Triluma Cream for Melasma Treatment

by | Nov 1, 2022 | Melasma | 0 comments

Triluma cream is the only FDA-approved melasma treatment with three active ingredients, uniquely combined and more effective than treatments containing only two ingredients. It is a triple combination topical therapy for the short treatment of the dark spots associated with moderate to severe facial melasma.   

  • Fluocinolone acetonide 0.01%- It is a mild corticosteroid that reduces inflammation
  • Hydroquinone 4%- It is a depigmenting agent that interrupts the formation of melanin (pigment) to help lighten the skin.  
  • Tretinoin 0.05%- It increases the skin cell turnover rate, which helps exfoliate the skin. 

The triple combination medicine should always be used with sun avoidance measures, like wearing sunscreens and protective clothing. Regular use of Tri-luma cream may improve the appearance of melasma but is not a cure. Keep reading to learn almost everything you know about using Triluma cream Buy online to get the best price of melasma formulation.   

What to expect from Triluma cream

Melasma is a common hyperpigmentation disorder affecting the face and associated with considerable psychological impacts. The management of melasma is challenging and requires a long treatment plan. Therapeutic goals for hyperpigmentation include destroying melanosomes, inhibiting melanocyte formation, and delaying the spread of melanocytes.  

Hydroquinone is a commonly prescribed topical therapy for melasma, but it is combined with other medications due to its lower effectiveness as monotherapy and relapse. The combination of hydroquinone, tretinoin, and topical steroids can provide better therapeutic outcomes and can also be tolerated by patients. Hydroquinone is the main treatment for melasma but is relatively low efficacy as a monotherapy, and recurrences are common. The whitening effect of hydroquinone is seen after 2 to 3 weeks of daily use. However, the desired effects take longer.         

How to apply tri-luma cream

Tri-luma cream should always be used as instructed by the dermatologist. Follow the below tips to use the topical medications:

  1. Apply the cream at night, at least half an hour before bedtime.
  2. Gently wash your face with a mild cleanser. Rinse and pat your skin dry.
  3. Put a pea-sized amount or half an inch or less on your fingertip. Apply a thin coat onto the discoloured spots.
  4. After you have used the topical medicine for a while, you may find that you need slightly less to do the job.   
  5. Rub the medicine uniformly into the skin. This way, the medicine should become invisible almost once. If you can still see, you are using too much.
  6. Keep the topical medicine away from the corners of your nose, eyes, mouth, and open wounds. Spread away from these areas when applying for medicine.
  7. Please do not use this medication or apply it more often than your doctor recommends. Too much of this medicine may irritate your skin and not give you faster or better results.  
  8. Do not cover the treated area with anything after applying This triple combination formulation.
  9. While using Triluma may experience dryness, burning, peeling, itching, or other skin irritation. If your skin gets too irritated, discontinue using the cream and inform your doctor. The triple combination cream may also cause a gradual blue-black darkening of your skin; if this happens, discontinue therapy immediately and talk to your doctor. To help avoid skin dryness, you may have to use a moisturizer in the morning after you wash your face.
  10. You may also use other cosmetics during the day.
  11. Use a sunscreen of SPF at least 30 and a wide-brimmed hat over the treated areas. It requires only a small amount of sunlight, not just a sunburn, to worsen melasma. If you get sunburned, discontinue therapy with Triluma cream until your skin is healed. After treatment discontinuation, continue to protect your skin from sunlight.

Only your dermatologist knows which other medicines may be helpful during treatment and will inform you if required. Please do not use other medicines unless your dermatologist approves them.


Triluma is a combination of fluocinolone acetonide 0.01%, hydroquinone 4%, and tretinoin 0.05%, indicated for the short-term treatment of moderate to severe facial melasma in the presence of measures for sun avoidance, including the use of sunscreens. Hydroquinone may cause gradual blue-black darkening of the skin; therefore, it should be best used under the supervision of a dermatologist. Triluma cream, when used appropriately, helps fade the appearance of dark spots and patches of melasma.   

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