Retino AC Gel
Available Dosages
| Description | Clindamycin and Tretinoin Gel |
|---|---|
| SKU | 255 |
| Generic For | Velac |
| Strength | 0.025% + 1% (15 gm) |
| Manufacturer | Johnson & Johnson |
| Active Ingredient | Clindamycin and Tretinoin |
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Retino AC Gel – Affordable Velac Alternative for Acne Treatment
Retino AC Gel (Clindamycin and Tretinoin )
Retino AC gel is a gel formulation combining Tretinoin 0.025% and Clindamycin 1%. It is licensed for the treatment of acne vulgaris when blackheads, pustules, and papules are present in patients aged at least 12.The medicine combines the antibiotic and anti-inflammatory effects of Tretinoin and Clindamycin. Tretinoin is a first generation topical retinoid, which regulates the cell growth and regenerates the outer layer of the skin.
Clindamycin is an antibiotic agent useful for the treatment of the number of bacterial infections. It is used to treat acne vulgaris, which typically leads to suppression of cutaneous Propionibacterium acnes (a gram-positive human skin commensal that is involved in the pathogenesis of acne.
What is Retino AC 15g used for?
Retino AC is lincosamide and retinoid combination drug indicated for the topical application in the treatment of acne in patients 12 years and older. Acne vulgaris is characterized by areas of pimples, whiteheads, blackheads, and greasy skin, and may result in scarring. It occurs when the skin pores become clogged with dead skin cells and oil from the skin.
How does Retino AC 15g work?
Retino AC comprises of two active ingredients Tretinoin and Clindamycin. Clindamycin is a semisynthetic derivative of lincomycin reveals potent activity against gram-negative and gram-positive bacterial infections. The drug inhibits bacterial protein synthesis, thereby stopping bacterial growth.
Another active pharmaceutical ingredient Tretinoin, being a metabolite of retinol, is both structurally and pharmacologically related to vitamin A, which regulates the cell growth and regenerates the outer layer of the skin. It makes the surface layer of the skin thinner and pores less likely to become blocked, reducing the occurrence of blackheads, whiteheads, and pimples.
What are the different doses of Retino AC 15g?
Retino AC Gel is available to purchase online from premiumrxdrugs.com in 15g strength. Buy Retino AC 15g online far cheaper than other local pharmacies.
What does Retino AC 15g contain?
Retino AC contains two active ingredients Clindamycin and Tretinoin. Each 15g tube contains o.o25% of Tretinoin and 1% of Clindamycin.
What are the side effects of Retino AC 15g?
The reported side effects are typical of the component drugs and included mild erythema, itching, burning, and stinging with a severity similar to that of comparator medicines; the severity of scaling was between that of Clindamycin and Tretinoin.
Other side effects not mentioned in this medication guide may occur in some patients. Inform your physician if you observe anything that is making you feel unwell.
What medications interact with Retino AC 15g?
- You should not use Retino AC if you are using another antibiotic called erythromycin, or using other skin medications that contain erythromycin.
- Keep a list of all your topical agents and give to your physician. Also, do not start new prescription, herbals products, over-the-counter medicines, and dietary supplements without telling your physician.
When should Retino AC 15g not be used?
- Retino AC is contraindicated in patients with known hypersensitivity to preparations containing Clindamycin, Tretinoin or other ingredients present in this formulation.
- It should not be used by patients with regional enteritis, ulcerative colitis, or a history of antibiotic-associated colitis.
- The drug is not recommended for use in patients with a family history of cancer, a history of acute eczemas, perioral dermatitis, and rosacea or deep cystic nodular acne.
- Also, the gel should not be used during pregnancy.
How should Retino AC 15g be used?
- The recommended dose of Retino AC is one pea-sized amount applied evenly to the face or the affected areas once daily at bedtime. No dose adjustment is recommended for age or impaired clearance.
- Before using Retino AC gel, wash the entire face with a mild soap and warm water. Apply a thin layer directly to each acne lesions or to affected areas. Rub it well into the skin.
- It should not be applied to the eyes, eyelids, nostrils, and lips. Remember, your hands should be washed after application.
- Patients treated with Retino AC gel acne treatment may use cosmetics, but the affected area to be treated should be cleansed thoroughly before the medicine is applied.
- Consult your physician immediately the moment you realize that high quantity of Retino AC gel has been used.
How long should you use Retino AC 15g?
A clinical therapeutic response may not be apparent for several weeks; continuous use of Retino AC should not exceed twelve weeks without careful evaluation.
Missed dose of Retino AC 15g?
Always remember to use Retino AC on time. If you miss a dose, then use it as soon as you remember.
How should Retino AC 15g be stored?
- The contents of Retino AC gel are flammable, keep the medicine away from heat and flame
- Store the gel at room temperature. Do not freeze it
- Keep it out of the reach of children and away from pets
What is Retino AC Gel used for?
Retino AC Gel contains clindamycin phosphate 1% and tretinoin 0.025% — a fixed-dose combination topical gel for acne vulgaris. It combines two complementary mechanisms: clindamycin inhibits P. acnes bacteria (the primary acne-causing bacterium) by blocking bacterial protein synthesis, reducing inflammation; tretinoin normalises follicular keratinocyte turnover, prevents comedone formation, and expels existing microcomedones. Together they address all three primary pathological factors in acne: bacterial overgrowth, follicular hyperkeratinisation, and comedone formation. Indicated for mild-to-moderate acne vulgaris including both comedonal and inflammatory subtypes — particularly effective for mixed acne where comedones and pustules coexist.
How should Retino AC Gel be applied for acne?
Apply Retino AC Gel once daily in the evening to the entire acne-prone area after gentle cleansing and thorough drying (wait 20–30 minutes — applying retinoids to damp skin increases irritation). Use a pea-sized amount for the entire face. Avoid eyes, nostrils, lips, and corners of the mouth. As this is a combination gel with tretinoin: apply strictly in the evening as tretinoin is photodegraded by UV. Apply SPF 30+ sunscreen every morning throughout treatment. Begin with every-other-night application for the first 2 weeks if skin is sensitive or retinoid-naive before progressing to nightly use. Expect a purging phase (temporary acne worsening) in the first 4–8 weeks as tretinoin expels microcomedones.
What is the advantage of Retino AC Gel over separate clindamycin and tretinoin applications?
Retino AC Gel's fixed-dose combination offers several advantages over separate application of clindamycin 1% gel and tretinoin 0.025% cream: (1) convenience — one evening application replaces two separate products; (2) potentially reduced antibiotic resistance — tretinoin's comedolytic action complements clindamycin's antibacterial effect, reducing selective pressure that drives resistance; (3) cost savings vs. purchasing two separate products; (4) optimised vehicle — the single formulation is designed for simultaneous stability of both actives. Disadvantage: less flexibility — separate products allow independent adjustment of each component's concentration. The combination is particularly valuable for patients with mixed comedonal and inflammatory acne where both mechanisms are needed simultaneously.
Is Retino AC Gel safe in pregnancy?
Retino AC Gel is contraindicated in pregnancy due to the tretinoin component — all topical retinoids are avoided in pregnancy. The clindamycin component (Category B) is safe in pregnancy and may be used as monotherapy (Clindac A gel) for acne management during pregnancy if needed. Women of childbearing potential should use reliable contraception while using Retino AC Gel. If pregnancy is confirmed while using this combination gel, stop immediately and consult an obstetrician. For acne management during pregnancy: switch to plain clindamycin 1% gel (topical antibiotic — safe) combined with azelaic acid cream (Category B — safe). Do not use during breastfeeding without medical guidance due to the tretinoin component.
What drug interactions apply to Retino AC Gel?
Local interactions: do not use benzoyl peroxide simultaneously with Retino AC Gel — benzoyl peroxide oxidises tretinoin (use benzoyl peroxide in the morning only if needed). Avoid other topical retinoids concurrently. Avoid alcohol-based toners, astringents, and abrasive scrubs — these increase tretinoin irritation. Clindamycin component: topical clindamycin and erythromycin antagonise each other — do not use Retino AC Gel alongside any topical or oral erythromycin. The tretinoin component causes photosensitisation — strict morning SPF 30+ sunscreen is mandatory. Systemic drug interactions are not expected given minimal systemic absorption of both components from topical application.
How long should topical clindamycin (in Retino AC) be used before considering antibiotic resistance?
Topical clindamycin should be limited to 3–6 months of continuous use to minimise the risk of P. acnes antibiotic resistance. After 3–6 months: reassess response. If acne is controlled: transition to tretinoin monotherapy (without clindamycin) for maintenance — this avoids ongoing antibiotic use while maintaining comedolytic benefit. If significant acne persists: consider adding oral antibiotics (doxycycline) under medical supervision or refer for isotretinoin evaluation for severe/persistent cases. Combination with tretinoin (as in Retino AC) reduces (but does not eliminate) resistance risk compared to topical antibiotic monotherapy. Do not use Retino AC Gel indefinitely as a long-term maintenance product — transition to tretinoin-only maintenance after clearing.
Is Retino AC Gel equivalent to Veltin or Ziana Gel?
Yes. Retino AC Gel (clindamycin 1% + tretinoin 0.025%) is equivalent in composition to branded Veltin Gel (USA) and Ziana Gel — all contain the same active ingredients at the same concentrations. Retino AC is the generic/equivalent alternative providing the same combination acne therapy at significantly lower cost. PremiumRxDrugs.com stocks authentic manufacturer-sourced Retino AC Gel verified for quality and therapeutic equivalence.
Can I order Retino AC Gel from PremiumRxDrugs for international delivery?
Yes. PremiumRxDrugs.com ships Retino AC Gel to the USA, UK, Australia, and many other countries. Our genuine manufacturer-verified combination acne gel, competitive pricing, and free worldwide shipping on qualifying orders make us a reliable international source for clindamycin-tretinoin combination therapy.
What side effects does Retino AC Gel cause?
Tretinoin component effects: skin dryness and peeling; erythema (redness); purging (initial acne worsening — 4–8 weeks); photosensitisation (increased sunburn susceptibility). Clindamycin component effects: mild local irritation; very rare cases of contact dermatitis; systemic absorption is negligible from topical application (oral clindamycin's GI side effects do not apply). Combination effects: cumulative dryness and irritation from both active components — manage with gentle ceramide moisturiser and ensure skin is dry before application. Severe skin reactions (blistering, severe burning) are uncommon — if they occur, stop and seek medical review. Rare: folliculitis or acneiform eruption from clindamycin.
When should a patient on Retino AC Gel be referred for isotretinoin consideration?
Consider isotretinoin referral (dermatologist) when: (1) acne is severe (nodular/cystic — large painful lesions >5mm); (2) acne is causing significant scarring despite 3–4 months of Retino AC + oral antibiotic combination therapy; (3) acne is significantly affecting quality of life (depression, social withdrawal, severe self-esteem impact); (4) repeated courses of antibiotics with recurrence after stopping; (5) acne localised to the back/chest covering large areas not adequately treated topically. Isotretinoin (oral) is the most effective acne treatment available — achieving prolonged remission in 85% of patients after a single course. It requires specialist initiation, mandatory pregnancy prevention in women, and regular monitoring (LFTs, lipids) but provides outcomes that topical treatments cannot match for severe disease.
How should Retino AC Gel be stored?
Store Retino AC Gel at room temperature (15–25°C) away from direct sunlight, UV light, and heat — both tretinoin (light-sensitive) and clindamycin require stable conditions for potency. Do not freeze. Keep the tube tightly capped when not in use to prevent oxidation of tretinoin and evaporation. Keep out of reach of children. Check the expiry date before use. An opened tube should be used within 12 months (per product label). If the gel yellows significantly or develops an unusual odour, replace with a fresh tube. The alcohol-based gel vehicle is flammable — keep away from open flames. Store upright to prevent any gel settling or separation.
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