Istavel 100mg
Available Dosages
| SKU | 1012 |
|---|---|
| Generic For | Januvia |
| Strength | 100mg |
| Manufacturer | Sun Pharma |
| Active Ingredient | Sitagliptin |
| Pack Size | Qty | Price Per Pill or Unit | Price | Cart | |
|---|---|---|---|---|---|
| 50 Tablet/s | US$ 0.70 | US$ 35.00 | |||
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| 100 Tablet/s | US$ 0.65 | US$ 65.007%US$ 70.00 | |||
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Istavel 100mg – Affordable Januvia Alternative for Type 2 Diabetes
Istavel 100mg tablet is an oral diabetes medicine that helps you control blood sugar levels. This medicine can regulate the levels of insulin that your body generates after a meal. Istavel is prescribed only to the people with type-2 diabetes. This medicine can be used alone or in combination with certain other medicines like insulin, metformin, sulphonylureas, and glitazones. Sitagliptin is an active ingredient of of the medicine that can increase the levels of insulin in the body.
What is Istavel 100mg used for?
Istavel 100mg is a dipeptidyl peptidase-4 inhibitor, which is used as an adjunct to diet and exercise to improve glycemic control in adults with type-2 diabetes mellitus. This medicine can be used alone as well as in combination with certain other medicines as prescribed by your doctor.
How does Istavel 100mg work?
Sitagliptin, an active ingredient of Istavel 100mg, is an anti-diabetic drug that works by increasing levels of natural substances called incretins. These substances help to control blood sugar by increasing insulin release. Insulin is a very crucial hormone that helps to control the levels of sugar in your blood. In this way, Sitagliptin can decrease the amount of sugar that your liver makes. It also reduces the amount of a substance called glucagon that pancreas produces.
What are the medications interact with Istavel?
Istavel may interact with digoxin, probenecid, non-steroidal anti-inflammatory drugs (NSAIDs), aspirin or other salicylates, sulfa drugs, monoamine oxidase inhibitors (MAOIs), or beta-blockers. There was a slight increase in the area under the curve and mean peak drug concentration of digoxin when it’s administered along with Istavel.
The clinical studies find that Sitagliptin does not meaningfully alter the pharmacokinetics of metformin, glyburide, simvastatin, rosiglitazone, warfarin, sulfonylureas, thiazolidinediones or oral contraceptives. Patients receiving digoxin should be monitored appropriately. No dosage adjustment of digoxin or ISTAVEL is recommended. Clinical data also suggest that Sitagliptin is not susceptible to clinically meaningful interactions with coadministered medications.
When should Istavel not be used?
There are some cases of inflammation of the pancreas (pancreatitis) in patients taking Istavel. To achieve a better result from Istavel medicine, you have to follow some precautions as:
- Leave alcohol as it can increase the levels of triglycerides in the blood
- Be careful if you have any past or present kidney problems
- Tell your doctor about any allergic reactions to Sitagliptin
- Low blood sugar may occur when taking this medicine in combination with a sulphonylurea medicine
- Severe and disabling arthralgia has been reported in patients taking DPP-4 inhibitors, so discontinue medication if appropriate
- Assessment of renal function is recommended prior to taking this medicine and periodically thereafter.
What are the side effects of Istavel 100mg?
The consumers of Istavel drug may experience its side effects such as:
- Hives
- Fast heart rate
- Vomiting
- Difficulty breathing
- Loss of appetite
- Swelling of face, lips, tongue, or throat
- Weight gain
- Less urine release
- Nausea
Some other side effects may include pancreatitis (a severe pain in upper stomach spreading to your back), skin pain, rash, burn feeling in the eyes, headache, muscle pain, etc. You have to stop taking Istavel and tell your doctor right away if you are experiencing allergic reactions to Sitagliptin.
How should Istavel be taken?
The recommended dose of Istavel 100mg is once daily. You can take it with or without food. For patients with moderate renal insufficiency, the dose of Istavel is 50 mg once a day is sufficient.
How long should you take Istavel?
Continue using Istavel 100mg tablet for as long as your physician recommends you to.
Missed dose of Istavel?
If you have missed a dose of Istavel 100mg then take it as soon as possible, but, don’t make it double to make up the damage due to the skipped dose.
How should Istavel be stored?
Store this medicine at room temperature. Keep it away from heat and moisture, and don’t take it if its date has been expired.
What is Istavel 100mg used for?
Istavel 100mg contains sitagliptin 100mg — the standard therapeutic dose of this DPP-4 inhibitor for adults with normal or mildly reduced renal function (eGFR ≥50 ml/min). It is indicated for type 2 diabetes as monotherapy when metformin is contraindicated or not tolerated, or in combination with metformin, sulfonylureas, TZDs, or insulin. It improves HbA1c by 0.5–1.0% as monotherapy, or 0.7–1.5% in combination, without causing hypoglycaemia or weight gain.
How does sitagliptin 100mg work to improve type 2 diabetes control?
Sitagliptin 100mg inhibits DPP-4 by approximately 90%, prolonging the action of GLP-1 and GIP incretin hormones throughout the day. This amplifies glucose-dependent insulin secretion after each meal and suppresses inappropriate glucagon release. The result is improved post-prandial glucose control. Unlike GLP-1 receptor agonists (which are injected), sitagliptin works by preserving endogenous hormones — producing more modest but well-tolerated blood glucose lowering via an oral, once-daily tablet.
When and how should Istavel 100mg be taken?
Istavel 100mg is taken once daily, at any time of day, with or without food. The flexibility in timing is an advantage for patients with variable schedules. Once-daily dosing improves adherence compared to twice-daily agents. Set a daily reminder to ensure consistent dosing. If a dose is missed, take it the same day when remembered; if the next day has arrived, skip the missed dose and take the next one at the regular time. Never take two 100mg doses in the same day.
How long does Istavel 100mg take to lower HbA1c significantly?
Sitagliptin begins reducing post-prandial blood glucose within the first week of use. HbA1c improvement is fully assessable at 3 months. As monotherapy, sitagliptin 100mg typically reduces HbA1c by 0.5–1.0% over 3–6 months. In combination with metformin, the additional reduction is 0.7–1.0% above metformin alone. Patients with higher baseline HbA1c (>9%) see greater absolute reductions. HbA1c is reassessed every 3 months when adjusting therapy and every 6 months once stable.
Is Istavel 100mg safe to use long-term?
Sitagliptin 100mg has a well-established long-term safety profile backed by the TECOS cardiovascular outcomes trial (over 14,000 patients, median 3 years of follow-up) showing non-inferiority to placebo for cardiovascular events. Long-term users should be aware of rare late-onset side effects: bullous pemphigoid (blistering skin condition, reported in post-marketing data) and arthralgia (joint pain, sometimes severe). If joint pain develops, inform your doctor as sitagliptin may need to be discontinued.
Who should not use Istavel 100mg?
Istavel 100mg (full dose) is contraindicated in patients with eGFR <50 ml/min (use 50mg or 25mg instead), type 1 diabetes, DKA, and known hypersensitivity to sitagliptin. Prior history of pancreatitis is a relative contraindication — use with caution and patient counselling. Pregnancy and breastfeeding are not recommended. Heart failure is not a contraindication based on TECOS data, but patients with severe cardiac disease should be reviewed by their cardiologist.
How does Istavel 100mg compare to empagliflozin 10mg for type 2 diabetes?
Both are second-line diabetes agents with good tolerability profiles and minimal hypoglycaemia risk. Sitagliptin (Istavel): oral, once daily, weight-neutral, glucose-dependent mechanism, safe in CKD. Empagliflozin (Jardiance): oral, once daily, causes weight loss and blood pressure reduction, demonstrated cardiovascular and renal protection in high-risk patients (EMPA-REG OUTCOME trial), but causes genital mycotic infections and is not used in severe CKD. For patients with established cardiovascular disease or CKD progression risk, empagliflozin or other SGLT2 inhibitors are increasingly favoured. Otherwise, sitagliptin is well-validated.
Is Istavel 100mg the same as Januvia 100mg?
Yes. Istavel 100mg contains the same active ingredient — sitagliptin 100mg — as branded Januvia 100mg. Both are manufactured to bioequivalence standards with identical DPP-4 inhibition, HbA1c reduction, and safety profiles. Istavel is the generic formulation providing the same therapeutic quality as Januvia at a substantially lower cost, making this effective, well-tolerated diabetes medication more accessible.
Can I order Istavel 100mg from PremiumRxDrugs for delivery to Australia?
Yes. PremiumRxDrugs.com ships Istavel 100mg to Australia, the USA, UK, and many other countries. Their genuine manufacturer-verified medicines, competitive pricing, and free worldwide shipping on qualifying orders make them a trusted international pharmacy for patients managing type 2 diabetes with sitagliptin.
What are the common side effects of Istavel 100mg?
Most common: nasopharyngitis (stuffy or runny nose), upper respiratory tract infections, headache, and GI discomfort. Urinary tract infections and genital infections occur slightly more frequently than with placebo. Arthralgia (joint pain) is an uncommon but well-documented effect — can be severe and persist after stopping the drug. Rare serious events: pancreatitis, severe allergic reactions (anaphylaxis, facial swelling — stop immediately), and bullous pemphigoid. Sitagliptin does not cause hypoglycaemia as monotherapy.
What precautions apply to Istavel 100mg users?
Check eGFR before and annually during treatment — reduce dose if renal function declines. Report any severe abdominal pain immediately. Report new blistering or raw skin areas. Report persistent joint pain. Stay alert for urinary tract infection symptoms (burning, urgency, fever) and treat promptly. When combining with insulin or sulfonylureas, monitor blood glucose more frequently. Inform all healthcare providers of sitagliptin use before adding new diabetes or cardiovascular medications.
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