Syncapone - (12.5+50+200) mg (Carbidopa, Levadopa, Entacapone)
Syncapone medicine is prescribed to treat Parkinson's disease (PD). It’s better known to improve the quality of life for people who have this disease. The medicine contains the three active ingredients, namely Levodopa, Carbidopa, and Entacapone. As an active element Levodopa is converted to a chemical called dopamine in the brain, and a combination of Syncapone and Levodopa is used to treat Parkinson symptoms such as spasms, poor muscle control, muscle stiffness, and tremors.
What is Syncapone used for?
Syncapone (12.5+50+200) mg tablets are specifically formulated to treat Parkinson’s disease caused by carbon monoxide poisoning or manganese intoxication. This drug can prevent the breakdown of levodopa before it reaches the brain. It may also be used for other conditions if it’s prescribed by your doctor.
How does Syncapone work?
Syncapone medicine can prevent decarboxylation of levodopa, making more levodopa available to transport to the brain. As a single agent, this drug has no effect. But, when used with levodopa; syncapone can treat idiopathic Parkinson disease, postencephalitic Parkinsonism, and symptomatic Parkinsonism – all are associated with carbon monoxide or manganese poisoning.
What does Syncapone contain?
The key ingredients of Syncapone comprise Levodopa (100 mg), Entacapone (200 mg), and Carbidopa (25 mg).
Carbidopa is an inhibitor of DOPA decarboxylase. It prevents the conversion of levodopa to dopamine, reducing the peripheral adverse effects of Levodopa. Another element Entacapone is a reversible catechol-O-methyl transferase (COMT) inhibitor that is used to treat Parkinson’s disease, and Levodopa creates a natural dihydroxyphenylalanine and it’s an immediate precursor of dopamine.
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What does Syncapone contain?
Each tablet contains three active components, namely Levodopa, Carbidopa, and Entacapone.
What are the side effects of Syncapone?
The common side effects of this drug include:
- Nervousness
- Confusion and forgetfulness
- Staying asleep
- Diarrhea
- Headache
- Nightmares
- Dry mouth
- Constipation
- Mood changes
- Nausea or vomiting
- Dizziness
- Loss of appetite
- Uncontrolled movements of the body
Some rare side effects of Syncapone may include:
- Fibrotic complications
- Asthenia
- Cardiac irregularities
- Urticaria
- Pruritus
- Angioedema
- Dark Color (red, brown or black) may appear in bodily secretions
- Possible increase in dyskinesia
- Chest pain
- Back Pain, shoulder pain and muscle cramps
The potentially fatal side effect of this medication is Rhabdomyolysis.
What are the drug interactions with Syncapone?
There are some drugs that interact and change the effects of Syncapone in which pyridoxine comes first, and Type-B MAOIs also have synergistic effects. Moreover, elements like phenothiazines, diazepam, oxazepam, haloperidol, reserpine, pyridoxine, chlordiazepoxide, phenobarbitone can reduce the effect of levodopa. On the other hand, anticholinergics, carbidopa, amantadine, and amphetamine can enhance its effects. Some food interactions are also registered, as food items like beans, liver, yeast, wheat germ, and skimmed milk can reduce the effects of levodopa, and neutral amino acids can affect the passage of blood across the brain. Concurrent application of drugs that interfere with biliary excretion may enhance plasma levels of entacapone.
When should Syncapone not be used?
Experts advise to avoid or take precautions in taking Syncapone tablets in certain conditions such as:
- Avoid vitamin products that have vitamin B6, as they may reduce the effectiveness of Syncapone.
- Don’t take this medicine, if you are allergic to any of the ingredients of the formulation.
- People suffering from malignant melanoma, heart problems, blood pressure, psychiatric disorder, intestinal bleeding or hormone problems should avoid this medication.
- Avoid taking Levodopa, if you are pregnant or breastfeeding.
- The medicine may cause drowsiness, dizziness, lightheadedness or sudden sleep, so you should not take it while driving.
How should Syncapone be taken?
It should be taken as recommended by your physician. Do not alter the dosing schedule by your own. Always ask your physician before stopping the medicine.
How long should Syncapone be taken?
Continue using it for as long as your physician recommends you to.
Missed dose of Syncapone?
If you have missed a dose of Syncapone then take it as soon as you remember, but don’t increase the number of tablets to make up the damage of missed doses.
How Syncapone should be stored?
You can store this medicine at room temperature (below 30oC). Keep it away from direct heat and moisture.
