Syndopa 275
Available Dosages
| SKU | 185 |
|---|---|
| Generic For | Sinemet |
| Strength | 25 + 250 mg |
| Manufacturer | Wyeth Pharmaceuticals |
| Active Ingredient | Carbidopa Levodopa |
| Pack Size | Qty | Price Per Pill or Unit | Price | Cart | |
|---|---|---|---|---|---|
| 30 Tablet/s | US$ 0.24 | US$ 7.16 | |||
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| 60 Tablet/s | US$ 0.24 | US$ 14.33 | |||
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| 90 Tablet/s | US$ 0.24 | US$ 21.48 | |||
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Syndopa (Carbidopa Levodopa) – Affordable Sinemet Alternative
Syndopa 275 contains two active components Carbidopa and Levodopa for the treatment of Parkinson's disease and syndrome. This medication is usually prescribed to treat symptoms of Parkinson-like symptoms such as difficulty moving, shakiness, stiffness. Its active ingredients are carbidopa and levodopa. Both are a crystalline compound that works as an aromatic amino acid. Parkinson's disease is largely caused by a substance (dopamine) in the brain. Syndopa is manufactured by SUN Pharmaceuticals, India.
What is Syndopa 25 250 mg used for?
Syndopa 275 is used to treat the symptoms of idiopathic Parkinson's disease as well as post-encephalitic parkinsonism, and symptomatic parkinsonism. Generally, these conditions occur following an injury to the nervous system due to the resort of carbon monoxide intoxication and/or manganese intoxication.
Levodopa is used to diagnose stiffness, tremors, spasms, and poor muscle control that is associated with Parkinson disease. Sometimes, some other drugs chlorpromazine, perphenazine, fluphenazine cause parkinsonism-like symptoms. These symptoms are also treated by the Syndopa medicine.
How does Syndopa 275 work?
Syndopa 275 consist of Levodopa as an active ingredient is a pro-drug and crosses the blood-brain barrier and it has the ability to change into dopamine in the brain, which helps to control body movement. On the other hand, Carbidopa can prevent the breakdown of Levodopa in the bloodstream so more Levodopa can enter the brain. Moreover, Carbidopa can reduce the side effects of Lvodopa too.
What medications interact with Syndopa 275mg ?
There are some possible drug interactions with Syndopa 275 that can influence its effectiveness. The probable drug interactions occur with the products including antipsychotic drugs like haloperidol, chlorpromazine, and thioridazine. The blood pressure medications like methyldopa, reserpine, and tetrabenazine may also invoke interactions. Moreover, Mao inhibitors like isocarboxazid, phenelzine, procarbazine, tranylcypromine, linezolid, methylene blue, and moclobemide may cause drug interactions with Syndopa tablets.
When should Syndopa 275 not be used?
Syndopa 25 tablets should be avoided if you are allergic to Carbidopa or Levodopa. Tell your doctor about your medical history, especially related to liver disease, glaucoma, intestinal ulcer, mental disorders, blood disorders, breathing problems, heart disease, kidney disease, seizures, and sleep disorders.
This drug may make you dizzy, so avoid driving immediately after taking it. Beware of side effects. During pregnancy, this medication should be taken under prescription only.
What are the side effects of Syndopa 275 mg tablets?
The common side effects of Syndopa 275 tablets are dyskinesias (choreiform, dystonic, and involuntary movements and nausea).
Some rare side effects of this medication include:
- Hypotension
- Orthostatic effects like orthostatic hypotension, hypertension, syncope, phlebitis, and palpitation
- Dark saliva
- Chest pain
- Asthenia
- Cardiac irregularities
- Dry mouth and taste alterations
- Agranulocytosis, hemolytic and non-hemolytic anemia, thrombocytopenia, leukopenia
- Back pain, shoulder pain, muscle cramps
- Gastrointestinal bleeding
- Development of duodenal ulcer
- Anorexia
- Vomiting, diarrhea, constipation, and dyspepsia
- Psychotic episodes, including delusions, neuroleptic malignant syndrome, bradykinetic episodes, hallucinations, and paranoid ideation
- Confusion, agitation, dizziness, somnolence
- Insomnia, paresthesia, headache, depression
- Dementia, pathological gambling
- Increased libido including hypersexuality, impulse control symptoms
- Upper respiratory infection
- Rash, increased sweating, alopecia, and dark sweat
- Urinary tract infection, urinary frequency, and dark urine
How should Syndopa 275mg be used?
The optimum daily dosage of Syndopa 25 250mg is determined by your physician. Usually, a 1:4 ratio of carbidopa to levodopa (Syndopa 25-100) and 1:10 ratio (Syndopa 25-250 and Syndopa 10-100) are prescribed. Dosage may be started to 1 tablet every day to the maximum 2 tablets for four times a day until the problem is treated.
Missed dose of Syndopa 275mg
If you have missed a dose of Syndopa 275 mg tablets, then take it as soon as you remember, but don’t increase the number of tablets to make up the damage of missed application.
How should Syndopa 275mg be stored?
Storing this medicine at room temperature is ideal. You have to keep it away from heat and moisture.
What is Syndopa 275mg used for?
Syndopa 275mg contains carbidopa 25mg and levodopa 250mg — the high-strength carbidopa/levodopa tablet for moderate-to-advanced Parkinson's disease requiring higher levodopa doses. The 250mg levodopa component provides significantly stronger dopaminergic stimulation per tablet than 100mg-strength tablets, reducing the total number of tablets required and simplifying the medication burden. Syndopa 275 (25/250) is appropriate for patients established on levodopa therapy who require total daily levodopa doses exceeding 600–800mg/day.
When is the higher-strength Syndopa 275mg (25/250) used instead of 25/100?
Syndopa 275mg (25/250) is selected over 25/100 when total daily levodopa dose exceeds 600–800mg — typically 5+ tablets of 25/100 daily. Higher-strength tablets reduce pill burden and improve adherence. The 25mg carbidopa per tablet is the same as in 25/100 — at high levodopa doses (above 800mg/day), additional carbidopa supplementation may be needed to maintain full peripheral inhibition. Total daily carbidopa should ideally exceed 200–300mg in high-levodopa-dose regimens. Supplemental carbidopa tablets (Lodosyn) can be added independently if needed.
How is Syndopa 275mg dosed in advanced Parkinson's disease?
Syndopa 275mg dosing is highly individualised in advanced Parkinson's disease. A typical dose might be one to two tablets 3–4 times daily — equivalent to 750–2,000mg levodopa daily. Higher doses require careful titration with neurologist oversight. The dose interval is typically every 4–6 hours (4-hourly in patients with significant wearing-off). Additional 25/100 tablets may be combined with 25/250 for precise dose titration. Take 30–60 minutes before meals; protein redistribution diet is especially important at higher levodopa doses.
Is Syndopa 275mg more likely to cause dyskinesias than lower-strength tablets?
The risk of dyskinesias is related to total daily levodopa dose and duration of therapy — not to individual tablet strength. A patient taking 750mg/day levodopa via three Syndopa 275 tablets has the same dyskinesia risk as one taking 750mg via seven Syndopa 110 tablets. However, high-strength tablets produce sharper plasma levodopa peaks (more concentrated dose bolus), which may worsen peak-dose dyskinesias in susceptible patients. For patients with severe peak-dose dyskinesias, using more frequent smaller doses (from 100mg tablets) or controlled-release formulation provides smoother plasma levels.
What safety concerns apply specifically to high-dose levodopa therapy?
High-dose levodopa (>800mg/day) carries specific concerns: (1) homocysteine elevation — levodopa metabolism produces homocysteine, increasing cardiovascular and cognitive risk; folate and B12 supplementation are recommended; (2) neuropsychiatric effects — psychosis, hallucinations, impulse control disorders are more common at higher doses; (3) dyskinesias — severity correlates with peak dose; (4) dopamine dysregulation syndrome — compulsive levodopa self-medication; (5) peripheral neuropathy associated with long-term levodopa use. Regular neuropsychiatric assessment is essential.
Can I switch from Syndopa 110 (25/100) to Syndopa 275 (25/250)?
Yes — the switch is straightforward: multiply the number of 25/100 tablets per dose by 2.5 to find the equivalent 250mg-levodopa dose. For example, 2.5 tablets of 25/100 (250mg levodopa) = 1 tablet of 25/250 (250mg levodopa). Because carbidopa content per tablet is the same (25mg) whether 25/100 or 25/250, switching to fewer higher-strength tablets means less total carbidopa per day — may require supplemental carbidopa if total daily carbidopa falls below 75mg. Always confirm switch with a neurologist.
How does Syndopa 275mg compare to Sinemet CR 25/100?
Syndopa 275mg is an immediate-release 25/250 formulation (fast onset, 3–5 hour duration). Sinemet CR 25/100 is controlled-release 25mg carbidopa/100mg levodopa (slow onset, 6–8 hour duration, ~30% less bioavailable). These serve different clinical purposes: Syndopa 275 provides reliable, potent immediate motor control; Sinemet CR provides smoother, more sustained coverage at the cost of less predictable onset. They are not interchangeable milligram-for-milligram — Sinemet CR doses need to be about 30% higher to match IR bioavailability.
Is Syndopa 275mg the same as Sinemet 25/250?
Yes. Syndopa 275mg (carbidopa 25mg/levodopa 250mg) and branded Sinemet 25-250 are bioequivalent immediate-release formulations of the same active ingredients. Syndopa 275 is the generic formulation providing identical Parkinson's disease motor control at significantly lower cost — important for patients on high daily levodopa doses who have proportionally higher medication costs.
Can I order Syndopa 275mg from PremiumRxDrugs for delivery to the USA?
Yes. PremiumRxDrugs.com ships Syndopa 275mg to the USA, UK, Australia, and many other countries. Their genuine manufacturer-verified medications, competitive pricing, and free worldwide shipping on qualifying orders make them a reliable international pharmacy for high-dose levodopa requirements.
What side effects are most likely at the higher levodopa dose in Syndopa 275mg?
At higher doses (250mg levodopa per tablet), peak-dose dyskinesias are more pronounced — involuntary choreiform movements typically beginning 30–90 minutes after each dose. Psychiatric side effects (visual hallucinations, vivid dreams, paranoia) are more common. Orthostatic hypotension is more pronounced. Nausea is generally well controlled with adequate carbidopa but may recur at dose increases. Peripheral neuropathy may develop with years of high-dose therapy — monitor B12 and folate levels. Dopamine dysregulation syndrome (compulsive levodopa seeking) may emerge.
How often should neurological review occur for patients on Syndopa 275mg?
Patients on high-dose carbidopa/levodopa (25/250 tablets) require regular specialist neurology review — at minimum every 6 months when stable, more frequently (every 3 months) during dose adjustment phases or when complications arise. Key review points: motor diary assessment (on/off periods, dyskinesia timing and severity), neuropsychiatric screening (MoCA, hallucination, ICD assessment), blood pressure (lying and standing), and nutritional biochemistry (homocysteine, B12, folate). Physiotherapy, occupational therapy, and speech therapy referrals should be considered as disease progresses.
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