Aciloc 300 mg
Available Dosages
| SKU | 871 |
|---|---|
| Generic For | Zantac |
| Strength | 300mg |
| Manufacturer | Candila |
| Active Ingredient | Ranitidine |
| Pack Size | Qty | Price Per Pill or Unit | Price | Cart | |
|---|---|---|---|---|---|
| 20 Tablet/s | US$ 0.22 | US$ 4.50 | |||
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| 40 Tablet/s | US$ 0.12 | US$ 5.0044%US$ 9.00 | |||
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| 60 Tablet/s | US$ 0.12 | US$ 7.0048%US$ 13.50 | |||
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| 100 Tablet/s | US$ 0.10 | US$ 10.0056%US$ 22.50 | |||
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Aciloc 300 mg (Ranitidine) – Affordable Zantac Alternative
What is Aciloc 300 mg used for?
Aciloc is formulated for:
-
- Short-term treatment of active duodenal ulcers and benign gastric ulcers
- Maintenance therapy for gastric and duodenal ulcers after healing active ulcers
- Zollinger-Ellison syndrome
- Treatment of erosive esophagitis
- Treatment of gastroesophageal reflux disease (GERD)
- Treatment of acid indigestion, heartburn, and sour stomach
Aciloc contains the active ingredient Ranitidine, which belongs to a class of drugs known as H2 blockers. The main ingredient acts to reduce the amount of acid produced by your stomach. The medicine can be purchased with a physician’s prescription. It reduces the pain associated with conditions such as Zollinger-Ellison syndrome, stomach ulcers, duodenal ulcers, heartburn, reflux, and scleroderma esophagitis.
Like other medicines, Aciloc has risks and benefits. Your physician has weighed the risks of you taking medicine against the benefits they expect it will have for you.
How does Aciloc work?
Aciloc works by inhibiting the action of histamine at the H2-receptor site located primarily in gastric parietal cells, which leads to inhibition of gastric acid secretion. In this way, it heals and prevents ulcers, decreases symptoms of gastrointestinal reflux as well as secretion of gastric acid.
What does Aciloc contain?
Aciloc for oral administration is supplied as 300 mg tablets. Each tablet contains 300 mg of the active component Ranitidine.
What medications interact with Aciloc?
- Aciloc may decrease absorption of itraconazole, atazanavir, gefitinib, ketoconazole, delavirdine.
- Concurrent use may increase absorption of glipizide and triazolam.
- Coadministration of Aciloc with warfarin may increase the effects of warfarin.
- The drug may also increase procainamide levels.
When should Aciloc not be used?
- Aciloc should not be used in patients who are allergic to any of the ingredients of the formulation.
Use it carefully in the following conditions:
- Phenylketonuric patients (effervescent tablets containing phenylalanine.
- Geriatric patients- These patients are more susceptible to central nervous system side effects including confusion and dizziness. The decrease in the dosage is recommended.
- Renal impairment- In patients with the kidney problem, increase dose interval is recommended.
- Acute porphyria
- Hepatic impairment
- Pregnancy
- Lactation- If passes into breast milk can cause decreased stomach acid in infants
How should Aciloc be used?
- Swallow the tablet with a glass of water. It does not matter whether you take it before or after consuming food.
- Those patients who are taking OTC formulations are advised not to consume the maximum dose continuously for more than two weeks without consulting physician. You should notify your physician if you experience trouble swallowing, or abdominal pain.
- It is to notify that smoking disrupts the mode of action of the medicine. Patients are advised to quit smoking.
- Patients taking Aciloc should avoid taking alcohol containing products, the excessive amount of caffeine, products containing aspirin or NSAIDs, and food products that cause an increase in gastrointestinal irritation.
- Increase your fluid and fiber intake to minimize the risk of constipation.
- Patients are advised to report onset of fever, diarrhea, sore throat, confusion, tarry stools, rash, dizziness, confusion, or hallucination.
How long should you use Aciloc?
If you are taking Aciloc to heal an ulcer then you may need to continue with it for 4 to 8 weeks. If consuming for reflux disease, keep taking it for up to three months. It is very important that you complete the full course prescribed by your physician. Once you will finish the course, your physician may want you to continue with the drug in order to stop the problem from occurring again.
Missed dose of Aciloc
If you forget to take it, skip the dose you missed dose and take your next scheduled dose. Talk to, your physician to know what to do further for the missed dose.
How should Aciloc be stored?
Keep the tablets in a cool, dry place. Do not place it near the bathroom or other wet places. Keep the medicine in its blister pack until it is time to take them.
What are the side effects of Aciloc?
- Muscle or joint pain
- Sexual problems
- Headache
- Blurred vision
- Abdominal pain
- Constipation
- Diarrhea
- Difficulty sleeping
- Feeling sick
- Depression
- Confusion
- Jaundice
- Fever
- Chills
- Bleeding or bruising more easily than normal
- Signs of frequent infections such as a sore throat, mouth ulcers
You may need urgent medical attention if any of these become serious or persist for a long time.
What is Aciloc 300 used for?
Aciloc is formulated for:
- Short-term treatment of active duodenal ulcers and benign gastric ulcers
- Maintenance therapy for gastric and duodenal ulcers after healing active ulcers
- Zollinger-Ellison syndrome
- Treatment of erosive esophagitis
- Treatment of gastroesophageal reflux disease (GERD)
- Treatment of acid indigestion, heartburn, and sour stomach
What is Aciloc 300mg used for?
Aciloc 300mg contains ranitidine 300mg — the double dose for more intensive acid suppression in conditions requiring stronger H2 receptor blockade. It is used for active peptic ulcers (especially as once-nightly dosing for duodenal ulcers), Zollinger-Ellison syndrome (higher doses), pathological hypersecretion, and short-term healing of moderate-severe GERD. The 300mg bedtime dose provides maximum overnight acid suppression when most ulcer-related damage and acid secretion occur.
How effective is Aciloc 300mg at night for ulcer healing?
Ranitidine 300mg taken once at bedtime achieves significantly greater overnight acid suppression than the 150mg dose — reducing nocturnal gastric pH to above 4 for 8–10 hours. This is clinically important because night-time acid production, when the stomach is empty, is responsible for most duodenal ulcer damage and pain. Clinical trials demonstrate that ranitidine 300mg once nightly achieves duodenal ulcer healing rates of 85–95% at 4 weeks and near 100% at 8 weeks — equivalent to twice-daily 150mg regimens.
When and how should Aciloc 300mg be taken?
For peptic ulcer treatment: one 300mg tablet at bedtime — typically 8–10pm. Bedtime dosing maximises overnight acid suppression during the 8-hour nocturnal peak acid secretion period. Can be taken with or without food. Swallow whole with water. For Zollinger-Ellison syndrome or higher-dose acid suppression needs: 300mg twice daily or as directed by your gastroenterologist. If symptoms are inadequately controlled at 300mg daily, discuss switching to a PPI with your physician.
How does Aciloc 300mg bedtime dose compare to morning dosing?
For peptic ulcer treatment, bedtime dosing of 300mg is superior to morning dosing of the same dose. Basal acid secretion is highest during the night (10pm–2am), and the stomach is empty — acid directly contacts the ulcer base without food buffering. Once-nightly 300mg provides maximum protection during this vulnerable period. Morning dosing primarily covers daytime meal-stimulated acid. Both bedtime and split-dose regimens are clinically effective; once-nightly dosing improves adherence with equivalent healing outcomes.
Is Aciloc 300mg safe for patients with renal impairment?
Ranitidine is primarily renally excreted. In moderate renal impairment (eGFR 20–50 ml/min), the dose should be reduced to 150mg once daily at bedtime — not 300mg. In severe renal impairment, further dose reduction or alternative medications are recommended. Elderly patients with reduced renal function on 300mg are at higher risk of neurological side effects (confusion, delirium). Always check eGFR before initiating ranitidine in elderly patients and adjust dose accordingly.
Why might a PPI be more appropriate than Aciloc 300mg?
PPIs (pantoprazole, omeprazole, lansoprazole) provide superior acid suppression (90%+ over 24 hours) compared to ranitidine 300mg (70–80% overnight, with daytime gaps). For healing of erosive oesophagitis or severe peptic ulcers, PPIs achieve higher healing rates faster. The 2020 NDMA ranitidine recall reinforced the shift toward PPIs and famotidine as preferred acid-suppression options. Where ranitidine remains available, Aciloc 300mg remains effective for ulcer healing; PPIs are simply more potent options.
How does Aciloc 300mg compare to famotidine 40mg for ulcer treatment?
Ranitidine 300mg and famotidine 40mg are both H2 antagonists used for peptic ulcer treatment, but they are not directly equivalent on a milligram basis. Famotidine is 6–8 times more potent than ranitidine per milligram. Famotidine 40mg nightly provides acid suppression comparable to ranitidine 300mg nightly. Famotidine has fewer drug interactions (ranitidine inhibits CYP enzymes; famotidine does not). Following NDMA concerns with ranitidine, famotidine 40mg is now the preferred H2 antagonist for ulcer treatment where ranitidine is unavailable.
Is Aciloc 300mg the same as Zantac 300mg?
Yes. Aciloc 300mg contains ranitidine 300mg — the same active ingredient and dose as branded Zantac 300mg. Both provide identical H2 receptor antagonism. As noted, Zantac was withdrawn from US and EU markets in 2020 due to NDMA contamination. Aciloc 300mg availability varies by market and regulatory status. Check current local regulations and NDMA testing certification before purchasing ranitidine products.
Can I order Aciloc 300mg from PremiumRxDrugs with international shipping?
PremiumRxDrugs.com ships internationally to the USA, UK, Australia, and many countries worldwide. Our licensed pharmacy model, over a decade of trusted service, competitive pricing, and free worldwide shipping on qualifying orders make us a dependable source for verified medications. For ranitidine products, please confirm current availability and regulatory status for your country before ordering.
What side effects does Aciloc 300mg cause?
Side effects at 300mg are similar to but potentially more pronounced than at 150mg. Headache, dizziness, and GI symptoms (constipation, diarrhoea) are most common. Neurological effects (confusion, hallucinations) are more likely in elderly patients with renal impairment at the higher dose. Rare: thrombocytopenia, hepatitis, bradycardia. Drug interactions with warfarin, procainamide, and triazolam require monitoring. The main safety concern is NDMA contamination with long-term storage or improper conditions.
What precautions are important with Aciloc 300mg?
Reduce dose to 150mg in renal impairment. Monitor elderly for confusion. Check for drug interactions, particularly warfarin — ranitidine inhibits CYP enzymes and can increase INR. Store at room temperature away from heat and humidity (to minimise NDMA formation). Verify NDMA testing certification for the batch. Do not use to suppress undiagnosed upper GI symptoms without endoscopic investigation in patients over 55 with alarm features. Switch to famotidine or a PPI if ranitidine is unavailable or concern about NDMA exists.
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