Erlonat 100mg (Erlotinib)
Erlonat is formulated for the treatment of non-small cell lung cancer (NSCLC) that has spread to surrounding tissues or other parts of the body. It is also useful in treating metastatic pancreatic cancer. The medicine has the active component Erlotinib, which is a member of a class of targeted anticancer drugs. It is an FDA-approved drug for the treatment of NSCLC after the failure of at least one prior chemotherapy regimen and is the first such drug to demonstrate an increase in survival in patients with advanced NSCLC.
What is Erlonat used for?
Erlonat is useful in:
- First line therapy of metastatic NSCLC
- Maintenance treatment of locally advanced and metastatic NSCLC when the disease has not progressed after four cycles of platinum based first line chemotherapy
- Locally advanced and metastatic NSCLC that has not responded to ≥ one previous chemotherapy regimen.
- First line therapy for locally advanced, surgically unresectable, or metastatic pancreatic cancer.
How does Erlonat work?
Erlonat works by inhibiting the enzyme tyrosine kinase, which is associated with human epidermal growth factor receptor (EGFR). It blocks the growth stimulation signals in cancer cells and decreases spread of lung or pancreatic cancer with increased survival.
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What does Erlonat contain?
Erlonat contains Erlotinib as the main active ingredient. Each tablet delivers 100 mg of the active component.
What are the side effects of Erlonat?
- Respiratory system disorders- interstitial lung disease, cough, dyspnea
- Cardiovascular system disorders- myocardial infarction and ischemia
- Dermatological issues- dry skin, rash, bullous an exfoliative skin disorders, and pruritus
- Hematological issues- microangiopathic hemolytic anemia with thrombocytopenia
- Central nervous system disorders- fatigue, cerebrovascular accident
- EENT- corneal ulceration, conjunctivitis, corneal perforation
- Genitouetrine disorders- renal failure
- Gastrointestinal issues- diarrhea, anorexia, hepatotoxicity, stomatitis, increased liver enzymes, nausea, vomiting, gastrointestinal perforation, and abdominal pain
What medications interact with Erlonat?
- Drugs such as clarithromycin, nefazodone, indinavir, atazanavir, voriconazole, ketoconazole, ritonavir, telithromycin, itraconazole, and saquinavir increase levels and the risk of toxicity. In this case, dose reduction is considered.
- Drugs such as rifabutin, phenytoin, phenobarbital, rifampin, rifapentine, and carbamazepine decreases levels and may decrease response. In this case, alternative therapy or increase dose should be considered.
- Concurrent use with ciprofloxacin may increase levels and risk of toxicity.
- Erlonat may decrease midazolam.
- Bleeding may occur if used along with warfarin.
- Avoid concurrent use of proton inhibitors and H2 blockers.
When should Erlonat not be used?
Erlonat is contraindicated in pregnant women and lactating women.
Use it with caution in the following conditions:
- Hepatic impairment
- Metastatic lung disease
- Pre-existing disease
- Pediatric patients
- Patients with child bearing potential
How should Erlonat be used?
- For adults, the recommended dose for the treatment of NSCLC is 150 mg daily. Take it one hour before or two hours after consuming food.
- 100 mg once daily is the recommended dose for the treatment of pancreatic cancer.
- Patients should be assessed for respiratory function periodically during the treatment. Discontinue Erlonat, if cough, dyspnea, or fever occurs.
- Patients are instructed to exercise caution while use highly effective contraceptive during and for at least two weeks after completion of treatment. Female patients are advised to inform their health care professional if pregnancy is planned or suspected.
- Patients are instructed to discontinue smoking during the treatment. Smoking decreases blood levels of Erlotinib.
- Patients are advised to wear sunscreen and protective clothing to decrease skin reaction.
- Patients are advised to notify health care specialist if severe, persistent, anorexia, diarrhea, vomiting, onset of worsening of skin rash, cough, unexplained dyspnea, and nausea may occur.
How long should Erlonat be used?
The duration of treatment with Erlonat varies, depending on your condition and your individual response to the treatment. Keep taking the medicine until your health care specialist tells you to stop.
Missed dose of Augmentin
Do not take an extra dose of Erlonat 100 mg. Wait until the next scheduled dose and take your normal dose then. Don’t try to make up for the missed dose by taking extra doses at a time. If you are not sure what to do, ask your health care professional.
How should Erlonat be stored?
- Keep your tablets in its original pack until it is time to take them out.
- Keep it in a cool, dry place, at controlled room temperature.
- Do not place it in the bathroom or near a sink. Keep it away from wet places.
- Keep the medicine where children and pets cannot reach.