Seroflo Rotacaps 50mcg 500mcg
Available Dosages
| Description |
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|---|---|
| SKU | 926 |
| Generic For | Advair Rotacaps |
| Strength | 50mcg + 500mcg |
| Active Ingredient | Salmeterol + Fluticasone Propionate |
| Pack Size | Qty | Price Per Pill or Unit | Price | Cart | |
|---|---|---|---|---|---|
| 30 Rotacaps | US$ 0.52 | US$ 15.50 | |||
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| 60 Rotacaps | US$ 0.50 | US$ 30.003%US$ 31.00 | |||
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| 90 Rotacaps | US$ 0.47 | US$ 42.0010%US$ 46.50 | |||
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Seroflo Rotacaps 50mcg 500mcg – Affordable Advair Rotacaps Alternative
Seroflo Rotacaps 500mcg is prescribed for preventing asthma and chronic obstructive pulmonary disease (COPD). The combination medicine is a long-term treatment to prevent or decrease breathing problems and wheezing caused by asthma or ongoing lung disease. The multi Haler does not work immediately and should not be used for sudden asthma attacks.
The physician prescribes it for the maintenance treatment of asthma and patients requiring oral corticosteroid therapy for asthma. The combination formulation is the only treatment for asthma and a controlling agent for COPD; it should not be used as a cure for the problem.
Seroflo Rotacaps 500mcg Haler contains two active ingredients: Fluticasone Propionate and Salmeterol. Both drugs work together to prevent asthma attacks. Fluticasone propionate falls into the corticosteroid category; it helps keep a check on releasing the substance that causes inflammation. Salmeterol Xinafoate, another active ingredient of the medication, is a bronchodilator, which works by relaxing the muscles and allowing easy breathing by opening up the airways in the lungs.
Precautions and warning
Seroflo Rotacaps 500mcg may affect the working of other drugs, and other drugs may affect the mechanism of action of Fluticasone Propionate and Salmeterol.
Please tell your doctor if you are taking or have recently taken any other drugs, including drugs obtained without a prescription.
The following medicines should be avoided if the doctor prescribes you a Seroflo Multihaler to avoid possible drug interactions.
- Boceprevir
- Diuretics
- Linezolid
- Macrolides
- Telithromycin
- Macrolides
- Xanthines
- Sympathomimetics drugs
- Atenolol
- Nefazodone
- Digitalis
- Ketoconazole
- Telithromycin
Seroflo Multi Haler should not be used in patients with a known hypersensitivity to Fluticasone Propionate, Salmeterol, and any other components of the preparation. It is not recommended for children under four years of age. Pregnant or expecting women should consult a gynecologist if they are prescribed this medicine.
Some common side effects of Seroflo Rotacaps 500 mcg include mild fever, nausea, bleeding of the nose, tightness in the chest, cough, vomiting, stuffy nose, hoarseness in the voice, sneezing, sores on the lips or mouth, and sinus pain.
The most commonly reported side effects of Salmeterol are given below:
- Nervousness
- Shaking hands
- Headache
- Inability to sleep
- Low potassium levels in the blood
- Rash
- Very fast heart rate
How to use?
While using the Seroflo Multihaler, you need to keep a few things in mind:
- The dosage of Seroflo multihaler depends on the age and severity of the condition. Therefore, use this medication only as directed by your physician.
- Before starting to inhale, you need to shake the multihaler gently. Shake it for every five seconds after each spray.
- It is recommended to rinse the mouth after each spray as this will reduce the risk of yeast infection in the mouth.
- Seroflo mutihaler should be used as long as the physician recommends. You must always consult your physician before stopping or altering the dosage.
Ask your physician if you have any queries about using this medicine.
You should not attempt to double your next dose if you miss one. Skip the missed dose if the time to take the next dose is near, and then take your next dose as per the recommended dosing schedule.
Seroflo Rotacaps 500mcg should be stored at room temperature in an airtight container. Always keep it away from heat and moisture.
What are Seroflo Rotacaps 50/500mcg used for?
Seroflo Rotacaps 50/500mcg contain salmeterol 50mcg and fluticasone propionate 500mcg in a dry powder inhaler (DPI) rotacap format. This is the highest-strength combination formulation, used for severe asthma in adults who are not adequately controlled on medium-high dose ICS/LABA therapy. The 500mcg fluticasone dose provides near-maximal anti-inflammatory benefit. These rotacaps are loaded into a Rotahaler device and inhaled as dry powder.
How do Seroflo Rotacaps work differently from the pressurised inhaler?
Seroflo Rotacaps are dry powder inhaler (DPI) formulations — no propellant is needed. The patient loads a rotacap into a Rotahaler device, which pierces the capsule on actuation. Inhaling forcefully draws the dry powder into the lungs. DPIs are breath-actuated (no coordination required), making them easier for some patients than pMDIs. The 50mcg salmeterol and 500mcg fluticasone per rotacap delivers a higher fluticasone dose than the pMDI formulations, intended for severe or difficult-to-control asthma.
How should Seroflo Rotacaps be used correctly?
Load one rotacap into the Rotahaler device. Close the device to pierce the capsule. Breathe out fully (away from the device), place mouthpiece to lips, and inhale rapidly and deeply. Hold breath for 10 seconds, then exhale slowly. Check the capsule is empty after each use. The standard dose is one rotacap (50/500mcg) twice daily. Rinse mouth after each use. Store rotacaps at room temperature in their foil strip, removing only immediately before use.
When should Seroflo 50/500mcg be stepped up to from lower strength formulations?
Seroflo 50/500mcg is used when step-up is required from 25/125mcg or 25/250mcg pMDI formulations in patients with persistent uncontrolled asthma. Step-up to 500mcg fluticasone daily is considered when: significant nocturnal symptoms persist, rescue inhaler use exceeds 3 times per week, FEV1 remains significantly reduced, or recurrent acute exacerbations occur despite lower doses. Stepping up should be followed by reassessment at 4–8 weeks and step-down when control is achieved.
Is 500mcg fluticasone safe for daily use?
Fluticasone 500mcg per rotacap (1000mcg/day total from twice-daily dosing) is a high-dose ICS. Systemic effects — HPA axis suppression, reduced bone density, skin bruising, cataracts — are more likely with prolonged high-dose use than with lower doses. The aim should be to achieve control and then step down to the lowest effective dose. Annual bone density monitoring, ophthalmological review, and growth monitoring in children are recommended. High-dose ICS is still substantially safer than regular oral corticosteroids.
Who should not use Seroflo Rotacaps 50/500mcg?
High-dose ICS/LABA is not appropriate for initial asthma management. These rotacaps should not be used as rescue inhalers. They are not recommended in patients below the age requiring severe-asthma treatment. Patients with active pulmonary tuberculosis, severe milk protein allergy (DPI formulations contain lactose), or those unable to generate sufficient inspiratory flow for DPI devices should consider alternative formulations. Use during pregnancy requires careful respiratory monitoring.
How does Seroflo 50/500mcg compare to Seretide Accuhaler 50/500mcg?
Seroflo 50/500mcg Rotacaps and Seretide Accuhaler 50/500mcg (Advair Diskus 50/500 in the USA) both contain the same active ingredients in DPI format. Seretide uses an Accuhaler (Diskus) device; Seroflo uses the Rotahaler capsule device. Both deliver equivalent drug doses. The device preference varies by patient — some prefer the convenience of the Accuhaler; others adapt well to the Rotahaler. Both are bioequivalent formulations with the same efficacy and safety profiles.
Is Seroflo 50/500mcg the strongest available salmeterol/fluticasone combination?
Yes, 50/500mcg is the highest dose available in the salmeterol/fluticasone range (Seretide/Seroflo product family). The salmeterol dose is 50mcg per puff (100mcg/day from twice-daily dosing) — the approved maximum LABA dose in this combination. Beyond this strength, asthma management escalates to add-on therapies (LAMA, biologicals) rather than higher ICS/LABA doses. Regular specialist review is appropriate for patients requiring this high-strength maintenance.
Can I order Seroflo 50/500mcg from PremiumRxDrugs for international delivery?
Yes. PremiumRxDrugs.com ships Seroflo Rotacaps 50/500mcg to the USA, UK, Australia, and many countries worldwide. Our genuine manufacturer-verified medicines, transparent pricing, and free worldwide shipping on qualifying orders makes us a trusted source for patients managing severe asthma requiring high-dose combination inhaler therapy.
What side effects are associated with Seroflo Rotacaps 50/500mcg?
At the 500mcg fluticasone dose, the risk of systemic corticosteroid effects is higher than with lower ICS doses. Oral candidiasis and hoarseness are common local effects — mouth rinsing after each dose is essential. Salmeterol 50mcg may cause tremor, palpitations, and hypokalaemia, particularly in patients also using SABA inhalers or diuretics. With prolonged high-dose use: easy skin bruising, reduced bone density, and adrenal suppression are possible. Report unexplained weight gain or fatigue to your doctor.
What precautions are essential for users of Seroflo 50/500mcg rotacaps?
At this high ICS dose: rinse mouth and throat after every dose without exception. Annual DXA bone scans are advisable for long-term users. Regularly review with a respiratory specialist whether stepping down is possible. Never stop abruptly. Carry a short-acting reliever inhaler at all times. Inform all doctors and dentists you are on high-dose ICS as it may affect wound healing and infection risk. Children on high-dose ICS should have growth monitored every 6 months.
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