SKU	843
Generic For	Pyzina
Strength	750mg
Active Ingredient	Pyrazinamide

Product Description

Pyzina (Pyrazinamide)

Pyzina 750 mg consists of Pyrazinamide as active ingredient is largely bacteriostatic, but can be bacteriocidal on actively replicating tuberculosis bacteria. It is only used in combination with other drugs such as rifampin and isoniazid in the treatment of mycobacterium tuberculosis. Pyrazinamide is a potent antiuricosuric medicine and consequently has an off label use in the diagnosis of causes of hyperuricosuric and hyperuricemia. The drug acts on URAT1. Each Pyzina tablets contains Benazepril as an active medicinal substance.

What is Pyzina 750 mg used for?

Pyzina 750 mg is used with other medicines to treat tuberculosis. Pyrazinamde as an antibiotic treats only bacterial infections. It will not work for viral infections such as flu, common cold etc.

How does Pyzina 750mg work?

Pyrazina is a prodrug that stops the growth of Myobacterium tuberculosis, where the enzyme pyrazinamidase converts pyrazinamidase to pyrazinoic acid (an active form). Under acidic conditions, the active form, parazinoic acid that slowly leaks out converts to the protonated conjugate acid, which is thought to diffuse easily back into the bacilli and accumulate.

Precautions

What medications interact with Pyzina?

The following medicines should be avoided, in case doctor recommends you Pyzina to avoid possible drug interactions.

Probenecid
Colchicines
Vitamins
Ethionamide
Zyloprim
Benemid

When should Pyzina not be used?

Tell the doctor before consuming Pyzina:

If you are hypersensitive to the drug, or its components.
If you have ever had kidney disorders, liver disorders or gout.
If you have a history of diabetes mellitus.
You have impaired kidney fuctions. The doctor may decide to adjust dose of Pyzina.
If you are undergoing a surgery.
If you have a history of alcohol use. Alcohol may increase the risk of occurring liver disease.
If you are pregnant or intending to become pregnant. You should discuss the benefits and risks of Pyzina tablets during pregnancy. Breastfeeding women are advised not to take Pyzina as it may pass into breast milk and harm the nursing baby.
The drug may cause dizziness. Do not drive or use machinery, while taking Pyrazinamide as these activities may require a high degree of mental attention.

How should Pyzina be stored?

Do not forget to see the expiry date of the product.
Keep the drug reach out of children.
Store the medicine below 30⁰C. It should be kept away from moisture.
Try to keep the medicine in the original packet.
It should not be given to anybody, even if they have the same problems.
Always keep the written record of your medications.

Dosage Instructions

Side Effects

What are Side effects of Pyzina 750mg?

Like other medicines, Pyzina may cause adverse effects. Seek medical attention, in case the following troubles arise:

Mild diarrhea
Stomach upset
Fatigue

Some adverse effects of Pyzina can be serious. Visit the doctor immediately, in the following situations.

Darkened urine
Unusual bleeding and bruising
Pain and swelling in the joints
Vomiting
Loss of appetite
Itching
Severe dizziness
Swelling on the face, throat and tongue
Trouble breathing
Skin rashes
Darkened urine
Difficulty in urination
Fever
Yellowing of eyes and skin

How to Use

How should Pyzina 750mg be taken?

Pyazina comes in the form of tablets. Take the tablet with or without food. Swallow the tablet with one glass of water.
Try to take the tablet at the same time each day.
The drug should be taken once every day or twice weekly, or as recommended by the doctor. Pyzina doses is based on your age, weight, health condition and response to treatment.
Take the tablet exactly as prescribed by the doctor. Do not alter the dosage plan.
Overdose: Seek medical attention immediately, in the case of an overdose of Pyrazinamide. Symptoms of an overdose include:

Missed dose of Pyzina 750mg:

If you have forgotten a dose, take it as soon you remember and go back to your usual dosing schedule. If the time to take the next dose is near, leave the forgotten dose and take the next dose. Do not double up the dose to compensate the missed one.

Take the tablet for as long as your doctor recommended.

Infographics

FAQ

What is Pyzina used for?

Pyzina (pyrazinamide) is one of the four key medicines in the standard 6-month regimen for treating active tuberculosis (TB) — a serious bacterial lung infection caused by Mycobacterium tuberculosis. TB can also affect other parts of the body such as the lymph nodes, bones, kidneys, and brain. Pyrazinamide is used during the first 2 months (the intensive phase) of TB treatment, alongside isoniazid, rifampicin, and ethambutol. It is uniquely effective at killing dormant, slow-growing TB bacteria hidden inside immune cells — helping to clear the infection more rapidly and allowing the total treatment course to be completed in 6 months rather than 12–18 months.

How is the dose of Pyzina calculated?

Pyrazinamide is always dosed based on the patient's body weight, not a standard fixed dose for all adults. The recommended dose is typically 20–30mg per kilogram of body weight per day, given as a single daily dose. Your TB doctor or specialist nurse will calculate your exact daily dose and specify how many tablets to take. The dose is reviewed at each clinic appointment, particularly if body weight changes significantly during treatment. All TB medicines are calculated by weight to ensure each patient receives an effective dose — both under-dosing and over-dosing carry risks in TB treatment.

How should Pyzina tablets be taken?

Pyrazinamide tablets should be taken as a single daily dose, usually in the morning, along with the rest of your TB medicines. They can be taken with or without food — taking them with breakfast helps to reduce nausea, which is common when starting TB treatment. Swallow the tablets whole with a full glass of water. Never split the dose throughout the day without specific medical instructions. Taking all TB medicines together at the same time every day builds the discipline needed to complete the full 6-month course — consistency is the single most important factor in TB treatment success.

What happens if TB treatment is not completed?

Incomplete TB treatment is one of the most dangerous consequences a TB patient can face. If the full 6-month course is not completed — even if symptoms resolve after 2–3 months — the remaining bacteria (which are slower-growing and more resistant) are not killed. These bacteria multiply again, causing the TB to relapse. More critically, incomplete courses are a major driver of drug-resistant TB (DR-TB and MDR-TB — multi-drug resistant TB), where the bacteria become resistant to the standard medicines. Treating drug-resistant TB is far more difficult, requires 18–24 months of treatment with more toxic medicines, is much more expensive, and has a lower success rate.

Is Pyzina safe during pregnancy or breastfeeding?

The management of TB in pregnancy requires specialist care. Untreated TB in pregnancy carries serious risks — to both the mother and the developing baby — including premature birth, low birth weight, and in severe cases, congenital TB (TB in the newborn). Most TB specialist guidelines recommend including pyrazinamide in the standard treatment regimen during pregnancy, as the benefits of treating TB effectively outweigh the theoretical risks. Breastfeeding can generally continue during TB treatment. All decisions about TB medicines in pregnancy are made by specialist TB physicians who will closely monitor both mother and baby throughout treatment.

Can I drink alcohol while taking Pyzina?

No — alcohol must be completely avoided during TB treatment, and this applies with particular force while taking pyrazinamide. Pyrazinamide is one of the TB medicines most associated with liver toxicity, and alcohol adds significantly to this risk. Rifampicin (another medicine always taken alongside pyrazinamide) also affects the liver enzyme system. Together, the combination of pyrazinamide, rifampicin, and alcohol creates a very high risk of serious liver damage. Even one or two drinks can be harmful during TB treatment. Abstaining from alcohol for the full 6-month treatment course — particularly the first 2 months — is a firm and non-negotiable medical recommendation for all TB patients.

What is Directly Observed Treatment (DOT) and why is it used with Pyzina?

Directly Observed Treatment (DOT) is an approach to TB treatment where a healthcare worker, TB nurse, or trained community volunteer watches the patient swallow each dose of their TB medicines. DOT is used because the consequences of missed or irregular dosing in TB — treatment failure and drug resistance — are so serious that many health systems build in this additional safeguard. It is recommended by the WHO for all TB patients, and is particularly important for patients who may find it difficult to maintain a daily medication routine. DOT also allows the healthcare worker to monitor for side effects and provide regular support, significantly improving completion rates.

Does Pyzina interact with other medicines?

Pyrazinamide can interact with several medicines. It raises uric acid levels, which can interfere with medicines used to treat gout — such as allopurinol (which lowers uric acid) — making gout control more difficult. If you take anti-gout medicines, your doctor will monitor uric acid levels closely and may adjust your gout treatment during the TB course. Pyrazinamide can interact with other TB medicines (rifampicin also affects liver enzymes) — this is why liver monitoring is essential during the combined regimen. Always inform all your doctors (including any treating you for other conditions) that you are currently on TB treatment.

Why is pyrazinamide only used for the first 2 months of TB treatment?

Pyrazinamide is a sterilising medicine — it is particularly effective at killing dormant and slowly replicating TB bacteria that are not killed by other antibiotics. During the first 2 months of TB treatment, there is a large population of these dormant bacteria, and pyrazinamide eliminates them rapidly. After 2 months, the active bacterial burden has been dramatically reduced and the remaining bacteria are in a different phase — isoniazid and rifampicin (which continue for the remaining 4 months) are more appropriate and effective at this stage. Continuing pyrazinamide beyond the first 2 months adds liver toxicity risk without additional benefit.

What regular blood tests are needed while taking Pyzina?

Regular blood tests are an essential part of safe TB treatment when pyrazinamide is included. Liver function tests (LFTs) are checked before starting treatment and then monthly throughout the pyrazinamide phase — to detect any early signs of liver inflammation or damage. Uric acid levels are also monitored, as pyrazinamide consistently raises uric acid and can trigger gout attacks or lead to kidney stone formation in susceptible individuals. A full blood count may also be checked periodically. Do not miss any scheduled blood test appointments — these tests are as important as taking the medicine itself for the safety of your treatment.

What are the common side effects of pyrazinamide?

The most common side effects of pyrazinamide include nausea, vomiting, and reduced appetite — these are best managed by taking the dose with a meal. Joint aches and stiffness — particularly in larger joints — are frequently reported and are caused by the rise in uric acid levels that pyrazinamide produces. A skin rash and increased sensitivity to sunlight (making the skin burn more easily) are also reported. Mild elevation of liver enzymes in blood tests is common and is why monthly monitoring is arranged. Most joint pain and digestive side effects are manageable and do not require stopping treatment.

What side effects of pyrazinamide need urgent medical attention?

Contact your TB doctor immediately if you develop symptoms of liver toxicity — yellowing of the skin or eyes (jaundice), very dark urine (described as looking like cola or strong tea), unusually pale stools, severe nausea and vomiting, or persistent pain on the right side of the abdomen. These are warning signs of drug-induced hepatitis. Do not stop all TB medicines without medical guidance — stopping incorrectly can cause more harm. Also report a sudden, extremely painful swollen joint (especially the big toe or knee) which may indicate a gout attack. Severe skin reactions (blistering, widespread rash with fever) also require urgent medical review.

Pyzina 750mg