Zidovir 300mg
Available Dosages
| SKU | 1204 |
|---|---|
| Generic For | Retrovir |
| Strength | 300 mg |
| Active Ingredient | Zidovudine |
Out Of Stock
Zidovir 300mg (Zidovudine) – Affordable Retrovir Alternative
Zidovir 300 mg contains Zidovudine as an active ingredient. Zidovudine belongs to a class of nucleoside reverse-transcriptase inhibitor (NRTI). It is a blood brain barrier permeable. Zidovudine is an antiretroviral medicine used to treat HIV infection. It is used along with other HIV medications to treat HIV.
What is Zidovir 300 mg used for?
Zidovir 300 mg is used:
- To treat Human Immunodeficiency Virus (HIV-1) infection.
- To prevent Maternal-fetal HIV-1 transmission.
Buy Zidovir 300 mg online for the treatment and prevention of HIV infection.
How does Zidovir work?
Zidovir works by blocking an HIV enzyme called, HIV reverse transcriptase. By doing this, it prevents HIV from replicating and decreases the amount of HIV in the blood.
What are the different doses of Zidovir?
Zidovir is available to order online from premiumrxdrugs.com. You can buy Zidovir 300 mg online at an unbeatable price.
How should Zidovir be taken?
- Zidovir comes in the form of a capsule. Taking Zidovir capsule, with a glass of water will help you to swallow it.
- To treat HIV infection in adults: The usual dose of Zidovir is 600 mg/ day, and it should be taken in divided doses. It is to be taken together with other antiretrovirals agents.
- To treat HIV in pediatrics who aged 4 -<18 years, the dosage regimen is based upon the body weight. Your doctor will prescribe this medicine according to the weight of your child. Alternatively, treatment with Zidovir may also be based on body surface area for every child. The usual dose is of Zidovudine is 480mg/m2 in divided doses (240 mg/m2 two times a day or 160 mg/m2 three times a day).
- For the prevention of mother-to-child HIV-1 transmission:
Maternal Dosing- The usual dose of Zidovir is 100 mg five times a day, until the labor start. During labor and delivery, 2mg/kg of the medicine should be administered intravenously over one hour followed by 1 mg/kg/hour until clamping of the navel string.
Neonatal Dosing: The usual dose of Zidovir is 2 mg/kg every 6 hours starting within twelve hours after the birth of a child, and the treatment should be continued for 6 weeks of age. In neonates, Zidovir should be administered intravenously at 1.5 mg/kg, infused over 30 minutes every six hours.
- Do not take more or less amount of capsule than your doctor has prescribed.
- Do not stop taking the capsules without asking your doctor.
- Take the medicine continuously as long as your doctor recommends you. Zidovir is a drug that prevents further damage caused by the HIV, but it does not cure your condition. You should not stop taking the drug and continue taking it, even if you feel better. Because stopping the intake of the drug may reverse your improving condition.
- Overdose: If you accidently take an extra capsule, call your doctor or hospital casualty department immediately.
Missed dose of Zidovir:
Take the missed dose as soon as you remember. Leave the missed dose, if it is almost time for your next dose. Do not take an extra dose to make up the missed one. Try to take the drug on the same day as this reduces the chance of missing the dose.
What are Side effects of Zidovir?
Like all drugs, Zidovir can cause side-effects although, not everyone gets them. Contact your doctor, if any of the following symptoms appear:
- Constipation
- Nausea
- Diarrhea
- Blurred vision
- Vomiting
- Constipation
- Headache
Some side effects of Zidovir can be serious. Call your doctor immediately, if you experience:
- Chills
- Numbness, tingling or burning sensation
- Liver problems
- Skin rashes
- Hives
The side effects that are mentioned above are not the only ones that you may experience due to Zidovir. If you get any serious adverse effects due to Zidovir, call your doctor right away.
What medications interact with Zidovir?
The following medicines should be avoided, in case doctor recommends you Zidovir to avoid possible drug interactions.
- Ganciclovir
- Rifampicin
- Doxorubicin
- Sulfa drugs
- Lamivudine
- Sulfa drugs
When should Zidovir not be used?
Talk to your doctor, before taking Zidovir if:
- You are allergic to Zidovir, or any of the ingredients of Zidovudine
- You drink or have drunk a large amount of alcohol
- You have Anaemia
- You have epilepsy
- You are pregnant or planning to become pregnant. You need to discuss the risks and benefits of taking the medicine during pregnancy
- You are or will be breastfeeding
- You may feel dizzy while driving or using machines. Try not to involve in a motor activity.
How should Zidovir be stored?
- Store away from heat, moisture, and light. Do not store in the bathroom. Keep the drug out of the reach of children and away from pets
- Always check the expiry date on the cover of the medicine
What is Zidovir 300mg used for?
Zidovir 300mg contains zidovudine 300mg — the standard adult dose of this HIV NRTI in a single tablet. It is used as part of combination antiretroviral therapy for HIV-1 infection, typically combined with lamivudine (3TC) and a third agent. The 300mg tablet is taken twice daily (600mg/day total), providing convenient dosing compared to the original 200mg/day dose used in early HIV trials. Zidovudine 300mg twice daily forms one component of the widely used combination Duovir (zidovudine 300mg + lamivudine 150mg), providing the two-NRTI backbone of triple HIV therapy.
How does the 300mg dose of Zidovir compare to earlier lower-dose regimens?
Early HIV treatment used zidovudine at 500–1,200mg/day in multiple daily doses — higher doses that caused more bone marrow toxicity. Clinical evidence established 600mg/day (300mg twice daily) as the optimal balance of antiviral efficacy and tolerability in combination therapy (where additional agents contribute potency). At 300mg BID within triple therapy, zidovudine provides its NRTI contribution to the backbone while keeping side effects manageable. The important principle: AZT at 600mg/day in three-drug therapy achieves equivalent viral suppression with less toxicity than AZT monotherapy at 1,200mg/day (which predated combination therapy).
How should Zidovir 300mg be taken?
Take one Zidovir 300mg tablet twice daily — approximately 12 hours apart. Take with food or milk to reduce nausea (bioavailability is not significantly affected by food). Maintain consistent twice-daily timing for optimal plasma drug level consistency. If using as a component of a triple regimen (alongside lamivudine + a third agent), take all components simultaneously for convenience. A fixed-dose combination tablet (Duovir 150/300mg = lamivudine 150 + zidovudine 300) simplifies therapy to one tablet twice daily. Adherence above 95% is required for sustained viral suppression.
Is Zidovir 300mg appropriate for post-exposure prophylaxis (PEP)?
Yes — zidovudine 300mg twice daily is a core component of HIV PEP following occupational (healthcare workers) or non-occupational exposures. Recommended PEP: Zidovir 300mg + lamivudine 150mg twice daily (or Duovir 150/300mg BID) plus raltegravir 400mg BID or lopinavir/ritonavir for 28 days — initiated within 72 hours (ideally within 2 hours) of potential HIV exposure. PEP reduces HIV seroconversion risk by approximately 81% for high-risk percutaneous exposures. Complete the full 28 days even if exposure is later assessed as low risk — stopping early reduces effectiveness.
What monitoring is required during Zidovir 300mg therapy?
Mandatory monitoring: FBC at baseline, 4 weeks, then every 3 months — haemoglobin and neutrophil count (bone marrow toxicity); HIV viral load every 3–6 months (target: undetectable <50 copies/mL); CD4 count every 3–6 months; LFTs every 6 months; fasting glucose and lipids annually; CPK if symptoms of myopathy (proximal muscle weakness); serum lactate if symptoms of lactic acidosis (nausea, abdominal pain, dyspnoea, weakness). Report any unexplained muscle weakness, significant fatigue, abdominal pain, or yellowing of skin/eyes — these require prompt investigation.
Can Zidovir 300mg be safely combined with stavudine?
No — zidovudine and stavudine should never be combined. Both are thymidine nucleoside analogues that compete for the same intracellular phosphorylation enzymes. They are pharmacological antagonists — stavudine inhibits AZT phosphorylation to its active triphosphate form, effectively negating zidovudine's antiviral activity. Clinical data confirms the antagonism: HIV viral suppression is worse with the AZT+d4T combination than with either agent as part of a properly selected backbone. This combination is explicitly listed as contraindicated in all major HIV treatment guidelines.
How does Zidovir 300mg compare to emtricitabine as an NRTI partner for lamivudine?
Zidovir 300mg (zidovudine) and emtricitabine are both NRTI medicines used in HIV treatment along with lamivudine or other antiretroviral drugs. Emtricitabine is generally preferred in many modern HIV treatment plans because it is easier to take, usually causes fewer side effects, and is better tolerated long term. Zidovudine is still effective but may cause side effects such as anemia, tiredness, or muscle weakness in some patients. Both medicines help lower the amount of HIV in the body and support immune system health.
Is Zidovir 300mg the same as Retrovir 300mg?
Yes. Zidovir 300mg and branded Retrovir 300mg both contain zidovudine 300mg in bioequivalent formulations. Zidovir is the generic alternative providing the same HIV NRTI treatment at significantly lower cost — making zidovudine-based HIV therapy accessible in cost-sensitive settings and programmes.
Can I order Zidovir 300mg from PremiumRxDrugs for international delivery?
Yes. PremiumRxDrugs.com ships Zidovir 300mg to the USA, UK, Australia, and many other countries. Our genuine manufacturer-verified antiretrovirals, competitive pricing, and free worldwide shipping on qualifying orders make us a reliable international source for zidovudine-based HIV combination therapy.
What side effects should I watch for with Zidovir 300mg?
Monitor for: anaemia (fatigue, pallor, shortness of breath — FBC required), nausea (improves with food; anti-nausea medication if severe), headache, and myopathy (proximal muscle weakness, muscle pain after >12 months). Long-term: lipoatrophy (fat wasting in face, buttocks, limbs — cosmetically distressing; consider switching to TAF or ABC-based regimen), macrocytosis (common and harmless), and lactic acidosis (rare but serious — abdominal pain, shortness of breath, muscle weakness; stop AZT immediately and seek emergency care if suspected). Annual lipid, glucose, and renal function monitoring supports long-term safety management.
What lifestyle modifications help manage Zidovir 300mg side effects?
Managing AZT side effects: nausea — take with food, eat small frequent meals, avoid strong odours; keep well hydrated. Fatigue from anaemia — adequate rest, iron-rich diet (with haematology guidance on supplementation), erythropoietin for severe anaemia if continuing AZT is essential. Headache — paracetamol (avoid NSAIDs with HIV antiretrovirals if renal function is marginal). For myopathy risk — avoid vigorous exercise that stresses proximal muscles; report any unexplained muscle weakness promptly. For lipoatrophy prevention — switching to a tenofovir alafenamide or abacavir-based regimen at earliest opportunity is the most effective intervention.
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