Xafinact 100mg
| SKU | 2628 |
|---|---|
| Generic For | Xadago |
| Manufacturer | Sun Pharmaceuticals Ltd |
| Active Ingredient | Safinamide |
| Pack Size | Qty | Price Per Pill or Unit | Price | Cart | |
|---|---|---|---|---|---|
| 30 Tablet/s | US$ 1.01 | US$ 30.30 | |||
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| 60 Tablet/s | US$ 0.91 | US$ 54.5410%US$ 60.60 | |||
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| 90 Tablet/s | US$ 0.73 | US$ 66.0027%US$ 90.90 | |||
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Xafinact 100mg (Safinamide) – Affordable Xadago Alternative
Xafinact 100 mg is indicated as adjunctive treatment to levodopa/carbidopa in patients with Parkinson’s disease experiencing off episodes. It contains the active ingredient safinamide, which belongs to a class of medication known as monoamine oxidase type B (MAO-B) inhibitor. It is not known if this medication is effective in treating Parkinson’s when used as a single medicine.
Xafinact 100mg is contraindicated in patients with:
Concomitant use of the following medications:
- Other monoamine oxidase inhibitors or other medications that are potent inhibitors of monoamine oxidase, for example, linezolid.
- Opioid drugs such as meperidine, tramadol, and related derivatives, antidepressants, cyclobenzaprine, amphetamine, methylphenidate, st. John Wort
- Dextromethorphan
Xafinact should not be given to patients with a history of hypersensitivity to safinamide and severe hepatic impairment.
Let your health care provider know before taking safinamide as it may:
- Cause or worsen hypertension
- Cause serotonin syndrome when used with MAO inhibitors, opioid medications, or antidepressants
- Cause falling asleep during activities of daily living
- Cause or worsening of dyskinesia; consider levodopa dose reduction
- Cause problems with compulsive behaviors
- Cause hallucinations and psychotic behavior
- Cause withdrawal emergent hyperpyrexia and confusion
Avoid certain foods and beverages high in tyramine, such as fermented, aged, cured, smoked, and pickled. Do not drive, operate machinery, or perform other dangerous activities until you know how Xafinact affects you. It is not known if safinamide is safe and effective in children.
The most common side effects of Xafinact 100 mg are falls, nausea, dyskinesia, and insomnia. The medicine may cause serious side effects as well. These include high blood pressure, serotonin syndrome, falling asleep during normal activities, uncontrolled sudden movement, hallucinations, unusual urges, and problems with the retina in your eye.
The treatment usually starts with 50 mg orally once daily at the same time of the day; after two weeks, the regular dosage may increase to 100 mg once a day, based on individual requirements and tolerability. Take this medication exactly as your healthcare provider tells you to take it. You can take the medication before or after consuming food.
What is Safinamide and what condition does it treat?
Safinamide is a monoamine oxidase-B (MAO-B) inhibitor used as add-on therapy for Parkinson's disease. Marketed as Xafinact 100mg and other brand names, this medication helps manage motor fluctuations in patients already taking levodopa/carbidopa combinations. Safinamide works alongside existing Parkinson's treatments to reduce 'off' episodes—periods when medication effectiveness diminishes and symptoms return. This dopaminergic agent is particularly valuable for mid-to-late stage Parkinson's patients experiencing movement difficulties despite standard therapy. The active ingredient provides both dopaminergic and non-dopaminergic effects, making it a unique option within the MAO-B inhibitor class for Parkinson's disease management.
How does Safinamide work in the body?
Safinamide functions through a dual mechanism that sets it apart from other Parkinson's medications. As an MAO-B inhibitor, Xafinact 100mg blocks the enzyme that breaks down dopamine in the brain, increasing dopamine availability to improve motor control. Additionally, this medication modulates glutamate release by blocking sodium and calcium channels, providing neuroprotective benefits. This combined dopaminergic and glutamatergic action helps reduce motor fluctuations and 'off' time in Parkinson's patients taking levodopa. The reversible MAO-B inhibition means Safinamide selectively targets this enzyme without affecting MAO-A, reducing interaction risks compared to older non-selective inhibitors.
How long does Xafinact 100mg take to work?
Xafinact 100mg typically begins showing therapeutic effects within two to four weeks of consistent daily use, though individual response varies. As an add-on therapy for Parkinson's disease, Safinamide gradually builds up in your system to provide optimal MAO-B inhibition. Some patients notice reduced 'off' time and improved motor function within the first week, while full benefits may take up to eight weeks. This medication works cumulatively with your existing levodopa regimen rather than providing immediate symptom relief. Your neurologist will monitor your response during the initial treatment period and may adjust dosing based on how quickly you experience improvement in daily functioning.
When and how should I take Xafinact 100mg?
Take Xafinact 100mg once daily at the same time each day, with or without food. Most patients find morning dosing convenient to align with their levodopa schedule. Swallow the tablet whole with water—do not crush, chew, or split it. Treatment typically starts at 50mg daily for two weeks before increasing to the maintenance dose of 100mg, allowing your body to adjust to this MAO-B inhibitor gradually. Consistency is crucial for managing Parkinson's disease effectively, so set a daily reminder if needed. Inform your doctor about all medications you're taking, particularly antidepressants, opioids, and sympathomimetics, as Safinamide requires careful monitoring when combined with certain drugs.
Is Xafinact 100mg safe for long-term use?
Xafinact 100mg is designed for long-term management of Parkinson's disease when used as directed. Clinical trials have demonstrated Safinamide's safety profile over extended periods, with most patients tolerating this MAO-B inhibitor well as ongoing adjunctive therapy. Long-term use requires periodic monitoring of liver function, blood pressure, and eye health, as these are areas your healthcare provider will check during follow-up visits. The medication's reversible enzyme inhibition contributes to its favorable long-term safety compared to older irreversible MAO inhibitors. Many patients continue Safinamide therapy for years as part of their comprehensive Parkinson's treatment regimen, experiencing sustained improvement in motor fluctuations.
Can I take Xafinact 100mg with other medicines?
Xafinact 100mg is specifically designed as add-on therapy with levodopa for Parkinson's disease, making it compatible with standard Parkinson's medications. However, Safinamide requires careful consideration with certain drug classes. Avoid combining this MAO-B inhibitor with other MAO inhibitors, most antidepressants (particularly SSRIs, SNRIs, and tricyclics), St. John's Wort, dextromethorphan, and certain opioids like meperidine or tramadol due to serotonin syndrome risk. Sympathomimetic amines in decongestants also require caution. Always provide your pharmacist and doctor with a complete medication list, including over-the-counter products and supplements, before starting Safinamide to identify potential interactions.
How does Xafinact 100mg compare to similar medicines in its class?
Xafinact 100mg offers distinct advantages within the MAO-B inhibitor class used for Parkinson's disease. Unlike rasagiline and selegiline, Safinamide provides dual-action therapy through both dopamine modulation and glutamate regulation, potentially offering superior neuroprotection. This medication demonstrates lower interaction risks than older non-selective MAO inhibitors while providing comparable 'off' time reduction. Clinical comparisons show Safinamide's once-daily dosing and unique mechanism may benefit patients who haven't achieved adequate control with other adjunctive therapies. The reversible MAO-B inhibition of Xafinact 100mg also presents a different pharmacological profile compared to COMT inhibitors like entacapone, giving neurologists another valuable option for optimizing individual Parkinson's treatment plans.
Is the generic Safinamide as effective as branded versions?
Generic Safinamide contains the identical active ingredient as branded Xafinact 100mg and must meet the same rigorous efficacy and safety standards set by regulatory authorities. Both generic and branded versions deliver equivalent therapeutic outcomes for Parkinson's disease management when manufactured to pharmaceutical standards. The active molecule, dosage strength, and mechanism as an MAO-B inhibitor remain identical regardless of branding. Generic medications undergo bioequivalence testing to ensure they perform identically in the body, providing the same dopaminergic and glutamatergic effects. Many patients choose generic Safinamide for cost savings while receiving the same clinical benefits, making effective Parkinson's treatment more accessible without compromising quality or symptom control.
Why do patients choose PremiumRxDrugs for Xafinact 100mg?
Patients consistently choose PremiumRxDrugs for Xafinact 100mg because of reliable access to authentic Safinamide at competitive prices. As a licensed pharmacy, we have been serving patients managing Parkinson's disease for over ten years, building trust through manufacturer-sourced medications and professional service. Convenient features like easy prescription management and reordering simplify ongoing MAO-B inhibitor therapy, while discreet packaging respects patient privacy. International shipping to the USA, UK, Australia, Canada, and beyond, including free shipping options, makes continuing treatment affordable and accessible. The combination of pharmaceutical authenticity, competitive pricing on both branded and generic versions, and dependable worldwide delivery creates a comprehensive solution for patients requiring consistent access to their Parkinson's medications.
What are the common side effects of Safinamide?
Common side effects of Safinamide include involuntary movements (dyskinesia), falls, nausea, and insomnia, which typically occur as your body adjusts to this MAO-B inhibitor. Some patients experience orthostatic hypotension (dizziness when standing), headache, or digestive issues during initial treatment. These effects often diminish as therapy continues. Less common reactions include visual disturbances, impulse control problems, or elevated liver enzymes. Because Safinamide enhances dopaminergic activity when combined with levodopa for Parkinson's disease, dyskinesia may increase initially but often improves with dose adjustment. Most patients tolerate this medication well, with side effects generally mild to moderate. Contact your healthcare provider if symptoms persist or worsen significantly during treatment.
Who should avoid taking Safinamide?
Safinamide is contraindicated for patients taking other MAO inhibitors, most antidepressants, certain opioids (meperidine, tramadol, methadone), cyclobenzaprine, dextromethorphan, or St. John's Wort due to serious interaction risks. Individuals with severe liver impairment should avoid this MAO-B inhibitor, as should those with albinism, retinal degeneration, uveitis, inherited retinopathy, or severe diabetic retinopathy. Pregnant or breastfeeding women require careful evaluation before starting Safinamide for Parkinson's disease. Patients with uncontrolled hypertension, history of impulse control disorders, or psychosis need specialist assessment. Those with rare hereditary galactose intolerance should discuss alternatives. Always disclose your complete medical history and current medications before beginning this dopaminergic therapy.
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