient is Domperidone, which works by blocking dopamine receptors found in the upper end of your digestive tract. The action speeds up the passage of food through the stomach into the intestine that helps prevent vomiting and reduces feeling of sickness, fullness, and bloating. It also blocks the dopamine receptors found in the area of brain.

Precautions

What medications interact with Pantocid DSR?

Pantocid DSR interacts with many drugs and produces some serious health effects. Here are the common drugs that may interact with Pantocid DSR:

Medicines used to treat Human Immunodeficiency syndrome
Ketoconazole
Erythromycin
Methotrexate
Ampicillin
Digoxin
Warfarin
Iron
Atazanavir
Itraconazole
Phenprocoumon that affects the thinning and thickening of the wall
Posaconazole used to treat fungal infections
Erlotinib used to treat cancer

Ask your physician for a complete list of drugs to be avoided so that you can prevent any negative interactions between the drugs.

When should Pantocid DSR not be used?

It should not be used in patients with hypersensitivity to any component of the formulation or to other proton pump inhibitors.

Dosage Instructions

How should Pantocid DSR be taken?

You can take Pan tablets with food or an empty stomach. Swallow the tablet whole with a glass full of water.
If you have difficulty swallowing a Pan 40 mg tablet, you can take two 20 mg tablets instead. Do not crush or chew the tablet.
Never stop the dosage or change the dosage without your physician's advice as it may cause adverse reactions or withdrawal symptoms.
Take the medicine regularly to get the best results.
In case you accidentally take an overdose of the drug, then immediately contact your physician in case you feel any discomfort. Use the medicines regularly and wisely to avoid an overdose of the drug.
The dosage regimen may differ from the information contained in this document. In the case of any confusion, please talk to your physician.

How long should you take Pantocid DSR?

Continue taking it for as long as your physician recommends. Take your medicine at the same time each day as this will help you to remember to take it regularly. If you have trouble remembering your doses, ask your physician for some tips.

Missed dose of Pantocid DSR

In the case of miss a dose do not panic and take the dose as soon as you remember, but if it is less 12 hours left for the dose of this drug then leave the missed dose and take the next dose at the correct time.

How should Pantocid DSR be stored?

Keep the drug away from heat and moisture.
Place it away from the reach of children.
Do not store it in the bathroom or near a sink.

Side Effects

What are the side effects of Pantocid DSR?

Pantocid DSR, just like many other drugs, may also show some side effects. The side effects may vary from being very mild to severe. Here are a few common side effects of this drug:

Diarrhea
Anxiety
Weakness
Fluctuation in weight
Joint pain
Insomnia
Dizziness
Drowsiness
Confusion
Trouble concentrating
Memory loss
Feeling of choking
Nervousness
Seizures
Trouble breathing
Stomach pain
Swelling of the ankles, hands, and feets

The side effects should not disturb you or prevent you from taking the drug beforehand. In case you take the drug and are feeling any of the above-mentioned side effects then you must visit your physician immediately.

How to Use

Infographics

FAQ

What is Pantocid DSR 40+30mg used for?

Pantocid DSR 40+30mg is a dual-release combination capsule containing pantoprazole 40mg (delayed-release) and domperidone 30mg (sustained-release). It is used for managing gastroesophageal reflux disease (GERD) complicated by slow gastric emptying, functional dyspepsia with acid-related symptoms, and post-meal bloating or regurgitation. Pantoprazole suppresses acid production; domperidone SR accelerates gastric emptying, reduces nausea, and prevents regurgitation. The combination addresses both acid and motility components of upper GI symptoms simultaneously.

How do pantoprazole and domperidone SR work together?

In Pantocid DSR, pantoprazole (delayed-release bead) suppresses gastric acid by irreversibly inhibiting the H+/K+-ATPase proton pump — reducing acid output by 90% over 24 hours. Simultaneously, domperidone (sustained-release bead) blocks gastric D2 receptors, increasing lower oesophageal sphincter tone, accelerating gastric emptying, and reducing post-meal bloating and regurgitation. Together, they provide both acid suppression and improved GI motility — two complementary mechanisms that reduce reflux by decreasing acid and removing the physiological basis for regurgitation.

How and when should Pantocid DSR be taken?

Pantocid DSR is taken once daily, 30–60 minutes before breakfast. The delayed-release pantoprazole component requires pre-meal administration to be activated when parietal cells are stimulated by food. Swallow the capsule whole — do not crush or chew, as this disrupts both the delayed-release (pantoprazole) and sustained-release (domperidone) mechanisms. Consistent once-daily morning dosing maximises both components' effectiveness. If symptoms are primarily nocturnal, your doctor may prescribe an evening dose.

How long should Pantocid DSR be taken for GERD?

For acute GERD or functional dyspepsia: typically 4–8 weeks. Many patients experience significant symptom relief within 2 weeks of once-daily use. After initial healing, many GERD patients require long-term maintenance — the domperidone component provides prokinetic benefit alongside PPI maintenance. However, the domperidone component carries a cardiac (QT prolongation) concern with long-term use — the EMA recommends limiting domperidone use to 1 week where possible. For long-term use, discuss the benefit-risk balance with your gastroenterologist.

Is the domperidone SR component in Pantocid DSR safe long-term?

The 30mg sustained-release domperidone in Pantocid DSR delivers drug gradually — the SR formulation was designed to reduce peak plasma concentrations and associated QT risk compared to immediate-release domperidone. However, the EMA's 2014 review recommended limiting all domperidone use to the lowest effective dose and shortest duration due to cardiac arrhythmia risk. For long-term acid management, switching to pantoprazole monotherapy after initial DSR treatment may be more appropriate, with domperidone SR reserved for symptoms that do not respond to PPI alone.

Who should not take Pantocid DSR?

Pantocid DSR is contraindicated in patients taking potent CYP3A4 inhibitors (clarithromycin, ketoconazole, itraconazole, ritonavir) — these dramatically increase domperidone plasma levels and QT prolongation risk. It is contraindicated with other QT-prolonging medications. Severe hepatic impairment contraindicates the domperidone component. Known hypersensitivity to pantoprazole or domperidone, prolactinoma, and GI perforation/obstruction are also contraindications. The nelfinavir antiretroviral interaction with pantoprazole is relevant (reduced antiretroviral efficacy).

How does Pantocid DSR compare to plain Pantocid 40mg?

Pantocid 40mg (pantoprazole alone) provides acid suppression without motility improvement. Pantocid DSR adds domperidone 30mg SR for patients whose GERD or dyspepsia is complicated by slow gastric emptying, frequent belching, nausea, or regurgitation. If symptoms are primarily heartburn and acid-related without significant motility issues, Pantocid 40mg alone may be adequate. If post-meal bloating, nausea, and regurgitation are prominent alongside acid reflux, the addition of domperidone SR in Pantocid DSR provides superior symptom control for the combined presentation.

Is Pantocid DSR available as a generic?

Pantocid DSR is a widely prescribed branded formulation from Sun Pharma. Various generic combinations of pantoprazole 40mg + domperidone 30mg SR are available in several markets. The specific dual-release bead technology in Pantocid DSR provides simultaneous release of both components in the appropriate sections of the GI tract. When using generic alternatives, confirm the formulation provides the same delayed/sustained-release mechanism for optimal efficacy.

Where can I buy Pantocid DSR 40+30mg online?

Pantocid DSR 40+30mg is available at PremiumRxDrugs.com, which ships to the USA, UK, Australia, and worldwide. Our licensed pharmacy provides authentic manufacturer-sourced combination acid + motility capsules at competitive prices. Free shipping on qualifying orders, discreet delivery, and easy prescription management make this dual-symptom GERD treatment accessible internationally.

Can I order Pantocid DSR from PremiumRxDrugs for delivery to the UK?

Yes. PremiumRxDrugs.com ships Pantocid DSR to the UK, USA, Australia, and many other countries. Our genuine manufacturer-verified GI medications, transparent pricing, and free worldwide shipping on qualifying orders make us a reliable source for patients requiring combination acid suppression and prokinetic therapy.

What side effects does Pantocid DSR cause?

Pantoprazole component: headache, diarrhoea, nausea, abdominal pain. Long-term: hypomagnesaemia, B12 deficiency, C. difficile risk, interstitial nephritis (rare). Domperidone component: QT prolongation risk (cardiac arrhythmia — more relevant with CYP3A4 inhibitors or electrolyte imbalances), galactorrhoea, gynaecomastia with prolonged use, dry mouth, headache, dizziness. Combined: rare extrapyramidal symptoms from domperidone. Palpitations or irregular heartbeat should prompt immediate medical review — may indicate arrhythmia.

What precautions should I take with Pantocid DSR?

Take 30–60 minutes before breakfast. Swallow whole — never crush. Avoid all CYP3A4 inhibitors (certain antibiotics, antifungals, HIV medications). Report palpitations or irregular heartbeat immediately. Correct electrolyte abnormalities before use. Use for the shortest necessary duration for the domperidone component. Monitor B12 and magnesium with long-term pantoprazole use. Do not use nelfinavir (HIV antiretroviral) with pantoprazole. Alert all prescribers to this medication to avoid inadvertent QT-prolonging drug combinations.

SKU	785
Generic For	Pantocid DSR
Strength	40 mg + 30 mg
Active Ingredient	Pantoprazole + Domperidone