Acamprol 333mg
| SKU | 2 |
|---|---|
| Generic For | Campral |
| Strength | 333mg |
| Active Ingredient | Acamprosate |
| Pack Size | Qty | Price Per Pill or Unit | Price | Cart | |
|---|---|---|---|---|---|
| 30 Tablet/s | US$ 0.48 | US$ 14.43 | |||
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| 60 Tablet/s | US$ 0.48 | US$ 28.88 | |||
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| 90 Tablet/s | US$ 0.48 | US$ 43.32 | |||
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Acamprol 333mg (Acamprosate) – Affordable Campral Alternative
Acamprol 333mg tablets contain Acamprosate calcium, a synthetic compound with a chemical structure similar to that of the endogenous amino acid homotaurine. Homotaurine is a structural analogue of the amino acid neuromodulator taurine and the amino acid neurotransmitter γ-aminobutyric acid. Acampral is a prescription drug to help those people who are dependent on alcohol. Acamprosate is the third drug after Naltrexone and Disulfiram, to get FDA approval for post-withdrawal maintenance of alcohol abstinence.
What is Acamprol 333 mg used for?
Acamrol 333 mg is used for the maintenance of abstinence from alcohol in patients with alcohol dependence who are abstinence at treatment initiation. Treatment with Acamprol should be part of a comprehensive management program that includes psychosocial support and counseling.
How does Acamprol work?
Acamprol 333 mg contains Acamprosate as an active ingredient. Acamprosate works by modulating or normalising the alcohol-disrupted brain activity in the GABA and glutamate neurotransmitter systems. Although Acamprosate’s mode of action has not been clearly established, it may work by reducing subacute withdrawal symptoms such as fatigue, anxiety, and insomnia.
What does Acamprol contain?
Each Acamprol tablet contains Acamprosate Calcium 333 mg, equivalent to 300 mg of Acamprosate. Acamprosate (calcium acetyl homotaurine) is a new prescription drug to help people who are alcohol dependent.
Effects of alcohol on Acamprol
Drinking alcohol while consuming Acamprol 333mg does not make you feel sick, however, do not drink alcohol at all during the treatment. Even if you drink a small quantity of alcohol while taking Acamprol, you run the risk of making your treatment fail, and you may end up drinking in large quantities.
What medications interact with Acamprol 333mg?
Acamrol 333 mg has not been shown to interfere significantly with other medicines. If you are presently taking a medicine, whether prescribed or non-prescribed, tell your doctor or pharmacist. Monitor Naltrexone closely.
It may not be the complete list of all interactions that may take place. Ask your doctor, if Acamprol may interact with other drugs that you take. Check with your doctor before you start, stop or change the dose of any drug.
When should Acamprol not be used?
You should not take Acamprol if you:
are previously demonstrated hypersensitivity to Acamprosate or to any of the other ingredients of Acamprosate 333 mg
have severe renal impairment
What are the side effects of Acamprol 333mg?
Like other medicine, Acamprol 333 mg can cause side effects, although not everyone gets them. The most common side effects of Acamprol include: diarrhea, itchiness, muscle weakness, intestinal cramps, nausea, vomiting, insomnia, anxiety, flatulence, dizziness, and dizziness, etc.
The less common, but serious side effects of Acamprol include:
- Change in the behaviour
- Self hurting
- Suicidal risk
If you experience any of the above side effects with Acamprol tablets, STOP taking the tablets and talk to your doctor immediately.
How should Acamprol be taken?
- Treatment with Acamprol 333mg should be started as soon as possible after the withdrawal period and should be maintained if the patient relapses.
- The tablets should be taken with food, and swallowed whole with water. Do not chew or crush the tablet.
- Based on the tolerance and clinical response, the daily dose is fixed according to body weight.
- The suggested dose for addicts who weigh 60 kg or more is two tablets taken thrice daily, in the morning, in the afternoon and at night.
- For addicts weighing less than 60 kg, the dose is two Acamprol tablets in the morning, one at midday, and one at night.
- Do not change your treatment regimen, unless your doctor advises you to do so.
- Take the medicine regularly to get the best results. To help you remember, take the tablets at the same time each day.
How long should you take Acamprol?
The recommended period of treatment is one year. Therefore, you need to keep taking the medicine for one year as per your doctor’s prescription. Discontinuation of Acamprol tablets may be considered once a patient has attained stable abstinence from alcohol, reports reduced craving, and has established a sound plan and support for ongoing recovery.
Missed dose of Acamprol?
- Do not double the dose to make up the forgotten one.
- If you forget to take a dose take it as soon as you remember and then take the next dose at the right time.
How should Acamprol be stored?
- Keep your Acamprol 333 mg tablets at 25°C. Do not freeze Acamprol tablets.
- Keep Acamprosate 333 mg tablets out of the reach of children.
- Do not use the medicine after the expiry date, which is mentioned on the packet after ‘EXP’.
What is Acamprol 333mg used for?
Acamprol 333mg contains acamprosate calcium 333mg — an anti-craving medication for alcohol use disorder (AUD). It is used to maintain alcohol abstinence in patients who have already achieved abstinence (detoxification) and are receiving concurrent psychosocial support. Acamprosate does not reduce withdrawal symptoms — it is started after detoxification is complete. Mechanism: acamprosate modulates glutamate and GABA neurotransmitter systems in the brain, which are disrupted by chronic alcohol use. It restores neurochemical balance in the reward and craving centres, reducing the unpleasant symptoms of post-acute withdrawal (anxiety, insomnia, restlessness, dysphoria) that drive relapse. It is most effective when combined with counselling, support groups, and behavioural therapy as part of a comprehensive AUD treatment programme.
How should Acamprol 333mg be taken for alcohol abstinence maintenance?
Take Acamprol 333mg as follows: standard dose — 666mg (two 333mg tablets) three times daily with meals (morning, midday, and evening). For patients <60kg: dose may be reduced to 333mg in the morning and 666mg at midday and evening. Start acamprosate as soon as alcohol detoxification is complete — ideally within a few days of achieving abstinence. Swallow tablets whole with water. Continue taking even if a relapse (drinking epiSodiume) occurs — acamprosate's benefit persists with continued therapy. Recommended treatment duration: at least 12 months; many guidelines recommend continuing for 1–2 years as relapse risk remains elevated. Take at consistent times each day for reliable blood levels. Renal dose adjustment is needed for reduced kidney function.
What is the difference between acamprosate and naltrexone for alcohol use disorder?
Acamprosate (Acamprol) and naltrexone are the two most evidence-based pharmacotherapies for alcohol use disorder maintenance. Acamprosate mechanism: modulates glutamate/GABA systems, reducing post-acute withdrawal dysphoria and craving. Naltrexone mechanism: opioid receptor antagonist — blocks alcohol's euphoric reward effect (reduces positive reinforcement of drinking). Key differences: acamprosate is most effective for maintaining abstinence in patients motivated to remain completely abstinent; naltrexone is more effective for reducing heavy drinking days and craving reduction — suitable for patients using a 'harm reduction' (reduced drinking) approach. Acamprosate requires normal kidney function (renally excreted — avoid in severe renal impairment); naltrexone requires normal liver function (hepatically metabolised — avoid in significant liver disease). Both are FDA-approved; choice depends on patient goals and organ function.
What drug interactions apply to Acamprol 333mg?
Acamprosate has minimal drug interactions — it is not significantly metabolised by CYP enzymes (eliminated renally unchanged) and has low protein binding. Alcohol: acamprosate does not cause a disulfiram-like reaction if alcohol is consumed — patients can continue treatment through relapses without adverse interaction (unlike disulfiram, which causes a severe reaction with alcohol). Tetracyclines and antacids: concomitant use of antacids containing aluminium, magnesium, or calcium may slightly reduce acamprosate absorption — separate by at least 2 hours. Naltrexone: can be combined with acamprosate (additive benefits in some studies); no pharmacokinetic interaction. No clinically significant interactions with common psychiatric medications (antidepressants, antipsychotics, benzodiazepines) used in AUD co-morbidity treatment.
Is Acamprol 333mg safe in patients with liver disease from alcoholism?
Acamprosate is safe in liver disease — unlike naltrexone (which is hepatotoxic and requires caution in liver disease). Acamprosate is excreted renally unchanged without significant hepatic metabolism — patients with alcoholic liver disease (common in AUD patients) can safely use acamprosate without dose adjustment based solely on liver impairment. Renal function is the critical consideration: acamprosate is renally cleared — dose reduction or avoidance is required in moderate-to-severe renal impairment (creatinine clearance <30ml/min). Before starting acamprosate: check renal function (eGFR/creatinine) alongside standard liver function assessment. This renal-clearance-without-hepatic-metabolism profile makes acamprosate the preferred pharmacotherapy when hepatic impairment is the concern.
Is Acamprol 333mg equivalent to Campral 333mg?
Yes. Acamprol 333mg and branded Campral EC 333mg both contain acamprosate calcium 333mg in equivalent enteric-coated tablet formulations. Acamprol is the generic alternative providing the same evidence-based alcohol abstinence maintenance therapy at significantly lower cost. PremiumRxDrugs.com stocks authentic manufacturer-sourced Acamprol 333mg verified for quality and bioequivalence.
Can I order Acamprol 333mg from PremiumRxDrugs for international delivery?
Yes. PremiumRxDrugs.com ships Acamprol 333mg to the USA, UK, Australia, and many other countries. Our genuine manufacturer-verified acamprosate tablets, competitive pricing, and free worldwide shipping on qualifying orders make us a reliable international source for alcohol abstinence medication.
What side effects does Acamprol 333mg cause?
Very common: diarrhoea (up to 30% of patients — the most common reason for discontinuation); nausea and abdominal discomfort. GI side effects are usually mild and diminish after the first 1–2 weeks. Other common effects: headache, flatulence, pruritus (itching — particularly on the skin). Psychiatric effects: depression, anxiety (may reflect underlying post-acute withdrawal rather than direct drug effect — monitor carefully). Suicidality: patients with AUD have elevated suicide risk regardless of medication — monitor for depression and suicidal ideation during treatment. Very rare: allergic reactions including anaphylaxis. Sexual dysfunction reported rarely. Acamprosate has no abuse potential, no withdrawal syndrome on stopping, and no known hepatotoxicity — a favourable safety profile for long-term use.
How effective is Acamprol 333mg for preventing alcohol relapse?
Clinical trial evidence: acamprosate approximately doubles abstinence rates compared to placebo over 12 months — from approximately 20–25% (placebo) to 40–45% (acamprosate + psychosocial support). Meta-analyses (Cochrane reviews) confirm acamprosate's efficacy for extending abstinence and reducing relapse risk. Predictors of better response: strong motivation to remain abstinent; concurrent psychosocial support (12-step programmes, CBT, motivational interviewing); good medication adherence; absence of significant psychiatric comorbidity. Effectiveness in practice: combination treatment (acamprosate + psychosocial support) consistently outperforms either treatment alone — medication is not a substitute for counselling and social support. Real-world abstinence rates are lower than clinical trial rates due to variable adherence.
Should Acamprol 333mg be continued during a relapse?
Yes — acamprosate should be continued even if the patient experiences a relapse (drinking epiSodiume) during treatment. This is a critical distinction from disulfiram (which causes severe adverse reactions with alcohol) and from medication discontinuation being equated with treatment failure. Rationale: acamprosate has no adverse interaction with alcohol — there is no safety concern in continuing during a relapse. A single relapse is expected in AUD treatment (approximately 70% of patients relapse at some point) and does not represent treatment failure — it is part of the recovery process. Stopping acamprosate at first relapse removes the pharmacological support precisely when it is needed most. Encourage the patient to recommit to abstinence, intensify psychosocial support, and continue acamprosate throughout the recovery journey.
Is Acamprol 333mg safe in pregnancy for women with alcohol use disorder?
Acamprosate is FDA Category C in pregnancy — animal studies show some developmental toxicity at high doses; human data is very limited. In pregnant women with AUD, the risks of continued alcohol use significantly outweigh the theoretical risks of acamprosate therapy. However: acamprosate is not the pharmacotherapy of choice for AUD in pregnancy — behavioural therapies, psychosocial support, and motivational interviewing are first-line. If pharmacotherapy is required, careful specialist assessment is needed. Naltrexone (also Category C) has similar pregnancy data limitations. For alcohol detoxification in pregnancy (acute withdrawal): benzodiazepines under medical supervision are used, then psychosocial approaches. Discuss risk-benefit of any pharmacotherapy for AUD with the obstetrician and addiction specialist.
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