Pyzina 500mg (Pyrazinamide)

Name: Pyzina 500mg
Brand: Pyzina
SKU: 842
Availability: InStock

Pyzina 500 mg consists of Pyrazinamide as active ingredient is largely bacteriostatic, but can be bacteriocidal on actively replicating tuberculosis bacteria. It is only used in combination with other drugs such as rifampin and isoniazid in the treatment of mycobacterium tuberculosis. Pyrazinamide is a potent antiuricosuric medicine and consequently has an off label use in the diagnosis of causes of hyperuricosuric and hyperuricemia. The drug acts on URAT1. Each Pyzina tablets contains Benazepril as an active medicinal substance.

What is Pyzina 500 mg used for?

Pyzina 500 mg is used with other medicines to treat tuberculosis. Pyrazinamde as an antibiotic treats only bacterial infections. It will not work for viral infections such as flu, common cold etc. Buy Pyzina 500 mg to treat medical condition that is mentioned above.

How does Pyzina work?

Pyrazina is a prodrug that stops the growth of Myobacterium tuberculosis, where the enzyme pyrazinamidase converts pyrazinamidase to pyrazinoic acid (an active form). Under acidic conditions, the active form, parazinoic acid that slowly leaks out converts to the protonated conjugate acid, which is thought to diffuse easily back into the bacilli and accumulate.

How should Pyzina 500mg be taken?

Pyazina comes in the form of tablets. Take the tablet with or without food. Swallow the tablet with one glass of water.
Try to take the tablet at the same time each day.
The drug should be taken once every day or twice weekly, or as recommended by the doctor. Pyzina doses is based on your age, weight, health condition and response to treatment.
Take the tablet exactly as prescribed by the doctor. Do not alter the dosage plan.
Overdose: Seek medical attention immediately, in the case of an overdose of Pyrazinamide. Symptoms of an overdose include:

Missed dose of Pyzina 500mg :

If you have forgotten a dose, take it as soon you remember and go back to your usual dosing schedule. If the time to take the next dose is near, leave the forgotten dose and take the next dose. Do not double up the dose to compensate the missed one.

Take the tablet for as long as your doctor recommended.

What are Side effects of Pyzina 500mg?

Like other medicines, Pyzina may cause adverse effects. Seek medical attention, in case the following troubles arise:

Mild diarrhea
Stomach upset
Fatigue

Some adverse effects of Pyzina can be serious. Visit the doctor immediately, in the following situations.

Darkened urine
Unusual bleeding and bruising
Pain and swelling in the joints
Vomiting
Loss of appetite
Itching
Severe dizziness
Swelling on the face, throat and tongue
Trouble breathing
Skin rashes
Darkened urine
Difficulty in urination
Fever
Yellowing of eyes and skin

What medications interact with Pyzina 500mg?

The following medicines should be avoided, in case doctor recommends you Pyzina to avoid possible drug interactions.

Probenecid
Colchicines
Vitamins
Ethionamide
Zyloprim
Benemid

When should Pyzina not be used?

Tell the doctor before consuming Pyzina:

If you are hypersensitive to the drug, or its components.
If you have ever had kidney disorders, liver disorders or gout.
If you have a history of diabetes mellitus.
You have impaired kidney fuctions. The doctor may decide to adjust dose of Pyzina.
If you are undergoing a surgery.
If you have a history of alcohol use. Alcohol may increase the risk of occurring liver disease.
If you are pregnant or intending to become pregnant. You should discuss the benefits and risks of Pyzina tablets during pregnancy. Breastfeeding women are advised not to take Pyzina as it may pass into breast milk and harm the nursing baby.
The drug may cause dizziness. Do not drive or use machinery, while taking Pyrazinamide as these activities may require a high degree of mental attention.

How should Pyzina be stored?

Do not forget to see the expiry date of the product.
Keep the drug reach out of children.
Store the medicine below 30⁰C. It should be kept away from moisture.
Try to keep the medicine in the original packet.
It should not be given to anybody, even if they have the same problems.
Always keep the written record of your medications.

Precautions

Dosage Instructions

Side Effects

How to Use

Infographics

FAQ

What is Pyzina 500mg used for?

Pyzina 500mg contains pyrazinamide, one of the core antibiotic medicines used to treat tuberculosis (TB). TB is a serious bacterial infection caused by Mycobacterium tuberculosis that primarily affects the lungs but can spread to other parts of the body including the bones, kidneys, lymph nodes, and brain. Pyrazinamide is used as part of the standard 6-month first-line TB treatment regimen — specifically during the initial 2-month intensive phase, alongside isoniazid, rifampicin, and ethambutol. It is particularly valuable because it kills bacteria that are hiding inside cells, where other antibiotics cannot reach easily.

Who should not take Pyzina 500mg?

Pyzina 500mg should not be taken by anyone allergic to pyrazinamide. It should be avoided in people with severe liver disease, as pyrazinamide is processed entirely in the liver and can cause serious liver damage in those with pre-existing liver problems. People with severe gout (a condition where uric acid crystals form in the joints) should use it with caution, as pyrazinamide raises uric acid levels in the blood. Routine liver function tests and uric acid monitoring are arranged before and during treatment. Pregnant women should discuss risks and benefits with a TB specialist before starting pyrazinamide.

What is the usual dose of Pyzina 500mg and how is it taken?

The dose of pyrazinamide is calculated based on body weight. The standard weight-based dose for the intensive phase of TB treatment is typically 20–30mg per kilogram of body weight per day, taken as a single daily dose. For most adults, this works out to approximately 1,000–2,000mg per day — so 2–4 of the 500mg tablets taken together once daily. Pyrazinamide is only used during the first 2 months (intensive phase) of TB treatment. Your TB doctor (chest physician or infectious disease specialist) will calculate your exact dose. TB medicines must always be taken every day without fail.

Should Pyzina 500mg be taken with food?

Pyzina 500mg can be taken with or without food. However, taking it with a meal can reduce stomach upset and nausea, which are among the more common side effects. All TB medicines — including pyrazinamide — are often taken together as a single daily dose in the morning. For patients who experience significant nausea, taking the full daily dose with a substantial breakfast can markedly reduce this. Your TB nurse or doctor may give you specific advice on the best time of day to take your TB medicines as a coordinated daily regimen.

Why must pyrazinamide always be taken alongside other TB medicines?

TB bacteria are extraordinarily adaptable and develop resistance quickly if treated with just one antibiotic. Even a small number of naturally resistant bacteria in the population of TB bacteria infecting a patient can multiply and replace the sensitive bacteria if only one drug is used. Combination therapy — using four antibiotics simultaneously during the intensive phase — overwhelms the bacteria's resistance mechanisms and prevents any individual resistant strain from surviving. Pyrazinamide uniquely kills dormant bacteria hiding inside macrophages (immune cells), shortening the overall treatment duration. Taking it alone, or skipping doses, dramatically increases the risk of developing multi-drug resistant TB (MDR-TB).

Is Pyzina 500mg safe during pregnancy or breastfeeding?

Pyrazinamide's safety in pregnancy is not as fully established as some other TB medicines. Many TB treatment guidelines recommend using pyrazinamide during pregnancy as part of the standard regimen, as the risk of untreated TB in pregnancy — which can be severe and life-threatening to both mother and baby — generally outweighs the theoretical risks of the medicine. Breastfeeding can usually be continued during TB treatment, as the amount of TB medicines reaching breast milk is small. However, decisions about TB treatment in pregnancy are made by specialist TB physicians who will weigh all the risks and benefits carefully.

Can I drink alcohol while taking Pyzina 500mg?

Alcohol should be avoided entirely during TB treatment, and this is particularly important when taking pyrazinamide. Pyrazinamide is a known cause of liver toxicity, and alcohol places additional strain on the liver. Combining the two can significantly increase the risk of serious liver damage (drug-induced hepatitis). Rifampicin — another TB medicine typically taken alongside pyrazinamide — also affects the liver. Regular liver function blood tests are arranged during TB treatment to monitor liver health. Drinking any amount of alcohol during TB treatment (especially during the pyrazinamide-containing phase) is strongly discouraged by TB doctors worldwide.

How does pyrazinamide help shorten TB treatment to 6 months?

Before pyrazinamide was introduced into TB treatment regimens, the standard course was 12–18 months. Pyrazinamide's ability to target and kill dormant Mycobacterium tuberculosis bacteria — specifically those hiding inside acidic environments within immune cells (macrophages) — allows the treatment to clear the infection much more completely in a shorter period. Other TB medicines (isoniazid and rifampicin) are less effective against these dormant bacteria. By including pyrazinamide in the first 2 months, the total treatment course can be shortened to 6 months while maintaining very high cure rates — this is now the standard worldwide.

What monitoring is needed during a course of Pyzina 500mg?

Regular blood tests are essential during pyrazinamide treatment. Liver function tests (LFTs) are checked at the start of treatment and then regularly (usually monthly) to detect early signs of liver damage. Uric acid levels are also monitored, as pyrazinamide raises uric acid and can trigger gout attacks or worsen existing gout. Visual acuity testing is arranged for the entire TB regimen (mainly for ethambutol monitoring). Your TB doctor or nurse will arrange a structured monitoring schedule. Always attend all monitoring appointments — they are as important as taking the medicine itself.

What should I do if I accidentally miss a dose of Pyzina 500mg?

Never skip a TB medicine dose intentionally, and if a dose is accidentally missed, take it as soon as you remember on the same day. If you only remember on the following day, do not take a double dose — take the next regular dose as scheduled and inform your TB nurse or doctor that you missed a dose. Consistent daily dosing is critical in TB treatment — irregular or interrupted dosing is the most important driver of treatment failure and the development of drug-resistant TB. Many TB programmes offer Directly Observed Treatment (DOT), where a healthcare worker watches the patient take each dose — this is recommended for patients who find daily self-dosing difficult.

What are the common side effects of pyrazinamide?

The most frequently reported side effects of pyrazinamide include nausea, vomiting, and loss of appetite — these can usually be managed by taking the medicine with food. Joint pain and stiffness — particularly in large joints like the knees, hips, and shoulders — are common because pyrazinamide raises uric acid levels in the blood. A skin rash, photosensitivity (sun sensitivity causing the skin to burn more easily), and flushing of the skin can also occur. Mild liver enzyme elevation is common and is monitored with regular blood tests. Most joint pains associated with pyrazinamide can be managed with analgesics if needed, under medical guidance.

What side effects of pyrazinamide require urgent medical attention?

Seek immediate medical review if you develop signs of liver toxicity — yellowing of the skin or eyes (jaundice), very dark (cola-coloured) urine, pale stools, nausea, vomiting, or severe right-sided abdominal pain. These are warning signs of drug-induced hepatitis, which can be serious if ignored. Stop pyrazinamide and contact your TB doctor urgently — do not stop all TB medicines without medical guidance as this requires careful management. Gout attacks (sudden, severe joint pain and swelling, most commonly in the big toe or knee) need medical review. A severe skin reaction (blistering or peeling) also warrants immediate attention.

SKU	842
Generic For	Pyzina
Strength	500mg
Active Ingredient	Pyrazinamide

Pyzina 500mg