Sebifin 250mg
Available Dosages
| SKU | 1093 |
|---|---|
| Generic For | Lamisil |
| Strength | 250mg |
| Manufacturer | Sun Pharma Medisales Pvt Ltd. |
| Active Ingredient | Terbinafine HCl |
| Pack Size | Qty | Price Per Pill or Unit | Price | Cart | |
|---|---|---|---|---|---|
| 30 Tablet/s | US$ 1.00 | US$ 30.03 | |||
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| 60 Tablet/s | US$ 0.99 | US$ 59.46 | |||
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| 90 Tablet/s | US$ 1.08 | US$ 97.30 | |||
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Sebifin 250mg – Affordable Lamisil Alternative for Nail & Skin Fungus
Sebifin 250 mg is a prescription for treating fungal infections of the fingernails and toenails, ringworm infections of the groin and body, and athlete’s foot. It effectively treats fungal skin infections that do not respond to the topical treatment. It contains the active component Terbinafine, which belongs to a class of drugs known as antifungals. Terbinafine interferes with the production of a substance called ergosterol, which the fungus requires to grow, and causes a build-up of another substance in the cells. These actions ultimately destroy the fungus and eliminate the infection.
Precautions (warning, allergy, things to remember)
Sebifin 250 is contraindicated in patients with a known hypersensitivity to Terbinafine or any of the ingredients in the medicine. It should also not be given to individuals with chronic or active hepatic disease.
Before you use Sebifin 250 mg, speak to your healthcare provider if you
- Are allergic to Terbinafine
- Are you pregnant or trying to become pregnant while using Terbinafine
- Are breastfeeding, Terbinafine is excreted in breast milk
- Have blood disorders with symptoms such as weakness, bruising, unusual bleeding, sore throat, and frequent infections.
Sebifin 250 mg can cause serious unwanted effects, which include liver problems, ultimately leading to the need for a liver transplant or death.
Inform your healthcare provider if you get symptoms of liver problems, which include nausea, tiredness, poor appetite, vomiting, dark urine, upper right stomach, pale or light-colored stools, or yellowing of skin or eyes.
Change in taste or loss of taste may occur with Sebifin 250 mg. This usually improves within several weeks after Terbinafine discontinuation but may last longer or become permanent.
Depressive symptoms - The symptoms include loss of energy or interest in daily activities, feeling sad or worthless, a change in sleep pattern, mood changes, and restlessness.
Serious allergic reactions include hives, skin rash, blisters, skin peeling, and swelling of the face, lips, eyes, tongue, and throat.
New or worsening of an autoimmune disease, lupus. Discontinue treatment and tell your healthcare provider if you experience progressive skin rash that is red, scaly, shows scarring, and loss of pigment.
The most common side effects of Sebifin include diarrhea, headache, rash, dyspepsia, pruritus, nausea, taste disturbance, flatulence, abdominal pain, liver enzyme abnormalities, and flatulence. Tell your healthcare specialist if you develop any side effects that bother you or don’t go away.
To help resolve the infection completely, you must keep taking the drug for the prescribed period even if your symptoms resolve or you begin to feel better in a few days. Since fungal infections take time to clear up, treatment discontinuation too soon can cause the fungal infection or related symptoms to flare up again.
For adults, the dose prescribed by the healthcare provider will depend on the type of infection and its nature (mild or serious). The suggested dose is 250 mg once daily. You should swallow the pills with a glass of water. You can take the tablet before or after consuming food. If you suffer from kidney problems, your healthcare provider may reduce your dose to half the recommended dose. Your healthcare specialist will tell you how long your terbinafine treatment will last. Your treatment of general fungal skin infection will probably last for four weeks. Treatment for the groin or body will normally last between 2 to 4 weeks, and that affecting the feet may last between 2 to 4 weeks and that affecting feet may last between 2 to 6 weeks. Your treatment of nail infections may last between 2 to 6 weeks, although toenail infection treatment may continue for six months or longer. Complete removal of the fungal infection may not occur until the infection is cured several weeks after treatment discontinuation. Sebifin is not recommended for children and adolescents under 18 years of age.
What is Sebifin 250mg used for?
Sebifin 250mg contains terbinafine 250mg — the standard oral tablet for systemic antifungal treatment. Primary indications: onychomycosis (nail fungus) — toenail 250mg daily for 12 weeks (70–80% mycological cure), fingernail 250mg daily for 6 weeks; tinea capitis (scalp ringworm — requires systemic treatment); extensive or resistant tinea corporis/pedis not responding to topical therapy; and Majocchi's granuloma (follicular tinea in hair follicles). Oral terbinafine concentrates highly in keratinised tissues (nails, skin, hair) through lipophilicity and protein binding — making it ideal for these keratinophilic dermatophyte infections.
How does oral Sebifin 250mg treat nail fungus?
After oral absorption, terbinafine is lipophilic and keratin-affine — it binds strongly to keratin in nails, skin, and hair. It concentrates to very high levels in the nail plate (reaching concentrations 5–10× above the MIC for dermatophytes) and persists for weeks after oral therapy stops (keratinophilic retention). This sustained nail concentration means that even after 12 weeks of oral terbinafine 250mg, antifungal levels remain therapeutic in the nail for a further 2–6 months — during which the diseased nail is replaced by new healthy nail. Clinical assessment of treatment success is made at 12 months (3 months after completing therapy) when the new nail has fully grown out.
How should Sebifin 250mg be taken for toenail onychomycosis?
Sebifin 250mg: one tablet once daily for 12 weeks for toenail onychomycosis. Take with or without food — bioavailability is slightly improved with food. Consistent daily dosing maximises keratinous tissue accumulation. LFTs should be checked at baseline — terbinafine is hepatotoxic in approximately 1 in 45,000–120,000 cases; higher risk in patients with pre-existing liver disease. Clinical cure (clear nail) assessed at 12 months — allow 9–12 months for the full toenail to grow out following treatment. 70–80% mycological cure (no viable fungi) at 12 months; 35–50% complete clinical cure (clear nail appearance). Combination with topical amorolfine nail lacquer weekly may improve clinical outcomes.
What is the hepatotoxicity risk with Sebifin 250mg?
Oral terbinafine can cause serious hepatotoxicity — including cholestatic hepatitis and fulminant hepatic failure (very rare, estimated 1 in 45,000–120,000 courses). Symptoms: nausea, fatigue, anorexia, jaundice, dark urine, right upper quadrant pain. Monitoring: LFTs at baseline; recheck at 4–6 weeks (particularly if symptoms develop); routine monthly monitoring is not required for healthy patients but is recommended in those with pre-existing liver disease. Stop terbinafine immediately if LFTs exceed 2× upper limit of normal or if symptomatic hepatitis occurs. Contraindicated in active hepatic disease. The absolute hepatotoxicity risk is very low but the consequence can be severe — baseline LFTs are mandatory.
Is Sebifin 250mg safe in patients with kidney disease?
Terbinafine is primarily hepatically metabolised; its metabolites are renally cleared. In mild renal impairment (eGFR 40–60): no dose adjustment required but monitor. In moderate-to-severe renal impairment (eGFR <30): terbinafine is generally not recommended (insufficient PK data, risk of metabolite accumulation). Dialysis does not effectively remove terbinafine due to its high lipophilicity and protein binding. Assess renal function before prescribing 12-week toenail courses. In patients with both hepatic and renal impairment, terbinafine should be avoided or used only with specialist guidance.
What drug interactions affect Sebifin 250mg?
Terbinafine is a potent CYP2D6 inhibitor — significant interactions: tricyclic antidepressants (amitriptyline, nortriptyline — levels doubled; risk of arrhythmias, anticholinergic toxicity); SSRIs metabolised by CYP2D6 (fluoxetine, paroxetine — increased levels); antipsychotics (haloperidol, risperidone — increased levels); beta-blockers (metoprolol, propranolol — increased levels, bradycardia risk). Rifampicin reduces terbinafine levels by 100% (enzyme induction) — no co-administration. Cimetidine increases terbinafine levels by 33%. Caffeine metabolism reduced. Warfarin: some reports of INR changes; monitor. No significant CYP3A4 interactions — terbinafine has a more limited interaction profile than triazoles.
How does Sebifin 250mg compare to fluconazole for onychomycosis?
Oral terbinafine 250mg daily for 12 weeks and fluconazole 150mg weekly for 12–18 months both treat toenail onychomycosis. Terbinafine is significantly superior: mycological cure rates 70–80% vs. 40–50% for weekly fluconazole. Terbinafine is the gold standard oral treatment for dermatophyte nail fungus in all major guidelines. Fluconazole's advantages: once-weekly dosing (better adherence), broader spectrum (also effective against Candida nail infections), and fewer drug interactions through CYP2D6 only. For Candida onychomycosis (more common in fingernails and immunocompromised patients), fluconazole or itraconazole may be preferred. For dermatophyte toenail fungus, terbinafine is first-line.
Is Sebifin 250mg equivalent to Lamisil 250mg?
Yes. Sebifin 250mg and branded Lamisil 250mg both contain terbinafine hydrochloride 250mg in bioequivalent oral formulations. Sebifin is the generic alternative providing the same antifungal efficacy for nail fungus and other systemic fungal infections at significantly lower cost.
Can I order Sebifin 250mg from PremiumRxDrugs for international delivery?
Yes. PremiumRxDrugs.com ships Sebifin 250mg to the USA, UK, Australia, and many other countries. Our genuine manufacturer-verified antifungal medications, competitive pricing, and free worldwide shipping on qualifying orders make us a reliable international source for oral terbinafine.
What side effects does Sebifin 250mg cause?
Common: GI symptoms (nausea, diarrhoea, abdominal discomfort — take with food), headache, and rash. Taste disturbance (dysgeusia) — a characteristic and reversible side effect in 2–3% of patients, ranging from taste changes to complete loss of taste (ageusia); usually resolves within weeks of stopping but can rarely persist for months. Hepatotoxicity (see above). Skin: generalised pruritus, urticaria, and rarely serious skin reactions (SJS — very rare). Haematological: rarely neutropenia, thrombocytopenia. Worsening psoriasis and lupus-like reactions reported. Report any severe skin reactions, jaundice, unusual tiredness, or taste changes to your doctor promptly.
How is treatment response to Sebifin 250mg assessed and what does success look like?
Terbinafine treatment response assessment: after completing 12 weeks, new nail growth should be visible at the proximal nail fold (nail base). Clear nail growing down from the base is a positive sign. Full toenail replacement takes 9–12 months from treatment completion — assessment of mycological and clinical cure is made at 12 months. Success criteria: mycological cure (negative nail culture and microscopy) in 70–80%; clinical cure (completely clear nail) in 35–50%; complete cure (both) in 25–50%. Poor responders: distal/lateral nail involvement, total nail dystrophy, or nail matrix involvement are harder to cure. Oral terbinafine 250mg for a second 12-week course is sometimes required for partial responders.
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