Zidovir 100mg
Available Dosages
| SKU | 1203 |
|---|---|
| Generic For | Retrovir |
| Strength | 100 mg |
| Active Ingredient | Zidovudine |
Out Of Stock
Zidovir 100mg (Zidovudine) – Affordable Retrovir Alternative
Zidovir 100mg (Zidovudine)
Zidovir 100mg contains Zidovudine as an active ingredient. Zidovudine belongs to a class of nucleoside reverse-transcriptase inhibitor (NRTI). It is a blood brain barrier permeable. Zidovudine is an antiretroviral medicine used to treat HIV infection. It is used along with other HIV medications to treat HIV.
What is Zidovir 100 mg used for?
Zidovir 100mg is used:
- To treat Human Immunodeficiency Virus (HIV-1) infection.
- To prevent Maternal-fetal HIV-1 transmission.
Buy Zidovir 100 mg online for the treatment and prevention of HIV infection.
How does Zidovir work?
Zidovir works by blocking an HIV enzyme called, HIV reverse transcriptase. By doing this, it prevents HIV from replicating and decreases the amount of HIV in the blood.
What are the different doses of Zidovir?
Zidovir is available to order online from premiumrxdrugs.com. You can buy Zidovir 100 mg online at an unbeatable price.
How should Zidovir be taken?
- Zidovir comes in the form of a capsule. Taking Zidovir capsule, with a glass of water will help you to swallow it.
- To treat HIV infection in adults: The usual dose of Zidovir is 600 mg/ day, and it should be taken in divided doses. It is to be taken together with other antiretrovirals agents.
- To treat HIV in pediatrics who aged 4 -<18 years, the dosage regimen is based upon the body weight. Your doctor will prescribe this medicine according to the weight of your child. Alternatively, treatment with Zidovir may also be based on body surface area for every child. The usual dose is of Zidovudine is 480mg/m2 in divided doses (240 mg/m2 two times a day or 160 mg/m2 three times a day).
- For the prevention of mother-to-child HIV-1 transmission:
Maternal Dosing- The usual dose of Zidovir is 100 mg five times a day, until the labor start. During labor and delivery, 2mg/kg of the medicine should be administered intravenously over one hour followed by 1 mg/kg/hour until clamping of the navel string.
Neonatal Dosing: The usual dose of Zidovir is 2 mg/kg every 6 hours starting within twelve hours after the birth of a child, and the treatment should be continued for 6 weeks of age. In neonates, Zidovir should be administered intravenously at 1.5 mg/kg, infused over 30 minutes every six hours.
- Do not take more or less amount of capsule than your doctor has prescribed.
- Do not stop taking the capsules without asking your doctor.
- Take the medicine continuously as long as your doctor recommends you. Zidovir is a drug that prevents further damage caused by the HIV, but it does not cure your condition. You should not stop taking the drug and continue taking it, even if you feel better. Because stopping the intake of the drug may reverse your improving condition.
- Overdose: If you accidently take an extra capsule, call your doctor or hospital casualty department immediately.
Missed dose of Zidovir:
Take the missed dose as soon as you remember. Leave the missed dose, if it is almost time for your next dose. Do not take an extra dose to make up the missed one. Try to take the drug on the same day as this reduces the chance of missing the dose.
What are Side effects of Zidovir?
Like all drugs, Zidovir can cause side-effects although, not everyone gets them. Contact your doctor, if any of the following symptoms appear:
- Constipation
- Nausea
- Diarrhea
- Blurred vision
- Vomiting
- Constipation
- Headache
Some side effects of Zidovir can be serious. Call your doctor immediately, if you experience:
- Chills
- Numbness, tingling or burning sensation
- Liver problems
- Skin rashes
- Hives
The side effects that are mentioned above are not the only ones that you may experience due to Zidovir. If you get any serious adverse effects due to Zidovir, call your doctor right away.
What medications interact with Zidovir?
The following medicines should be avoided, in case doctor recommends you Zidovir to avoid possible drug interactions.
- Ganciclovir
- Rifampicin
- Doxorubicin
- Sulfa drugs
- Lamivudine
- Sulfa drugs
When should Zidovir not be used?
Talk to your doctor, before taking Zidovir if:
- You are allergic to Zidovir, or any of the ingredients of Zidovudine
- You drink or have drunk a large amount of alcohol
- You have Anaemia
- You have epilepsy
- You are pregnant or planning to become pregnant. You need to discuss the risks and benefits of taking the medicine during pregnancy
- You are or will be breastfeeding
- You may feel dizzy while driving or using machines. Try not to involve in a motor activity.
How should Zidovir be stored?
- Store away from heat, moisture, and light. Do not store in the bathroom. Keep the drug out of the reach of children and away from pets
- Always check the expiry date on the cover of the medicine
What is Zidovir 100mg used for?
Zidovir 100mg contains zidovudine 100mg — one of the original HIV antiretroviral agents (approved 1987), still used in specific clinical contexts. Key uses: prevention of mother-to-child HIV transmission (PMTCT) — zidovudine is given to HIV-positive pregnant women and neonates; part of dual or triple antiretroviral combinations when other agents are not tolerated; post-exposure prophylaxis (PEP) for HIV; and HIV treatment in patients where established combinations including zidovudine are effective and tolerated. The 100mg strength allows precise low-dose prescribing for paediatric use and PMTCT protocols.
How does zidovudine in Zidovir 100mg work against HIV?
Zidovudine (AZT/ZDV) is a thymidine nucleoside reverse transcriptase inhibitor. After phosphorylation to zidovudine triphosphate by cellular kinases, it competitively inhibits HIV reverse transcriptase and is incorporated into viral DNA — causing obligate chain termination (no 3'-hydroxyl group for next nucleotide). This blocks HIV RNA-to-DNA conversion essential for viral replication. Zidovudine also penetrates the blood-brain barrier well — useful for CNS HIV manifestations. Its antiviral potency is good but its toxicity profile (bone marrow suppression, mitochondrial toxicity) has led to replacement by newer, better-tolerated NRTIs in first-line regimens.
How is Zidovir 100mg dosed for HIV prevention of mother-to-child transmission?
PMTCT protocols vary by guideline. A typical regimen: maternal zidovudine 300mg twice daily from 14–28 weeks gestation through delivery, plus IV zidovudine 2mg/kg loading then 1mg/kg/hour continuous infusion during labour. Neonatal prophylaxis: zidovudine 2mg/kg every 6 hours (or 4mg/kg BID) for 4–6 weeks starting within 12 hours of birth. The 100mg capsule is used in specific PMTCT contexts. Modern WHO guidelines increasingly prefer dolutegravir-based triple therapy over zidovudine monotherapy PMTCT — but where triple therapy is unavailable, AZT-based PMTCT remains important.
What bone marrow toxicity does Zidovir 100mg cause and how is it monitored?
Zidovudine's primary toxicity is bone marrow suppression — anaemia (most common, particularly macrocytic anaemia) and neutropenia. Risk factors: low CD4 count, advanced HIV disease, vitamin B12/folate deficiency, and other myelosuppressive agents. Monitoring: FBC at baseline, 2 weeks, 4 weeks, then every 3 months. Action thresholds: Hb <7.5g/dL or neutrophils <750/mm³ — interrupt or reduce zidovudine. Consider epoetin alfa for AZT-associated anaemia to allow continuation. G-CSF (filgrastim) for severe neutropenia. Most patients tolerate zidovudine with adequate monitoring — anaemia develops in approximately 1–4% at standard doses.
Is Zidovir 100mg safe during pregnancy?
Zidovudine has the most extensive pregnancy safety data of any antiretroviral — used since 1994 for PMTCT. Decades of pregnancy registry data show no increase in major birth defects. AZT can cause fetal anaemia when used late in pregnancy — monitor neonatal haemoglobin at birth. Neonatal zidovudine prophylaxis is well established and effective. While current WHO guidelines prefer dolutegravir-based triple therapy for pregnant women with HIV, zidovudine remains an essential component of PMTCT protocols in many settings and can be safely used throughout pregnancy when clinically indicated.
What drug interactions are most important with Zidovir 100mg?
Ribavirin antagonises zidovudine's antiviral activity via IMPDH inhibition — reduces AZT phosphorylation; avoid combination where possible. Stavudine (d4T) is a direct pharmacological antagonist of AZT — the two thymidine analogues compete for intracellular phosphorylation; never combine. Ganciclovir and other myelosuppressive drugs add to AZT-induced bone marrow suppression. Doxorubicin and vincristine inhibit AZT glucuronidation — increase AZT exposure. Rifampicin substantially reduces AZT plasma levels (55% reduction). Fluconazole increases AZT exposure by ~74% — monitor for AZT toxicity. Probenecid increases AZT levels — reduce dose if combined.
How does Zidovir 100mg compare to tenofovir for HIV treatment?
Zidovudine (Zidovir 100mg, multiple daily doses) and tenofovir DF (300mg once daily) are both NRTIs but differ significantly. TDF is now preferred in guidelines: once-daily dosing (vs. AZT's twice or three-times daily), better tolerability (no bone marrow toxicity), and activity against HBV. AZT's advantages: superior CNS penetration (useful for HIV-associated dementia/encephalitis), excellent pregnancy safety data for PMTCT, and decades of clinical experience. For HIV treatment initiation in non-pregnant adults, TDF-based regimens are preferred over AZT-based regimens in most settings where TDF is available.
Is Zidovir 100mg the same as Retrovir 100mg?
Yes. Zidovir 100mg and branded Retrovir 100mg both contain zidovudine 100mg in bioequivalent formulations. Zidovir is the generic alternative providing the same HIV antiviral activity as branded Retrovir at significantly lower cost — especially important in PMTCT programmes where cost determines coverage and access.
Can I order Zidovir 100mg from PremiumRxDrugs for international delivery?
Yes. PremiumRxDrugs.com ships Zidovir 100mg to the USA, UK, Australia, and many other countries. Our genuine manufacturer-verified antiretrovirals, competitive pricing, and free worldwide shipping on qualifying orders make us a reliable international source for zidovudine therapy.
What side effects does Zidovir 100mg cause beyond bone marrow suppression?
Beyond haematological effects: nausea and vomiting (most common early — usually resolves after first month; take with food or milk); headache and fatigue; myopathy (proximal muscle weakness with long-term high-dose use — monitor CK if symptomatic); hyperpigmentation of nails (dark nail bands — harmless cosmetic effect); lactic acidosis (nucleoside class effect — rare but potentially fatal; risk increases with prolonged use and female sex); lipoatrophy (fat redistribution with long-term AZT — loss of subcutaneous fat in face and limbs); macrocytosis (elevated MCV without anaemia — harmless marker of AZT use).
How does Zidovir 100mg help prevent HIV transmission after needlestick injury?
Zidovudine is a cornerstone of HIV post-exposure prophylaxis (PEP) for healthcare workers after needlestick injury or other HIV exposure. Current recommended PEP: AZT 300mg + lamivudine 150mg twice daily (or combined Duovir 150/300mg BID) plus a third agent (raltegravir or lopinavir/ritonavir) for 28 days — started within 2 hours of exposure (maximum benefit) and no later than 72 hours. PEP reduces HIV seroconversion risk by approximately 81% for percutaneous exposures. The 100mg strength allows dose adjustment for body weight-based dosing in paediatric PEP (neonatal and infant occupational or non-occupational exposures).
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