Syncapone 150
Available Dosages
| SKU | 182 |
|---|---|
| Generic For | Stalevo |
| Strength | (37.5+200+150)mg |
| Active Ingredient | Carbidopa , Entacapone and Levodopa |
| Pack Size | Qty | Price Per Pill or Unit | Price | Cart | |
|---|---|---|---|---|---|
| 30 Tablet/s | US$ 0.34 | US$ 10.14 | |||
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| 60 Tablet/s | US$ 0.34 | US$ 20.28 | |||
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| 90 Tablet/s | US$ 0.34 | US$ 30.40 | |||
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Syncapone (Carbidopa) – Affordable Stalevo Alternative
Syncapone 150 (Carbidopa, Levadopa, Entacapone)
Syncapone 150 tabket contains the three active ingredients Levodopa, Carbidopa, and Entacapone. This medicine is prescribed to treat Parkinson's disease (PD). It’s better known to improve the quality of life for people who have this disease. As an active element Levodopa is converted to a chemical called dopamine in the brain, and a combination of Syncapone and Levodopa is used to treat Parkinson symptoms such as spasms, poor muscle control, muscle stiffness, and tremors.
What is Syncapone 150 used for?
Syncapone 150 tablets are specifically formulated to treat Parkinson’s disease caused by carbon monoxide poisoning or manganese intoxication. This drug can prevent the breakdown of levodopa before it reaches the brain. It may also be used for other conditions if it’s prescribed by your doctor.
How does Syncapone 150 work?
Syncapone 150 medicine works by preventing decarboxylation of levodopa, making more levodopa available to transport to the brain. As a single agent, this drug has no effect. But, when used with levodopa; syncapone can treat idiopathic Parkinson disease, postencephalitic Parkinsonism, and symptomatic Parkinsonism – all are associated with carbon monoxide or manganese poisoning.
What does Syncapone contain?
The key ingredients of Syncapone comprise Levodopa (200 mg), Entacapone 150, and Carbidopa (37.5 mg).
Carbidopa is an inhibitor of DOPA decarboxylase. It prevents the conversion of levodopa to dopamine, reducing the peripheral adverse effects of Levodopa. Another element Entacapone is a reversible catechol-O-methyl transferase (COMT) inhibitor that is used to treat Parkinson’s disease, and Levodopa creates a natural dihydroxyphenylalanine and it’s an immediate precursor of dopamine.
What are the drug interactions with Syncapone?
There are some drugs that interact and change the effects of Syncapone in which pyridoxine comes first, and Type-B MAOIs also have synergistic effects. Moreover, elements like phenothiazines, diazepam, oxazepam, haloperidol, reserpine, pyridoxine, chlordiazepoxide, phenobarbitone can reduce the effect of levodopa. On the other hand, anticholinergics, carbidopa, amantadine, and amphetamine can enhance its effects. Some food interactions are also registered, as food items like beans, liver, yeast, wheat germ, and skimmed milk can reduce the effects of levodopa, and neutral amino acids can affect the passage of blood across the brain. Concurrent application of drugs that interfere with biliary excretion may enhance plasma levels of entacapone.
When should Syncapone not be used?
Experts advise to avoid or take precautions in taking Syncapone tablets in certain conditions such as:
- Avoid vitamin products that have vitamin B6, as they may reduce the effectiveness of Syncapone.
- Don’t take this medicine, if you are allergic to any of the ingredients of the formulation.
- People suffering from malignant melanoma, heart problems, blood pressure, psychiatric disorder, intestinal bleeding or hormone problems should avoid this medication.
- Avoid taking Levodopa, if you are pregnant or breastfeeding.
- The medicine may cause drowsiness, dizziness, lightheadedness or sudden sleep, so you should not take it while driving.
How should Syncapone be taken?
It should be taken as recommended by your physician. Do not alter the dosing schedule by your own. Always ask your physician before stopping the medicine.
How long Syncapone should be taken?
Continue using it for as long as your physician recommends you to.
Missed dose of Syncapone?
If you have missed a dose of Syncapone then take it as soon as you remember, but don’t increase the number of tablets to make up the damage of missed doses.
How Syncapone should be stored?
You can store this medicine at room temperature (below 30oC). Keep it away from direct heat and moisture.
What are the side effects of Syncapone?
The common side effects of this drug include:
- Nervousness
- Confusion and forgetfulness
- Staying asleep
- Diarrhea
- Headache
- Nightmares
- Dry mouth
- Constipation
- Mood changes
- Nausea or vomiting
- Dizziness
- Loss of appetite
- Uncontrolled movements of the body
Some rare side effects of Syncapone may include:
- Fibrotic complications
- Asthenia
- Cardiac irregularities
- Urticaria
- Pruritus
- Angioedema
- Dark Color (red, brown or black) may appear in bodily secretions
- Possible increase in dyskinesia
- Chest pain
- Back Pain, shoulder pain and muscle cramps
The potentially fatal side effect of this medication is Rhabdomyolysis.
What is Syncapone 25/100mg used for?
Syncapone 25/100mg contains carbidopa 25mg and levodopa 100mg — the standard carbidopa/levodopa combination for Parkinson's disease. This 25/100 ratio provides optimal peripheral decarboxylase inhibition, maximising levodopa delivery to the brain while minimising peripheral nausea and cardiovascular side effects. It is first-line dopaminergic therapy for Parkinson's disease in elderly patients, patients unable to tolerate dopamine agonists, and patients with moderate-to-severe motor disability requiring potent symptomatic treatment.
Why is carbidopa 25mg combined with levodopa 100mg?
Carbidopa inhibits aromatic amino acid decarboxylase (DOPA decarboxylase) in peripheral tissues — preventing levodopa conversion to dopamine outside the brain (which causes nausea, vomiting, and cardiac arrhythmias). The 25mg carbidopa dose provides near-complete peripheral inhibition (approximately 75mg/day threshold needed), enabling the 100mg levodopa dose to cross the blood-brain barrier more efficiently. Without carbidopa, levodopa doses of 1,500–2,000mg/day would be needed; with carbidopa, 300–800mg/day achieves equivalent motor control.
How is Syncapone 25/100mg dosed for Parkinson's disease?
Initiate with one tablet three times daily, increasing by one tablet daily or every other day as tolerated until adequate motor control is achieved. Most patients require 4–8 tablets daily (400–800mg levodopa/day). Divide doses throughout the day at consistent intervals — typically every 4–6 hours. Take 30–60 minutes before meals for best absorption, or with a small low-protein snack if nausea is problematic. Never skip doses abruptly — gradual dose changes prevent withdrawal symptoms and dyskinesia changes.
Can Syncapone 25/100mg be cut or split?
Standard Syncapone 25/100mg immediate-release tablets can be halved if scored, but should not be crushed or chewed as this can affect absorption. Half-tablet dosing is sometimes used for fine-tuning levodopa dose or for bedtime doses when a lower levodopa amount is preferred. Controlled-release (CR) formulations of carbidopa/levodopa should never be crushed or split — doing so destroys the extended-release mechanism and delivers the full dose rapidly. Always check whether your specific formulation is immediate-release or controlled-release before splitting.
Is Syncapone 25/100mg safe in advanced Parkinson's disease?
Carbidopa/levodopa remains the most effective motor treatment throughout all Parkinson's disease stages. In advanced disease, it is typically combined with other agents (dopamine agonists, MAO-B inhibitors, COMT inhibitors) to manage fluctuations and dyskinesias. Cognitive effects, hallucinations, and psychiatric symptoms are more common in advanced disease regardless of medication — carefully review all dopaminergic agents if these occur. In very advanced disease with severe swallowing difficulty, levodopa/carbidopa intestinal gel (Duodopa) provides continuous intestinal infusion.
What happens if Syncapone 25/100mg is stopped suddenly?
Sudden carbidopa/levodopa discontinuation causes neuroleptic malignant syndrome-like presentation (hyperpyrexia, muscle rigidity, altered consciousness, autonomic instability) — a life-threatening emergency. Motor function deteriorates rapidly and profoundly. Never stop levodopa abruptly. If oral route becomes unavailable (hospitalisation, surgery), alternative levodopa routes must be established urgently. Parkinson's disease teams should be notified immediately when a patient is hospitalised to prevent inadvertent carbidopa/levodopa omission by non-specialist teams.
How does Syncapone 25/100mg compare to Sinemet CR (controlled release)?
Syncapone 25/100mg is immediate-release — peak effect at 30–60 minutes, duration 3–5 hours, requiring 3–4 daily doses. Sinemet CR (carbidopa/levodopa extended-release) has a slower onset (1–2 hours), longer duration (5–8 hours), and more gradual peak — reducing dose frequency but providing less predictable on periods. CR formulations are approximately 30% less bioavailable — doses need to be increased by roughly 30% when switching from IR to CR. Most patients prefer IR for reliable on periods; CR is used for overnight dosing to cover early-morning off.
Is Syncapone 25/100mg equivalent to Sinemet 25/100?
Yes. Syncapone 25/100 and branded Sinemet 25-100 both contain carbidopa 25mg and levodopa 100mg in bioequivalent immediate-release formulations. Syncapone is the generic alternative providing the same Parkinson's disease treatment quality as Sinemet at significantly lower cost — critical for patients on lifelong polypharmacy.
Can I order Syncapone 25/100mg from PremiumRxDrugs for delivery to the USA?
Yes. PremiumRxDrugs.com ships Syncapone 25/100mg to the USA, UK, Australia, and many other countries. Our genuine manufacturer-verified medications, competitive pricing, and free worldwide shipping on qualifying orders make us a trusted international pharmacy for patients on long-term Parkinson's disease therapy.
What dyskinesias does carbidopa/levodopa cause and how are they managed?
Peak-dose dyskinesias (involuntary choreiform movements at maximum levodopa concentration) are the most common type — managed by reducing individual levodopa doses while increasing frequency. Biphasic dyskinesias (at beginning and end of levodopa effect) are more difficult to manage. Diphasic dyskinesias may respond to continuous levodopa delivery. Amantadine 100mg TID reduces peak-dose dyskinesias significantly and is first-line treatment for this complication. Deep brain stimulation (DBS) of the subthalamic nucleus eliminates dyskinesias and motor fluctuations in eligible candidates.
What monitoring is needed during long-term Syncapone 25/100mg therapy?
Long-term monitoring includes: motor diary (on/off periods, dyskinesia timing and duration) — reviewed at each clinic visit; neuropsychiatric assessment (hallucinations, impulse control, depression, anxiety, cognitive decline); blood pressure lying and standing (orthostatic hypotension); renal function (levodopa is renally cleared); ophthalmology if visual hallucinations occur; and nutritional status — protein redistribution diet may improve motor fluctuations. Annual DaTscan is not routinely needed. Cognitive assessment with MoCA is recommended at least annually.
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