The Usage of Aromasin 25mg

11 Aug
2018
By Marie

Aromasin 25mg is basically prescribed to treat breast cancer. This medication is an anti-estrogen that can prevent the synthesis of estrogen by producing aromatase, which is an enzyme, to reduce the risk of breast cancer. Aromasin tablets are widely recommended for the treatment of breast cancer in postmenopausal women who experience the consistent progress of this disease following the intake of tamoxifen for metastatic disease or as adjuvant therapy. It has no adverse effect on adrenal biosynthesis of corticosteroids or aldosterone.

Working and Usage of Aromasin 25mg:

The primary function of Aromasin 25 mg is to lower the amount of estrogen (natural female hormone) in the body. It is an aromatase inhibitor that prevents the conversion of androgens into estrogens both in pre- and postmenopausal women so the risk of breast cancer is lowered. In premenopausal women, the main source of estrogen (primarily estradiol) is the ovary, where conversion of adrenal and ovarian androgens (androstenedione and testosterone) into estrogens (estrone and estradiol) takes place. The aromatase enzyme in peripheral tissues instigates this process. Aromasin 25mg tabs inhibit such estrogens for the treatment in the postmenopausal women with hormone-dependent breast cancer. It is indicated for adjuvant treatment of postmenopausal women with estrogen receptor-positive early breast cancer who have received two to three years of tamoxifen. However, Aromasin is not advised to administer in premenopausal women.

The content of Aromasin 25mg

The active ingredient of the off-white Aromasin tablet is exemestane. Also, it has some inactive ingredients that include mannitol, crospovidone, magnesium stearate, simethicone, cetyl esters wax, talc, carnauba wax, polyethylene glycol 6000, colloidal silicon dioxide, microcrystalline, Polysorbate 80, hypromellose, cellulose, sodium starch glycolate, sucrose, magnesium carbonate, titanium dioxide, methylparaben, and polyvinyl alcohol.

Side Effects of Aromasin 25mg:

The probable side effects (including major and minor) of Aromasin 25 mg tablet include:

  • Mental depression
  • Bone and joint pain
  • Weight gain
  • Difficult or painful urination
  • Hypersensitivity
  • Shortness of breath
  • Hot flushes
  • Increased sweating
  • Trouble sleeping
  • Chest pain
  • Swelling of ankles or feet

Some other side effects associated with Aromasin are fatigue, increased sweating, low-grade nausea, hot flashes, and increased appetite. However, these side effects are rare, and if you experience any serious conditions, consult your doctor for medical aid.

Medications Interact with Aromasin 25mg: 

The active ingredient exemestane is metabolized by cytochrome and Aldo ketoreductases. The co-medications of rifampicin, phenytoin, carbamazepine, or Phenobarbital may decrease the exposure to exemestane. Exemestane 25mg should not be co-administered with estrogen-containing medications (hormone replacement therapy or birth control pills) as these drugs can interfere with its action. However, no extreme drug interaction with exemestane is found in the clinical trial so far.

When should Aromasin 25mg not be used?

Aromasin 25 mg tablet is not safe to take for pregnant women. Research studies have shown significant adverse effects on the fetus. It is also not safe to use during lactation; exemestane may cause toxicity to the baby. The consumption of Aromasin tablet may feel you dizzy, sleepy, or tired, so avoid driving or concentrating on the computer screen immediately after taking it.

The correct way to consume Aromasin:

Aromasin 25mg tablets can be taken orally. Usually, one tablet a day is prescribed. You have to complete the medication course as per the advice of your doctor.

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