SKU	754
Generic For	Floxin
Strength	400mg
Manufacturer	FDC
Active Ingredient	Ofloxacin

Product Description

Zo 400 mg (Ofloxacin) – Affordable Floxin Alternative

ZO 400 mg tablets contain Ofloxacin. It is a quinolone antibiotic, known for treating a wide variety of bacterial infections in many different parts of the body. However, this medicine will not work for colds, flu, or other virus infections.

What is ZO used for?

ZO 400 mg is an antibiotic, belongs to a quinolone family of medicines used in the treatment of the bacterial infections. This drug is indicated for the treatment of sinusitis, chest infections, urine infections, prostatis, anthrax or plague, kidney infections, ear and lung infection, gonorrhea and some skin infections.

How does ZO work?

ZO-400 mg is an antibiotic and its antibacterial activity resides primarily in the L-isomer. Norfloxacin and other fluoroquinolone antimicrobials works by inhibiting the bacteria IV and DNA gyrase enzymes which is an essential requirementfor DNA replication, transcription, repair and recombination. Thus, it kills the bacteria which are responsible for the infection. This way, it stops the growth of bacteria and cure infections.

What does ZO contain?

ZO 400 mg contains the active ingredient Ofloxacin, which is a quinolone antibiotic used to treat a wide variety of bacterial infections.

Effects of alcohol on ZO

ZO 400 mg tablets may cause dizziness and if it is taken with alcohol, the condition may get worsen. Therefore, it is safe to avoid alcohol consumption during the treatment with ZO.

Precautions

What medications interact with ZO?

Tell your doctor if you are consuming any other drugs, including prescription and non-prescription drugs, herbal supplements, and vitamins. Especially, tell your physician if you take:

Amiodarone
Antacids containing magnesium, calcium, or aluminum
Warfarin
Probenecid
Potassium citrate
Sodium citrate
Multivitamins
Cimetidine
Cyclosporine
NSAIDs such as ibuprofen
Amiodarone
Quinidine
Sotalol
Procainamide
Strontium
Acenocoumarol

Keep a list of medicines you take and show it to your physician every time you get a new medicine.

When should ZO not be used?

Do not take ZO 400 mg if:

You are suffering from glucose 6 phosphate deficiency
You have Myasthenia Gravis
You are pregnant or plan to get pregnant.
You have any kidney problem
You are allergic to any of the components in ZO 400 mg tablets.

Dosage Instructions

How should ZO be taken?

Take one ZO tablet every day. The medicine can be taken with or without food.
If you have taken overdose ZO tablets by mistake, contact your doctor immediately. Remember do not take any additional tablet until your doctor instructed you to do so.

Contact your doctor if you experience any health changes while taking this medicine.

How long should you take ZO?

Take ZO 400 mg exactly as prescribed by your physician. Keep taking the medicine for as long as your doctor prescribes it for you.

Missed dose of ZO?

If you miss the dose take it as soon as you remember, skip the missed dose if it is too late and take the next dose at the correct scheduled time. Never take two doses at one time.

How should ZO be stored?

Do not store it or any other medicine in the bathroom or near a sink.
Keep away from heat, moisture, and light.
Keep the medicine where children cannot reach.

Side Effects

What are the side effects of ZO 400mg?

ZO 400 mg may cause serious side effects including:

Heart disease. Patients who have a history of heart disease and who take ZOmay have a slight increase in heart problems, therefore it is advised to discuss your medical history with your doctor before taking ZO 200 mg.
Liver problems. The drug may cause inflammation of the liver. Your doctor may monitor you for mild to moderate liver problems.
Mental Disorder. If the patient is having a mental disorder, epilepsy problem or any other condition that cause fit, ZO may cause some serious side effect, therefore tell your doctor about your medical problem before taking this medication to avoid any unwanted side-effect.
Diabetes. This drug is not suitable for diabetes patients, it may cause serious changes in blood sugar. In this case, consult your doctor before taking this medicine.
Tendonitis. If the patient has ever experienced a problem of tendons, called tendonitis, it may cause serious side effect therefore, in this case you should inform your doctor about your medical history before starting up this medicament.

Common side effects that may occur while taking ZO 200 mg tablets include:

Vomiting
Diarrhea
Stomach upset, gas
Trouble in sleeping
Unusual tiredness
Constipation
Nausea
Headache
Fast or irregular heartbeat
Extra systole
Trouble breathing
Fast heart rate
Unusual weakness
Mood swings
Chest pain
Seizures
Abdominal or stomach pain
Cramping
Blood or mucus in your stool

How to Use

Infographics

FAQ

What is Zo 400mg used for?

Zo 400mg contains ofloxacin 400mg, a higher-strength fluoroquinolone antibiotic used to treat more serious bacterial infections. It is prescribed for complicated urinary tract infections, lower respiratory tract infections like pneumonia and severe bronchitis, skin infections, bone and joint infections, and sexually transmitted infections including gonorrhoea and pelvic inflammatory disease. The higher 400mg dose provides greater antibiotic levels in the body for tackling more resistant or difficult-to-reach infections.

When is the 400mg dose of ofloxacin needed instead of 200mg?

The 400mg dose is prescribed when the infection is more severe, affects deeper tissues, or involves bacteria that require higher antibiotic concentrations to be effectively killed. For example, pneumonia, complicated urinary infections, gonorrhoea, and bone infections typically require the 400mg twice-daily dose rather than the 200mg dose. Your doctor makes this decision based on your diagnosis, the likely bacteria involved, and how well your kidneys are working, as ofloxacin is cleared by the kidneys.

How should Zo 400mg be taken?

Take one Zo 400mg tablet twice daily (every 12 hours), with a full glass of water. It can be taken with or without food. Avoid taking antacids, iron tablets, calcium supplements, or dairy products within 2 hours of your dose, as these can reduce how well ofloxacin is absorbed into your body. Drink extra fluids throughout the day to help your kidneys flush the medicine through and reduce the risk of crystallisation in the urine, which is a rare but possible side effect.

How long is a typical course of Zo 400mg?

The length of treatment depends on the infection. Simple sexually transmitted infections like gonorrhoea may be treated in a single large dose. Chest infections typically require 5–10 days. Complicated urinary infections may need 7–14 days. Bone and joint infections may require several weeks. Always follow your doctor's prescribed duration exactly. If you feel better before finishing the course, do not stop — finishing the full course prevents bacteria from surviving and developing antibiotic resistance.

Is Zo 400mg effective against sexually transmitted infections?

Yes, ofloxacin 400mg is effective against certain sexually transmitted infections, including gonorrhoea (caused by Neisseria gonorrhoeae) and chlamydia (caused by Chlamydia trachomatis). However, gonorrhoea resistance to fluoroquinolones like ofloxacin has increased significantly in many countries, so local testing and antibiotic sensitivity results may be needed before treating gonorrhoea with ofloxacin. Your sexual health clinic or doctor will advise on the most effective current treatment based on local resistance patterns.

How does Zo 400mg compare to levofloxacin 500mg for chest infections?

Both ofloxacin 400mg twice daily and levofloxacin 500mg once daily are fluoroquinolone antibiotics effective for chest infections, including community-acquired pneumonia and bronchitis. Levofloxacin is the active half of ofloxacin and is often preferred because its once-daily dosing improves compliance. Levofloxacin also has stronger coverage against Streptococcus pneumoniae, a common cause of pneumonia. However, ofloxacin remains effective and is chosen in some clinical situations. Your doctor will choose based on your specific infection.

What should I do if I experience tendon pain while taking Zo 400mg?

Stop taking Zo 400mg immediately and contact your doctor if you notice pain, swelling, or tenderness in any tendon — particularly the large tendon at the back of your ankle (the Achilles tendon). Fluoroquinolone antibiotics can rarely cause tendon inflammation or even tendon rupture. The risk is higher in people over 60, those taking corticosteroids, and those with kidney problems. Resting the affected area and seeking prompt medical advice is very important if you experience any tendon symptoms.

Can Zo 400mg cause sensitivity to sunlight?

Yes, ofloxacin can increase your skin's sensitivity to sunlight, making you more likely to get sunburned faster than usual. While taking Zo 400mg, apply high-factor sunscreen (SPF 30 or above) when going outdoors, wear protective clothing and a hat, and avoid sunbeds or prolonged sun exposure. If you develop a skin rash, redness, or blistering after sun exposure while on ofloxacin, contact your doctor. This side effect is usually temporary and resolves once you finish the course.

What are the side effects of ofloxacin 400mg?

At the 400mg dose, ofloxacin side effects can include nausea, diarrhoea, stomach pain, dizziness, headache, and skin sensitivity to sunlight. Some people experience sleep disturbances or feel anxious. Rare but serious side effects include tendon pain or rupture, heart rhythm changes (QT prolongation), severe skin reactions, and in very rare cases, confusion or hallucinations. If you notice any unusual mental symptoms, heart palpitations, or severe skin reaction, seek medical help immediately.

Does ofloxacin interact with other medicines?

Yes, ofloxacin interacts with several medicines. Antacids, sucralfate, iron, calcium, and zinc supplements reduce its absorption — take these at least 2 hours apart. Ofloxacin can increase the effect of blood thinners like warfarin, raising the risk of bleeding. Combined with NSAIDs, it may increase the risk of seizures. It can also affect heart rhythm when taken with other QT-prolonging medicines. Always give your doctor or pharmacist a full list of everything you take before starting ofloxacin.

Can I buy Zo 400mg online from PremiumRxDrugs?

Yes, Zo 400mg (ofloxacin 400mg) is available at PremiumRxDrugs.com. PremiumRxDrugs is a licensed pharmacy with over 10 years of experience delivering genuine, manufacturer-sourced antibiotics to customers worldwide. We offer discreet packaging, international shipping, and free shipping on qualifying orders. All medicines are quality-verified for authenticity and efficacy, giving you peace of mind that you are receiving effective, reliable treatment for your infection.

What infections does ofloxacin 400mg NOT treat?

Ofloxacin is an antibiotic and has no effect on viral infections such as colds, flu, COVID-19, or most sore throats — using it for viruses is ineffective and contributes to antibiotic resistance. It also cannot treat fungal infections like thrush. Even for bacterial infections, not all bacteria respond to ofloxacin — some have developed resistance, particularly some strains of gonorrhoea. Your doctor may order culture tests to confirm the bacteria causing your infection and check that ofloxacin is the right antibiotic before prescribing it.

Zo 400 mg