Pletoz - 50mg
|Pack Size||Qty||Price Per Pill or Unit||Price||Cart|
|30 Tablet/s||US$ 0.30||US$ 9.09|
|60 Tablet/s||US$ 0.30||US$ 18.20|
|90 Tablet/s||US$ 0.30||US$ 27.30|
Pletoz– 50 mg (Cilostazol)
Pletoz is recommended for patients with intermittent claudication, a condition in which pain in the legs is caused by the obstruction of the arteries. Its administration improves the oxygen and blood flow that could help longer distance when walking before pain develops. The medicine widens the blood vessels in the legs and reduces the possibility of a blood clot. It contains the active component Cilostazol , which a quinolone derivative and a selective phosphodiesterase inhibitor.
Pletoz general information
What is Pletoz used for?
Pletoz is prescribed to reduce the symptoms of intermittent claudication as measured by increased walking distance. It may also be indicated for other purposes not mentioned in this document.
How does Pletoz work?
Pletoz comprises of the active ingredient Cilostazol, which works by inhibiting the cyclic adenosine monophosphate phosphodiesterase III enzyme. The activity results in increased adenosine monophosphate in blood vessels and platelets, producing hindrance of platelet vasodilation aggregation. In this way, the medicine works to reduce the symptoms of intermittent claudication with improved walking distance.
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What does Pletoz contain?
Pletoz is supplied in the form of tablets for oral administration. Its active component is Cilostazol, a quinolone derivate that inhibits cellular phosphodiesterase III to reduce the signs of intermittent claudication.
Effects of grape juice on Pletoz
The concomitant use of grapefruit juice should be avoided as the timing and magnitude of the interaction between grapefruit juice, and Pletoz has not been specifically evaluated and grapefruit juice has been appeared to inhibit cytochrome P-450 isoenzyme 3A4. Concurrent use should be avoided.
What are the side effects of Pletoz?
The common side effects are given below:
- Abnormal stools
- Pain in the abdomen
- Peripheral edema
- Increased cough
- Back pain
- Abnormal stools
Some serious side effects that results in discontinuation of the medicine are given below:
What medications interact with Pletoz?
- The coadministration of fluconazole, itraconazole, erythromycin, sertraline, ketoconazole, omeprazole, diltiazem, fluvoxamine, nefazodone, and miconazole decreases metabolism and increases the level and activity of Pletoz.
- The concomitant use of aspirin with Cilostazol has additive effects on platelet function.
When should Pletoz not be used?
- Pletoz should not be used in patients with known hypersensitivity to the active component or other inactive ingredients in the formulation.
- It is not indicated for patients with congestive heart failure of any severity.
- The medicine is not suitable for use in pregnant women as it may cause congenital defects, stillbirth, and, low birth weight.
- It is not indicated for lactating mothers as it may cause the nursing infants. Discontinue the medicine or bottle feed.
How should Pletoz be used?
Pletoz should be administered orally two times a day, at least two hours before a meal. The recommended dose for the symptomatic management of intermittent claudication in adults is 100 mg twice a day. The treatment should be started at 50 mg twice daily in patients receiving concomitant treatment with drugs such as erythromycin, ketoconazole, omeprazole diltiazem, or itraconazole.
Patients may get relief from the symptoms within 2 to 4 weeks following the initiation of the treatment. It is recommended that it takes up to twelve weeks to obtain the optimum therapeutic effect.
How long should Pletoz be used?
Take the medicine as long as it is recommended to you. Do not use it more than the recommended period. Please ask your physician if you have any doubt related to the usage of the medicine.
Missed dose of Pletoz
If you miss a dose of Pletoz 50 mg, take it as soon as you remember. Do not take the missed dose if the time to take the next dose is near. Taking multiple doses near to each other can lead to excess medication in your body which can be harmful.
How should Pletoz be stored?
Keep the medicine away from heat and moisture. Store it at room temperature. Ensure that your children and pets don't have access to the medication.