Triluma Cream for Melasma Care

by | Aug 18, 2023 | Melasma | 0 comments

Triluma combines fluocinolone acetonide, hydroquinone, and tretinoin to cause a reduction in the appearance of dark spots associated with moderate to severe melasma. It is the only FDA-approved prescription, fixed-dose combination medicine for facial melasma.

Triluma: Melasma treatment that’s one of a kind 

  1. Help reduce inflammation 

Fluocinolone acetonide 0.01% is a corticosteroid that has anti-inflammatory effects. It works by inhibiting melanin synthesis by decreasing cellular metabolism.    

  • Even our skin tone

Hydroquinone 4% is a depigmenting agent that interferes with the formation and synthesis of melanin to help lighten skin tone.    

  • Effective in protecting skin for long term

Tretinoin 0.05% is a retinoid that may help in the prevention of the oxidation of hydroquinone and improves skin penetration and skin cell turnover, causing pigment elimination and reducing the risk of skin atrophy.   

Facts about melasma

If you suspect you may have melasma; you are not alone; over five million people are dealing with melasma. Although the skin problem’s exact cause is unknown, facial melasma can be triggered by excessive sun exposure, pregnancy, birth control pills, and hormone therapy. While melasma can affect, it is more common among women with darker skin tones.  

Triluma cream may improve the appearance of facial melasma, but it is not a cure and should always be used with sun avoidance measures. Protect your skin using an SPF of 30 or higher and wearing protective clothing. It is important to note that even a small amount of exposure to the sun can trigger or worsen melasma. The more you know this skin condition, the better you can control its impact. Ask your dermatologist for more details and if FDA-approved Triluma cream is appropriate.   

Side Effects of Triluma

Some patients may get severe allergic reactions to Tri-luma cream due to sulfites in the formulation. In some cases, these allergic adverse effects may contribute to severe asthma attacks that can be life-threatening. While you apply Triluma cream, your skin develops mild to moderate redness, itching, burning, dryness, and peeling. Because this melasma formulation carries a corticosteroid medicine as one of its active components, some side effects have been reported with regular application of corticosteroids on the skin. These include dryness, itching, irritation, acne, hair follicle infection, skin thinning, sweat problems, stretch marks, and skin infection. 

In addition, corticosteroids may produce reversible effects on the adrenal gland called hypothalamic-pituitary-adrenal axis suppression, so it is important to inform your healthcare provider if you are already dealing with a condition that may interfere with your adrenal function, such as Addison’s disease.

In some patients, Tri-luma cream can cause dark spots on their skin, increased skin sensitivity, acne, tingling, acne, rash, and skin redness caused by rosacea, blisters, skin bumps, or blood vessels showing through the skin. The triple combination cream may also cause blue-black skin darkening; if this occurs, discontinue melasma treatment immediately and talk to your dermatologist. If you are concerned about how your skin reacts to this melasma preparation, speak to your dermatologist. 

Things to avoid while using Triluma cream

One should avoid natural sunlight and sunlamp/tanning booths. Triluma cream may increase your risk of sunburn or developing other unwanted effects from the sun’s ultraviolet rays. Your existing patches may also become darker when your skin is exposed to sunlight. Any level of sun exposure can trigger melasma, and you don’t have to develop sunburned to make your melasma worse. Skin protection against the sun is key to preventing the darkening of existing dark patches and the formation of new ones. 

Furthermore, staying away from the sun is especially important for women on contraceptives or hormone replacement therapy and for people who have developed patches in the past.  

Be sure to follow these guidelines regarding sun exposure when using Triluma cream:

  • Use good quality sunscreen when you step out, even on hazy days. Use sunblock year around areas of the skin that are exposed to sunlight, such as your face and hands. If possible, try to protect your treated area from sun exposure.  
  • If you can’t resist sun exposure and spend much time in the sun, be especially careful. Discuss with your dermatologist what level of SPF you may need for a high level of protection. Your protective clothing should also include a hat.  

Melasma in men and women can be lightened with Triluma cream, making them barely visible. Melasma therapy can completely transform the skin.  


Triluma cream is the only FDA-approved topical treatment available for treating dark spots associated with moderate to severe facial melasma for the short term for up to eight weeks. The precise combination of three active ingredients works to deliver clear results. Triluma buy Online at an affordable price at Premiumrxdrugs.

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