Pletoz 50mg
Available Dosages
| SKU | 239 |
|---|---|
| Generic For | Pletal |
| Strength | 50mg |
| Active Ingredient | Cilostazol |
| Pack Size | Qty | Price Per Pill or Unit | Price | Cart | |
|---|---|---|---|---|---|
| 30 Tablet/s | US$ 0.50 | US$ 15.00 | |||
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| 60 Tablet/s | US$ 0.42 | US$ 25.0017%US$ 30.00 | |||
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| 100 Tablet/s | US$ 0.35 | US$ 35.0030%US$ 50.00 | |||
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Pletoz 50mg (Cilostazol) – Affordable Pletal Alternative
Pletoz 50mg is recommended for patients with intermittent claudication, a condition in which pain in the legs is caused by the obstruction of the arteries. Its administration improves the oxygen and blood flow that could help longer distance when walking before pain develops. The medicine widens the blood vessels in the legs and reduces the possibility of a blood clot. It contains the active component Cilostazol , which a quinolone derivative and a selective phosphodiesterase inhibitor.
What is Pletoz 50mg used for?
Pletoz is prescribed to reduce the symptoms of intermittent claudication as measured by increased walking distance. It may also be indicated for other purposes not mentioned in this document.
How does Pletoz 50 mg work?
Pletoz comprises of the active ingredient Cilostazol, which works by inhibiting the cyclic adenosine monophosphate phosphodiesterase III enzyme. The activity results in increased adenosine monophosphate in blood vessels and platelets, producing hindrance of platelet vasodilation aggregation. In this way, the medicine works to reduce the symptoms of intermittent claudication with improved walking distance.
What does Pletoz contain?
Pletoz 50 mg is supplied in the form of tablets for oral administration. Its active component is Cilostazol, a quinolone derivate that inhibits cellular phosphodiesterase III to reduce the signs of intermittent claudication.
What medications interact with Pletoz?
- The coadministration of fluconazole, itraconazole, erythromycin, sertraline, ketoconazole, omeprazole, diltiazem, fluvoxamine, nefazodone, and miconazole decreases metabolism and increases the level and activity of Pletoz.
- The concomitant use of aspirin with Cilostazol has additive effects on platelet function.
When should Pletoz not be used?
- Pletoz should not be used in patients with known hypersensitivity to the active component or other inactive ingredients in the formulation.
- It is not indicated for patients with congestive heart failure of any severity.
- The medicine is not suitable for use in pregnant women as it may cause congenital defects, stillbirth, and, low birth weight.
- It is not indicated for lactating mothers as it may cause the nursing infants. Discontinue the medicine or bottle feed.
What are the side effects of Pletoz?
The common side effects are given below:
- Headache
- Pharyngitis
- Vertigo
- Nausea
- Dizziness
- Abnormal stools
- Pain in the abdomen
- Tachycardia
- Myalgia
- Rhinitis
- Infection
- Dyspepsia
- Peripheral edema
- Increased cough
- Back pain
- Abnormal stools
- Diarrhea
- Palpitations
- Flatulence
Some serious side effects that results in discontinuation of the medicine are given below:
- Headache
- Diarrhea
- Palpitations
How should Pletoz be used?
Pletoz should be administered orally two times a day, at least two hours before a meal. The recommended dose for the symptomatic management of intermittent claudication in adults is 100 mg twice a day. The treatment should be started at 50 mg twice daily in patients receiving concomitant treatment with drugs such as erythromycin, ketoconazole, omeprazole diltiazem, or itraconazole.
Patients may get relief from the symptoms within 2 to 4 weeks following the initiation of the treatment. It is recommended that it takes up to twelve weeks to obtain the optimum therapeutic effect.
How long should Pletoz be used?
Take the medicine as long as it is recommended to you. Do not use it more than the recommended period. Please ask your physician if you have any doubt related to the usage of the medicine.
Missed dose of Pletoz
If you miss a dose of Pletoz 50 mg, take it as soon as you remember. Do not take the missed dose if the time to take the next dose is near. Taking multiple doses near to each other can lead to excess medication in your body which can be harmful.
How should Pletoz be stored?
Keep the medicine away from heat and moisture. Store it at room temperature. Ensure that your children and pets don't have access to the medication.
What is Cilostazol and what condition does it treat?
Cilostazol is a vasodilator and antiplatelet medication commonly sold under the brand name Pletoz 50mg. It treats intermittent claudication, a circulatory condition causing leg pain and cramping during walking due to reduced blood flow. This peripheral arterial disease symptom occurs when arteries narrow, limiting oxygen-rich blood to leg muscles. Cilostazol improves walking distance and reduces discomfort by widening blood vessels and preventing blood cells from clumping. The medicine belongs to a class of phosphodiesterase inhibitors that enhance circulation in patients unable to walk comfortably due to arterial blockages.
How does Cilostazol work in the body?
Cilostazol works through a dual-action mechanism as both a vasodilator and platelet aggregation inhibitor. Pletoz 50mg blocks the enzyme phosphodiesterase type 3, increasing cyclic AMP levels in blood vessels and platelets. This causes arterial walls to relax and widen, improving blood circulation to the legs. Simultaneously, it prevents platelets from sticking together and forming clots that could further narrow arteries. The combined effect increases oxygen delivery to muscles during physical activity, reducing claudication pain and extending walking capacity. This antiplatelet vasodilator action makes Cilostazol effective for peripheral vascular disease management.
How long does Pletoz 50mg take to work?
Pletoz 50mg containing Cilostazol typically requires two to four weeks before noticeable improvement in walking distance occurs. Some patients experience initial benefits within the first two weeks, but maximum therapeutic effects usually develop after eight to twelve weeks of consistent use. This peripheral arterial disease medication works gradually as blood vessel function improves and circulation enhances over time. Clinical studies show progressive increases in pain-free walking distance throughout the first three months of treatment. The vasodilator effects begin immediately, but measurable symptom relief from intermittent claudication builds cumulatively, requiring patience and regular administration for optimal results.
When and how should I take Pletoz 50mg?
Take Pletoz 50mg exactly as prescribed, typically twice daily—one tablet in the morning and one in the evening. Cilostazol should be taken at least thirty minutes before meals or two hours after eating, as food significantly increases absorption and may intensify side effects. Swallow the antiplatelet medication whole with water; do not crush or chew tablets. Maintain consistent timing each day for optimal blood levels of this vasodilator. Always follow your healthcare provider's specific instructions regarding dosage and duration, as treatment plans vary based on individual circulatory conditions and response to therapy.
Is Pletoz 50mg safe for long-term use?
Pletoz 50mg is generally considered safe for long-term management of intermittent claudication when used under medical supervision. Clinical trials have evaluated Cilostazol for extended periods, demonstrating acceptable safety profiles in patients with peripheral arterial disease requiring ongoing treatment. This vasodilator medication is often prescribed for months or years to maintain improved walking capacity and circulation. Regular monitoring through follow-up appointments helps assess effectiveness and detect any adverse reactions. Long-term antiplatelet therapy with Cilostazol has shown sustained benefits in reducing claudication symptoms, though individual tolerance varies and periodic health assessments ensure continued appropriateness for each patient's cardiovascular condition.
Can I take Pletoz 50mg with other medicines?
Pletoz 50mg can interact with several medications, requiring careful coordination with your healthcare provider. Cilostazol should not be combined with other antiplatelet drugs or anticoagulants without medical approval, as bleeding risk increases significantly. This vasodilator also interacts with certain antibiotics, antifungals, and medications metabolized by specific liver enzymes. Grapefruit juice may affect Cilostazol blood levels. Drugs for heart conditions, blood pressure, or cholesterol may require dosage adjustments. Always inform your doctor about all medications, supplements, and herbal products you use before starting this peripheral arterial disease treatment to prevent dangerous interactions.
How does Pletoz 50mg compare to similar medicines in its class?
Pletoz 50mg stands out among intermittent claudication treatments as a phosphodiesterase-3 inhibitor with dual vasodilator and antiplatelet properties. Unlike pentoxifylline, another medication for peripheral arterial disease, Cilostazol typically provides superior improvement in walking distance with more robust clinical evidence. Compared to simple blood thinners, this medication specifically targets circulation in leg arteries while preventing platelet aggregation. Pletoz 50mg offers a unique mechanism not found in standard anticoagulants or basic vasodilators. Many vascular specialists prefer Cilostazol for symptomatic claudication relief due to its proven efficacy in increasing pain-free walking capacity beyond alternative oral therapies.
Is generic Cilostazol as effective as branded versions like Pletoz?
Generic Cilostazol is bioequivalent to branded versions like Pletoz 50mg, meaning it delivers the same therapeutic effect for intermittent claudication treatment. Regulatory agencies require generic vasodilators to contain identical active ingredients in the same strength and dosage form as brand-name medications. Clinical efficacy for improving walking distance and reducing claudication pain remains consistent across approved generic and branded Cilostazol products. The antiplatelet and circulation-enhancing properties function identically regardless of manufacturer. Cost differences exist, but quality standards ensure generic versions meet strict pharmaceutical requirements. Both options effectively manage peripheral arterial disease symptoms when obtained from reputable source.
Why do patients choose PremiumRxDrugs for Pletoz 50mg?
Patients choose PremiumRxDrugs for Pletoz 50mg because it combines pharmaceutical legitimacy with practical convenience. As a licensed online pharmacy, we guarantee authentic Cilostazol sourced directly from manufacturers, never generic substitutes without consent. Competitive pricing makes this peripheral arterial disease medication more affordable than at local pharmacies in the USA, UK, Australia, and Canada. Discreet worldwide shipping respects privacy, while free shipping options reduce overall costs. Easy prescription management and reorder systems simplify long-term treatment adherence for intermittent claudication. Over ten years of reliable service, we have built customer trust in their antiplatelet vasodilator supply. This combination of authenticity, affordability, and accessibility explains their popularity.
What are the common side effects of Cilostazol?
Common side effects of Cilostazol include headache, diarrhea, and abnormal stools, affecting approximately one in ten patients taking this antiplatelet vasodilator. Dizziness, palpitations, and faster heartbeat occur as the medication affects cardiovascular function. Some people experience gastrointestinal discomfort, nausea, or indigestion, particularly when not taking the medicine on an empty stomach as directed. Peripheral edema or mild swelling in legs and ankles may develop. Runny nose and increased susceptibility to infection have been reported. Most side effects from this intermittent claudication treatment are mild and diminish as your body adjusts, but persistent or severe reactions warrant medical attention.
Who should avoid taking Cilostazol?
Cilostazol is contraindicated in patients with congestive heart failure of any severity, as this antiplatelet medication can worsen cardiac complications. People with bleeding disorders, active bleeding, or recent hemorrhagic events should avoid this vasodilator due to increased bleeding risk. Those with severe kidney or liver impairment require alternative treatments, as Cilostazol metabolism may be compromised. Pregnant or breastfeeding women should not use this peripheral arterial disease medication without explicit medical guidance. Patients with blood pressure abnormalities or certain heart rhythm disorders need careful evaluation. Anyone allergic to Cilostazol or similar phosphodiesterase inhibitors must choose different intermittent claudication therapies under professional supervision.
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