Sazo EN 500mg
| SKU | 1034 |
|---|---|
| Generic For | Sulfasalzine |
| Strength | 500mg |
| Manufacturer | Wallace, India |
| Active Ingredient | Sulphasalazine |
| Pack Size | Qty | Price Per Pill or Unit | Price | Cart | |
|---|---|---|---|---|---|
| 30 Tablet/s | US$ 0.47 | US$ 14.00 | |||
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| 60 Tablet/s | US$ 0.33 | US$ 20.0029%US$ 28.00 | |||
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| 90 Tablet/s | US$ 0.24 | US$ 22.0048%US$ 42.00 | |||
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Sazo EN 500mg (Sulphasalazine) – Affordable Sulfasalzine Alternative
Scientists have been specially formulated Sazo EN for people who are suffering from rheumatoid arthritis. A health care specialist may also prescribe this medication to treat other health disorders like Chrohn’s disease, Psoriatic arthritis, and ulcerative colitis. The active component of the medicine is Sulfasalazine, which is known to have anti-inflammatory effects and to decrease the action of the immune system. Its regular administration to patients with rheumatoid arthritis reduces pain and swelling. By limiting joint damage, it prevents disability in the long term. The medicine falls into the category of drugs known as disease modifying anti-rheumatic drugs (DMARDs). It not only relieves the pain during arthritis but also reduce the damage to the joints.
What is Sazo EN used for?
Sazo EN is useful in treating mild to moderate ulcerative colitis or as adjunctive treatment in severe ulcerative colitis. You will also get this medication to treat your rheumatoid arthritis unresponsive or intolerant to non-steroidal anti-inflammatory drugs and salicylates.
How does Sazo EN work?
The medication exerts its anti-inflammatory action in the colon and works by reducing the symptoms of ulcerative colitis or rheumatoid arthritis.
What does Sazo EN contain?
The active component is Sulfasalazine. Each capsule contains 500 mg of the active substance.
What medications interact with Sazo EN?
- Sazo EN may cause toxicity from oral hypoglycemic medications such as zidovudine, warfarin, methotrexate, or phenytoin.
- There is a risk of crystalluria with concurrent use with methenamine.
- Drug induced hepatitis may develop if used along with hepatotoxic agents.
- Your anti-rheumatic drug may increase toxicity if used with thioguanine or mercaptopurine.
How long should Sazo EN be used?
Treatment with Sazo EN- 500 mg should be continued as long as a patient continues to benefit or as prescribed by the physician. Do not stop the treatment otherwise; you will not get rid of rheumatoid or ulcerative colitis.
Missed dose of Sazo EN
If you are using Sulfasalazine (Sazo EN) on a regular basis and miss a dose, take that dose as when you remember on an empty stomach. The missed dose should not be taken if the time to take the next dose is near. Do not take a double dose to make up for any missed dose.
How should Sazo EN be stored?
Store the tablets out of the reach of children, away from heat, light, and moisture. Keep it at room temperature. Do not keep the tablets near the window sill as heat can destroy some medications.
What are the side effects of Sazo EN?
- Gastrointestinal issues- diarrhea, vomiting, nausea, drug induced hepatitis, anorexia
- Dermatological issues- photosensitivity, stevens-johnson syndrome, toxic epidermal necrolysis, exfoliative dermatitis, yellow discoloration.
- Neurological issues- peripheral neuropathy
- Genitouterine disorders- infertility, orange yellow discoloration of urine, oligospermia, crystalluria, infertility
- Miscellaneous issues- Hypersensitivity reactions including fever, anaphylaxis
How should Sazo EN be used?
Ulcerative colitis
For adults- The recommended initial dose is 500 mg every 12 hours. The recommended maintenance dose is 500 mg every six hours.
For children above two years of age- The initial recommended dose is 6.7 to 10 mg/kg every 4 hr or 10 to 15 mg/kg every 6 hours or 13.3 to 20 mg/kg every 8 hour. 7.5 mg/kg every 6 hour is the preferred maintenance dose. The maximum dose should not exceed 2 g daily.
Rheumatoid Arthritis
For adults- The recommended dose is 500 mg to 1 g daily for one week. Your health care specialist may then increase your dose by 500 mg daily every week to 2 g daily in two divided doses. In case there are no results seen after a period of 12 weeks, the dose may increase to 3 g daily and must be given in two divided doses.
For children above six years of age- 30 to 50 mg/kg daily is the suggested dose which should be given in two divided doses. The maximum dose must not exceed 2 g daily.
When should Sazo EN not be used?
- The anti-rheumatic medication is not made for patients who are hypersensitive to salicylates, sulphonamides, sulfasalazine, or other excipients of the medication.
- Porphyria
- Urinary tract or intestinal obstruction
- pediatrics
What is Sulphasalazine and what condition does it treat?
Sulphasalazine is a disease-modifying antirheumatic drug (DMARD) and aminosalicylate used primarily to treat inflammatory conditions. Sazo EN 500mg contains this active ingredient and is prescribed for ulcerative colitis, an inflammatory bowel disease causing colon inflammation, and rheumatoid arthritis, a chronic joint condition. It's also used for Crohn's disease in some cases. This anti-inflammatory medication works by reducing inflammation in the gut lining and joints, helping manage symptoms like pain, swelling, and digestive discomfort. Sulphasalazine has been a trusted treatment option for decades, offering relief for patients with these autoimmune and inflammatory disorders.
How does Sulphasalazine work in the body?
Sulphasalazine breaks down in the intestines into two active compounds: sulfapyridine and 5-aminosalicylic acid (5-ASA). The 5-ASA component acts locally in the bowel to reduce inflammation by blocking prostaglandins and other inflammatory chemicals. When used for rheumatoid arthritis, Sazo EN 500mg works systemically as an immunosuppressant, dampening overactive immune responses that attack healthy joint tissue. This dual-action anti-inflammatory medicine helps decrease swelling, pain, and tissue damage in both inflammatory bowel conditions and arthritic disorders. The enteric-coated formulation ensures the medication reaches the intestines intact for optimal effectiveness.
How long does Sazo EN 500mg take to work?
Response time varies by condition. For ulcerative colitis, Sazo EN 500mg typically begins reducing symptoms like diarrhea and rectal bleeding within two to four weeks, though full benefits may take up to twelve weeks. When treating rheumatoid arthritis, this DMARD medication usually requires six to twelve weeks before noticeable improvement in joint pain and stiffness occurs. Some patients experience earlier symptom relief, while others need several months. Sulphasalazine works gradually to control inflammation rather than providing immediate pain relief. Patience is important, as consistent daily use allows the anti-inflammatory effects to build up and modify disease progression effectively over time.
When and how should I take Sazo EN 500mg?
Take Sazo EN 500mg exactly as prescribed, typically two to four times daily with food or immediately after meals to minimize stomach upset. Swallow the enteric-coated tablets whole with a full glass of water—never crush, chew, or break them, as this damages the protective coating. Spacing doses evenly throughout the day maintains steady sulphasalazine levels in your bloodstream. Drink plenty of fluids while on this medication to prevent kidney stones. Your doctor will usually start with a lower dose and gradually increase it. Always follow your healthcare provider's specific instructions, as dosing varies based on your condition and individual response to treatment.
Is Sazo EN 500mg safe for long-term use?
Sulphasalazine is commonly prescribed for extended periods, with many patients taking Sazo EN 500mg safely for years to manage chronic conditions like rheumatoid arthritis and ulcerative colitis. As a maintenance therapy, this DMARD helps prevent disease flares and progression. Long-term use requires regular monitoring through blood tests to check liver function, kidney health, and blood cell counts, typically every few months initially, then less frequently once stable. Most patients tolerate the medication well over time. Your healthcare provider weighs ongoing benefits against potential risks and adjusts treatment as needed to ensure continued safety and effectiveness.
Can I take Sazo EN 500mg with other medicines?
Sulphasalazine can interact with certain medications, so disclosure of all current medicines is essential. It may reduce the effectiveness of digoxin and folic acid absorption, while increasing effects of blood thinners like warfarin. Combining Sazo EN 500mg with methotrexate or other immunosuppressants requires careful monitoring. This anti-inflammatory drug may interact with diabetes medications, certain antibiotics, and antacids. Always inform your doctor and pharmacist about all prescription drugs, over-the-counter medicines, supplements, and herbal products you're taking. They'll assess potential interactions and adjust dosages or timing to ensure safe, effective treatment with your complete medication regimen.
How does Sazo EN 500mg compare to similar medicines in its class?
Among aminosalicylates for inflammatory bowel disease, sulphasalazine differs from mesalamine (5-ASA) products like Asacol or Pentasa because it contains both sulfapyridine and 5-ASA components. This makes Sazo EN 500mg effective for both IBD and rheumatoid arthritis, unlike pure mesalamine formulations. Compared to other DMARDs for arthritis like methotrexate or hydroxychloroquine, sulphasalazine has a different side effect profile and may cause fewer severe complications. It's often chosen as a first-line DMARD due to its established safety record. The enteric-coated formulation reduces gastric irritation compared to non-coated versions, improving tolerability for long-term inflammatory disease management.
Is the generic Sulphasalazine as effective as branded versions?
Generic sulphasalazine contains the identical active ingredient in the same strength as branded products like Sazo EN 500mg and must meet strict regulatory standards for bioequivalence. Both generic and branded versions deliver the same therapeutic effects for treating ulcerative colitis, Crohn's disease, and rheumatoid arthritis. The anti-inflammatory and immunosuppressive actions are equivalent. Inactive ingredients like coatings or fillers may differ slightly between manufacturers, occasionally affecting individual tolerance, but efficacy remains comparable. Regulatory authorities including the FDA and UK MHRA require generic DMARDs to perform identically to brand-name medicines. Choosing between generic and branded sulphasalazine often comes down to cost considerations and personal preference.
Why do patients choose PremiumRxDrugs for Sazo EN 500mg?
Patients prefer PremiumRxDrugs for their sulphasalazine needs because of reliable access to authentic medications at competitive prices. As a licensed pharmacy, we have been serving customers for more than a decade, building trust through consistent quality. Our prescription management system makes reordering this maintenance DMARD straightforward for those on long-term treatment. Discreet worldwide shipping respects patient privacy while delivering to the USA, UK, Australia, Canada, and beyond. Both branded Sazo EN 500mg and generic sulphasalazine options are available, giving patients cost flexibility. Free shipping on eligible orders further reduces treatment expenses. For chronic conditions like rheumatoid arthritis and inflammatory bowel disease requiring ongoing medication, this combination of authenticity, affordability, and convenience proves valuable.
What are the common side effects of Sulphasalazine?
Common sulphasalazine side effects include nausea, loss of appetite, stomach upset, and headache, particularly when starting treatment. Some patients experience dizziness, mouth sores, or temporary orange-yellow discoloration of urine and skin. Digestive issues like vomiting or diarrhea may occur. These effects often diminish as your body adjusts to the medication. Less common but notable reactions include rash, fever, or increased sensitivity to sunlight. Serious side effects are rare but require immediate medical attention: severe skin reactions, signs of blood disorders (unusual bruising, persistent sore throat), liver problems (yellowing skin), or allergic reactions. Taking this anti-inflammatory medicine with food and staying well-hydrated helps minimize gastrointestinal discomfort.
Who should avoid taking Sulphasalazine?
People with sulfa drug allergies or aspirin/salicylate sensitivity should avoid sulphasalazine, as severe allergic reactions can occur. This medication is contraindicated for those with intestinal or urinary blockages, severe kidney disease, liver dysfunction, or porphyria. Patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency risk serious blood complications. Men concerned about fertility should discuss alternatives, as this DMARD may temporarily reduce sperm count. Pregnant women, particularly in the third trimester, and breastfeeding mothers need careful evaluation, though the medicine is sometimes used when benefits outweigh risks. Children under two years typically shouldn't receive sulphasalazine. Always provide your complete medical history before starting this inflammatory bowel disease and arthritis treatment.
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